Digital Commons Network^™

Legacy Specimens In The Ohio State Collection, James Hine, Bill Whan

Ohio Cardinal

No abstract provided.

Building A Better Infarct: Modulation Of Collagen Cross-Linking To Increase Infarct Stiffness And Reduce Left Ventricular Dilation Post-Myocardial Infarction, Andrew P. Voorhees, Kristine Y. Deleon-Pennell, Yonggang Ma, Ganesh V. Halade, Andriy Yabluchanskiy, Rugmani Padmanabhan Iyer, Elizabeth Flynn, Courtney A. Cates, Merry L. Lindsey, Hai Chao Han

Internal Medicine Faculty Publications

Matrix metalloproteinase-9 (MMP-9) deletion attenuates collagen accumulation and dilation of the left ventricle (LV) post-myocardial infarction (MI); however the biomechanical mechanisms underlying the improved outcome are poorly understood.The aim of this study was to determine the mechanisms whereby MMP-9 deletion alters collagen network composition and assembly in the LV post-MI to modulate the mechanical properties of myocardial scar tissue. Adult C57BL/6J wild-type (WT; n = 88) and MMP-9 null (MMP-9-/-; n = 92) mice of both sexes underwent permanent coronary artery ligation and were compared to day 0 controls (n = 42). At day 7 post-MI, WT LVs displayed a …

The Role Of Type Iii-Nrg1 Signaling In Excitatory Transmission In The Nucleus Accumbens, Ifeanyi Vincent Obiorah

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Nrg1-ErbB4 signaling is important for the maintenance of synaptic plasticity, and the fine-tuning of GABAergic, dopaminergic, cholinergic and glutamatergic neurotransmission. The Type III-isoforms of Nrg1 are predominantly targeted to dendrites and axons, and are expressed by the principal neurons of the hippocampus, cortex and amygdala. These neurons all send glutamatergic inputs into the nucleus accumbens, which expresses the Nrg1 receptor ErbB4. Integration of the information encoded by these Nrg1-expressing inputs, together with midbrain dopamine inputs is crucial for normal functioning of the accumbens. Based on the expression pattern of Type III-Nrg1 and its receptor, ErbB4, I propose that presynaptic Type …

Prometheus & Atlas: An Inquiry Into The Spectral Essence Of Technoscience, Jason Reza Jorjani

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Technological science has shattered the worldviews of all traditional cultures subjected to it, at times provoking reactionary religious responses that only underscore the traumatic force of this worldwide development. Yet, as I argue, this world-colonizing force is not neutral. The anticipatory projection and world-building characteristic of scientific theorization are grounded in a practical comportment, so that the essence of technology or Craft is ontologically prior to theoretical science. In other words, science is always already Technoscience. Moreover the theoretical concepts and methodologies involved in predictive calculation and in crafting frameworks that model and mold the world are derived from pre-conceptual …

Multilingual And Multicultural Identity Exploration, Tyler Mccloud

Honors College Theses

This Honors thesis is an attempt to analyze different aspects of Susana Chávez-Silverman’s identity as they emerge in her writing, Spanglish being the medium through which she voices this complexity.

An Investigation Of The Effect Of Malathion On Adaptive Plasticity Of Pseudacris Sierra, Michael Jonathan Maples

Master's Theses

This thesis is composed of two chapters. Chapter one reviews what is known about adaptive plasticity in response to predators, describes the physiological systems involved in such plasticity, and outlines the evolutionary consequences of adaptive plasticity. Chapter two describes a scientific experiment that investigates how malathion may impact adaptive plasticity in the Sierran Treefrog, Pseudacris sierra. Anuran tadpoles suffer high mortality rates due to predation. In response to strong selective forces relating to these high predation rates, tadpoles evolved the ability to adaptively respond to predators through morphological and behavioral plasticity. The morphological and behavioral responses are varied and depend …

Signature Simulation And Characterization Of Mixed Solids In The Visible And Thermal Regimes, Tyler D. Carson

