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2014

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Mitochondrial Gene Expression In Human Mononuclear Cells, Monika Ruchala Jan 2014

Mitochondrial Gene Expression In Human Mononuclear Cells, Monika Ruchala

Theses and Dissertations

MITOCHONDRIAL GENE EXPRESSION IN HUMAN MONONUCLEAR CELLS By Monika D. Ruchała, M.S. A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science at Virginia Commonwealth University. Virginia Commonwealth University, 2014. Director: Dr. James P. Bennett Jr, M.D., Ph.D., Bemiss Professor Departments of Neurology, Psychiatry and Physiology and Biophysics Adult neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS), have been intensively studied in recent years in pursuit of mechanisms responsible for origin and progression. One emerging theme is mitochondrial energetic deficiency as a mechanism of neuronal death. Recent descriptions of protocols to generate induced pluripotent stems …

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Development Of A Collaborative Goal Setting Measure For Patients With Diabetes, Heather Morris Jan 2014

Development Of A Collaborative Goal Setting Measure For Patients With Diabetes, Heather Morris

Theses and Dissertations

Introduction: The potential benefits of collaborative goal setting in the clinical setting have been shown. However, we have a limited understanding about what needs to have transpired between a patient and his or her clinician for them to report that they engaged in collaborative goal setting. Therefore, our ability to monitor and foster collaborative goal setting remains limited. Methods: My three-manuscript dissertation used a mixed-methods approach utilizing both qualitative and quantitative research methods. The aims of my study were to: (1) develop a conceptual model of collaborative goal setting as perceived by patients; (2) generate a list of survey items …

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Characteristics Of Effective Communication About Mental Health In An African American Urban Community: A Qualitative Analysis, Jeannette Porter Jan 2014

Characteristics Of Effective Communication About Mental Health In An African American Urban Community: A Qualitative Analysis, Jeannette Porter

Theses and Dissertations

Research has shown African Americans experience mental health issues at the same rate as the general population but seek treatment at only one-third that rate. Eleven African American low-income urban community leaders with basic training in mental health issues were interviewed about their perceptions of African American patterns of communication on mental health issues. Findings included a general consensus that the topic is generally not discussed, although passing references to a party’s perceived mental illness may be made using humor. When such discussion does take place, it happens only in a “safe space” with a trusted dialogue partner. Non-verbal cues …

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Multiferroic Nanomagnetic Logic: Hybrid Spintronics-Straintronic Paradigm For Ultra-Low Energy Computing, Mohammad Salehi Fashami Jan 2014

Multiferroic Nanomagnetic Logic: Hybrid Spintronics-Straintronic Paradigm For Ultra-Low Energy Computing, Mohammad Salehi Fashami

Theses and Dissertations

Excessive energy dissipation in CMOS devices during switching is the primary threat to continued downscaling of computing devices in accordance with Moore’s law. In the quest for alternatives to traditional transistor based electronics, nanomagnet-based computing [1, 2] is emerging as an attractive alternative since: (i) nanomagnets are intrinsically more energy-efficient than transistors due to the correlated switching of spins [3], and (ii) unlike transistors, magnets have no leakage and hence have no standby power dissipation. However, large energy dissipation in the clocking circuit appears to be a barrier to the realization of ultra low power logic devices with such nanomagnets. …

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The Impact Of A Primary Care Psychology Training Program On Medical Utilization In A Community Sample, Autumn Lanoye Jan 2014

The Impact Of A Primary Care Psychology Training Program On Medical Utilization In A Community Sample, Autumn Lanoye

Theses and Dissertations

Mental illness and psychological distress is associated with higher rates of medical service usage and treatment of these issues results in more appropriate medical utilization rates. Little research has been conducted in an integrated care clinic, wherein health psychologists or behavioral health specialists work together with physicians to provide patient care. The current study examines the effects of brief behavioral and mental health interventions on patient medical utilization in this setting with care delivered by medical residents and doctoral psychology trainees. Access to the health system’s electronic billing records allowed for objective measures of annual healthcare utilization in terms of …

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Characterization Of The Effects Of Iron On Neisseria Gonorrhoeae Surface Protein Modulation And Host Cell Interactions, Aminat Oki Jan 2014

Characterization Of The Effects Of Iron On Neisseria Gonorrhoeae Surface Protein Modulation And Host Cell Interactions, Aminat Oki

