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Elaboration And Design Of Α7 Nachr Negative Allosteric Modulators, Osama I. Alwassil

Theses and Dissertations

α7 Neuronal nicotinic acetylcholine receptors are one of two major classes of receptors responsible for cholinergic neurotransmission in the central nervous system. The existence of α7 neuronal nAChRs in different regions of the nervous system suggests their involvement in certain essential physiological functions as well as in disorders such as Alzheimer’s disease (AD), drug dependence, and depression. This project was aimed toward the discovery and development of small–molecule arylguanidines that modulate α7 nAChR function with improved subtype-selectivity through an allosteric approach. Identifying the required structural features of these small molecules allowed optimization of their negative allosteric modulator (NAM) actions at …

Oropouche Virus Infection And Pathogenesis Are Restricted By Mavs, Irf-3, Irf-7, And Type I Interferon Signaling Pathways In Nonmyeloid Cells, Jose Luiz Proenca-Modena, Renata Sesti-Costa, Amelia K. Pinto, Justin M. Richner, Helen M. Lazear, Tiffany Lucas, Jennifer L. Hyde, Michael S. Diamond

Open Access Publications

No abstract provided.

Instrumentation And Development Of A Mass Spectrometry System For The Study Of Gas-Phase Biomolecular Ion Reactions, Ziqing Lin

Open Access Dissertations

Gas-phase reactions of biomolecular ions are highly relevant to the understanding of structures and functions of the biomolecules. Mass spectrometry is a powerful tool in investigating gas-phase ion chemistry. Various mass spectrometers have been developed to explore ion/molecule reactions, ion/ion reactions, ion/photon reactions, ion/radical reactions etc., both at atmospheric pressure and in vacuum. In-vacuum reactions have an advantage of involving pre-selecting the ions for the reactions using a mass analyzer. Over the decades, a variety of mass analyzers have been employed in the research of ion chemistry. Hybrid configurations, such as quadrupole ion trap with a time-of-flight and or a …

Synthesis, Characterization, And Rna Reactivity Of Amino-Acid-Linked Cisplatin Analogues, Xun Bao

Wayne State University Dissertations

The essential role of ribosomal RNA (rRNA) in the cell life cycle is highlighted by protein synthesis; therefore, the ribosome is considered to be an ideal drug target. Ribosomal RNAs exhibit a high level of structural diversity. The well-known anticancer drug cisplatin was previously applied as a chemical probe of rRNA structure to determine solvent accessible purines (guanosine) in vivo and in vitro. Cisplatin accumulates faster on RNA than DNA, with less chance of repair. As such, designing new RNA-targeting Pt compounds is not only a promising direction for chemical-probing applications, but also for the design of anticancer drugs that …

Plant Species Rather Than Climate Greatly Alters The Temporal Pattern Of Litter Chemical Composition During Long-Term Decomposition, Yongfu Li, Na Chen, Mark E. Harmon, Yuan Li, Xiaoyan Cao, Mark A. Chappell, Jingdong Mao

Chemistry & Biochemistry Faculty Publications

A feedback between decomposition and litter chemical composition occurs with decomposition altering composition that in turn influences the decomposition rate. Elucidating the temporal pattern of chemical composition is vital to understand this feedback, but the effects of plant species and climate on chemical changes remain poorly understood, especially over multiple years. In a 10-year decomposition experiment with litter of four species (Acer saccharum, Drypetes glauca, Pinus resinosa, and Thuja plicata) from four sites that range from the arctic to tropics, we determined the abundance of 11 litter chemical constituents that were grouped into waxes, carbohydrates, …

Chmy 223.01: Organic Chemistry Ii, Orion B. Berryman

University of Montana Course Syllabi

No abstract provided.

Potential Antineoplastic Structural Variations Of Uracil Mustard (Uramustine) Retaining Cytotoxic Activity And Drug-Likeness Suitable For Oral Administration, Ronald Bartzatt

Chemistry Faculty Publications

Aims: To present 12 new variants of uracil mustard having drug-like properties and cytotoxic functional group, by utilizing uracil mustard (uramustine) as a lead compound. Utilize rigorous substructure and similarity of a molecular scaffold to determine drug like variants. Physicochemical properties determined indicate the variants have favorable drug-likeness.

Study Design: Conduct molecular database search utilizing features of substructure and similarity based upon uracil mustard. Place and Duration of Study: Department of Chemistry, Medicinal Chemistry Study Section, University of Nebraska at Omaha, Omaha Nebraska between January 2015 to March 2015.

Methodology: Uracil mustard consists of the pyrimidine derivative uracil, …

Synthesis And Characterization Of Cyclodextrin Functionalized Ionic Liquid Polymer For The Extraction Of Phenols / Muggundha Raoov A/L Ramachandran, Muggundha Raoov Ramachandran

Student Works (2010-2019)

β-Cyclodextrin functionalized ionic liquid polymer (βCD-BIMOTs-TDI) was first synthesized by functionalized β-cyclodextrin (CD) with 1-benzylimidazole (BIM) to form monofunctionalized CD (βCD-BIMOTs), and was further polymerized using toluene diisocyanate (TDI) as a linker to form insoluble βCD-BIMOTs-TDI. The βCDBIMOTs- TDI was characterized using various tools and the results obtained were compared with those derived from the native β-cyclodextrin polymer (βCD-TDI). The scanning electron microscope (SEM) results showed that the presence of ionic liquid (IL) increased the pore size, while the thermo gravimetric analysis (TGA) results showed that the presence of IL increased the stability of the βCD-BIMOTs-TDI. Meanwhile, Brunauer-Emmett-Teller (BET) result …

Preparation And Characterization Of Self-Assembled Monolayers And Mesoscale Protein Patterning, Panae Noomuna