Theses

Solid target signatures vary due to geometry, chemical composition and scene radiometry. Although radiative transfer models and function-fit physical models may describe certain targets in limited depth, the ability to incorporate all three of these signature variables is difficult. This work describes a method to simulate the transient signatures of mixed solids and soils by first considering scene geometry that was synthetically created using 3-d physics engines. Through the assignment of spectral data from the Nonconventional Exploitation Factors Data System (NEFDS) and other libraries, synthetic scenes are represented as a chemical mixture of particles. Finally, first principles radiometry is modeled …

A Deep Dive Into Liquefied Natural Gas ("Lng"): Is Lng A Clean Enough And Positive Energy Source For Globalized Trade Or A Port Nuisance?, Sydney Weathersby

Valparaiso University Law Review

No abstract provided.

Effects Of Land Management On Mammalian Species Abundance And Richness Among Four Sites In West-Central Georgia, Kelsey A. Champagne

Theses and Dissertations

No abstract provided.

Microbial Source Tracking Of Nonpoint Source Pollution In New Jersey Rivers, Matthew John Newton

Theses, Dissertations and Culminating Projects

The bodies of water of New Jersey serve many different purposes from recreational to agricultural and drinking to waste water treatment. Due to the vast diversity of usage and the many people that rely on these water bodies for everyday life it is essential that the health and quality of the water bodies is monitored and maintained regularly. Sources of pollution that affect the health of rivers, lakes and streams include biological, microbial, physical and chemical contaminants. All of these pollutions can impact the health of the water body, the organisms living in it and those who come into contact …

Pharmacodynamics Of Folic Acid Receptor Targeted Antiretroviral Nanotherapy In Hiv-1-Infected Humanized Mice., Pavan Puligujja, Mariluz Araínga, Prasanta Dash, Diana L. Palandri, R. Lee Mosley, Santhi Gorantla, Larisa Y Poluektova, Joellyn Mcmillan, Howard Gendelman

Journal Articles: Pharmacology & Experimental Neuroscience

Long-acting nanoformulated antiretroviral therapy (nanoART) can sustain plasma drug levels and improve its biodistribution. Cell targeted-nanoART can achieve this and bring drug efficiently to viral reservoirs. However, whether such improvements affect antiretroviral responses remains unknown. To these ends, we tested folic acid (FA)-linked poloxamer407-coated ritonavir-boosted atazanavir (FA-nanoATV/r) nanoparticles for their ability to affect chronic HIV-1 infection in humanized mice. Following three, 100mg/kg FA-nanoATV/r intramuscular injections administered every other week to infected animals, viral RNA was at or below the detection limit, cell-associated HIV-1p24 reduced and CD4+ T cell counts protected. The dosing regimen improved treatment outcomes more than two fold …

Prevalence Of A Chytrid Pathogen (Batrachochytrium Dendrobatidis) In Eastern Hellbender Salamanders In New York And Pennsylvania, Linxuan Wu

Biology Theses

Amphibian populations are currently declining globally. There are many possible causes for these declines, among which an emerging infectious disease, chytridiomycosis, has been implicated. Chytridiomycosis in the U.S.A. is mainly caused by the Batrachochytrium dendrobatidis. In this study, I used qPCR assays to detect the existence of this pathogen in the Eastern Hellbender (Cryptobranchus alleganiensis alleganiensis) populations in the Allegheny and Susquehanna River drainages of New York and Pennsylvania. Chytrid is most often tested by using skin swabs, but in this study, tail clips, dorsal skin, blood and eggs were tested as well. Batrachochytrium dendrobatidis was detected …

The Sea Lamprey Meiotic Map Improves Resolution Of Ancient Vertebrate Genome Duplications, Jeramiah James Smith, Melissa C. Keinath