Theses and Dissertations

Iron is an essential nutrient that is sequestered by iron-binding proteins in the human host resulting in a hostile environment for microbes. Neisseria gonorrhoeae, however, can utilize numerous iron-binding proteins such as transferrin and lactoferrin to acquire this nutrient. During initial infection, gonococci have access to transferrin and lactoferrin present in semen and vaginal fluids, as well as to hemoglobin present in blood during menses or disseminated infections. Consequently, the gonococcus likely encounters conditions of high iron at some stages in the course of natural infection. Potential contributions of iron to gonococcal invasion have however been largely over looked in …

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Evaluation Of The Allometric Exponents In Prediction Of Human Drug Clearance, Da Zhang Jan 2014

Evaluation Of The Allometric Exponents In Prediction Of Human Drug Clearance, Da Zhang

Theses and Dissertations

Background. Allometric scaling (AS) is widely used in predicting human clearance (CL) based on animal data. Substantial prediction errors have been commonly observed and various modifications to AS have not provided a broad reliable improvement. In this study, an extensive data set was assembled including animal and human systemic CL and physiochemical properties. The allometric exponents were calculated based on multiple species AS and single-species AS methods. The correlations between the allometic exponents and physiochemical properties were evaluated in an attempt to find covariates that may explain the inter-compound variability in the allometric exponents. Lastly, the statistical approaches in analyzing …

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Computational Study Of Protein-Protein Interactions In Misfolded States, Oscar Bastidas Jan 2014

Computational Study Of Protein-Protein Interactions In Misfolded States, Oscar Bastidas

Theses and Dissertations

Protein-protein interactions (PPI’s) play important roles in biological systems. In particular, intra-protein interactions help create and maintain correctly folded protein states and mutations that result in misfolded states may be associated with significant changes in PPI behavior. Six unrelated protein systems with known structure files, each consisting of a wild-type and mutant strain, were studied using the computational algorithm OpenContact©. OpenContact© is a simple tool that can be used to rapidly identify or map interactions “hot-spots” in a protein and was, consequently, used in this study as a starting point to examine the potential or possible role of PPI’s on …

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Discovering Spam On Twitter, Ioana-Alexandra Bara Jan 2014

Discovering Spam On Twitter, Ioana-Alexandra Bara

Theses and Dissertations

Twitter generates the majority of its revenue from advertising. Third parties pay to have their products advertised on Twitter through: tweets, accounts and trends. However, spammers can use Sybil accounts (fake accounts) [21] to advertise and avoid paying for it. Sybil accounts are highly active on Twitter performing advertising campaigns to serve their clients [5]. They aggressively try to reach a large audience to maximize their influence. These accounts have similar behavior if controlled by the same master. Most of their spam tweets include a shortened URL to trick users into clicking on it. Also, since they share resources with …

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Prediction Of Human Systemic, Biologically Relevant Pharmacokinetic (Pk) Properties Using Quantitative Structure Pharmacokinetic Relationships (Qspkr) And Interspecies Pharmacokinetic Allometric Scaling (Pk-As) Approaches For Four Different Pharmacological Classes Of Compounds, Gopichand Gottipati Jan 2014

Prediction Of Human Systemic, Biologically Relevant Pharmacokinetic (Pk) Properties Using Quantitative Structure Pharmacokinetic Relationships (Qspkr) And Interspecies Pharmacokinetic Allometric Scaling (Pk-As) Approaches For Four Different Pharmacological Classes Of Compounds, Gopichand Gottipati

Theses and Dissertations

This research developed and validated QSPKR models for predicting in-vivo human, systemic biologically relevant PK properties (i.e., reflecting the disposition of the unbound drug) of four, preselected, pharmacological classes of drugs, namely, benzodiazepines (BZD), neuromuscular blocking agents (NMB), triptans (TRP) and class III antiarrhythmic agents (AAR), as well as PK allometric scaling (PK-AS) models for BZD and NMB, using pertinent human and animal systemic PK information (fu, CLtot, Vdss and fe) from published literature. Overall, lipophilicity (logD7.4) and molecular weight (MW) were found to be the most important and statistically significant molecular properties, affecting biologically relevant systemic PK properties, and …

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The Effect Of Simultaneous, Irrelevant Auditory And Visual Stimuli On A Forced-Attention Dichotic Listening Test, Keri Davis Jan 2014

The Effect Of Simultaneous, Irrelevant Auditory And Visual Stimuli On A Forced-Attention Dichotic Listening Test, Keri Davis

