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Quantification Of Protoporphyrin Ix Accumulation In Glioblastoma Cells – A New Technique, John E Lawrence

Journal Articles

5-Aminolevulinic Acid (5-ALA) is a precursor of heme synthesis. A metabolite, protoporphyrin IX (PpIX), selectively accumulates in neoplastic tissue including glioblastoma. Presurgical administration of 5-ALA forms the basis of fluorescence-guided resection (FGR) of glioblastoma (GBM) tumors. However, not all gliomas accumulate sufficient quantities of PpIX to fluoresce, thus limiting the utility of FGR. We therefore developed an assay to determine cellular and pharmacological factors that impact PpIX fluorescence in GBM. This assay takes advantage of a GBM cell line engineered to express yellow fluorescent protein. Methods. The human GBM cell line U87MG was transfected with a YFP expression vector. After …

Five Rules Of Marketing Insights From The Superior Engine Story, Bruce C. Sherony, Irvin A. Zaenglein, Michael F. Strahan

Journal Articles

In the late 1890s, an exceptional product line of marine engines was developed in Marquette, Michigan. The authors trace the roots of these innovations and posit abstract marketing lessons from their insights. Five rules about marketing insights are suggested to play an important role in new product development. It is suggested that marketing people who practice these rules could improve their product and service innovativeness.

Recognition Of Two New Species Of Freshwater Crabs From The Seychelles Based On Molecular Evidence (Potamoidea: Potamonautidae)., Neil Cumberlidge, Savel Regan Daniels Phd

Journal Articles

The Afrotropical freshwater crab genus Seychellum is endemic to the granitic Seychelles in the Indian Ocean (Mahé, Silhouette, Praslin, La Digue and Frégate). Here we describe two new cryptic species of Seychellum that represent two evolutionarily separate lineages of a previously monotypic genus. This raises to three the number of species of freshwater crabs known from Seychelles. Each species is endemic to either one island (Silhouette) or to a pair of islands (Mahé and Frégate, or Praslin and La Digue). The three species can be clearly distinguished as separate lineages by DNA analysis, haplotyping and examination of gonopod characters. The …

Global Patterns Of Freshwater Species Diversity, Threat And Cross-Taxon Congruence, Ben Collen Phd, Felix Whitton Phd, Ellie E. Dyer, Jonathan E.M. Baillie Phd, Neil Cumberlidge, William Darwall, Caroline Pollack, Nadia Richman Phd, Anne-Marie Soulsby, Monica Bohm Phd

Journal Articles

Aim Global-scale studies are required to identify broad-scale patterns in the distributions of species, to evaluate the processes that determine diversity and to determine how similar or different these patterns and processes are among different groups of freshwater species. Broad-scale patterns of spatial variation in species distribution are central to many fundamental questions in macroecology and conservation biology. We aimed to evaluate how congruent three commonly used metrics of diversity were among taxa for six groups of freshwater species.

Location Global.

Methods We compiled geographical range data on 7083 freshwater species of mammals, amphibians, reptiles, fishes, crabs and crayfish to …

International Standards For Fetal Growth Based On Serial Ultrasound Measurements: The Fetal Growth Longitudinal Study Of The Intergrowth-21st Project, Aris T. Papageorghiou, Eric O. Ohuma, Douglas G. Altman, Tullia Todros, Leila Cheikh Ismail, Ann Lambert, Yasmin A. Jaffer, Enrico Bertino, Michael G. Gravett, J Alison Noble, Ruyan Pang, Cesar G. Victora, Fernando C. Barros, Maria Carvalho, Laurent J. Salomon, Zulfiqar A. Bhutta, Stephen H. Kennedy, José Villar

Obstetrics and Gynaecology, East Africa

Background: In 2006, WHO produced international growth standards for infants and children up to age 5 years on the basis of recommendations from a WHO expert committee. Using the same methods and conceptual approach, the Fetal Growth Longitudinal Study (FGLS), part of the INTERGROWTH-21st Project, aimed to develop international growth and size standards for fetuses.