Biology Faculty Publications

It is generally accepted that many genes present in vertebrate genomes owe their origin to two whole-genome duplications that occurred deep in the ancestry of the vertebrate lineage. However, details regarding the timing and outcome of these duplications are not well resolved. We present high-density meiotic and comparative genomic maps for the sea lamprey (Petromyzon marinus), a representative of an ancient lineage that diverged from all other vertebrates ~550 million years ago. Linkage analyses yielded a total of 95 linkage groups, similar to the estimated number of germline chromosomes (1n ~ 99), spanning a total of 5570.25 cM. …

Assuming The Risk After Hubner: New Jersey Supreme Court Opinion Spurs Revision Of The Equestrian Activities Liability Act, Vito J. Petitti

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

Delta Narratives: Saving The Historical And Cultural Heritage Of The Sacramento-San Joaquin Delta, Steve Boilard, Robert Benedetti, Margit Aramburu, Gregg Camfield, Philip Garone, Jennifer Helzer, Reuben Smith, William Swagerty, Marcia Eymann, Tod Ruhstaller, David Stuart, Leigh Johnsen, Dylan Mcdonald, Michael J. Wurtz, Blake Roberts, Margo Lentz-Meyer

College of the Pacific Faculty Reports

From August 2014 through July 2015, the Delta Narratives project, on contract to the Delta Protection Commission, addressed two questions. First, in what ways does the historical experience of the Sacramento-San Joaquin Delta contribute to an understanding of key themes in regional and American history? Second, how might Delta stories gain wider appreciation within the region, throughout Northern California, and among people in the rest of California and beyond?

Scholars on the project team documented ways the history of the Delta illustrates trends in land management and reclamation, technological shifts in transportation and agriculture, the impact of ethnicity and labor …

A Comparative Study Of The Population Dynamics Of Four Amaranthaceae Species, Lauren Michele Schwartz

Dissertations

Some of the most problematic agricultural weeds found in the Midwest United States are found in the Amaranthaceae family, such as Amaranthus palmeri and A. tuberculatus. These summer annual weeds are troublesome due to their competitive ability, high seed production, and resistance to herbicides from several modes of action which complicates management in field crops and has led to significant yield loss. Achyranthes japonica and Iresine rhizomatosa are two perennial species in the same family as A. palmeri and A. tuberculatus that occur in similar habitats as one another, but differ in invasiveness. Achyranthes japonica is a non-native, invasive species …

Thedor Kullak's "Scenes From Childhood," Op. 62, And Op. 81: A Pedagogical Guide, Jennifer Lynn Kottke

Theses

Theodor Kullak (September 12, 1818 - March 1, 1882) composed "Scenes from Childhood," Op. 62 and Op. 81 for young piano students. This thesis is a guide for teaching these pieces to intermediate piano students. Following Kullak's biography, aspects of note-reading, fingering, rhythm, technique, and musicality are discussed and illustrated in specific examples from the music.

The Role Of Silver Carp In The Trophic Position And Diet Of River Otters In Illinois, Preston Feltrop

Theses

Invasive prey species pose a threat to ecosystems and can alter food web and community dynamics. Populations of silver carp (Hypophthalmichthys molitrix), recognized with bighead carp (H. nobilis) as “Asian carp,” are growing rapidly in Illinois and may make up a large fraction of available prey for river otters (Lontra canadensis) in larger waterbodies. Asian carp occupy a considerably lower trophic level than most commonly recognized otter prey. My goals were 1) to assess the influence of consuming silver carp on the trophic position of Illinois otters using stable isotopes of nitrogen (δ15N) and carbon (δ13C), and 2) to assess …

Bioenergy And African Transformation, Lee R. Lynd, Mariam Sow, Annie Chimphango, Luis Cortez, Carlos H. Brito Cruz, Mosad Elmissiry, Mark Laser

