Digital Commons Network^™

Association Of Adipokines With Insulin Resistance, Microvascular Dysfunction, And Endothelial Dysfunction In Healthy Young Adults., Cindy Cheng, Md, Phd, Constantine Daskalakis

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Proinflammatory adipokines (inflammation markers) from visceral adipose tissue may initiate the development of insulin resistance (IR) and endothelial dysfunction (ED). This study's objective was to investigate the association of five inflammation markers (CRP and four adipokines: IL-6, TNFα, PAI-1, and adiponectin) with IR (quantitative insulin resistance check index (QUICKI)), microvascular measures (capillary density and albumin-to-creatinine ratio (ACR)), and endothelial measures (forearm blood flow (FBF) increases from resting baseline to maximal vasodilation). Analyses were conducted via multiple linear regression. The 295 study participants were between 18 and 45 years of age, without diabetes or hypertension. They included 24% African Americans and …

October 13, 2015, The Dakota Student

The Dakota Student

No abstract provided.

Mitochondrial Mass, A New Metabolic Biomarker For Stem-Like Cancer Cells: Understanding Wnt/Fgf-Driven Anabolic Signaling., Rebecca Lamb, Gloria Bonuccelli, Béla Ozsvári, Maria Peiris-Pagès, Marco Fiorillo, Duncan L Smith, Generoso Bevilacqua, Chiara Maria Mazzanti, Liam A Mcdonnell, Antonio Giuseppe Naccarato, Maybo Chiu, Luke Wynne, Ubaldo E Martinez-Outschoorn, Federica Sotgia, Michael P. Lisanti

Kimmel Cancer Center Faculty Papers

Here, we developed an isogenic cell model of "stemness" to facilitate protein biomarker discovery in breast cancer. For this purpose, we used knowledge gained previously from the study of the mouse mammary tumor virus (MMTV). MMTV initiates mammary tumorigenesis in mice by promoter insertion adjacent to two main integration sites, namely Int-1 (Wnt1) and Int-2 (Fgf3), which ultimately activates Wnt/β-catenin signaling, driving the propagation of mammary cancer stem cells (CSCs). Thus, to develop a humanized model of MMTV signaling, we over-expressed WNT1 and FGF3 in MCF7 cells, an ER(+) human breast cancer cell line. We then validated that MCF7 cells …

Gsk-3Β Regulates Tumor Growth And Angiogenesis In Human Glioma Cells., Peng Zhao, Qi Li, Zhumei Shi, Charlie Li, Lin Wang, Xue Liu, Chengfei Jiang, Xu Qian, Yongping You, Ning Liu, Ling-Zhi Liu, Lianshu Ding, Bing-Hua Jiang

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND: Glioma accounts for the majority of primary malignant brain tumors in adults.

METHODS: Glioma specimens and normal brain tissues were analyzed for the expression levels of GSK-3β and p-GSK-3β (Ser9) by tissue microarray analysis (TMA) and Western blotting. Glioma cells over-expressing GSK-3β were used to analyze biological functions both in vitro and in vivo.

RESULTS: The levels of p-GSK-3β (Ser9), but not total GSK-3β, are significantly up-regulated in glioma tissues compared to normal tissues, and are significantly correlated with the glioma grades. Ectopic expression of GSK-3β decreased the phosphorylation levels of mTOR and p70S6K1; and inhibited β-catenin, HIF-1α and …

Motifs Of Vdac2 Required For Mitochondrial Bak Import And Tbid-Induced Apoptosis., Shamim Naghdi, Péter Várnai, György Hajnóczky

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Voltage-dependent anion channel (VDAC) proteins are major components of the outer mitochondrial membrane. VDAC has three isoforms with >70% sequence similarity and redundant roles in metabolite and ion transport. However, only Vdac2(-/-) (V2(-/-)) mice are embryonic lethal, indicating a unique and fundamental function of VDAC2 (V2). Recently, a specific V2 requirement was demonstrated for mitochondrial Bak import and truncated Bid (tBid)-induced apoptosis. To determine the relevant domain(s) of V2 involved, VDAC1 (V1) and V2 chimeric constructs were created and used to rescue V2(-/-) fibroblasts. Surprisingly, the commonly cited V2-specific N-terminal extension and cysteines were found to be dispensable for Bak …

