Digital Commons Network^™

The Current Prevalence Of Caprine Arthritis-Encephalitis Virus In Midwestern Goat Herds, Bradley Todd Jones

School of Veterinary and Biomedical Sciences: Dissertations, Theses, and Student Research

Caprine Arthritis-Encephalitis Virus (CAEV) is an incurable disease of goats that has both social and economic impacts. Clinical disease in goats includes encephalitis in kids; chronic arthritis, inflammatory mastitis and progressive respiratory disease in adults. In the last 25 years there have been significant changes in the United States goat industry with rapid growth in the meat and dairy industries. Recent prevalence studies are lacking and historic studies may not reflect changes in the industry. The purpose of this study was to establish the prevalence of CAEV in Midwestern herds that are not routinely acquiring new animals from known negative …

Development And Application Of Combined Quantum Mechanical And Molecular Mechanical Methods, Rui Lai

Department of Chemistry: Dissertations, Theses, and Student Research

Compromising of computational cost and accuracy, combined quantum mechanical and molecular mechanical (QM/MM) methods are practical methods for studying large molecular systems. The use of induced dipole polarizable force fields can significantly improve the accuracy of MM and QM/MM methods. However, induced dipole models tend to overestimate the polarization energy at short interaction distances. Damping functions can be applied to reduce the over polarization. MM-MM damping schemes have been developed to correct the overestimated polarization between MM atoms; QM-MM damping scheme has not been developed. In this thesis, a QM-MM damping scheme is developed for the damping of the MM …

The Crebh In Hepatic Lipid And Lipoprotein Metabolism: Implication For The Pathogenesis Of Hyperlipidemia And Metainflammation, Miaoyun Zhao

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

Hyperlipidemia is reemerging as an important cardiovascular disease risk factor and other metabolic disorders, such as obesity, insulin resistance and type-2 diabetes. Hepatic de novo lipogenesis is controlled by a family of the b-zip transcription factors, the sterol regulatory element-binding proteins (SREBPs), which targets downstream genes involved in free fatty acids, triglycerides and cholesterol synthesis. Regulation of SREBPs signaling is controlled by a cluster of the ER membrane-bound proteins, the insulin induced gene-1(Insig-1) and gene-2 (Insig-2) and the SCAP protein. The cAMP responsive element binding protein H (CREBH) is a recently identified member of this family. CREBH is selectively and …

Dynamic Hip Screw Fixation For Inter-Trochanteric Fractures: Determinants Of Outcomes, Adil Aijaz Shah, Santosh Kumar, Abdull Rehman

Department of Surgery Docs

bstract

OBJECTIVE:

To evaluate factors associated with revision of dynamic hip screw implant in patients undergoing the procedure for the fixation of intertrochanteric fractures.

METHODS:

The retrospective study was conducted at the Aga Khan University Hospital, Karachi, and comprised records of patients who had undergone dynamic hip screw fixation surgery between 2008 and 2012. Medical records and data for all patients were obtained from the medical records office. For all patients, the record files were systematically reviewed using a structured, pre-defined data extraction sheet. SPSS 20 was used statistical analysis.

RESULTS:

Out of 317 patients who had undergone the procedure, …

Artificial, Bree Scott

The Prairie Light Review

No abstract provided.

Riding With Gary, Raymond Ziemer

The Prairie Light Review

No abstract provided.

Engulfed, Dodi Dolendi

The Prairie Light Review

No abstract provided.

Tranquil Moment, Dee Hudson

The Prairie Light Review

No abstract provided.

Forest Of A Thousand Pencils, Mardelle Fortier

The Prairie Light Review

No abstract provided.

Cernnunos, Marianne Hentges

The Prairie Light Review

No abstract provided.

Dependence, Haley Prokaski

The Prairie Light Review

No abstract provided.

Shielded, Taylor Carso

The Prairie Light Review

No abstract provided.

Interpretative Ingredients: Formulating Art And Natural History In Early Modern Brazil, Amy Buono

Art Faculty Articles and Research

"In this article I look at two early modern texts that pertain to the natural history of Brazil and its usage for medicinal purposes. These texts present an informative contrast in terms of information density and organization, raising important methodological considerations about the ways that inventories and catalogues become sources for colonial scholarship in general and art history in particular."