Dartmouth Scholarship

Among the world’s continents, Africa has the highest incidence of food insecurity and poverty and the highest rates of population growth. Yet Africa also has the most arable land, the lowest crop yields, and by far the most plentiful land resources relative to energy demand. It is thus of interest to examine the potential of expanded modern bioenergy production in Africa. Here we consider bioenergy as an enabler for development, and provide an overview of modern bioenergy technologies with a comment on application in an Africa context. Experience with bioenergy in Africa offers evidence of social benefits and also some …

Therese Sellers, With Illustrations By Lucy Bell Jarka-Sellers, Alpha Is For Anthropos. Boston, Massachusetts: Ascanius, The Youth Classics Institute, 2013. Pp. 56. Cloth (Isbn 978-1-62847-491-6) $35.00., Nell Wright

New England Classical Journal

No abstract provided.

Genotype-By-Sequencing Of The Plant-Pathogenic Fungi Pyrenophora Teres And Sphaerulina Musiva Utilizing Ion Torrent Sequence Technology, Jared M. Leboldus, Kasia Kinzer, Jonathan Richards, Zhu Ya, Changhui Yan, Timothy L. Friesen, Robert Brueggeman

Faculty Publications

Genetic and genomics tools to characterize host-pathogen interactions are disproportionately directed to the host because of the focus on resistance. However, understanding the genetics of pathogen virulence is equally important and has been limited by the high cost of denovo genotyping of species with limited marker data. Non-resource-prohibitive methods that overcome the limitation of genotyping are now available through genotype-by-sequencing (GBS). The use of a two-enzyme restriction-associated DNA (RAD)-GBS method adapted for Ion Torrent sequencing technology provided robust and reproducible high-density genotyping of several fungal species. A total of 5783 and 2373 unique loci, 'sequence tags', containing 16441 and 9992 …

Point Of No Return From Water Loss In Coptotermes Formosanus (Isoptera: Rhinotermitidae), Bal K. Gautam, Gregg Henderson

Faculty Publications

Describing desiccation stages based on the physical appearance of termites has not been evaluated previously. Formosan subterranean termites were studied to determine the rate of water loss, singly and in groups, in the laboratory. The stages of water loss are described based on changes in physical appearance and percent total body water loss evaluated at 2- to 8-h time intervals up to 32 h.Workers in groups lost water slower than individual worker trials. Weight loss was linear over time for worker groups and individuals, as was individual soldier only trials. Water loss in individual workers was significantly faster than in …

Infectious Disease And Red Wolf Conservation: Assessment Of Disease Occurrence And Associated Risks, Kristin E. Brzeski, Rebecca B. Harrison, William T. Waddell, Karen N. Wolf, David R. Rabon, Sabrina S. Taylor

Faculty Publications

Infectious diseases pose a significant threat to global biodiversity and may contribute to extinction. As such, establishing baseline disease prevalence in vulnerable species where disease could affect persistence is important to conservation. We assessed potential disease threats to endangered red wolves (Canis rufus) by evaluating regional (southeastern United States) disease occurrences in mammals and parasite prevalence in red wolves and sympatric coyotes (Canis latrans) in North Carolina. Common viral pathogens in the southeast region, such as canine distemper and canine parvovirus, and numerous widespread endoparasites could pose a threat to the red Wolf population. The most prevalent parasites in red …

Effects Of Feeding Baleage To Beef Calves On Performance, Rumen Fermentation, And Metabolic Response During The Fall Backgrounding Period, R. M. Martin, R. S. Walker, M. T. Kearney, C. C. Williams

Faculty Publications

A total of 180 spring-born beef calves (BW = 217 ± 20.6 kg) were fed bermudagrass (Cynodon dactylon) or rye (Secale cereale) and ryegrass (Lolium multiflorum) baleage to evaluate performance, blood metabolites, rumen fermentation, and forage refusal for 60 d after weaning. Calves were stratified by BW, sex, and breed to 1 of 9 paddocks and fed 1 of 3 diets: 47-d-regrowth bermudagrass hay (BERH), 43-d-regrowth bermudagrass baleage (BERB), or late-bloom ryeryegrass baleage (LRRG). A CP liquid supplement was provided ad libitum for 60 d. Calves were weighed on d -1, 0, 29, 30, 60, and 61 for comparison of …