Calcaneal Quantitative Ultrasound Indicates Reduced Bone Status Among Physically Active Adult Forager-Horticulturalists, Jonathan Stieglitz, Felicia C. Madimenos, Hillard Kaplan, Michael Gurven

ESI Publications

Six months of exclusive breastfeeding (EBF) is considered optimal for infant health, though globally most infants begin complementary feeding (CF) earlier—including among populations that practice prolonged breastfeeding. Two frameworks for understanding patterns of early CF emerge in the literature. In the first, maternal and infant needs trade-off, as “maternal-centric” factors—related to time and energy demands, reproductive investment, cultural influences, and structural barriers— favor supplanting breastfeeding with earlier and increased CF. A second framework considers that “infant-centric” factors—related to infant energetic needs—favor CF before six months to supplement breastfeeding.

We apply these two frameworks in examining early CF among the Tsimane—a …

Dynamic Ubiquitination Drives Herpesvirus Neuroinvasion, Nicholas J. Huffmaster, Patricia J. Sollars, Alexsia L. Richards, Gary E. Pickard, Gregory A. Smith

School of Veterinary and Biomedical Sciences: Faculty Publications

Neuroinvasive herpesviruses display a remarkable propensity to enter the nervous system of healthy individuals in the absence of obvious trauma at the site of inoculation. We document a repurposing of cellular ubiquitin during infection to switch the virus between two invasive states. The states act sequentially to defeat consecutive host barriers of the peripheral nervous system and together promote the potent neuroinvasive phenotype. The first state directs virus access to nerve endings in peripheral tissue, whereas the second delivers virus particles within nerve fibers to the neural ganglia. Mutant viruses locked in either state remain competent to overcome the corresponding …

Executive Committee - Agenda, 10/13/2015, Academic Senate

Academic Senate Agendas

No abstract provided.

The Parthenon, October 13, 2015, Jocelyn Gibson

The Parthenon

The Parthenon, Marshall University’s student newspaper, was published by students Monday through Friday during the regular semester and weekly on Thursdays during the summer. Due to budgetary constraints, beginning with the 2015 Fall semester, the newspaper is only published four days a week. There is no issue on Mondays, physical issues are printed on Tuesdays and Fridays, and online issues only are published on Wednesdays and Thursdays. The editorial staff is responsible for the news and the editorial content.

Exploring Ecosystems And Health By Shifting To A Regional Focus: Perspectives From The Oceania Ecohealth Chapter, Jonathan Kingsley, Rebecca Patrick, Pierre Horwitz, Margot Parkes, Aaron Jenkins, Charles Massy, Claire Henderson-Wilson, Kerry Arabena

Research outputs 2014 to 2021

This article highlights contributions that can be made to the public health field by incorporating “ecosystem approaches to health” to tackle future environmental and health challenges at a regional level. This qualitative research reviews attitudes and understandings of the relationship between public health and the environment and the priorities, aspirations and challenges of a newly established group (the Oceania EcoHealth Chapter) who are attempting to promote these principles. Ten semi-structured interviews with Oceania EcoHealth Chapter members highlighted the important role such groups can play in informing organisations working in the Oceania region to improve both public health and environmental outcomes …

Structure Based Drug Design Targeting Bacterial Antibiotic Resistance And Alzheimer's Disease, Eric Michael Lewandowski

USF Tampa Graduate Theses and Dissertations

Structure based drug design is a rapidly advancing discipline that examines how protein targets structurally interact with small molecules, or known inhibitors, and then uses this information to lead inhibitor optimization efforts. In the case of novel inhibitors, protein structural information is first obtained via X-ray crystallography, NMR studies, or a combination of both approaches. Then, computational molecular docking is often used to screen, in silico, millions of small molecules and calculate the potential interactions they may have with the target protein’s binding pocket, in hopes of identifying novel low affinity inhibitors. By examining the interactions these small, low affinity, …