Methods: The multicentre, population-based FGLS assessed fetal growth in geographically defined urban populations in eight countries, in which most of the health and nutritional needs of mothers were met and adequate antenatal care was provided. We used ultrasound to take fetal anthropometric measurements prospectively from …

Characteristics Of Participants In An Hiv Prevention Intervention For Youth In Rwanda: Results From A Longitudinal Study, Hanne Celis, Brian A. Jingwa, Olivier Degomme, Ronan Van Rossem, Marleen Temmerman, Kristien Michielsen

Obstetrics and Gynaecology, East Africa

Introduction: This paper studies determinants of participation in a peer-led school-based HIV prevention intervention in Rwanda.

Methods: A baseline survey among 1071 students (mean age 17 years) assessed potential determinants of participation, while a follow-up six months in the intervention measured actual participation in the intervention. Statistical models were built using multivariate linear and multinomial regression analysis predicting overall participation, participation in group discussions and individual counseling.

Results: Those who recently had sex, had been tested for HIV, feel more susceptible to HIV, have a higher sexual self-concept, a more positive future perspective (only for non-sexually active), and boys, were …

Pregnancy Outcomes In Benghazi, Libya, Before And During The Armed Conflict In 2011, Z. Bodalal, K. Agnaeber, N. Nagelkerke, B. Stirling, Marleen Temmerman, O. Degomme

Obstetrics and Gynaecology, East Africa

Stressful life events experienced by pregnant women may lead to adverse obstetric outcomes. This study in Benghazi compared the rates of preterm, low-birth-weight and caesarean-section births at Al-Jamhouria hospital in the months before and during the armed conflict in Libya in 2011. Data were collected on all women admitted to the delivery ward during February to May 2011 (the months of the most active fighting in the city) (n = 7096), and October to December 2010 (the months immediately before the war) (n = 5935). Compared with the preceding months there was a significant rise during the conflict in the …

A Cross-Sectional Study On Attitudes Toward Gender Equality, Sexual Behavior, Positive Sexual Experiences, And Communication About Sex Among Sexually Active And Non-Sexually Active Adolescents In Bolivia And Ecuador, Sara De Meyer, Lina Jaruseviciene, Apolinaras Zaborskis, Peter Decat, Bernardo Vega, Kathya Cordova, Marleen Temmerman, Olivier Degomme, Kristien Michielsen

Obstetrics and Gynaecology, East Africa

Background: It is widely agreed upon that gender is a key aspect of sexuality however, questions remain on how gender exactly influences adolescents’ sexual health.

Objective: The aim of this research was to study correlations between gender equality attitudes and sexual behavior, sexual experiences and communication about sex among sexually active and non-sexually active adolescents in 2 Latin American countries.

Design: In 2011, a cross-sectional study was carried out among 5,913 adolescents aged 14–18 in 20 secondary schools in Cochabamba (Bolivia) and 6 secondary schools in Cuenca (Ecuador). Models were built using logistic regressions to assess the …

Sexual Health Is Dead In My Body: Participatory Assessment Of Sexual Health Determinants By Refugees, Asylum Seekers And Undocumented Migrants In Belgium And The Netherlands, Ines Keygnaert, Nicole Vettenburg, Kristien Roelens, Marleen Temmerman

Obstetrics and Gynaecology, East Africa

Background: Although migrants constitute an important proportion of the European population, little is known about migrant sexual health. Existing research mainly focuses on migrants’ sexual health risks and accessibility issues while recommendations on adequate sexual health promotion are rarely provided. Hence, this paper explores how refugees, asylum seekers and undocumented migrants in Belgium and the Netherlands define sexual health, search for sexual health information and perceive sexual health determinants.

Methods: Applying Community-based Participatory Research as the overarching research approach, we conducted 223 in-depth interviews with refugees, asylum seekers and undocumented migrants in Belgium and the Netherlands. The Framework Analysis Technique …

Promoting Reproductive Options For Hiv-Affected Couples In Sub-Saharan Africa, Okeoma Mmeje, Craig R. Cohen, Alfred Murage, John Ong’Ech, James Kiarie, Sheryl Van Der Poel

Obstetrics and Gynaecology, East Africa

HIV-affected couples have unique challenges that require access to information and reproductive services which prevent HIV transmission to the uninfected partner and offspring while allowing couples to fulfill their reproductive goals. In high HIV prevalent regions of sub-Saharan Africa, HIV-affected couples require multipurpose prevention technologies (MPTs) to enhance their reproductive healthcare options beyond contraception and prevention of HIV/sexually transmitted infections (STIs) to include assistance in childbearing. The unique characteristics of the condom and its accepted use in conjunction with safer conception interventions allow HIV-serodiscordant couples an opportunity to maintain reproductive health, prevent HIV/STI transmission, and achieve their reproductive goals while …