Theses and Dissertations

Many of the studies examining cognitive control during selective attention across different sensory modalities conflict. This study was designed to study the effect of an irrelevant visual stimulus and an auditory distraction of backward speech on a forced attention dichotic listening test. I predicted that the visual stimulus and backward speech would not have a significant effect on the ear advantage. The results showed that all subjects were able to force their attention to the ear regardless of the visual or auditory distracters. In addition, I found that an irrelevant visual stimulus affects auditory attention more so in the left …

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Applications Of 4-State Nanomagnetic Logic Using Multiferroic Nanomagnets Possessing Biaxial Magnetocrystalline Anisotropy And Experiments On 2-State Multiferroic Nanomagnetic Logic, Noel D'Souza Jan 2014

Applications Of 4-State Nanomagnetic Logic Using Multiferroic Nanomagnets Possessing Biaxial Magnetocrystalline Anisotropy And Experiments On 2-State Multiferroic Nanomagnetic Logic, Noel D'Souza

Theses and Dissertations

Nanomagnetic logic, incorporating logic bits in the magnetization orientations of single-domain nanomagnets, has garnered attention as an alternative to transistor-based logic due to its non-volatility and unprecedented energy-efficiency. The energy efficiency of this scheme is determined by the method used to flip the magnetization orientations of the nanomagnets in response to one or more inputs and produce the desired output. Unfortunately, the large dissipative losses that occur when nanomagnets are switched with a magnetic field or spin-transfer-torque inhibit the promised energy-efficiency. Another technique offering superior energy efficiency, “straintronics”, involves the application of a voltage to a piezoelectric layer to generate …

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Early Prediction Of Fracture In Bodies Bounded By Random Rough Surfaces, Hector Medina Jan 2014

Early Prediction Of Fracture In Bodies Bounded By Random Rough Surfaces, Hector Medina

Theses and Dissertations

Under certain loading conditions, surfaces topography coupled with materials degree of brittleness can significantly compromise the mechanical performance of structures. The foregoing remains valid even if roughness is intentionally introduced for engineering reasons. In either case, stress can concentrate. The case of the stress concentration in surfaces having randomly distributed pits is a problem that, although being very practical, yet it remains unsolved. The complexity of a random configuration renders difficult the problem of analytically finding relationships between surface parameters and markers indicative of mechanical failure. Another difficulty is the reproducibility of replicates of specimens possessing random rough surfaces, for …

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Joining And Hermetic Sealing Of Silicon Carbide Using Iron, Chromium, And Aluminum Alloys, Andrew Morgan Jan 2014

Joining And Hermetic Sealing Of Silicon Carbide Using Iron, Chromium, And Aluminum Alloys, Andrew Morgan

Theses and Dissertations

Silicon Carbide (SiC) is increasingly gaining attention as a potential fuel cladding material, on account of its favorable thermo-mechanical and neutronic properties. The major limitations of such a cladding is currently associated with joining and hermetic sealing. The work presented here investigated the use of Al, Cr and Fe metals and a specialized alloy (FeCrAl) to achieve hermetic sealing of SiC tubes as well as a joining technology of SiC. Major part of solving this issue requires addressing joining of ceramic and metallic components, which are largely dissimilar in both thermal and mechanical properties. Preliminary experiments to bond SiC with …

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The Role Of Toll-Like Receptor 9 In Periodontitis, Paul Kim Jan 2014

The Role Of Toll-Like Receptor 9 In Periodontitis, Paul Kim

Theses and Dissertations

Periodontitis is a biofilm-initiated inflammatory disease, resulting in soft tissue damage and alveolar bone loss. A nucleic acid sensor, toll-like receptor 9 (TLR9), has been recently implicated in periodontal inflammation. This study utilized an in vivo periodontitis model using TLR9 knockout (TLR9-/-) mice to assess the role of TLR9 in periodontitis. Significant bone loss was observed in wild type, but not in TLR9-/- mice. Further experiments using ex vivo assays revealed significantly higher IL-6 production in splenocytes of wild type mice compared to knockout cells in response to Porphyromonas gingivalis (a keystone pathogen for periodontitis) challenge. In conclusion, TLR9 contributes …

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Transitioning From A Traditional Nursing Home Environment To Green House Homes: What Are Stakeholders' Attitudes Toward And Satisfaction With The Small House Care Environment, Christine Harrop-Stein Jan 2014

Transitioning From A Traditional Nursing Home Environment To Green House Homes: What Are Stakeholders' Attitudes Toward And Satisfaction With The Small House Care Environment, Christine Harrop-Stein

