Digital Commons Network^™

Evaluating The Guideline Enhancement Tool (Get): An Innovative Clinical Training Tool To Enhance The Use Of Hypertension Guidelines In General Practice, Chinthaka Balasooriya, Joel Rhee, Boaz Shulruf, Rosa Canalese, Nicholas Zwar

Medical Papers and Journal Articles

Background: This project aims to evaluate the effectiveness of an innovative educational intervention in enhancing clinical decision making related to the management of hypertension in general practice. The relatively low level of uptake of clinical practice guidelines by clinicians is widely recognised as a problem that impacts on clinical outcomes. This project addresses this problem with a focus on hypertension guidelines. Hypertension is the most frequently managed problem in general practice but evidence suggests that management of Hypertension in general practice is sub-optimal.

Methods/design: This study will explore the effectiveness of an educational intervention named the ‘Guideline Enhancement Tool (GET)’. …

Unmet Needs Of Patients With Chronic Obstructive Pulmonary Disease (Copd): A Qualitative Study On Patients And Doctors, S Wong, N Abdullah, A Abdullah, S Liew, S Ching, E Khoo, M Jiwa, Y Chia

Medical Papers and Journal Articles

Background: Chronic Obstructive Pulmonary Disease (COPD) is a chronic disease with repeated exacerbations resulting in gradual debilitation. The quality of life has been shown to be poor in patients with COPD despite efforts to improve self-management. However, the evidence on the benefit of self-management in COPD is conflicting. Whether this could be due to other unmet needs of patients have not been investigated. Therefore, we aimed to explore unmet needs of patients from both patients and doctors managing COPD.

Methods: We conducted a qualitative study with doctors and patients in Malaysia. We used convenience sampling to recruit patients until data …

Management Of Behavioural Change In Patients Presenting With A Diagnosis Of Dementia: A Video Vignette Study With Australian General Practitioners, M Jiwa, P Nichols, P Magin, G Pagey, X Meng, R Parsons, V Pillai

Medical Papers and Journal Articles

Objective: To test the impact of feedback on the proposed management of standardised patients presenting with behavioural change with a diagnosis of dementia in Australian primary care.

Materials and methods: A video vignette study was performed with Australian general practitioners (GPs) in 2013. Participants viewed six pairs of matched videos depicting people presenting changed behavior in the context of a dementia diagnosis in two phases. In both phases GPs indicated their diagnosis and management. After phase 1, GPs were offered feedback on management strategies for the patients depicted. Analyses focused on identification of change in management between the two phases …

Rating General Practitioner Consultation Performance In Cancer Care: Does The Specialty Of Assessors Matter? A Simulated Patient Study, M Jiwa, G Halkett, X Meng, M Berg

Medical Papers and Journal Articles

Background: Patients treated for prostate cancer may present to general practitioners (GPs) for treatment follow up, but may be reticent to have their consultations recorded. Therefore the use of simulated patients allows practitioner consultations to be rated. The aim of this study was to determine whether the speciality of the assessor has an impact on how GP consultation performance is rated.

Methods: Six pairs of scenarios were developed for professional actors in two series of consultations by GPs. The scenarios included: chronic radiation proctitis, Prostate Specific Antigen (PSA) ‘bounce’, recurrence of cancer, urethral stricture, erectile dysfunction and depression or anxiety. …

A Randomised Trial Deploying A Simulation To Investigate The Impact Of Hospital Discharge Letters On Patient Care In General Practice, M Jiwa, X Meng, C O'Shea, P Magin, A Dadich, V Pillai

Medical Papers and Journal Articles

Objective: To determine how the timing and length of hospital discharge letters impact on the number of ongoing patient problems identified by general practitioners (GPs).

Trial design: GPs were randomised into four groups. Each viewed a video monologue of an actor-patient as he might present to his GP following a hospital admission with 10 problems. GPs were provided with a medical record as well as a long or short discharge letter, which was available when the video was viewed or 1 week later. GPs indicated if they would prescribe, refer or order tests for the patient’s problems.

