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Articles 130981 - 131010 of 135668
Full-Text Articles in Entire DC Network
Neuronal Activity Regulates Extracellular Tau In Vivo, Kaoru Yamada, Jerrah K. Holth, Fan Liao, Floy R. Stewart, Thomas E. Mahan, Hong Jiang, John R. Cirrito, Tirth K. Patel, Katja Hochgräfe, Eva-Maria Mandelkow, David M. Holtzman
Neuronal Activity Regulates Extracellular Tau In Vivo, Kaoru Yamada, Jerrah K. Holth, Fan Liao, Floy R. Stewart, Thomas E. Mahan, Hong Jiang, John R. Cirrito, Tirth K. Patel, Katja Hochgräfe, Eva-Maria Mandelkow, David M. Holtzman
Open Access Publications
Tau is primarily a cytoplasmic protein that stabilizes microtubules. However, it is also found in the extracellular space of the brain at appreciable concentrations. Although its presence there may be relevant to the intercellular spread of tau pathology, the cellular mechanisms regulating tau release into the extracellular space are not well understood. To test this in the context of neuronal networks in vivo, we used in vivo microdialysis. Increasing neuronal activity rapidly increased the steady-state levels of extracellular tau in vivo. Importantly, presynaptic glutamate release is sufficient to drive tau release. Although tau release occurred within hours in response to …
Potential Role Of Orexin And Sleep Modulation In The Pathogenesis Of Alzheimer's Disease, Jee Hoon Roh, Hong Jiang, Mary Beth Finn, Floy R. Stewart, Thomas E. Mahan, John R. Cirrito, Ashish Heda, B. Joy Snider, Mingjie Li, Masashi Yanagisawa, Luis De Lecea, David M. Holtzman
Potential Role Of Orexin And Sleep Modulation In The Pathogenesis Of Alzheimer's Disease, Jee Hoon Roh, Hong Jiang, Mary Beth Finn, Floy R. Stewart, Thomas E. Mahan, John R. Cirrito, Ashish Heda, B. Joy Snider, Mingjie Li, Masashi Yanagisawa, Luis De Lecea, David M. Holtzman
Open Access Publications
Age-related aggregation of amyloid-β (Aβ) is an upstream pathological event in Alzheimer's disease (AD) pathogenesis, and it disrupts the sleep-wake cycle. The amount of sleep declines with aging and to a greater extent in AD. Poor sleep quality and insufficient amounts of sleep have been noted in humans with preclinical evidence of AD. However, how the amount and quality of sleep affects Aβ aggregation is not yet well understood. Orexins (hypocretins) initiate and maintain wakefulness, and loss of orexin-producing neurons causes narcolepsy. We tried to determine whether orexin release or secondary changes in sleep via orexin modulation affect Aβ pathology. …
Endothelial Cells Use Dynamic Actin To Facilitate Lymphocyte Transendothelial Migration And Maintain The Monolayer Barrier, Olivia L. Mooren, Jinmei Li, Julie Nawas, John A. Cooper
Endothelial Cells Use Dynamic Actin To Facilitate Lymphocyte Transendothelial Migration And Maintain The Monolayer Barrier, Olivia L. Mooren, Jinmei Li, Julie Nawas, John A. Cooper
Open Access Publications
No abstract provided.
High-Coverage Sequencing And Annotated Assemblies Of The Budgerigar Genome, Ganeshkumar Ganapathy, Wesley C. Warren, Et Al
High-Coverage Sequencing And Annotated Assemblies Of The Budgerigar Genome, Ganeshkumar Ganapathy, Wesley C. Warren, Et Al
Open Access Publications
No abstract provided.
A Central Support System Can Facilitate Implementation And Sustainability Of A Classroom-Based Undergraduate Research Experience (Cure) In Genomics, David Lopatto, Jeremy Buhler, Elaine Mardis, Wilson Leung, Christopher D. Shaffer, Jennifer Threlfall, Et Al
A Central Support System Can Facilitate Implementation And Sustainability Of A Classroom-Based Undergraduate Research Experience (Cure) In Genomics, David Lopatto, Jeremy Buhler, Elaine Mardis, Wilson Leung, Christopher D. Shaffer, Jennifer Threlfall, Et Al
Open Access Publications
No abstract provided.