Theses and Dissertations

This dissertation research was designed as two independent research studies. The first study, qualitative, and non-experimental, aimed to examine residents’, family members’, and staff members’ (stakeholders’) satisfaction with, and attitudes toward Green House living one month prior to moving and again at one and three months after moving. Focus groups were the primary method of data collection. Thirty residents and 40 staff members transitioned to one of three Green House homes beginning January, 2013. Data collected began in December, 2012. Following each focus group, tape recordings were transcribed, and coded. Using grounded theory and the constant comparative method of analysis, …

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Long-Term Outcomes Of Prolonged Exposure And Naltrexone For Patients With Comorbid Posttraumatic Stress Disorder And Alcohol Dependence, Shelley Avny Jan 2014

Long-Term Outcomes Of Prolonged Exposure And Naltrexone For Patients With Comorbid Posttraumatic Stress Disorder And Alcohol Dependence, Shelley Avny

Theses and Dissertations

A growing body of research is examining effective treatment(s) for individuals with comorbid posttraumatic stress disorder (PTSD) and alcohol dependence (AD). However, treatments for this comorbid population have been inadequately studied in the longer term. This study represents a long-term follow-up assessment of a randomized controlled trial that compared combined therapy (prolonged exposure + naltrexone) with monotherapies (prolonged exposure or naltrexone) for patients with PTSD and AD (see Foa, Yusko, McLean et al., 2013). Attempts were made to contact 120 participants 5-10 years after the original trial to assess the maintenance of treatment gains. Nineteen individuals were located and agreed …

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A Low Cost Implementation Of Autonomous Takeoff And Landing For A Fixed Wing Uav, Thomas Carnes Jan 2014

A Low Cost Implementation Of Autonomous Takeoff And Landing For A Fixed Wing Uav, Thomas Carnes

Theses and Dissertations

The take-off and landing of an Unmanned Aerial Vehicle (UAV) is often the most critical and accident prone portion of its mission. This potential hazard coupled with the time and resources necessary to train a remote UAV pilot makes it desirable to have autonomous take-off and landing capabilities for UAVs. However, a robust, reliable, and accurate autonomous takeoff and landing capability for fixed-wing aircraft is not an available feature in many low-cost UAV flight control systems. This thesis describes the design of an autonomous take-off and landing algorithm implemented on an existing low-cost flight control system for a small fixed …

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Historical Tidal Forest Composition And Contemporary Woody Recruitment Following Dam Removal From A Mid-Atlantic Coastal Plain Tidal Freshwater Wetland, Richard E. Ward Jr. Jan 2014

Historical Tidal Forest Composition And Contemporary Woody Recruitment Following Dam Removal From A Mid-Atlantic Coastal Plain Tidal Freshwater Wetland, Richard E. Ward Jr.

Theses and Dissertations

Tidal freshwater forest restoration after dam removal has been unexplored to date. This study elucidated pre-dam forest composition, as well as post-dam edaphic and microtopographical attributes and woody species recruiting along a narrow ecotone of a 29.3-ha tidal freshwater wetland. The ≈65-year-old historical forest (15 species, 200 stems ha-1) and ≈7-year-old contemporary forest (40 species and 11,009 stems ha-) community dominants were dissimilar (Fraxinus spp. vs. Liquidambar styraciflua, respectively). Pre-dam environmental conditions were unknown. Post-dam edaphic water content, organic matter, redox potential and microtopography differed significantly across tidal sites but were less variable in non-tidal sites. Shifts in the contemporary …

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The Role Of Nitric Oxide Scavenging In Hemoglobin-Based Oxygen Carrier Induced Hypertension: Systemic And Microvascular Effects, Alan Ottarson Jan 2014

The Role Of Nitric Oxide Scavenging In Hemoglobin-Based Oxygen Carrier Induced Hypertension: Systemic And Microvascular Effects, Alan Ottarson

Theses and Dissertations

The purpose of this study was to identify the effects of a hemoglobin-based oxygen carrier, HBOC-201, on the cardiovascular system. Systemic cardiovascular parameters of mean arterial pressure (MAP), pulse pressure, heart rate, and oxygen saturation, as well as vascular resistance, were examined. A murine model of the cardiovascular system and microvasculature was employed. Sprague-Dawley rats (male; 230-530g; N = 13) were anaesthetised and surgically prepared for intravital microscopy of the spinotrapezius muscle. Increasing doses of HBOC-201 (2 mg/kg, 22 mg/kg, 230 mg/kg, and 780 mg/kg) and an iso-oncotic volume control were administered to assess for a dose-response relationship. MAP displayed …