Methods: Setting Primary …

Genomic Catastrophes Frequently Arise In Esophageal Adenocarcinoma And Drive Tumorigenesis, K Nones, N Waddell, N Wayte, A Patch, P Bailey, F Newell, O Holmes, J Fink, M Quinn, Y Tang, G Lampe, K Quek, K Loffler, S Manning, S Idrisoglu, D Miller, Q Xu, N Waddell, P Wilson, T Bruxner, A Christ, I Harliwong, C Nourse, E Nourbakhsh, M Anderson, S Kazakoff, C Leonard, S Wood, P Simpson, L Reid, L Krause, D Hussey, D Watson, R Lord, D Nancarrow, W Phillips, D Gotley, B Smithers, D Whiteman, N Hayward, P Campbell, J Pearson, S Grimmond, A Barbour

Medical Papers and Journal Articles

Oesophageal adenocarcinoma (EAC) incidence is rapidly increasing in Western countries. A better understanding of EAC underpins efforts to improve early detection and treatment outcomes. While large EAC exome sequencing efforts to date have found recurrent loss-offunction mutations, oncogenic driving events have been underrepresented. Here we use a combination of whole-genome sequencing (WGS) and single-nucleotide polymorphism-array profiling to show that genomic catastrophes are frequent in EAC, with almost a third (32%, n¼40/123) undergoing chromothriptic events. WGS of 22 EAC cases show that catastrophes may lead to oncogene amplification through chromothripsis-derived double-minute chromosome formation (MYC and MDM2) or breakage-fusion-bridge (KRAS, MDM2 and …

Health Inequalities And Development Plans In Iran: An Analysis Of The Past Three Decades (1984–2010), H Zare, A Trujillo, J Driessen, M Ghasemi, G Gallego

Medical Papers and Journal Articles

Introduction: Reducing inequalities in health care is one of the main challenges in all countries. In Iran as in other oil-exporting upper middle income countries, we expected to witness fewer inequalities especially in the health sector with the increase in governmental revenues.

Methods: This study presents an inequalities assessment of health care expenditures in Iran. We used data from the Household Income and Expenditure Survey (HIES) in Iran from 1984–2010. The analysis included 308,735 urban and 342,532 rural households.

Results: The results suggest heightened inequality in health care expenditures in Iran over the past three decades, including an increase in …

Robot-Assisted Gastrectomy And Oesophagectomy For Cancer, Dan Falkenback, Christopher W. Lehane, Reginald V.N Lord

Medical Papers and Journal Articles

Background: Robot-assisted surgery is a technically feasible alternative to open and laparoscopic surgery, which is being more frequently used in general surgery. We undertook this review to investigate whether robotic assistance provides a significant benefit for oesophagogastric cancer surgery.

Methods: Electronic databases were searched for original English-language publications for robotic-assisted gastrectomy and oesophagectomy between January 1990 and October 2013.

Results: Sixty-one publications were included. Thirty-five included gastrectomy, 31 included oesophagectomy and five included both operations. Several publications suggest that robot-assisted subtotal gastrectomy can be as safe and effective as an open or laparoscopic procedure, with equal outcomes with regard to …

Financial Reporting Opacity And Expected Crash Risk: Evidence From Implied Volatility Smirks, Jeong-Bon Kim, Liandong Zhang

Research Collection School Of Accountancy

The recent financial crisis has stimulated a renewed interest in understanding the determinants of stock price crash risk (i.e., left tail risk). Recent research shows that opaque financial reports enable managers to hide and accumulate bad news for extended periods. When the accumulated bad news reaches certain tipping point, it will be suddenly released to the market at once, resulting in an abrupt decline in stock price (i.e., a crash). This study extends this line of research by examining the impact of financial reporting opacity on perceived or expected crash risk. Prominent economists, such as Olivier Blanchard, argue that removing …

Beauty And Academic Career, Hai Lu, Yanju Liu, Kevin Veenstra

Research Collection School Of Accountancy

We examine the impact of beauty on the academic career success of tenure-track accounting professors at top business schools in America, and show that beauty plays a significant role. Specifically, after controlling for gender, ethnicity, publication history, work experience, and quality of alma mater, more attractive professors obtain better first school placements post-PhD and are granted tenure in a shorter period of time. Interestingly, there is no incremental benefit of attractiveness for the career progression from associate to full professor. These findings are consistent with our conjecture that when the signal of an individual’s potential is noisy, beauty becomes a …

Stock Liquidity And The Pricing Of Earnings: A Comparison Of China’S Floating And Non-Floating Shares, Jiwei Wang, Kevin Chen, Hongqi Yuan

Research Collection School Of Accountancy

The reform to convert non-floating shares to floating in China provides a setting in which shares are subject to different liquidity constraint. We show that the severity of this constraint is inversely related to the extent to which earnings information is reflected in the share prices. Specifically, before the reform, the transfer prices of non-floating shares reflect much less earnings information than the market prices of floating shares. After the reform, however, both types of transfer reflect more earnings information, although the weights are still less than that found in the market prices. Thus, China's unique setting shows that share …

Governing A Digital Business Ecosystem: Lessons From One.Motoring Portal, Gary Pan, See Liang Foo, Shongye Tan

Research Collection School Of Accountancy

While the IT innovation topic has gathered significant research interests, the existing discourse on IT innovation is centered on internal organizational processes such as IT capability development and organizational learning rather than IT innovation networks as the primary means for achieving superior enterprise performance. This is an important topic because a networked perspective of IT-enabled innovation is a critical dimension for the dynamics of collaborative innovation in today’s networked economy. In particular, the development and implementation of a digital business ecosystem (DBE); a specific type of business ecosystem defined as an IT-enabled business network of entities with differing interests bound …

Mandatory Financial Reporting Environment And Voluntary Disclosure: Evidence From Mandatory Ifrs Adoption, I-Hwa Yang, Balakrishnan K., Li X.