Tourism And Organic Food Production In Croatia: Case Study Of The Cetina Region, Marina Pavletic

Masters Theses

Croatia is an emerging tourist destination where attractive beaches, rich culture and culinary delights form a perfect combination for a great vacation. As the number of tourists visiting Croatia continues to grow, their demand for food is following suit. However, more than half of the food purchased in Croatia is imported, while agricultural land in many Croatian regions is neglected. As the largest number of Croatia’s tourists comes from the European Union, which spent €22 billion on organic food in 2014, this study looks at opportunities and challenges for organic farming in Croatia as an alternative to conventional agriculture in …

Nuestro Mundo A Martiano Exploration Of The Existential Impact Of Climate Change, Alejandro Chester Strong

Dissertations

This work is an account of meaning and value in the time of climate change. I use the findings and predictions of scientists to develop a philosophy of living that fits today's concerns. In essence the ideas put forward come from a single question: If humans can change the planet in such a way that it threatens the possibility of human life on Earth what does this mean for the place of humans on Earth? It is this question, which the every chapter hereafter works to answer. Establishing a philosophy of living and explaining a global ecological crisis is a …

Today - August 2015, Loma Linda University Health

TODAY

Inside this issue:

-- Final beam is placed for Loma Linda University Health - San Bernardino in topping-off ceremony
-- Loma Linda University Transplantation Institute leads all of Southern California in liver transplant survival
-- Cancer Center receives UniHealth Foundation grant
-- Innerweave The Wholeness Story
-- Center for Health Disparities holds annual research symposium
-- Off to work . . . one woman's story of retirement
-- Cheng Family Foundation presents $75,000 gift to Loma Linda University Eye Institute for children's intervention program
-- IndyCar racer visits Children's Hospital outpatient clinic
-- Loma Linda University Health reaches out to …

Intracellular Listeria Monocytogenes Comprises A Minimal But Vital Fraction Of The Intestinal Burden Following Foodborne Infection, Grant S. Jones, Kate M. Bussell, Tanya Myers-Morales, Abigail M. Fieldhouse, Elsa N. Bou Ghanem, Sarah E. F. D'Orazio

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Listeria monocytogenes is a highly adaptive bacterium that replicates as a free-living saprophyte in the environment as well as a facultative intracellular pathogen that causes invasive foodborne infections. The intracellular life cycle of L. monocytogenes is considered to be its primary virulence determinant during mammalian infection; however, the proportion of L. monocytogenes that is intracellular in vivo has not been studied extensively. In this report, we demonstrate that the majority of wild-type (strain EGDe) and mouse-adapted (InlA^m-expressing) L. monocytogenes recovered from the mesenteric lymph nodes (MLN) was extracellular within the first few days after foodborne infection. In addition, …

Amphiphilic Tobramycin Analogues As Antibacterial And Antifungal Agents, Sanjib K. Shrestha, Marina Y. Fosso, Keith D. Green, Sylvie Garneau-Tsodikova

Pharmaceutical Sciences Faculty Publications

In this study, we investigated the in vitro antifungal activities, cytotoxicities, and membrane-disruptive actions of amphiphilic tobramycin (TOB) analogues. The antifungal activities were established by determination of MIC values and in time-kill studies. Cytotoxicity was evaluated in mammalian cell lines. The fungal membrane-disruptive action of these analogues was studied by using the membrane-impermeable dye propidium iodide. TOB analogues bearing a linear alkyl chain at their 6″-position in a thioether linkage exhibited chain length-dependent antifungal activities. Analogues with C₁₂ and C₁₄ chains showed promising antifungal activities against tested fungal strains, with MIC values ranging from 1.95 to 62.5 mg/liter …

Coconut Paradise, Winston J. Craig

Lake Union Herald

No abstract provided.