Digital Commons Network^™

Law's Exposure: The Movement And The Legal Academy, Amna A. Akbar

Journal of Legal Education

No abstract provided.

Que Ondee Sola - November 2015, Juan Morales

Que Ondee Sola

Student publication founded in 1972, articles include: The Weapon of Poetry, El Sueno Americana- The American Dream, Puerto Rican Education and Social Justice: Promoting Transformative and Emancipatory Forms of Knowledge, The Face of the Puerto Rican Diaspora is manifested in Orlando, Student ACCESS Bill Campaign Launch, Three Cities One Voice National Lawyers Guild Annual Conference, Can We Imagine?, Semilla's Fight for Women's Rights from Chicago to Mexico

A Path To Empathy: Child And Family Communication, Sarah Ann Stone

Theses and Dissertations

This longitudinal study examined the association between communication in the family on the development of empathy in young children. Co-regulation and family expressiveness measured communication in parent-child dyads at age 12 months (N = 186), 24 months (N = 100), and 36 months (N = 78). A follow-up was conducted at 60 months (N = 47) to measure empathy-related responding in children. Co-regulation styles change over time, generally increasing in the most engaged, two-way style of communication (symmetrical) and decreasing in one-sided and less engaged types. Greater family expressiveness predicted higher levels of empathy as observed in an empathy-eliciting experiment, …

The Anatomy Of Porcine And Human Larynges: Structural Analysis And High Resolution Magnetic Resonance Imaging Of The Recurrent Laryngeal Nerve, Nena Lundgreen Mason

Theses and Dissertations

The recurrent laryngeal nerve (RLN) innervates all the intrinsic muscles of the larynx that are responsible for human vocalization and language. The RLN runs along the tracheoesophageal groove bilaterally and is often accidentally damaged or transected during head and neck surgical procedures. RLN palsy and vocal cord paralysis are the most common and serious post op complications of thyroid surgeries. Patients who suffer from RLN injury can develop unilateral or bilateral vocal fold paralysis (BVFP). Theoretically, selective reinnervation of the posterior cricoarytenoid muscle would be the best treatment for BVFP. The phrenic nerve has been shown in several studies to …

The Homeoprotein Dlx3 And Tumor Suppressor P53 Co-Regulate Cell Cycle Progression And Squamous Tumor Growth, Paul W. Bible, E. Palazzo, M. Kellett, C. Cataisson, A. Gormley, V. Pietroni, Et Al.

Computer Science Faculty publications

Epidermal homeostasis depends on the coordinated control of keratinocyte cell cycle. Differentiation and the alteration of this balance can result in neoplastic development. Here we report on a novel DLX3-dependent network that constrains epidermal hyperplasia and squamous tumorigenesis. By integrating genetic and transcriptomic approaches, we demonstrate that DLX3 operates through a p53-regulated network. DLX3 and p53 physically interact on the p21 promoter to enhance p21 expression. Elevating DLX3 in keratinocytes produces a G1-S blockade associated with p53 signature transcriptional profiles. In contrast, DLX3 loss promotes a mitogenic phenotype associated with constitutive activation of ERK. DLX3 expression is lost in human …

Table Of Contents: Annual Survey 2015

University of Richmond Law Review

No abstract provided.

Preface, John J. Hogan

University of Richmond Law Review

No abstract provided.

Developments In Animal Law: An Evolving Area In Virginia Law, Ryan Murphy

University of Richmond Law Review

No abstract provided.

Technology And Information Fusion Needs To Address The Food, Energy, Water Systems (Fews) Nexus Challenges, David Ebert, Christian Butzke, Melba Crawford, Philip Owens, Dimitrios Peroulis

Purdue VACCINE workshop reports

In response to the Food, Energy, Water Systems (FEWS) Nexus Challenge grant awarded by NSF, the team of investigators led by David Ebert, along with Christian Butzke, Melba Crawford, Phillip Owens, and Dimitrios Peroulis conducted a two-day workshop in Napa, California on November 5th and 6th, 2015. The workshop addressed the emerging issues in the food/energy/water systems throughout the diverse geography of the United States and over various crops and environmental conditions to better understand and model and ultimately devise a solution for the challenges to the FEWS nexus. One of the intended outcomes of the workshop was to generate …

Atg Interviews Alicia Wise, Director Of Access And Policy, Elsevier, Katina Strauch, Tom Gilson, Matthew Ismail

Against the Grain

No abstract provided.

