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Virtual Screening And Discovery Of Lead Compounds As Potential Dna Methyltransferase 1 Inhibitors And Anticancer Agents, Ogar Ofuka Ichire

Graduate Student Theses, Dissertations, & Professional Papers

Epigenetic changes consist of DNA methylation, histone modification, micro RNA and genome imprinting. DNA methylation of the CpG islands is one of the main methods of epigenetic inactivation of genes and aberrant methylations at promoter regions of tumor suppressor genes can alter gene expression and play an important role in cancer development. DNA methyltransferase I (Dnmt1) is the enzyme responsible for maintaining methylation patterns during cell division and it is overexpressed in many cancers. Thus, Dnmt1 is a promising therapeutic target for development of novel anticancer agents and epigenetic modulators. We have developed two promising class of lead candidates, compounds …

A Study Of Hydroclimatic Dynamics In Mountain Landscapes, Nicholas Loren Silverman

Graduate Student Theses, Dissertations, & Professional Papers

The hydroclimatic regime of mountain landscapes in the Pacific Northwest, USA plays a large role in collecting, storing, and distributing water throughout the greater United States. The complexities of the landscape, vegetation, and anthropogenic impacts within this region form a dynamic web of interactions that create unique challenges when quantifying hydrologic variables. This dissertation focuses on these challenges and introduces a new way of deciphering the driving mechanism of streamflow trends. The first project examines the differences between modeling techniques in mountain terrain. In this project, we use a physically-based regional climate model to dynamically downscale global climate estimates for …

Characterization Of Nipah Virus Pathogenicity In Vitro And In Vivo And Protection From Disease Using A Single Dose Recombinant Vaccine, Blair Lynn Debuysscher

Graduate Student Theses, Dissertations, & Professional Papers

Nipah virus is a zoonotic pathogen that infects a wide species range including humans. It was first discovered in Malaysia in 1998 during a large outbreak, but since has spread to Bangladesh and India causing almost yearly outbreaks in the region since 2001. The distinct geographic locations have led to two genetically varied strains. Infection of humans by Nipah virus leads to respiratory distress and acute encephalitis. Pathology caused by the virus is characterized by vasculitis, necrosis, and edema of small vessels of the lung and brain primarily. This work investigates differences of pathology and clinical signs in the hamster …

P115-Snare Interactions Reveal A New Model Of Function For The Tethering Factor P115, Ting Wang

Graduate Student Theses, Dissertations, & Professional Papers

The endomembrane system consists of several connected yet distinct compartments, constantly exchanging material via the flow of membrane-enclosed vesicles. Protein transport between the endoplasmic reticulum (ER) and the Golgi is one of the most fundamental trafficking pathways in eukaryotic cells, as well as the first step in the secretory pathway. The fusion between vesicles and target membranes requires the orchestration of tethers, Rabs, SM proteins and SNAREs. Tethering factors regulate the targeting of membrane-enclosed vesicles and enhance the efficiency as well as specificity of membrane fusion. P115, a Golgin family tether, has been shown to participate in multiple stages of …

Development Of Traffic Safety Zones And Integrating Macroscopic And Microscopic Safety Data Analytics For Novel Hot Zone Identification, Jaeyoung Lee

Electronic Theses and Dissertations

Traffic safety has been considered one of the most important issues in the transportation field. With consistent efforts of transportation engineers, Federal, State and local government officials, both fatalities and fatality rates from road traffic crashes in the United States have steadily declined from 2006 to 2011.Nevertheless, fatalities from traffic crashes slightly increased in 2012 (NHTSA, 2013). We lost 33,561 lives from road traffic crashes in the year 2012, and the road traffic crashes are still one of the leading causes of deaths, according to the Centers for Disease Control and Prevention (CDC). In recent years, efforts to incorporate traffic …

The Impact Of Race And Ethnicity On Sexual Violence: A Case Study On Underserved Populations In Minnesota, Lindsay Bolstad