Can’T Take A Joke? The Asymmetrical Nature Of The Politicized Sense Of Humor, Roger Gans

Proceedings of the New York State Communication Association

In an effort to tease out possible expressions of dispositional differences in people of different political ideologies, this study uses media preference and consumption data from the 2008 National Annenberg Election Survey (NAES08-Online) to examine characteristics of audiences for a range of television shows and genres. The individual shows include two political satires, The Daily Show with Jon Stewart, and The Colbert Report; a late-night comedy/variety show, The Tonight Show with Jay Leno; a hospital-based ensemble situation comedy, Scrubs; two animated comedies, The Simpsons, and The Family Guy; and two action-oriented dramas, 24, and CSI: Miami …

Lanthorn, Vol. 50, No. 14, October 12, 2015, Grand Valley State University

Volume 50, July 13, 2015 - June 6, 2016

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

Sex Differences And The Role Of Il-10 In Ischemic Stroke Recovery., Sarah E. Conway, Meaghan Roy O’Reilly, Brett Friedler, Ilene Staff, Gilbert Fortunato, Louise D. Mccullough

UCHC Articles - Research

Females experience poorer recovery after ischemic stroke compared to males, even after controlling for age and stroke severity. IL-10 is an anti-inflammatory cytokine produced by T regulatory cells and Th2 CD4⁺ helper T cells. In ischemic stroke, an excessive IL-10 response contributes to post-stroke immunosuppression, which worsens outcomes. However, it is unknown if sex differences exist in IL-10 levels after ischemic stroke. In this study, we found that higher levels of IL-10 were associated with poor acute and long-term outcomes after ischemic stroke in female patients but not in males. After controlling for confounders, IL-10 was not an independent …

Mitigating The Risk Of Extreme Water Scarcity And Dependency: The Case Of Jordan, Joep F. Schyns, Arwa Hamaideh, Arjen Y. Hoekstra, Mesfin Mekonnen, Marlou Schyns

Daugherty Water for Food Global Institute: Faculty Publications

Jordan faces great internal water scarcity and pollution, conflict over trans-boundary waters, and strong dependency on external water resources through trade. This paper analyzes these issues and subsequently reviews options to reduce the risk of extreme water scarcity and dependency. Based on estimates of water footprint, water availability, and virtual water trade, we find that groundwater consumption is nearly double the groundwater availability, water pollution aggravates blue water scarcity, and Jordan’s external virtual water import dependency is 86%. The review of response options yields 10 ingredients for a strategy for Jordan to mitigate the risks of extreme water scarcity and …

October 12, 2015, James Madison University

The Breeze, 2010-2019

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

The Broad-Spectrum Antiviral Favipiravir Protects Guinea Pigs From Lethal Lassa Virus Infection Post-Disease Onset, David Safronetz, Kyle Rosenke, Jonna B. Westover, Cynthia Martellaro, Atsushi Okumura, Yousuke Furuta, Joan Geisbert, Greg Saturday, Takashi Komeno, Thomas W. Geisbert, Heinz Feldmann, Brian B. Gowen

Plants, Soils, and Climate Faculty Publications

With up to 500,000 infections annually, Lassa virus (LASV), the cause of Lassa fever, is one of the most prevalent etiological agents of viral hemorrhagic fever (VHF) in humans. LASV is endemic in several West African countries with sporadic cases and prolonged outbreaks observed most commonly in Sierra Leone, Liberia, Guinea and Nigeria. Additionally several cases of Lassa fever have been imported into North America, Europe and Asia making LASV a global threat to public health. Despite this, currently no approved therapeutic or vaccine exists to treat or prevent LASV infections. Here, using a passaged strain of LASV that is …

The Statesman, V. 59, I. 7, Stony Brook University

Stony Brook Statesman-Sucolian

v. 59;i. 7

Animals And Causal Impotence: A Deontological View, Blake Hereth

Between the Species

In animal ethics, some ethicists such as Peter Singer argue that we ought not to purchase animal products because doing so causally contributes to unnecessary suffering. Others, such as Russ Shafer-Landau, counter that where such unnecessary suffering is not causally dependent on one’s causal contributions, there is no duty to refrain from purchasing animal products, even if the process by which those products are produced is morally abhorrent. I argue that there are at least two plausible principles which ground the wrongness of purchasing animal products produced by morally abhorrent means. First, respect for the wishes and dignity of animals …

Communiqué, October 11, 2015, Lindenwood University

Communiqué

The Communiqué was the faculty/staff newsletter for Lindenwood University/College from 1982 to 2016.