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Reversed-Phase Ion-Pairing Ultra Performance Liquid Chromatography-Mass Spectrometry In Characterization Of Glycosaminoglycans, Alhumaidi Alabbas Jan 2014

Reversed-Phase Ion-Pairing Ultra Performance Liquid Chromatography-Mass Spectrometry In Characterization Of Glycosaminoglycans, Alhumaidi Alabbas

Theses and Dissertations

Glycosaminoglycans (GAGs) are a family of linear bio-polysaccharides, which are heterogeneously modified with negatively charged sulfate and carboxylate groups. They are located on every cell surface, extracellular matrix or intracellular space in the body. GAGs are composed of alternating units of an amino sugars (glucosamine or galactosamine) and hexuronic acid/hexose (iduronic acid, glucoronic acid/ or galactose), which are linked by glycosidic bonds with different geometries. In recent years, GAGs have attracted considerable interest. GAGs play vital roles in fundamental biological processes, such as hemostasis, angiogenesis, cell signaling, growth and differentiation. Thus, GAGs contribute to a number of diseases such as …

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Fabrication Of Nanoporous Gold And Biological Applications, Badharinadh Uppalapati Jan 2014

Fabrication Of Nanoporous Gold And Biological Applications, Badharinadh Uppalapati

Theses and Dissertations

FABRICATION OF NANOPOROUS GOLD AND BIOLOGICAL APPLICATIONS By Badharinadh Uppalapati A Dissertation submitted in partial fulfillment of the requirements for the degree of Master of Science at Virginia Commonwealth University. Virginia Commonwealth University, 2014 Major Director: Maryanne M. Collinson, Professor, Department of Chemistry Fabrication of nanoporous gold electrodes by dealloying Au:Ag alloys has attracted much attention in sensing applications. In the first part of this work, the electrochemical response of the redox active molecule, potassium ferricyanide, in a solution of bovine serum albumin in buffer, serum or blood was studied using nanoporous gold and comparisons made to planar gold. Nanoporous …

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Development Of Bivalent Ligands Targeting The Putative Ccr5-Mor Heterodimer, Thomas Raborg Jan 2014

Development Of Bivalent Ligands Targeting The Putative Ccr5-Mor Heterodimer, Thomas Raborg

Theses and Dissertations

Chemokine receptor CCR5 (CCR5) is a G-protein coupled receptor (GPCR) predominantly expressed on leukocytes, or white blood cells.1–3 During inflammation, the body releases chemokines that bind to receptors such as CCR5 and attract leukocytes to the area of inflammation, leading to an immunological response.1 CCR5 is also an important receptor in the human immunodeficiency virus's (HIV-1) invasion of host cells, as CCR5 acts as a co-receptor that facilitates HIV-1 viral entry.4,5 The continued destruction of leukocytes as a result of HIV-1 viral entry produces a disease state called acquired immunodeficiency syndrome (AIDS).5 Of note, this receptor is also expressed on …

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Fabrication Of Micropatterns For The Spatial Control Of Cell Propagation And Differentiation, Mahmoud Moustafa Jan 2014

Fabrication Of Micropatterns For The Spatial Control Of Cell Propagation And Differentiation, Mahmoud Moustafa

Theses and Dissertations

Challenges in the development of successful cell therapies involve engineering and control of cues to regulate the balance between differentiation and self-renewal. However, the complexity of architecture and function make this an intriguing problem in the context of forming functional connections. Here we present the design and fabrication of microstructured scaffolds that present a biomimetic framework along which neural cell lines can organize into oriented constructs. Specifically, we show microfabricated non-linear architectures that promote cellular fate related to propagation of human neuroblastoma cells and directed differentiation towards neurons. By mimicking biological networks that allow for spreading of the cells instead …

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A Route To Discover Small Molecule Inhibitors Of Psaa, A Potential Target For Streptococcus Pneumoniae, Ahmad J. Obaidullah Jan 2014

A Route To Discover Small Molecule Inhibitors Of Psaa, A Potential Target For Streptococcus Pneumoniae, Ahmad J. Obaidullah

Theses and Dissertations

Due to the development of multidrug resistance in Streptococcus pneumoniae, research has begun to define new drug targets for pneumonia therapy. Different research groups have identified a lipoprotein, PsaA that is important for pneumonia virulence. PsaA is a manganese transporter that is required for bacterial virulence and growth. We have employed computer modeling to virtually screen a small-molecule database for inhibition of PsaA function by targeting the metal binding pocket, performing receptor-based virtual screening and molecular docking and scoring to identify potential inhibitors of PsaA function. We have developed an assay for screening compounds, including the use of a PsaA …