All Graduate Theses, Dissertations, and Other Capstone Projects

Sexual violence in Minnesota impacts hundreds of thousands of lives and costs billions of dollars each year. This qualitative case study describes how victims that are people of color experience sexual violence at disproportionately high rates and face additional barriers when seeking legal, medical, and mental health and crisis advocacy services in Minnesota. The methodology employed includes secondary data collection using books, scholarly articles, and archival data. Individual interviews and a focus group interview were used to collect primary research. The voluntary interview participants were advocates that provide services for victims of sexual violence in Minnesota. The interviews were audio-recorded …

Climate And Landscape Controls On Seasonal Water Balance At The Watershed Scale, Xi Chen

Electronic Theses and Dissertations

The main goal of this dissertation is to develop a seasonal water balance model for evaporation, runoff and water storage change based on observations from a large number of watersheds, and further to obtain a comprehensive understanding on the dominant physical controls on intra-annual water balance. Meanwhile, the method for estimating evaporation and water storage based on recession analysis is improved by quantifying the seasonal pattern of the partial contributing area and contributing storage to base flow during low flow seasons. A new method for quantifying seasonality is developed in this research. The difference between precipitation and soil water storage …

The Effect Of Interpersonal Relationships On The Body Image Of First Year, Women Of Color Studying At Predominately White Undergraduate Institutions, Lauren Kross

All Graduate Theses, Dissertations, and Other Capstone Projects

"The Effect of Interpersonal Relationships on the Body Image of First Year, Women of Color Studying at Predominately White Undergraduate Institutions" by Lauren Kross, a 2014 graduate student in the Gender and Women's Studies Department at Minnesota State University Mankato, focuses on how relationships and peer groups positively or negatively impact the body image of first year women of color studying at Minnesota State University Mankato, a predominately white undergraduate institution. The first year of college is a time that students experience many changes in their environment, academics, interests, and identity development. Their previously formed and newly formed relationships play …

Pursuit Of Empowerment: The Evolution Of The Romance Novel And Its Readership In Fifty Shades Of Grey, Amy Elizabeth Quale

All Graduate Theses, Dissertations, and Other Capstone Projects

This thesis examines the new-adult romance work Fifty Shades of Grey by E L James and the novel's readership to identify the evolution of the romance genre and the ways in which the genre is used as a tool for empowerment. As the genre evolves, subgenres develop with the new "empowering" characteristics. As new technologies present themselves to readers, readers have more opportunities to participate with one another and affect the genre's evolution. I assert that Fifty Shades of Grey and the romance community are limited by the patriarchal values traditionally portrayed by the genre; however, the nature of the …

Recreating Paris In Les Miserables, Joel Schiebout

All Graduate Theses, Dissertations, and Other Capstone Projects

This document is a thesis submitted in partial fulfillment of the Master of Fine Arts degree in theatre. It is a detailed account of author Joel Schiebout's technical process in the construction of the set for Minnesota State University, Mankato's production of Les Misérables in the fall of 2013. The thesis chronicles the author's technical process from pre-production through post-production in five chapters: an early production analysis, a historical and critical perspective, a construction process journal, a post-production analysis and a process development analysis. Appendices and works cited are included.

Testing The Fertility And Allelopathic Abilities Of Arctotheca Prostrata (Salisb.) Britten (Asteraceae, Arctotideae), A South African Plant Species That Has Naturalized In California, Jordy Veit

All Graduate Theses, Dissertations, and Other Capstone Projects

Arctotheca prostrata is a perennial plant species native to South Africa that reproduces vegetatively by long runners. In South Africa it also reproduces sexually, producing fruits with fertile seeds. The species was brought to California to serve as a ground cover but fruits had not been reported. Historically, it has been said to be infertile. This study tested the fertility of A. prostrata in California by crossing plants from California with each other and with plants grown from imported South African seeds. Pollen viability was tested and morphological measures were made on heads, leaves, and pollen. Mean Californian and South …