“Danger Is My Business”: The Right To Manufacture Unsafe Products, Richard C. Ausness

Law Faculty Scholarly Articles

While no one would dispute that safety is a desirable objective, it may not always be an absolute priority. Rather, in some cases, other societal interests such as personal autonomy, consumer choice, product cost, and performance may trump legitimate safety goals. This is reflected in some of the doctrines and defenses that have evolved to protect the producers of unsafe products against tort liability. Some of these doctrines, such as those determining liability for the producers of optional safety equipment, inherently dangerous products, products with obvious hazards, and prescription drugs and medical devices, are part of the law of products …

Sabbaticals, Kevin F. Hallock

Economics Faculty Publications

With the year end upon you and many workplaces closing, reducing hours or accommodating employee vacations because of the holidays, this column focuses on rewards in the form of time away from work that is not so common -- sabbaticals. Sabbaticals are a generous benefit to those workers who have them. And they can clearly be an important part of a total rewards package. According to inc.com, while 5% of firms in the US offer sabbaticals, 25% of the companies listed in "Best Companies to Work For" offer them. Corporate sabbaticals, however, aren't typically as generous in length as those …

Mapping The Spatial And Temporal Dynamics Of Sensorimotor Integration During The Perception And Performance Of Wallowing, Megan E. Cuellar

Theses and Dissertations (ETD)

Similar to other complex sequences of muscle activity, swallowing relies heavily upon ‘sensorimotor integration.’ It is well known that the premotor cortex and primary sensorimotor cortices provide critical sensorimotor contributions that help control the strength and timing of swallowing muscle effectors. However, the temporal dynamics of sensorimotor integration remains unclear, even when performed normally without neurological compromise. Recent advances in EEG analysis blind source separation techniques via independent component analysis offer a novel and exciting opportunity to measure cortical sensorimotor activity in realtime during swallowing, concurrently with muscle activity during swallow initiation. In the current study, mu components were identified, …

Mrp4-Dependent Regulation Of Fibroblast Migration, Chandrima Sinha

Theses and Dissertations (ETD)

Roles of cyclic nucleotides and cyclic nucleotide-dependent signaling molecules in regulating several signaling pathways including cell migration have long been known. However, the new and revolutionary concept is that it is not just the absence or presence of cyclic nucleotides, but a highly coordinated balance between these molecules regulates cell migration. Multi-drug resistance protein 4 (MRP4), is a member of the large family of ATP binding cassette (ABC) transporter proteins, that localizes to the plasma membrane and functions as a nucleotide efflux transporter and thus plays a pivotal role in the regulation of intracellular cyclic nucleotide dynamics. In our study …

Downregulation Of Prdm16 Is Critical For Hoxb4-Mediated Benign Hsc Expansion In Vivo, Hui Yu

Theses and Dissertations (ETD)

Overexpression of HOXB4 in hematopoietic stem cells (HSCs) leads to increased self-renewal without causing hematopoietic malignancies in transplanted mice. The molecular basis of HOXB4-mediated benign HSC expansion in vivo is not well understood. To gain further insight into the molecular events underlying HOXB4-mediated HSC expansion, we analyzed gene expression changes at multiple time points in Lin-Sca1+c-kit+ (LSK) cells from mice transplanted with bone marrow (BM) cells transduced with a MSCV-HOXB4-ires-YFP vector. A distinct HOXB4 transcriptional program was reproducibly induced and stabilized by 12 weeks after transplant. Dynamic expression changes were observed in genes critical for HSC self- renewal as well …

Strengths And Weaknesses Of Hybrid Tpr Technology For Obtaining Structural And Mechanistic Insights Into Tpr Proteins, Shanshan Yu

Theses and Dissertations (ETD)

Tetratricopeptide (TPR) repeats are a 34-residue helix-turn-helix motif that when repeated pack into a superhelical structure. TPR domains are frequently found mediating protein-protein interactions, often through a central groove. One protein complex bearing numerous TPR repeats is the Anaphase Promoting Complex (APC). The anaphase-promoting complex (APC) is a multi-subunit complex, which orchestrates mitotic cell cycles. APC is an E3 ligase in the ubiquitin cascade, and directs the 26S proteosome degradation of cell-cycle regulators. Throughout mitotic progression, proteins that are key regulators of the cell cycle are assembled with polyubiquitin chains by APC.

One domain of the human APC is comprised …

Reading And Math Outcome Equity Of Students, By Language, Ethnicity, And Gender Conditions, Required To Participate In An Attendance Court Program Based On Excessive School Absences, Kenneth E. Defrank

Student Work

The purpose of this study is to determine the reading and math outcome equity of students, by, language, ethnicity, and gender conditions required to participate in the Grand Island Public Schools Attendance program based on third-grade through eighth grade excessive school absences in the 2010–2011 school year. The data presented in the study indicates that overall the Grand Island Public School Attendance program improved attendance of students who were involved in the attendance program. In the third-grade 77% of students involved in the attendance program improved their attendance. In the fourth-grade 83% of students involved in the attendance program improved …

The Impact Of The Gradual Release Of Responsibility On Graduate Teacher Education Candidates’ Self-Efficacy With Ipads, Wendy L. Loewenstein