Treatment Of Metastatic Spinal Lesions With A Navigational Bipolar Radiofrequency Ablation Device: A Multicenter Retrospective Study, Praveen R. Anchala, Winston D. Irving, Travis J. Hillen, Michael V. Friedman, Bassem A. Georgy, Douglass M. Coldwell, Nam D. Tran, Frank D. Vrionis, Allan Brook, Jack W. Jennings
Treatment Of Metastatic Spinal Lesions With A Navigational Bipolar Radiofrequency Ablation Device: A Multicenter Retrospective Study, Praveen R. Anchala, Winston D. Irving, Travis J. Hillen, Michael V. Friedman, Bassem A. Georgy, Douglass M. Coldwell, Nam D. Tran, Frank D. Vrionis, Allan Brook, Jack W. Jennings
Open Access Publications
No abstract provided.
The Cavefish Genome Reveals Candidate Genes For Eye Loss, Suzanne E. Mcgaugh, Patrick Minx, Wesley C. Warren, Et Al
The Cavefish Genome Reveals Candidate Genes For Eye Loss, Suzanne E. Mcgaugh, Patrick Minx, Wesley C. Warren, Et Al
Open Access Publications
No abstract provided.
Integrated Analysis Of Germline And Somatic Variants In Ovarian Cancer, Krishna L. Kanchi, Kimberly J. Johnson, Charles Lu, Michael D. Mclellan, Michael C. Wendl, Qunyuan Zhang, Daniel C. Koboldt, Mingchao Xie, Cyriac Kandoth, Joshua F. Mcmichael, Matthew A. Wyczalkowski, David E. Larson, Heather K. Schmidt, Christopher A. Miller, Robert S. Fulton, Elaine R. Mardis, Todd E. Druley, Timothy A. Graubert, Richard K. Wilson, Li Ding, Et Al
Integrated Analysis Of Germline And Somatic Variants In Ovarian Cancer, Krishna L. Kanchi, Kimberly J. Johnson, Charles Lu, Michael D. Mclellan, Michael C. Wendl, Qunyuan Zhang, Daniel C. Koboldt, Mingchao Xie, Cyriac Kandoth, Joshua F. Mcmichael, Matthew A. Wyczalkowski, David E. Larson, Heather K. Schmidt, Christopher A. Miller, Robert S. Fulton, Elaine R. Mardis, Todd E. Druley, Timothy A. Graubert, Richard K. Wilson, Li Ding, Et Al
Open Access Publications
No abstract provided.
Secondhand Smoke Exposure And Severity Of Attention-Deficit/Hyperactivity Disorder In Preschoolers: A Pilot Investigation, Mini Tandon, Christina N. Lessov-Schlaggar, Rebecca Tillman, Melbourne F. Hovell, Joan Luby
Secondhand Smoke Exposure And Severity Of Attention-Deficit/Hyperactivity Disorder In Preschoolers: A Pilot Investigation, Mini Tandon, Christina N. Lessov-Schlaggar, Rebecca Tillman, Melbourne F. Hovell, Joan Luby
Open Access Publications
No abstract provided.
Genome-Wide Mapping Of The Distribution Of Card, Rnap Σa, And Rnap Β On The Mycobacterium Smegmatis Chromosome Using Chromatin Immunoprecipitation Sequencing, Robert Landick, Azra Krek, Michael S. Glickman, Nicholas D. Socci, Christina L. Stallings
Genome-Wide Mapping Of The Distribution Of Card, Rnap Σa, And Rnap Β On The Mycobacterium Smegmatis Chromosome Using Chromatin Immunoprecipitation Sequencing, Robert Landick, Azra Krek, Michael S. Glickman, Nicholas D. Socci, Christina L. Stallings
Open Access Publications
No abstract provided.
Illustrated Techniques For Performing The Cox-Maze Iv Procedure Through A Right Mini-Thoracotomy, Jason O. Robertson, Lindsey L. Saint, Jeremy E. Leidenfrost, Ralph J. Damiano Jr.