[Implied Depth]*, Hope Thier

All Graduate Theses, Dissertations, and Other Capstone Projects

While snooping through my great grandmother's belongings, I found late 19th and early 20th century photographs and stories of untold familial histories, from that of my own family and others. I have taken to adopting these families, and I am attracted to these almost forgotten narratives and developing these incomplete truths about past relatives into fictionalized characters and false histories. I strive to develop a chaotic but structured quality in my work. While doing so, I explore relationships. The relationships evolve between myself and the material, myself and the characters, and the characters and the material. By observing and learning …

All Things In All Ways, Amanda Nicole Crary

All Graduate Theses, Dissertations, and Other Capstone Projects

This thesis highlights our obliviousness to nonhuman nature and how this ignorance severs a great connection to the earth and our senses. My work explores this important connectedness. The natural world is filled with fleeting revelations that shatter habitual ways of seeing and experiencing; my paintings act as record of such moments. The exhibition was held at the Conkling Gallery in Nelson Hall from February 24th to March 5th, 2014. It consisted of twenty-two works including paintings, drawings, and prints. All works were produced during my time within the M.A. program, 2012-2014. Postcards and a brochure advertised the exhibition. The …

Perspectives Of Female Leaders In Athletic Training, Kyle Matthew Momsen

All Graduate Theses, Dissertations, and Other Capstone Projects

Previous research has found that women face barriers in athletic training and it appears that they are not represented in leadership positions in numbers equal to the demographics of athletic training. The purpose of this research was to explore the leadership experiences and perspectives of female athletic trainers who have earned a leadership position at the highest levels in athletic training. This qualitative investigation utilized semi-structured, open-ended interviews with 12 women that held national leadership positions in athletic training. The data from this investigation suggests that many of the barriers that previously faced women in athletic training have decreased or …

Different Times In Different Places, Wesley Oates Taylor

All Graduate Theses, Dissertations, and Other Capstone Projects

Wes earned a B.F.A. in photography at Utah State University and worked as a commercial/industrial photographer for a more than a decade in the photogenic state of Utah. He received a master's degree in instructional design and technology and was an IT director/manager for over 23 years. While working in IT he kept his photography alive both professionally and personally. He currently enjoys teaching art at South Central College, Mankato, MN. His photography has been published worldwide. Wes' most memorable photography moment was in 1984 when he received the best in show/purchase award from Ruth Bernhard at the Annual Utah …

Manifestaciones Del Teatro Del Absurdo En Las Obras De Cristian Cortez, Angela Rocio Rodriguez-Mora

All Graduate Theses, Dissertations, and Other Capstone Projects

This work presents a study of the characteristics of the Theatre of the Absurd in Latin America and in particular Ecuador, through the study of the work of the Ecuadorian author Cristian Cortez. We review the origins of the genre from the original works of its founders -such as Samuel Beckett and Eugene Ionesco in Europe- and base our analysis in the classification made by Martin Esslin in his book Theatre of the Absurd. This study pays particular attention to the conditions in which this genre developed in Latin America, the cultural, political, social and economic aspects, and the main …

Relationships Between Isolating Land Use And Amphibian Populations In Sub-Boreal Peatlands Of The Midwestern United States, Jeana Rose Albers

All Graduate Theses, Dissertations, and Other Capstone Projects

Successful conservation efforts of amphibians depend on the knowledge of habitat preferences because the biggest threat to amphibian populations is considered to be habitat loss. Sub-boreal peatlands in the Midwest may be a refuge for amphibian populations, but little is known about the flora and fauna of these peatlands. My study examined amphibian species richness and species diversity in 17 sub-boreal peatlands in Minnesota and Wisconsin in 2011 and 2012. I assessed the relationship between land use of lands adjacent to peatlands and use of those peatlands by amphibian populations at three spatial scales by examining landscapes surrounding peatlands in …

High Fat Diet Increased Serum Glutamate Dehydrogenase More Than Chronic Acetaminophen Dosing In Female Mice, Elizabeth Ruth Behmer