Electrical Infrastructure Mapping At Purdue, Purdue Physical Facilities

Purdue GIS Day

No abstract provided.

Handedness For Unimanual Grasping In 564 Great Apes: The Effect On Grip Morphology And A Comparison With Hand Use For A Bimanual Coordinated Task, A. Meguerditchian, Kimberley A. Phillips, A. Chapelain, L. M. Mahovetz, S. Milne, T. Stoinski, A. Bania, E. V. Lonsdorf, J. Schaeffer, J. Russell, William D. Hopkins

Psychology Faculty Research

A number of factors have been proposed to influence within and between species variation in handedness in non-human primates. In the initial study, we assessed the influence of grip morphology on hand use for simple reaching in a sample of 564 great apes including 49 orangutans Pongo pygmaeus, 66 gorillas Gorilla gorilla, 354 chimpanzees Pan troglodytes and 95 bonobos Pan paniscus. Overall, we found a significant right hand bias for reaching. We also found a significant effect of the grip morphology of hand use. Grasping with the thumb and index finger was more prevalent in the right …

The Power Of Nature: Developing Prosocial Behavior Toward Nature And Peers Through Nature-Based Activities, Ibrahim H. Acar, Julia C. Torquati

Department of Child, Youth, and Family Studies: Faculty Publications

An early childhood teacher nurtures children’s perspective taking and respect for another living thing. These interactions happen daily at the Schlitz Audubon Nature Center (SANC) Preschool in Milwaukee, Wisconsin. Experiences like this promote children’s development of prosocial behavior, consistent with the Early Childhood Environmental Education Programs: Guidelines for Excellence (NAAEE 2010). This article examines the research question, How can teachers nurture the development of prosocial behavior for preschool-aged children through nature-based play and activities? To address this question, five researchers (including the second author) conducted 74 running record observations of children’s behavior and social interactions over the course of two …

Characterization Of L-Type Calcium Channel Activity In Atrioventricular Nodal Myocytes From Rats With Streptozotocin-Induced Diabetes Mellitus, Kathryn H. Yuill, Lina T. Al Kury, Frank Christopher Howarth

All Works

© 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society. Cardiovascular complications are common in patients with Diabetes mellitus (DM). In addition to changes in cardiac muscle inotropy, electrical abnormalities are also commonly observed in these patients. We have previously shown that spontaneous cellular electrical activity is altered in atrioventricular nodal (AVN) myocytes, isolated from the streptozotocin (STZ) rat model of type-1 DM. In this study, utilizing the same model, we have characterized the changes in L-type calcium channel activity in single AVN myocytes. Ionic currents were recorded …

Repression Of Esophageal Neoplasia And Inflammatory Signaling By Anti-Mir-31 Delivery In Vivo., Cristian Taccioli, Michela Garofalo, Hongping Chen, Yubao Jiang, Guidantonio Malagoli Tagliazucchi, Gianpiero Di Leva, Hansjuerg Alder, Paolo Fadda, Justin Middleton, Karl J. Smalley, Tommaso Selmi, Srivatsava Naidu, John L. Farber, Carlo M. Croce, Louise Fong

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND: Overexpression of microRNA-31 (miR-31) is implicated in the pathogenesis of esophageal squamous cell carcinoma (ESCC), a deadly disease associated with dietary zinc deficiency. Using a rat model that recapitulates features of human ESCC, the mechanism whereby Zn regulates miR-31 expression to promote ESCC is examined.

METHODS: To inhibit in vivo esophageal miR-31 overexpression in Zn-deficient rats (n = 12-20 per group), locked nucleic acid-modified anti-miR-31 oligonucleotides were administered over five weeks. miR-31 expression was determined by northern blotting, quantitative polymerase chain reaction, and in situ hybridization. Physiological miR-31 targets were identified by microarray analysis and verified by luciferase reporter …

Factors Associated With High Risk Infant Follow-Up Attendance, Martha Grant Fuller

Dissertations

Prematurity is a significant public health problem and preterm infants face well described risks of adverse neurodevelopmental outcomes. Bronfenbrenner’s bioecological theory of development describes interactions between biological and environmental factors and explains how these interactions can impact development. Systematic follow-up of preterm, high-risk infants is recommended for early identification of problems and provision of interventions and support services. Most research on follow-up attendance has involved small, single sites. A retrospective analysis of population based data available in the California Children’s Services High Risk Infant Follow-up Quality of Care Initiative (HRIF-QCI) data system was performed to examine factors associated with attendance …