Illustrated Techniques For Performing The Cox-Maze Iv Procedure Through A Right Mini-Thoracotomy, Jason O. Robertson, Lindsey L. Saint, Jeremy E. Leidenfrost, Ralph J. Damiano Jr.
Open Access Publications
No abstract provided.
Cell Type-Specific Expression Analysis To Identify Putative Cellular Mechanisms For Neurogenetic Disorders, Xiaoxiao Xu, Alan B. Wells, David R. O'Brien, Arye Nehorai, Joseph D. Dougherty
Cell Type-Specific Expression Analysis To Identify Putative Cellular Mechanisms For Neurogenetic Disorders, Xiaoxiao Xu, Alan B. Wells, David R. O'Brien, Arye Nehorai, Joseph D. Dougherty
Open Access Publications
No abstract provided.
An Improved Predictive Recognition Model For Cys2-His2 Zinc Finger Proteins, Ankit Gupta, Ryan G. Christensen, Heather A. Bell, Mathew Goodwin, Ronak Y. Patel, Manishi Pandey, Metewo Selase Enuameh, Amy L. Rayla, Cong Zhu, Stacey Thibodeau-Beganny, Michael H. Brodsky, J Keith Joung, Scot A. Wolfe, Gary D. Stormo
An Improved Predictive Recognition Model For Cys2-His2 Zinc Finger Proteins, Ankit Gupta, Ryan G. Christensen, Heather A. Bell, Mathew Goodwin, Ronak Y. Patel, Manishi Pandey, Metewo Selase Enuameh, Amy L. Rayla, Cong Zhu, Stacey Thibodeau-Beganny, Michael H. Brodsky, J Keith Joung, Scot A. Wolfe, Gary D. Stormo
Open Access Publications
No abstract provided.
Comparison Of The Stand-Alone Cox-Maze Iv Procedure To The Concomitant Cox-Maze Iv And Mitral Valve Procedure For Atrial Fibrillation, Christopher P. Lawrance, Matthew C. Henn, Jacob R. Miller, Laurie A. Sinn, Richard B. Schuessler, Ralph J. Damiano Jr.
Comparison Of The Stand-Alone Cox-Maze Iv Procedure To The Concomitant Cox-Maze Iv And Mitral Valve Procedure For Atrial Fibrillation, Christopher P. Lawrance, Matthew C. Henn, Jacob R. Miller, Laurie A. Sinn, Richard B. Schuessler, Ralph J. Damiano Jr.
Open Access Publications
No abstract provided.
Hippocampal Long-Term Potentiation Is Disrupted During Expression And Extinction But Is Restored After Reinstatement Of Morphine Place Preference, George S. Portugal, Ream Al-Hasani, Amanda K. Fakira, Jose L. Gonzalez-Romero, Zare Melyan, Jordan G. Mccall, Michael R. Bruchas, Jose A. Moron
Hippocampal Long-Term Potentiation Is Disrupted During Expression And Extinction But Is Restored After Reinstatement Of Morphine Place Preference, George S. Portugal, Ream Al-Hasani, Amanda K. Fakira, Jose L. Gonzalez-Romero, Zare Melyan, Jordan G. Mccall, Michael R. Bruchas, Jose A. Moron
Open Access Publications
No abstract provided.
Electronic Health Record: Integrating Evidence-Based Information At The Point Of Clinical Decision Making, Susan A. Fowler, Lauren H. Yaeger, Feliciano Yu, Dwight Doerhoff, Paul Schoening
Electronic Health Record: Integrating Evidence-Based Information At The Point Of Clinical Decision Making, Susan A. Fowler, Lauren H. Yaeger, Feliciano Yu, Dwight Doerhoff, Paul Schoening
Open Access Publications
No abstract provided.
Whole-Genome Sequencing Of Salmonella Enterica Subsp. Enterica Serovar Cubana Strains Isolated From Agricultural Sources, George Weinstock, Et Al
Whole-Genome Sequencing Of Salmonella Enterica Subsp. Enterica Serovar Cubana Strains Isolated From Agricultural Sources, George Weinstock, Et Al
Open Access Publications
No abstract provided.