Protective Effect Of Deferiprone On 7-Ketocholesterol Formation In Hemin-Induced Ldl Oxidation, Usa Suwannasual, Thitima Pengsuparp, Rataya Luechapudiporn

The Thai Journal of Pharmaceutical Sciences

Hemin (iron (III)-protoporphyrin IX) is found that it is elevated in the plasma of thalassemic patients and is a possible cause of oxidative stress-promoting atherosclerosis. Deferiprone (L1), an iron chelator, can prevent free radical formation catalyze...

Development And Validation Of Rp-Hplc Method For Analysis And Stability Study Of 8-Carboxyphenyl-2'-Deoxyguanosine And 8-Bromo-2'-Deoxyguanosine, Kulwadee Sawatpaiboontawee, Panutsaya Sermthaveesub, Panuwat Sangsirimongkolying, Patratorn Kunakorntham, Sudarat Thongborriboon, Bodin Tuesuwan, Vorasit Vongsutilers

The Thai Journal of Pharmaceutical Sciences

Modifications on C8 position of purine base have been studied for their effects on B-DNA to Z-DNA conversion. The 8-bromo and 8-carboxyphenyl adduct are among the most potent Z-DNA facil tators and hence arc aimed to be utilized for Z-DNA based probe lor...

E5501: Phase Ii Study Of Topotecan Sequenced With Etoposide/Cisplatin, And Irinotecan/Cisplatin Sequenced With Etoposide For Extensive-Stage Small-Cell Lung Cancer., Taofeek K. Owonikoko, Joseph Aisner, Xin Victoria Wang, Suzanne E. Dahlberg, Eric H. Rubin, Suresh S. Ramalingam, Murugesan Gounder, Paul Gregory Rausch, Rita S. Axelrod, Md, Joan H. Schiller

Department of Medical Oncology Faculty Papers

PURPOSE: Sequence-dependent improved efficacy of topoisomerase I followed by topoisomerase 2 inhibitors was assessed in a randomized phase II study in extensive-stage small-cell lung cancer (SCLC).

METHODS: Patients with previously untreated extensive-stage SCLC with measurable disease, ECOG performance status of 0-3 and stable brain metastases were eligible. Arm A consisted of topotecan (0.75 mg/m(2)) on days 1, 2 and 3, etoposide (70 mg/m(2)) and cisplatin (20 mg/m(2)) (PET) on days 8, 9 and 10 in a 3-week cycle. Arm B consisted of irinotecan (50 mg/m(2)) and cisplatin (20 mg/m(2)) on days 1 and 8 followed by etoposide (85 mg/m(2) PO …

Blackness, Colorism, And Epidermalization Of Inferiority In Zora Neale Hurston’S Color Struck: A Fanonian Reading Of The Play, Mahshid Mirmasoomi, Farshid Nowrouzi Roshnavand

Khazar Journal of Humanities and Social Sciences

Ever since the first encounter between Columbus and Native Americans, the West has embarked on a subtle process of “Otherizing” non-whites as a means to maintain its hegemonic power over the subalternized groups. This strategy was also employed by the dominant whites in the United States, where a stereotypical representation of black slaves served as a justification for the institution of slavery. Through depicting blacks as irrational, lascivious, and eternally damned with a deviant pigmentation, the racis t representational strategy turned into a useful instrument to subjugate African slaves. Under such circumstances, blacks, merely due to their different skin color, …

Grains Highlights 2013 / 2014, Department Of Agriculture And Food, Western Australia

Grain and other field crops published reports

DAFWA strives to support growers and agribusiness with relevant and timely information, tools and services to make better business decisions.

Linking Local Weather To Climate Change: One Year Of Twitter In The Us, Tatiana Molodtsova

Theses and Dissertations

There is a high level of scientific consensus on climate change. Nevertheless for climate change research to have any practical value, to develop public support for climate policies, the climate research results must find the way to general public. That is why it is important to understand how the public perception of climate change forms.