Online Theses and Dissertations

Bottom-up approach was used to develop self-assembled monolayers of octadecyltrichlorosilane (OTS) and undecenyltrichlorosilane(UTS) on Si(100) wafer. Undecenyltrichlorosilane monolayer was oxidized at the vinyl terminal to generate a carboxylic acid group. Lysozyme protein was immobilized on the polar carboxylic acid group. The developed protein patterns were investigated using fluorescence microscopy. Lysozyme has an isoelectronic point of 11.35. At a pH below this value the protein is positively charged making it a good candidate for electrostatic adsorption on the negatively charge -COO- group. Fluorescence images confirm formation of lysozyme across the silicon wafer. The patterned Si(100) wafer can be used as a …

Upper Tropospheric Ozone Production From Lightning NoX-Impacted Convection: Smoke Ingestion Case Study From The Dc3 Campaign, E. C. Apel, R. S. Hornbrook, A. J. Hills, N. J. Blake, M. C. Barth, A. Weinheimer, C. Cantrell, S. A. Rutledge, B. Basarab, J. Crawford, G. Diskin, C. R. Homeyer, T. Campos, F. Flocke, A. Fried, D. R. Blake, W. Brune, I. Pollack, J. Peischl, T. Ryerson, P. O. Wennberg, J. D. Crounse, A. Wisthaler, T. Mikoviny, G. Huey, B. Heikes, D. O'Sullivan, D. D. Riemer

United States National Aeronautics and Space Administration: Publications

As part of the Deep Convective Cloud and Chemistry (DC3) experiment, the National Science Foundation/National Center for Atmospheric Research (NCAR) Gulfstream-V (GV) and NASA DC-8 research aircraft probed the chemical composition of the inflow and outflow of two convective storms (north storm, NS, south storm, SS) originating in the Colorado region on 22 June 2012, a time when the High Park wildfire was active in the area. A wide range of trace species were measured on board both aircraft including biomass burning (BB) tracers hydrogen cyanide (HCN) and acetonitrile (ACN). Acrolein, a much shorter lived tracer for BB, was also …

Upper Tropospheric Ozone Production From Lightning NoX‐ Impacted Convection: Smoke Ingestion Case Study From The Dc3 Campaign, E. C. Apel, R. S. Hornbrook, A. J. Hills, N. J. Blake, M. C. Barth, A. Weinheimer, C. Cantrell, S. A. Rutledge, B. Basarab, J. Crawford, G. Diskin, C. R. Homeyer, T. Campos, F. Flocke, A. Fried, D. R. Blake, W. Brune, I. Pollack, J. Peischl, T. Ryerson, P. O. Crounse, A. Wisthaler, T. Mikoviny, G. Huey, Brian G. Heikes, D. O'Sullivan, D. D. Riemer

Graduate School of Oceanography Faculty Publications

As part of the Deep Convective Cloud and Chemistry (DC3) experiment, the National Science Foundation/National Center for Atmospheric Research (NCAR) Gulfstream‐V (GV) and NASA DC‐8 research aircraft probed the chemical composition of the inflow and outflow of two convective storms (north storm, NS, south storm, SS) originating in the Colorado region on 22 June 2012, a time when the High Park wildfire was active in the area. A wide range of trace species were measured on board both aircraft including biomass burning (BB) tracers hydrogen cyanide (HCN) and acetonitrile (ACN). Acrolein, a much shorter lived tracer for BB, was also …

Nmr T₁ Studies Of Colloidal Unimolecular Polymer (Cup) Surface Water, Yousef Abobaker Dawib

Doctoral Dissertations

"This dissertation is subdivided into three topics: Experimental study of colloidal unimolecular polymer (CUP) hydration; probing of polymer chain dynamics by ¹³C solid state NMR technique; and the anticorrosive effect of 5-mercapto-1, 3, 4-thiadiazole-2(3H)-thione (MTT) derivatives.

The states of water in colloidal unimolecular polymer system were investigated by low field proton NMR. Bound and free water fractions were determined using spin-lattice relaxation measurements. A model equation was used to analyze the inversion recovery data.

The proton cross polarization and the pulse sequence for total spinning sideband suppression CP-TOSS NMR method were developed to determine the chain mobility of polymers …

The Effectiveness Of Online Homework Tutorials As Compared To Pen And Paper Tutorials, Molly Shuman

LSU Master's Theses

The purpose of this study was to determine if students learn more from completing web based homework (WBHW) compared to completing homework by traditional means with pen and paper. Determining the efficacy of WBHW is important because many schools are being pressured to implement technology in the classroom. To determine the effectiveness of WBHW, student normalized learning gains were calculated from pre and post-test scores for 62 students. Learning gains were then compared when students completed WBHW, traditional homework, or did not complete homework at all, over four units in a high school chemistry class. No difference in learning gains …

Chemically Patterned Surfaces As Test Platforms To Study Magnetic And Solvent-Responsive Properties At The Nanoscale: Investigations Using Scanning Probe Microscopy, Shalaka Kulkarni

LSU Doctoral Dissertations

Chemically patterned surfaces were fabricated using a combination of molecular self-assembly and particle lithography to generate billions of nanostructures of organosilane self-assembled monolayers (SAMs). Monodisperse mesospheres were used as surface masks to prepare nanostructures on flat surfaces using the simple benchtop chemistry steps of mixing, centrifuging, evaporation, and drying. Periodic arrays of well-defined organosilane nanostructures serve as discrete surface sites for the selective deposition of polymers and magnetic nanoparticles.

In this dissertation, particle lithography approaches for surface patterning provide new directions for studying surface chemistry at the molecular-level using high resolution investigations with scanning probe microscopy (SPM). Atomic force microscopy …