Partial Covariance Based Functional Connectivity Computation Using Ledoit-Wolf Covariance Regularization, Matthew R. Brier, Anish Mitra, John E. Mccarthy, Beau M. Ances, Abraham Z. Snyder

Mathematics Faculty Research

Highlights •We use the well characterized matrix regularization technique described by Ledoit and Wolf to calculate high dimensional partial correlations in fMRI data. •Using this approach we demonstrate that partial correlations reveal RSN structure suggesting that RSNs are defined by widely and uniquely shared variance. •Partial correlation functional connectivity is sensitive to changes in brain state indicating that they contain functional information. Functional connectivity refers to shared signals among brain regions and is typically assessed in a task free state. Functional connectivity commonly is quantified between signal pairs using Pearson correlation. However, resting-state fMRI is a multivariate process exhibiting a …

Challenges In The Pharmacokinetics Of Therapeutic Proteins, Wararat Limothai

Theses and Dissertations (ETD)

Due to the complex structure and complicated disposition pattern of therapeutic macromolecules, their pharmacokinetic interpretation has many challenges. Two of these challenges were investigated in this dissertation: 1) the error of classical bioavailability assessment observed during subcutaneous (SC) administration of therapeutic macromolecules that undergo target-mediated drug disposition (TMDD) and 2) the ontogeny of the neonatal Fc receptor (FcRn) expression along with its effect on the pharmacokinetics of monoclonal antibodies (mAbs) during development.

TMDD often well describes the pharmacokinetics of therapeutic proteins that have high specificity and affinity of binding to their target receptors. The target receptors can be saturated by …

Gouldian Finch Non Breeding Counts 2015: Ord-East Kimberley Expansion Project - Weaber Plain Development Area, Sarah R. Pryke

Irrigated Agricultural Development in the North

As part of the requirement for State approval under the Environment Protection and Biodiversity Conservation Act 1999, an assessment and regular monitoring of the endangered Gouldian finch (Erythrura gouldiae) is required during the operation of the Ord River Irrigation Area Weaber Plain Development Project in Kimberley, Western Australia. This report details the findings from surveys of non-breeding Gouldian finches.

In accordance with the EPBC Act (6AIV) and GFMP (3-4) conditions, this work specifically provides:

1) Gouldian finch counts of the non-breeding population.

A Historical Survey Of Healing And Exorcism, Cristian Dumitrescu

Journal of Adventist Mission Studies

No abstract provided.

Lessons From The Demoniac Of Mark 5, Conrad Vine

Journal of Adventist Mission Studies

No abstract provided.

Cultural Influence Of Storytelling: An Examination Of The Use Of Narratives In Political Campaigns, Charla Bansley

Masters Theses

Television has changed political discourse. The thirty second commercial has replaced typography and rhetoric. After losing the popular vote in 5 of the last 6 presidential elections, the Republican National Committee concluded that the GOP has lost the ability to persuade. Walter Fisher's Narrative Paradigm states that meaningful communication is in the form of storytelling, which enables public discourse to observe not only differences, but commonalities. In a postmodern culture that does not believe in absolute truth, this study asked the following question: Are conservatives still using statistics and facts to communicate conservative principles? The rhetorical research conducted here examined …

Book Review Of "Judging Statutes" By Robert Katzmann, Peter Strauss

Journal of Legal Education

No abstract provided.

Discovery Of Novel Tubulin Polymerization Inhibitors And Survivin Inhibitors As Potential Anticancer Agents, Min Xiao

Theses and Dissertations (ETD)

Melanoma is the most dangerous form of skin cancer and accounts for the majority of skin cancer death. Although considerable advances have been made in melanoma treatment in recent years, there are many problems associated with current therapies. Drug resistance to targeted therapies is almost inevitable after short term treatment. Immunotherapies generally have low response rate and the effects vary among patients. Therefore, the need to develop new and more effective treatment for melanoma is high.