Media Advisory: Nh Veterinary Diagnostic Lab Open House Oct. 14, Lori Wright

Media Relations

No abstract provided.

Columbia Chronicle (10/12/2015)

Columbia Chronicle

Student newspaper from October 12, 2015 entitled The Columbia Chronicle. This issue is 40 pages and is listed as Volume 51, Issue 6. Cover story: "College seeks higher security profile, students want more" Editor-in-Chief: Kyra Senese

Commonwealth Times 2015-10-12

Commonwealth Times, 1969-

No abstract provided.

Evaluating Faciltated Migration As A Climate Change Adaptation Approach In Southern Ontario's Sugar Maple Ecosystems, Kaitlyn Mcglade

Geography and Environmental Studies Major Research Papers

This research seeks to provide an explanation and evaluation of facilitated migration as an adaptation approach for improving the long-term resilience and sustainability of Acer saccharum (sugar maple) ecosystems and sugarbush production. The research concludes that faciliated migration is supported by producers and other industry stakeholders as a feasable adaptation approach for improving resilience and sustainability.

Daily Eastern News: October 12, 2015, Eastern Illinois University

October

No abstract provided.

Self-Authorship: A Teaching Approach During The After-School Community Program, Fatjona Lubonja

Theses and Dissertations

The purpose of this study was to examine the impact of integrating self-authorship pedagogy applied to a younger population. Integration of a self-authorship program during an after-school community program examined the self-authorship pedagogy approach following the developmental theory designed by Baxter Magolda (1999, 2001). Much of previous research in self-authorship was influenced by college student population. There was a literature gap on self- authorship theory applied to younger age population. This research investigated students' responses to the self-authorship program, the impact self-authorship had on students' learning, the impact self-authorship had on after-school programs, and my leadership throughout the research. The …

Mmu: 10/12/15–10/18/15, Student Bar Association

Monday Morning Update

The Monday Morning Update, or MMU as it is referred to by students, is a weekly email newsletter of news, events, and opportunities of special interest to Notre Dame Law School students.

Whalesong 2015-10-12, N/A N/A

Whalesong

No abstract provided.

Action Cameras: Bringing Aquatic And Fisheries Research Into View, Daniel P. Struthers, Andy J. Danylchuk, Alexander D.M. Wilson, Steven J. Cooke

School of Biological and Marine Sciences

Digital action cameras (ACs) are increasingly being utilized for aquatic research purposes due to their cost effectiveness, versatility, high-resolution imagery, and durability. Here we review the advantages of AC technology in research, with particular emphases on (a) research videography (both in the field and the laboratory), (b) animal-borne studies, and (c) outreach and education purposes. We also review some of the limitations of this technology as represented by environmental factors (e.g., depth, turbidity) and deployment considerations (e.g., lens choices, imaging settings, battery life). As AC technologies evolve in response to growing public interest in their application versatility, researchers are indirectly …

The Ecological Spirituality Of Elizabeth Ann Seton, Sung-Hae Kim S.C.

Vincentian Studies

Some ecologists believe that the global environmental crisis has been caused by placing humanity at the top of the ecosystem. They have asked religious traditions to help develop new ethics that restore equilibrium to the relationship between humanity and nature. One way to do this is to examine traditional texts from an ecological perspective. With extensive quotations, Sung-Hae Kim demonstrates how Elizabeth Seton saw the link between humanity and nature and how she experienced God in nature. Kim writes that Elizabeth learned to see suffering and death as transformative and part of an “ecological balance,” which led to trust in …