Student Work

Keeping up with technological innovations is a challenge for educational intuitions as they strive to prepare students to be competitive in a future workforce. This is an overwhelming task for educational leaders that extends beyond which technological device to purchase. This study examines the barriers to iPad integration in education and how the gradual release of responsibility method of instruction can be used to increase participants’ self-efficacy with iPads. The participants (N = 41) were teacher education graduate candidates enrolled in a Children’s Literature course in which they were provided access to iPads. Survey results revealed that candidates’ efficacy prior …

Tuning In And Tuning Out Technology, Jasmin Tahmaseb-Mcconatha

Psychology Faculty Publications

Clearly the picture is complex. A large percentage of Americans benefit from the use of technology. The Internet can serve as a valuable tool for people of all ages. It can empower to be better informed about our health and enable us to connect with family, friends. It can help us do our more efficiently. But these benefits have costs. Connectivity both increases and decreases social isolation.

Expression Levels Of Dna Damage Response Genes In Zebrafish (Danio Rerio) Following Treatment Methylnitrosourea, Doxorubicin, Or Ultraviolet Light (Abstract), J. Woolcock, H. Khan, K. Joseph, Erin E. Gestl

Biology Student Work

No abstract provided.

Determination Of Expression Levels Of All 20 Dna Polymerases In Zebrafish (Danio Rerio) Thoughout Development And Following Treatment With Mnu, Doxorubicin, And Uv Radiation (Abstract), J. Petovic, L. Sekela, B. Della Fera, L. Ver Steeg, J. Woolcock, M. Miller, Erin E. Gestl

Biology Student Work

No abstract provided.

Teaching Beyond The Assessment, Daniel R. Ilaria

Mathematics Faculty Publications

This paper discusses how students can learn mathematics assessed on standardized testing in a way that promotes deeper thinking about the mathematics. While potential assessments aligned to the Common Core Content Standards drive the focus of the curriculum, technology can provide a way for delving into conceptual understanding. Using two standardized test questions, this paper provides examples of how technology can promote deeper thinking about mathematical concepts than what is supposed to be assessed in the questions.

Hamilton Harty: Musical Polymath, By Jeremy Dibble (Review), Julian Onderdonk

Music Theory, History & Composition Faculty Publications & Performances

No abstract provided.

Media Sensationalism And Its Implications On The Public Understanding Of Science, Christopher Barsoum

HIM 1990-2015

Myths, misinformation, and sensationalism. These are common enemies that directly inhibit the public understanding of science. In particular, the media is often responsible for mishandling or otherwise misrepresenting scientific information, historically and presently speaking. Many sources can combat the public understanding of science through pseudoscientific means. This includes but is not limited to religion, the media, politics, or just simple hearsay. For example, Young Earth creationism is deeply rooted in Christian theology, but the beliefs hold no scientific basis. Yet, almost half of Americans still believe in Young Earth creationism. Another such example is anti-vaccination campaigns due to fears of …

An Examination Of The Instability And Exploitation In Congo From King Leopold Ii's Free State To The 2nd Congo War, Baldwin Beal

HIM 1990-2015

This thesis will analyze the Congo from King Leopold II's Free State to the 2nd Congo War. After a thorough investigation of the colonial period, this thesis will analyze the modern period. This thesis contends that the underdevelopment of the Congo, and its continuing warfare and poverty are the consequences of an exploitative colonial history. To be sure, King Leopold II of Belgium created the template for administering the Congo through the installation of concessionary companies that were more interested in harvesting huge profits than creating the conditions for a self-sustaining Congolese economy. Indeed, the policies implemented by King Leopold …

An Empire On The Brink Of Destruction: The Stability Of The Seleucid Empire Under Antiochus Iv (175 B.C. - 164 B.C.), Tyler Campbell

HIM 1990-2015

The Seleucid Empire expanded its territory to stretch from Thrace to India under the leadership of Antiochus III, making it one of the most expansive empires in the Hellenistic World. Antiochus III's subsequent loss at the Battle of Magnesia to Rome in 190 B.C. caused some of the satrapies of the empire to begin to rebel, and has led some historians to believe that the empire began an unrecoverable decline. In this investigation I will argue that the myth of decline in the post-Antiochus III era is invalid through analyzing the stability brought to the empire during the reign of …

Physical Health Outcomes Of The Stigmatizer, William Butler

HIM 1990-2015

This thesis explores physical health outcomes of individuals that hold stigma against those with mental illness. The stigmatizer is mentioned in the literature as an individual that holds a stigma towards another group. In this thesis, stigma refers to those that hold prejudice and may express discrimination towards a targeted group. Two studies were conducted that looked at multiple demographic variables as well as symptomology and degree of stigma towards those with mental illness. The first study looked at overall stigma without the stereotypical psychosomatic symptoms (chest pain and abdominal pain). The second study looked at a second dimension of …