Research Collection School Of Accountancy

No abstract provided.

Does Corporate Governance Make Financial Reports Better, Or Just Better For Equity Investors?, Dan Segal, Benjamin Segal, Shai Levi

Research Collection School Of Accountancy

Financial reports should provide useful information to both shareholders and creditors, according to U.S. accounting principles. However, directors of corporations have fiduciary duties only toward equity holders, and those fiduciary duties normally do not extend to the interests of creditors. We examine whether this slant in corporate governance biases financial reports in favor of equity investors, and in particular leads to a downward bias in reported debt that can hurt creditors. We focus on firms’ decision to issue structured debt securities that are classified as equity in financial reports and can circumvent debt covenants. We find that when the local …

Strategies For Surviving In China's Intellectual Property Minefield, David Llewelyn, Peter J. Williamson

Research Collection Yong Pung How School Of Law

Despite a slowdown in China’s GDP growth from the double-digit heights of the last decade, it is still expanding at over 7% per annum – a growth rate that looks more sustainable. Growth in the other major emerging economies including India, Brazil and Russia, by contrast, has all but collapsed, at least for the present. Growth in the developed economies, meanwhile, remains fragile in the wake of their post-2008 financial crisis recessions. It is not surprising, therefore, that the Boards of many foreign companies are counting on winning share in the China market to support their top-line growth in coming …

The Singapore Directorship Report 2014, Clarence Goh

Research Collection School Of Accountancy

Directors play an important role in the governance of firms. This reportprovides a comprehensive study of 3,670 directors on the boards of 717companies, business trusts and REITs listed on the Singapore Exchange(SGX) as at the end of 2013. This report specifically examines the structureof boards and their composition, director tenure, remuneration, meetingattendance, gender diversity and multiple directorships. It also documentscompliance with key aspects of the Singapore Code of CorporateGovernance 2012 (the Code) relating to some of these matters.

Mean Variance Analysis Of Asian Hedge Funds, Zhidong Bai, Kok Fai Phoon, Yongchang Hui, Wing-Keung Wong

Research Collection Lee Kong Chian School Of Business

No abstract provided.

Status Reports Of The Fisheries And Aquatic Resources Of Western Australia 2013/14. State Of The Fisheries, W.J Fletcher, K. Santoro

Status Reports of the Fisheries and Aquatic Resources

The Status Reports of the Fisheries and Aquatic Resources of Western Australia (SRFAR) provide the public with an annual update on the state of the fish stocks and other aquatic resources of Western Australia (WA) managed by the Department of Fisheries (Department). These reports outline the most recent assessments of the cumulative risk status for each of the aquatic resources (assets) within WA’s six Bioregions using an Ecosystem Based Fisheries Management (EBFM) approach.

Palliative Care Nurses' Recognition And Assessment Of Delirium Symptoms: A Qualitative Study Using Critical Incident Technique, Annmarie Hosie, Meera Agar, Elizabeth Lobb, Patricia M. Davidson, Jane Phillips

Health Sciences Papers and Journal Articles

Delirium is prevalent in palliative care inpatient settings and management is often challenging. Despite nurses’ integral patient care role, little is known about palliative care nurses’ capacity to recognise, assess and respond to patients’ delirium symptoms. Objective: To explore the experiences, views and practices of inpatient palliative care nurses in delirium recognition and assessment. Settings and participants: 30 nurses from nine Australian specialist palliative care inpatient services. Design and methods: Critical incident technique (CIT) guided a series of semi-structured interviews. Prior to interviews participants were given a vignette of a palliative care inpatient with an unrecognised hypoactive delirium, to prompt …

'Workshops In Healing' For Senior Medical Students: 5 Year Overview And Appraisal, John Kearsley, Elizabeth Lobb