All Graduate Theses, Dissertations, and Other Capstone Projects

This laboratory study examined the effects of acetaminophen overdose in normal fed and high-fat fed female mice. Forty female mice were placed on normal and high-fat diets at 4 weeks old. When the mice were significantly different in weight (between 6 and 9 months old), half the mice were dosed with acetaminophen. These mice were daily given an overdose of acetaminophen for 14 days. The dose used was 300 mg/kg mouse (LD50 = 338 mg/kg). The control group was given 10 µl water/g mouse. Levels of serum glutamate dehydrogenase (GDH) were measured to indicate liver damage. GDH is released from …

And The Road Will Take You There: What The Cartographer Said, Cassandra Sharri Labairon

All Graduate Theses, Dissertations, and Other Capstone Projects

This thesis of mixed-media pieces, The Cartographer series, combines, with stitches and rough lace work, miniature acrylic paintings, weavings, and various other elements. The materials come from three different spheres: traditional fine art materials, such as canvas and paint; handiwork materials, such as cross-stitch or needlepoint; reclaimed materials, such as burlap, wire, or string. Thread is used to both draw and connect. Stitches not only lock each element in place, they create links and relationships between painted pieces, thread, and empty space.

The mixed-media pieces were made in conjunction with chapbook of poetry titled, _And the Road Will Take You …

A Dynamic, Distributed Hydrologic Model For The Blue Earth River Watershed, Minnesota With Implications Regarding Land Use And Water Quality, Michael L. Merlini

All Graduate Theses, Dissertations, and Other Capstone Projects

The Blue Earth River (BER) watershed covers approximately one million acres of south-central Minnesota and northern Iowa. Modern farming practices have led to the loss of over 90 percent of the watershed's original wetlands. Corresponding changes in runoff and stream flow have led to dramatically reduced water quality in the BER's main stem following most precipitation events. The purpose of this research is to examine the relationships among precipitation, infiltration, base flow, and runoff in the Blue Earth River watershed basin.

This study developed a calibrated numerical hydrologic model for BER watershed using the distributed flow model, Vflo™. The model …

College Student Perceptions Of Mental Health Counseling At Minnesota State University, Mankato, Holly Barkeim

All Graduate Theses, Dissertations, and Other Capstone Projects

The Counseling Center at Minnesota State University, Mankato offers mental health counseling services to MNSU students that are free, confidential, and conveniently located on campus. Despite the range of services, the affordability and confidentiality, as well as current marketing strategies used by the Counseling Center, services appear to be significantly underutilized by students on campus. This study examines student perceptions of on campus mental health services and barriers that may prevent students from accessing services. The goal of the project is to assist the Counseling Center in improving their marketing strategies to students identified as being underserved.

Training And Burnout Among Paraprofessionals Who Work With Children With Ebd, Daniel Boston

All Graduate Theses, Dissertations, and Other Capstone Projects

The purpose of this project was to learn about the experiences of paraprofessionals who are working with children with emotional behavior disorders and, more specifically, their perceptions about the adequacy of training and the burnout they may experience.

Impact Evaluation On The Parents Support And Outreach Program (Psop) Olmsted County Child And Family Services, Lucy Matos

All Graduate Theses, Dissertations, and Other Capstone Projects

The purpose of this impact evaluation was to identify critical components that support the work done by PSOP by analyzing the effectiveness in serving all families, and to monitor the relative cost of providing these essential services to the at risk population in Olmsted County.

1. To obtain a sample of cases closed in 2011 and categorize them by type of services / determinations prior, during and after PSOP involvement.
2. To conduct a two-year follow up on PSOP impact; including a) maltreatment report by type and finding, and b) reentry for Child and Family Services by type and intensity (voluntary/involuntary).
3. To …

Positive Behavioral Interventions And Supports (Pbis): Lessons Learned From The Implementation Process Of An Evidence-Based Program, Tara Mershon

All Graduate Theses, Dissertations, and Other Capstone Projects

The purpose of this project is to assess the implementation process of PBIS in rural, consolidated school districts in southern Minnesota. The ideals of PBIS are in line with GFW Schools mission to foster lifelong learners in a caring environment. GFW schools aspire to promote positive social and emotional behavior and provide all students with a quality education to prepare them for future educational experiences. The recommendations from this project will inform the implementation of PBIS in the GFW School District, which is occurring in the 2014-2016 academic years.