Targeting The Programmed Cell Death 1: Programmed Cell Death Ligand 1 Pathway Reverses T Cell Exhaustion In Patients With Sepsis, Katherine Chang, Catherine Svabek, Cristina Vazquez-Guillamet, Bryan Sato, David Rasche, Strother Wilson, Paul Robbins, Nancy Ulbrandt, Joann Suzich, Jonathan Green, Andriani C. Patera, Wade Blair, Subramaniam Krishnan, Richard Hotchkiss
Targeting The Programmed Cell Death 1: Programmed Cell Death Ligand 1 Pathway Reverses T Cell Exhaustion In Patients With Sepsis, Katherine Chang, Catherine Svabek, Cristina Vazquez-Guillamet, Bryan Sato, David Rasche, Strother Wilson, Paul Robbins, Nancy Ulbrandt, Joann Suzich, Jonathan Green, Andriani C. Patera, Wade Blair, Subramaniam Krishnan, Richard Hotchkiss
Open Access Publications
No abstract provided.
Tax Inflicts Dna Damage Through Activation Of Nitric Oxide Production, Hicham H. Baydoun, Lee Ratner
Tax Inflicts Dna Damage Through Activation Of Nitric Oxide Production, Hicham H. Baydoun, Lee Ratner
Open Access Publications
No abstract provided.
Economic Evaluation Of Access To Musculoskeletal Care: The Case Of Waiting For Total Knee Arthroplasty, Richard C. Mather Iii, Kevin T. Hug, Lori A. Orlando, Tyler Steven Watters, Lane Koenig, Ryan M. Nunley, Michael P. Bolognesi
Economic Evaluation Of Access To Musculoskeletal Care: The Case Of Waiting For Total Knee Arthroplasty, Richard C. Mather Iii, Kevin T. Hug, Lori A. Orlando, Tyler Steven Watters, Lane Koenig, Ryan M. Nunley, Michael P. Bolognesi
Open Access Publications
No abstract provided.
Novel Treatment Option For Muc16-Positive Malignancies With The Targeted Trail-Based Fusion Protein Meso-Tr3, Gunjal Garg, Jesse Gibbs, Brian Belt, Matthew A. Powell, David G. Mutch, Peter Goedegebuure, Lynne Collins, David Piwnica-Worms, William G. Hawkins, Dirk Spitzer
Novel Treatment Option For Muc16-Positive Malignancies With The Targeted Trail-Based Fusion Protein Meso-Tr3, Gunjal Garg, Jesse Gibbs, Brian Belt, Matthew A. Powell, David G. Mutch, Peter Goedegebuure, Lynne Collins, David Piwnica-Worms, William G. Hawkins, Dirk Spitzer
Open Access Publications
No abstract provided.
A Cross-Sectional Study Of Differences In 6-Min Walk Distance In Healthy Adults Residing At High Altitude Versus Sea Level, Deirdre Caffrey, J. Jaime Miranda, Robert H. Gilman, Victor G. Davila-Roman, Lilia Cabrera, Russell Dowling, Talia Stewart, Antonio Bernabe-Ortiz, Robert Wise, Fabiola Leon-Velarde, William Checkley, Cronicas Cohort Study Group
A Cross-Sectional Study Of Differences In 6-Min Walk Distance In Healthy Adults Residing At High Altitude Versus Sea Level, Deirdre Caffrey, J. Jaime Miranda, Robert H. Gilman, Victor G. Davila-Roman, Lilia Cabrera, Russell Dowling, Talia Stewart, Antonio Bernabe-Ortiz, Robert Wise, Fabiola Leon-Velarde, William Checkley, Cronicas Cohort Study Group
Open Access Publications
No abstract provided.
The Bacterial Amyloid Curli Is Associated With Urinary Source Bloodstream Infection, Chia Hung, Jonas Marschall, Carey-Ann D. Burnham, Albert S. Byun, Jeffrey P. Henderson
The Bacterial Amyloid Curli Is Associated With Urinary Source Bloodstream Infection, Chia Hung, Jonas Marschall, Carey-Ann D. Burnham, Albert S. Byun, Jeffrey P. Henderson
Open Access Publications
No abstract provided.