Health Sciences Papers and Journal Articles

We report upon the design, content and feedback from an interactive, experiential series of Workshops in Healing for senior medical students. Fifty-six final year medical students enrolled in 2×3 h workshops designed around the core themes of ‘physician know thyself’ (Workshop 1) and ‘confronting suffering’ (Workshop 2). Of the 56 students who initially enrolled, 48 students completed both workshops and provided a written openended reflection of their learning experience. The study, undertaken over a consecutive 5-year period (2008–2012), employed an emergent, qualitative design using thematic analysis of the reflective comments. We found that the design and content of both workshops …

The Importance Of Translating Evidence Into Practice In Counseling Individuals With Life-Threatening Illness, Elizabeth Lobb

Health Sciences Papers and Journal Articles

A review of Counseling Individuals with Life-Threatening Illness (2nd Edition) by Kenneth J Doka. New York: Springer Publishing Company, 2013. 324 pp. (ISBN: 978-0826195814).

Early Infant Feeding And Adiposity Risk: From Infancy To Adulthood, W H. Oddy, T A. Mori, R C Huang, J A. Marsh, C E. Pennell, Paola Chivers, Beth Hands, P Jacoby, P Rzehak, B V. Koletzko, L J. Beilin

Health Sciences Papers and Journal Articles

Introduction: Systematic reviews suggest that a longer duration of breast-feeding is associated with a reduction in the risk of later overweight and obesity. Most studies examining breast-feeding in relation to adiposity have not used longitudinal analysis. In our study, we aimed to examine early infant feeding and adiposity risk in a longitudinal cohort from birth to young adulthood using new as well as published data.

Methods: Data from the Western Australian Pregnancy Cohort (Raine) Study in Perth, W.A., Australia, were used to examine associations between breast-feeding and measures of adiposity at 1, 2, 3, 6, 8, 10, 14, 17, and …

The Challenge To Deliver Cost Effective Care For Patients With Gestational Diabetes Mellitus, Julie Quinlivan

Health Sciences Papers and Journal Articles

The global rise in obesity and gestational weight gain, along with recent trials demonstrating improved pregnancy and neonatal outcomes associated with the treatment of mild hyperglycaemia, have resulted in a clinical challenge to deliver cost effective healthcare to manage the epidemic of Gestational Diabetes Mellitus (GDM). Whilst clinicians now have clear criteria by which to diagnose GDM, and the glycaemic targets to achieve, less clear are the pathways to achieve these outcomes in a cost effective manner. The value of using allied health providers such as dieticians compared to less trained patient educators, the effectiveness of individualised versus group dietician …

Integrative Taxonomy Of Acrapex Stem Borers (Lepidoptera: Noctuidae: Apameini): Combining Morphology And Poisson Tree Process Analyses, Bruno P. Le Ru, Claire Capdevielle-Dulac, Emmanuel F.A. Toussaint, Desmond Conlong, Johnnie Van Den Berg, Beatrice Pallangyo, George Ong'amo, Gilson Chipabika, Richard Molo, William A. Overholt, James P. Cuda, Gael J. Kergoat

All Peer-Reviewed Publications

Ten morphologically similar species of Acrapex from eastern and south-eastern Africa belonging to the A. stygiata and A. albivena groups are reviewed. Six species are described as new: A. brunneella, A. mitiwa, A. mpika, A. salmona, A. sporobola and A. yakoba. The Poaceae host plants of eight species are recorded; four species, A. mitiwa. A. subalbissima, A. syscia and A. yakoba, were found developing exclusively on Imperata cylindrica (L.) Beauv., (Andropogoneae); two species, A. sporobola and A. salmona, on I. cylindrica and Sporobolus macranthelus Chiov. (Zoysieae); and A. albivena on I. cylindrica, Miscanthus capensis (Nees) Andersson (Andropogoneae) and Cymbopogon sp. …

Molecular Markers Reveal Narrow Genetic Base And Culturing-Associated Genetic Drift In Teretrius Nigrescens Lewis Populations Released For The Biological Control Of The Larger Grain Borer In Africa, B. A. Omondi, J. Van Den Berg, D. Masiga, F. Schulthess

All Peer-Reviewed Publications

In biological control, successful establishment of a natural enemy species depends on its adaptability in the introduced range including its ability to re-establish desired ecological interactions with the pest. These are affected by genetic parameters hitherto largely unresolved in biological control. The larger grain borer (LGB), Prostephanus truncatus, an invasive species from meso-America, is the most important post-harvest pest of maize in Africa. We studied the genetic structure of Teretrius nigrescens, a predatory beetle previously released for the control of the pest in Africa, to test the hypothesis that establishment patterns were a result of ecotype-environment mismatch and to follow …

Integrated Decision Support For Sustainable And Profitable Land Management In The Lowlands Of Central Asia, Nodir Djanibekov, Rolf Sommer