Cpt Vs Pe For Ptsd? Literature Review On Efficacy Of Cpt And Pe Based On Gender, Chronicity, And Race/Ethnicity, Christelle C. Sackey

All Graduate Theses, Dissertations, and Other Capstone Projects

Post-traumatic stress disorder (PTSD) is a debilitating mental health condition that can be diagnosed on veterans who have been exposed to traumatic events. PTSD not only has negative physical symptoms, but it also compromises veterans’ chances of living a productive live. Efforts to find effective treatments for PTSD has led to the development of a few form of therapies, including Prolonged Exposure(PE) and Cognitive Processing Therapy (CPT) which have received special attention for military related PTSD. After more than 20 years of research, it has been proven that CPT and PE are the best treatments of choice for PTSD. However, …

Mental Health Services Among Children Involved In Child Welfare: Identifying Parental Views And Barriers To Accessing Services, Katrina Ohmann-Thai

All Graduate Theses, Dissertations, and Other Capstone Projects

• In the child welfare field there is an growing need for mental health support for children. This need is due to exposure to or victimization of abuse and neglect. On average only 15-25% of children identified as needing services are actually participating in some type of mental health support. This may be due to the many barriers that exist when seeking mental health support.
• This research project surveyed parents in Independent School District (ISD) 196 regarding potential mental health services offered through the School-Linked Mental Health Services grant. Information was collected through a survey of parents from two schools within …

Legalization Of Medical Marijuana In Minnesota: Implications For Rural Substance Treatment Centers, Ann Przybilla

All Graduate Theses, Dissertations, and Other Capstone Projects

The purpose of this project was to identify the anticipated impacts of legalization of medical marijuana (cannabis) in Minnesota on rural substance abuse treatment center professionals. The goal is to utilize the implications of those impacts to guide the implementation of the recently passed legislation and to provide recommendations for future policy regarding medical marijuana in Minnesota.

Training And Burnout Among Paraprofessionals Who Work With Children With Emotional Behavioral Disorders, Jenna Robinson

All Graduate Theses, Dissertations, and Other Capstone Projects

To assist the Waseca school district in addressing the training and self-care needs of paraprofessionals, keeping the overall mission in mind of empowering students to succeed in the academic environment, this project examined the training received and factors related to subsequent professional burnout among paraprofessionals in Waseca schools.

Expanding ‘Family Education’ Programs For Intensive Residential Treatment Services (Irts): A Study Of Minnesota Irts Programs, Abby Sharp

All Graduate Theses, Dissertations, and Other Capstone Projects

Intensive Residential Treatment Services (IRTS) programs provide mental health treatment to adults with a Severe and Persistent Mental Illness (SPMI). The programs are required by the state of Minnesota to offer family education and support to clients and their families while the clients are receiving IRTS treatment. The purpose of this project was to assess IRTS programs across the state, and in conclusion, provide an expansive family education program at Horizon Homes, Inc. IRTS program in South Central Minnesota.

Responding To A Community Need: Mobile Crisis Program Training Manuals, Kelsey Tollefson

All Graduate Theses, Dissertations, and Other Capstone Projects

The purpose of this project was to develop a training curriculum for the South Central Mobile Crisis Program, which is a part of Horizon Homes, Inc. Continued education and training is required for all mental health professionals, mental health practitioners, and rehabilitative staff. Because of the requirements outlined in Minnesota statute 256B.0944, 256B.0624,and the Department of Human Services, all staff within this program must receive at least thirty hours of crisis-related training prior to working with clients.