The work presented here focuses on discovery of novel anticancer agents for melanoma by targeting two important cancer targets: tubulin and survivin. Microtubules play …

Lyme Disease Ecology In San Luis Obispo County: The Role Of The Western Gray Squirrel, Ryan William Baker-Branstetter

Master's Theses

Despite the fact that eight cases of Lyme disease were diagnosed in San Luis Obispo County between 2005-2013, the identity of wildlife hosts serving as sources for tick infection in this region remained unidentified. The primary cause of Lyme disease in the U.S. is the spirochetal bacterium Borrelia burgdorferi sensu stricto, and this agent had not been previously isolated from the region. Borrelia bissettii, a related species that has not been implicated as a common causative agent of Lyme disease, was isolated in small rodents inhabiting coastal scrub and chaparral habitats in a previous San Luis Obispo County study. However, …

Open-Access Policies: Basics And Impact On Content Recruitment, Andrew Wesolek, Paul Royster

University of Nebraska-Lincoln Libraries: Faculty Publications

The allure of passing an institutional open-access (OA) policy as a strategy to populate an institutional repository is clear. After all, educating faculty to retain their rights to their scholarly publications through passage of such a policy, then requiring them to make those publications available through an IR seems a sure path to success. However, this approach of “if you pass it, they will comply” rings eerily similar to the early and decidedly misplaced optimism of populating institutional repositories through a “build it and they will come” proposition (Salo, 2007). The Registry of Open Access Repositories Mandatory Archiving Policies (ROARMAP) …

Resistant Starches For The Management Of Metabolic Diseases, Laure B. Bindels, Jens Walter, Amanda E. Ramer-Tait

Department of Food Science and Technology: Faculty Publications

Purpose of review—Recent clinical trials and animal studies indicate that resistant starches (RS) may be beneficial therapeutic tools for the management of metabolic diseases. The purpose of this review is to summarize these findings and discuss the established and proposed mechanisms by which RS exert their benefits. We also examine open questions regarding how RS improve metabolism and propose future research directions for the field.

Recent findings—Data from both humans and animal models clearly support a role for RS in improving a variety of metabolic features; however, discrepancies do exist regarding specific effects. Concomitant improvements in both insulin …

Traditional Grain Alcohol (Bai Jiu, 白酒) Production And Use In Rural Central China: Implications For Public Health, Ling Qian, Ian M. Newman, Wen Xiong, Yanyu Feng

Department of Educational Psychology: Faculty Publications

Background: An estimated 25 % of the alcohol consumed in China is traditional unrecorded alcohol produced and distributed informally. Consequently there is concern about its safety and its contribution to public health risk. Little has been written about this type of alcohol in China.

Methods: Researchers observed the manufacture of traditional bai jiu in a rural area of Hubei Province, Central China. Two hundred fifty-nine individuals were interviewed, either individually or in small groups, about their use of and attitudes toward bai jiu. Individuals who made or sold bai jiu were interviewed about local production, distribution, and sale. Key community …

Chemical Inhibition Of Fatty Acid Absorption And Cellular Uptake Limits Lipotoxic Cell Death, Constance Ahowesso, Paul N. Black, Nipun Saini, David Montefusco, Jessica Chekal, Chrysa Malosh, Craig W. Lindsley, Shaun R. Stauffer, Concetta Dirusso

Department of Biochemistry: Faculty Publications

Chronic elevation of plasma free fatty acid (FFA) levels is commonly associated with obesity, type 2 diabetes, cardiovascular disease and some cancers. Experimental evidence indicates FFA and their metabolites contribute to disease development through lipotoxicity. Previously, we identified a specific fatty acid transport inhibitor CB16.2, a.k.a. Lipofermata, using high throughput screening methods. In this study, efficacy of transport inhibition was measured in four cell lines that are models for myocytes (mmC2C12), pancreatic ß-cells (rnINS-1E), intestinal epithelial cells (hsCaco-2), and hepatocytes (hsHepG2), as well as primary human adipocytes. The compound was effective in inhibiting uptake with IC₅₀s between 3 …

The Effect Of Positive End-Expiratory Pressure On Inflammatory Cytokines During Laparoscopic Cholecystectomy, Firdevs Yılmazlar, Safinaz Karabayırlı, Muhammet Gözdemir, Burhanettin Usta, Murat Peker, Mehmet Namuslu, Hüsamettin Erdamar

Saudi Medical Journal

Objectives: To investigate effects of the positive end-expiratory pressure (PEEP) application of 10 cm H 2 O on the plasma levels of cytokines during laparoscopic cholecystectomy. Methods: A prospective study was conducted on 40 patients who presented to the Department of General Surgery, Medical Faculty, Turgut Özal University, Ankara, Turkey scheduled for laparoscopic cholecystectomy operation during a 10 month period from September 2012 to June 2013. Forty patients scheduled for laparoscopic cholecystectomy operation were randomly divided into 2 groups; ventilation through zero end-expiratory pressure (ZEEP) (0 cm H 2 O PEEP) (n=20), and PEEP (10 cm H 2 O PEEP) …