All Peer-Reviewed Publications

Land use and crop production in the Khorezm region in western Uzbekistan, exemplarily for the irrigated lowlands of Central Asia, are challenged by the excessive, non-sustainable use of irrigation water and repeated water shortages on one hand, and soil degradation by secondary salinization on the other hand. One of the research objectives of the German-Uzbek Khorezm project, funded by the German Ministry for Education and Research (BMBF) and led by Center of Development Research (ZEF) of Bonn University, was to better understand options for land use and choice of technology at the farm level in order to evaluate and propose …

Odorant And Gustatory Receptors In The Tsetse Fly Glossina Morsitans Morsitans, George F.O. Obiero, Paul O. Mireji, Steven R.G. Nyanjom, Alan Christoffels, Hugh M. Robertson, Daniel K. Masiga

All Peer-Reviewed Publications

Tsetse flies use olfactory and gustatory responses, through odorant and gustatory receptors (ORs and GRs), to interact with their environment. Glossina morsitans morsitans genome ORs and GRs were annotated using homologs of these genes in Drosophila melanogaster and an ab initio approach based on OR and GR specific motifs in G. m. morsitans gene models coupled to gene ontology (GO). Phylogenetic relationships among the ORs or GRs and the homologs were determined using Maximum Likelihood estimates. Relative expression levels among the G. m. morsitans ORs or GRs were established using RNA-seq data derived from adult female fly. Overall, 46 and …

Serological Surveillance Development For Tropical Infectious Diseases Using Simultaneous Microsphere-Based Multiplex Assays And Finite Mixture Models, Yoshito Fujii, Satoshi Kaneko, Samson Muuo Nzou, Matilu Mwau, Sammy M. Njenga, Chihiro Tanigawa, James Kimotho, Anne Wanjiru Mwangi, Ibrahim Kiche, Sohkichi Matsumoto, Mamiko Niki, Mayuko Osada-Oka, Yoshio Ichinose, Manabu Inoue, Makoto Itoh, Hiroshi Tachibana, Kazunari Ishii, Takafumi Tsuboi, Lay Myint Yoshida, Dinesh Mondal, Rashidul Haque, Shinjiro Hamano, Mwatasa Changoma, Tomonori Hoshi, Ken Ichi Kamo, Mohamed Karama, Masashi Miura, Kenji Hirayama

All Peer-Reviewed Publications

Background:A strategy to combat infectious diseases, including neglected tropical diseases (NTDs), will depend on the development of reliable epidemiological surveillance methods. To establish a simple and practical seroprevalence detection system, we developed a microsphere-based multiplex immunoassay system and evaluated utility using samples obtained in Kenya.Methods:We developed a microsphere-based immuno-assay system to simultaneously measure the individual levels of plasma antibody (IgG) against 8 antigens derived from 6 pathogens: Entamoeba histolytica (C-IgL), Leishmania donovani (KRP42), Toxoplasma gondii (SAG1), Wuchereria bancrofti (SXP1), HIV (gag, gp120 and gp41), and Vibrio cholerae (cholera toxin). The assay system was validated using appropriate control samples. The assay …

Volatile Phytochemicals As Mosquito Semiochemicals, Vincent O. Nyasembe, Baldwyn Torto

All Peer-Reviewed Publications

Plant biochemical processes result in the release of an array of volatile chemical substances into the environment, some of which are known to play important plant fitness enhancing functions, such as attracting pollinators, thermal tolerance of photosynthesis, and defense against herbivores. Cunningly, phytophagous insects have evolved mechanisms to utilize these volatiles to their own advantage, either to colonize a suitable host for feeding, reproduction and oviposition or avoid an unsuitable one. The volatile compounds involved in plant-insect chemical interactions have been widely exploited in the management of agricultural pests. On the other hand, use of plant volatiles in the management …

Spatial Analysis Of Human-Induced Vegetation Productivity Decline Over Eastern Africa Using A Decade (2001-2011) Of Medium Resolution Modis Time-Series Data, Tobias Landmann, Olena Dubovyk

All Peer-Reviewed Publications

Climate variation and land transformations related to exploitative land uses are among the main drivers of vegetation productivity decline and ongoing land degradation in East Africa. We combined analysis of vegetation trends and cumulative rain use efficiency differences (CRD), calculated from 250-m MODISNDVI time-series data, to map vegetation productivity loss over eastern Africa between 2001 and 2011.The CRD index values were furthermore used to discern areas of particular severe vegetation productivity loss over the observation period. Monthly 25-km Tropical Rainfall Measuring Mission (TRMM) datametrics were used to mask areas of rainfall declines not related to human-induced land productivity loss. To …