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Therapeutic Efficacy Of Combination Of Mtor Inhibitors And Ampk Activators In Non-Small Cell Lung Cancer., Grinal Corriea Jan 2014

Therapeutic Efficacy Of Combination Of Mtor Inhibitors And Ampk Activators In Non-Small Cell Lung Cancer., Grinal Corriea

Theses and Dissertations

Pemetrexed (PTX), an antifolate drug, has been approved by the US FDA for first line therapy of mesothelioma and non-small cell lung cancer. In addition to its primary site of action on thymidylate synthase (TS), PTX also inhibits the second folate-dependent enzyme of purine biosynthesis aminoimidazolecarboxamide ribonucleotide formyltransferase (AICART). The accumulation of the substrate for AICART, ZMP, in PTX-inhibited cancer cells leads to activation of AMP-activated protein kinase (AMPK) with subsequent inhibition of mammalian target of rapamycin (mTOR) and hypophosphorylation of its downstream targets responsible for protein synthesis and cell proliferation. Inhibitors of mTORC1 like Rapamycin and its analogs (rapalogs) …

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An Investigation Of Nurbs-Based Deformable Image Registration, Travis J. Jacobson Jan 2014

An Investigation Of Nurbs-Based Deformable Image Registration, Travis J. Jacobson

Theses and Dissertations

Deformable image registration (DIR) is an essential tool in medical image processing. It provides a means to combine image datasets, allowing for intra-subject, inter-subject, multi-modality, and multi-instance analysis, as well as motion detection and compensation. One of the most popular DIR algorithms models the displacement vector field (DVF) as B-splines, a sum of piecewise polynomials with coefficients that enable local shape control. B-splines have many advantageous properties in the context of DIR, but they often struggle to adequately model steep local gradients and discontinuities. This dissertation addresses that limitation by proposing the replacement of conventional B-splines with a generalized formulation …

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Affinity Enrichment And Mass Spectrometric Quantitation Of Protein Carbonyls, Suresh Narayanasamy Jan 2014

Affinity Enrichment And Mass Spectrometric Quantitation Of Protein Carbonyls, Suresh Narayanasamy

Theses and Dissertations

The importance of the role of oxidative stress in aging and numerous age-related diseases has become undeniable due to enormous weight of supporting evidence from the field of free radical biology. One of the most prominent oxidative modifications of proteins is the introduction of carbonyl groups. As with oxidative stress, protein carbonylation has been correlated with various disease states and natural aging. While protein carbonyls are relatively stable, reproducible detection and modification site localization are still challenging. This thesis details attempts to improve the analytical methodology used for the identification and quantitation of carbonylated proteins. We have studied the impact …

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An Automated Dental Caries Detection And Scoring System For Optic Images Of Tooth Occlusal Surface, Leila Ghaedi Jan 2014

An Automated Dental Caries Detection And Scoring System For Optic Images Of Tooth Occlusal Surface, Leila Ghaedi

Theses and Dissertations

Dental caries are one of the most prevalent chronic diseases. Worldwide 60 to 90 percent of school children and nearly 100 percent of adults experienced dental caries. The management of dental caries demands detection of carious lesions at early stages. The research of designing diagnostic tools in caries has been at peak for the last decade. This research aims to design an automated system to detect and score dental caries according to the International Caries Detection and Assessment System (ICDAS) guidelines using the optical images of the occlusal tooth surface. There have been numerous works that address the problem of …

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Development Of A Compact, Low-Cost Wireless Device For Biopotential Acquisition, Graham Kelly Jan 2014

Development Of A Compact, Low-Cost Wireless Device For Biopotential Acquisition, Graham Kelly

Theses and Dissertations

A low-cost circuit board design is presented, which in one embodiment is smaller than a credit card, for biopotential (EMG, ECG, or EEG) data acquisition, with a focus on EEG for brain-computer interface applications. The device combines signal conditioning, low-noise and high-resolution analog-to-digital conversion of biopotentials, user motion detection via accelerometer and gyroscope, user-programmable digital pre-processing, and data transmission via Bluetooth communications. The full development of the device to date is presented, spanning three embodiments. The device is presented both as a functional data acquisition system and as a template for further development based on its publicly-available schematics and computer-aided …

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