Regulation Of The Hsp104 Middle Domain Activity Is Critical For Yeast Prion Propagation, Jennifer E. Dulle, Kevin C. Stein, Heather L. True
Regulation Of The Hsp104 Middle Domain Activity Is Critical For Yeast Prion Propagation, Jennifer E. Dulle, Kevin C. Stein, Heather L. True
Open Access Publications
No abstract provided.
Over-Expression Of Tresk K(+) Channels Reduces The Excitability Of Trigeminal Ganglion Nociceptors, Zhaohua Guo, Yu-Qing Cao
Over-Expression Of Tresk K(+) Channels Reduces The Excitability Of Trigeminal Ganglion Nociceptors, Zhaohua Guo, Yu-Qing Cao
Open Access Publications
No abstract provided.
High Pressure Freezing/Freeze Substitution Fixation Improves The Ultrastructural Assessment Of Wolbachia Endosymbiont – Filarial Nematode Host Interaction, Kerstin Fischer, Wandy L. Beatty, Gary J. Weil, Peter U. Fischer
High Pressure Freezing/Freeze Substitution Fixation Improves The Ultrastructural Assessment Of Wolbachia Endosymbiont – Filarial Nematode Host Interaction, Kerstin Fischer, Wandy L. Beatty, Gary J. Weil, Peter U. Fischer
Open Access Publications
No abstract provided.
Age, Gender, And Cancer But Not Neurodegenerative And Cardiovascular Diseases Strongly Modulate Systemic Effect Of The Apolipoprotein E4 Allele On Lifespan, Alexander M. Kulminski, Konstantin G. Arbeev, Irina Culminskaya, Liubov Arbeeva, Svetlana V. Ukraintseva, Eric Stallard, Kaare Christensen, Nicole Schupf, Michael A. Province, Anatoli I. Yashin
Age, Gender, And Cancer But Not Neurodegenerative And Cardiovascular Diseases Strongly Modulate Systemic Effect Of The Apolipoprotein E4 Allele On Lifespan, Alexander M. Kulminski, Konstantin G. Arbeev, Irina Culminskaya, Liubov Arbeeva, Svetlana V. Ukraintseva, Eric Stallard, Kaare Christensen, Nicole Schupf, Michael A. Province, Anatoli I. Yashin
Open Access Publications
No abstract provided.
Il-15 Deficient Tax Mice Reveal A Role For Il-1Α In Tumor Immunity, Daniel A. Rauch, John C. Harding, Lee Ratner
Il-15 Deficient Tax Mice Reveal A Role For Il-1Α In Tumor Immunity, Daniel A. Rauch, John C. Harding, Lee Ratner
Open Access Publications
No abstract provided.
Wise Regulates Bone Deposition Through Genetic Interactions With Lrp5, Debra L. Ellies, Androulla Economou, Beth Viviano, Jean-Philippe Rey, Stephanie Paine-Saunders, Robb Krumlauf, Scott Saunders
Wise Regulates Bone Deposition Through Genetic Interactions With Lrp5, Debra L. Ellies, Androulla Economou, Beth Viviano, Jean-Philippe Rey, Stephanie Paine-Saunders, Robb Krumlauf, Scott Saunders
Open Access Publications
No abstract provided.
Exploration Of Bacterial Community Classes In Major Human Habitats, Yanjiao Zhou, Kathie A. Mihindukulasuriya, Hongyu Gao, Patricio S. La Rosa, Kristine M. Wylie, John C. Martin, Karthik Kota, William D. Shannon, Makedonka Mitreva, Erica Sodergren, George M. Weinstock
Exploration Of Bacterial Community Classes In Major Human Habitats, Yanjiao Zhou, Kathie A. Mihindukulasuriya, Hongyu Gao, Patricio S. La Rosa, Kristine M. Wylie, John C. Martin, Karthik Kota, William D. Shannon, Makedonka Mitreva, Erica Sodergren, George M. Weinstock
Open Access Publications
No abstract provided.