During the last decades there have been a number of studies on the factors affecting the level of public concern on climate change. Two major groups of factors are hypothesized to have the biggest influence on the level of public concern on climate change: extreme …

Determinants Of Gold Returns: An Austrian Perspective, Justin Nicholas Theriot

Theses and Dissertations

In this article, I offer a comprehensive analysis on the factors that influence the gold market in relation to returns to demonstrate that gold moves as a currency. I employed a wide range of macroeconomic and commodity variables to investigate the underlying movements in the gold market. The methodology followed four simple steps; 1) correlation tests, 2) vector autoregression model of two lags, 3) auto-regressive integrated moving average model and 4) generalized autoregressive conditional heoteroskedasticity. This methodology enabled me to

convey that gold moves more as a currency and not as an investment. The main findings of this paper provided …

A Comparison Of Solar Prominence Data Between Hα And Euv (He Ii-304Å), Jonathan Schiralli

Theses and Dissertations

Two spectral lines are often used to observe solar prominences: Hα and He II 304 Å. Both emission lines capture the same prominence structure but at vastly different temperatures: Hα is visible at ~10,000K while He II 304 Å. at ~80,000K. The He II 304 Å images provide the ability to identify the relatively hotter outer region of a prominence, although they lack the details seen in the cooler lower regions. Hα conversely shows great detail in the cooler lower regions of a prominence but lack any detail in the hotter outer region of a prominence. Two prominences will be …

A Comparative Study Of Spectrum Sensing Methods For Cognitive Radio Systems, Mohammad Shakib Apu

Theses and Dissertations

With the increase of portable devices utilization and ever-growing demand for greater data rates in wireless transmission, an increasing demand for spectrum channels was observed since last decade. Conventionally, licensed spectrum channels are assigned for comparatively long time spans to the license holders who may not over time continuously use these channels, which creates an under-utilized spectrum. The inefficient utilization of inadequate wireless spectrum resources has motivated researchers to look for advanced and innovative technologies that enable an efficient use of the spectrum resources in a smart and efficient manner.

The notion of Cognitive Radio technology was proposed to address …

Scott Pilgrim Vs. The Times, Brendan Gillett

Pomona Senior Theses

Bryan Lee O'Malley's "Scott Pilgrim" series is, arguably, one of the most important American literary works of the early twenty-first century. Evaluating this work w/r/t multimediality and simultaneous multiliteracy, emotions and affective states, friends and their informal economies, and the role of active fandoms in current artistic production, this thesis seeks to explain why "Scott Pilgrim" has found such deep resonance with a generation of kids growing up at the time of publication.

Watching The Match Burn After You've Set The House On Fire, Michael Opal

Pomona Senior Theses

An examination of synecdoche as the fundamental rhetorical form of phenomenology, and paranoia the motivating ideology.

Implementing Green Roofs On Movie Theaters And Shopping Centers: Business Cases In Profitable Sustainability, Ryan J. Miller

Pomona Senior Theses

This thesis presents the business case for installing green roofs on movie theaters and shopping centers. These businesses can then derive increased profits from the environmental benefits of reduced energy use and increased stormwater retention. After presenting the basic design and benefits of a green roof, the thesis develops stand-alone business plans for a movie theater and shopping center. The author finds that green roofs are a profitable sustainability solution for the commercial enterprise.

Factors Of Success In Beekeeping Development Projects And Their Application To South Africa’S Beekeeping Industry, Deirdre Lee

Pomona Senior Theses

Nearly every country in the world has its own history of beekeeping. From the Swiss leaf hive to the Kenyan top bar hive, the number of ways to keep bees is practically limitless. Such diversity allows for a unique opportunity in the field of development. Many development projects are denigrated for relying on the knowledge and generosity of “white saviors.” Many beekeeping projects are the brainchildren of well-meaning people in developed countries looking for a charitable outlet and attempting to use their “superior” knowledge to enlighten and improve the lives of those less fortunate. While these intentions may well be …

Wetlands And Greenhouse Gas Fluxes: Causes And Effects Of Climate Change – A Meta-Analysis, Robert E. Ventura

Pomona Senior Theses

Climate change is one of the largest problems facing this generation. Anthropogenically caused increases of greenhouse gas emissions is a significant culprit to this problem. Although the obvious problems such as cars, industry, and urbanism garnish a significant amount of the criticism, natural sources such as wetlands are also beginning to contribute to this issue. This is becoming increasingly significant as wetlands shift from being sinks of greenhouse gases to becoming sources as various anthropogenic impacts, including global warming itself, begin to affect the health of the wetlands. The aim of this project is to look at four common types …

The Chimerae Of Their Age:Twelfth Century Cistercian Engagement Beyond Monastic Walls, Daniel J. Martin

Pomona Senior Theses

One of the great paradoxes of the medieval period is the Albigensian Crusade (1209-1225), in which monks of the Cistercian Order took an active and violent role in campaigning against the heretics of the Languedoc. Why, and how, did this order officially devoted to prayer and contemplation become one of the prime orchestrators of one of medieval Europe’s most gruesome affairs? This thesis seeks to answer that question, not by looking at the crusading Cistercians themselves, but at their predecessor Bernard of Clairvaux, who—I will argue—made the Albigensian Crusade possible by making it permissible for monks to intervene in the …

Reconsidering Firmitas: Durability As An Integral Function Of The Sustainably Built Environment, Katherine P. Yzurdiaga

Pomona Senior Theses

Architecture is an inherently functional art – buildings have functions, some more vital than others, beyond the objective of sheer aesthetic appeal. Yet at the same time, aesthetic appeal is an integral part of the human experience that many agree is vital to sustainability objectives, including those of the built environment. Ideally, a building would be able to embody and honor both principles, both form and function, but some contend that in the current architectural climate, the emphasis on beauty has surpassed the importance placed on functionality. This discussion is particularly relevant to sustainability in the built environment: Sustainability as …

(De)Psychologizing Shangri-La: Recognizing And Reconsidering C.G. Jung's Role In The Construction Of Tibetan Buddhism In The Western Imagination, Alec M. Terrana

Pomona Senior Theses

Popular literature on Tibetan Buddhism often overemphasizes the psychological dimension of the religion's beliefs and practices. This misrepresentative portrayal is largely traceable to the writings of the psychoanalyst C.G. Jung. By employing distinctly psychological terminology and interpretive strategies in his analyses of the Tibetan Book of the Dead and mandala symbolism, Jung helped to establish precedents that were adopted in subsequent analyses of the religion. Imposing a psychological lens on Tibetan Buddhism obscures other essential elements of the tradition, such as cosmology, physiology, and ritualism, thereby silencing the voices of Tibetans in analyses of their own practices. Jung's imposition of …

International Relations Or International Sanitations? Exploring Student Perceptions Of Intro To Ir Course Content, Nick Sundback

Pomona Senior Theses

This thesis draws on student testimony, curriculum analysis, and statistical tests to explore 1) the degree to which gender, financial aid status, and race/ethnicity correlate with student perceptions of Intro to IR course content and 2) the degree to which students conceptualize IR as interrelated with social identities, as opposed to an abstracted state-centric discipline.

Bridging The Justice Gap: Exploring Approaches For Improving Indigent Access To Civil Counsel, Kelsey Atkinson

Pomona Senior Theses

The United States is among one of the only democratic industrialized nations in the world that does not provide guaranteed access to civil representation in cases involving basic human need. This leaves indigent litigants who are at risk of losing their homes or their children left to seek counsel through insufficient pro-bono programs or limited scope legal self-help centers. This thesis provides a history of the struggle for the right to civil counsel, known as Civil Gideon, and explores a variety of proposed solutions to bridge the justice gap for indigent litigants. Despite considerable support for Civil Gideon among scholars …

The Clarification Of Proposition 209: Gauging The Impact On Native Americans At The University Of California, Charles R. Herman

Pomona Senior Theses

Proposition 209 banned the consideration of race or ethnicity in admission decisions to the University of California (UC). The UC “clarified” their policy in 2008, recognizing that Native Americans enrolled in a federally recognized tribe enjoy a political status that enables them to be offered affirmative action, even when the consideration of race or ethnicity is banned. The Clarification led to a statistically significant surge in the Native American applicant share, acceptance rate, admit share, and enrollment share. Enrollment share increased by 56% from 2008 to 2010 at the UC, even as the three-tiered California system of higher education saw …