Digital Commons Network^™

Therapeutic Efficacy Of Combination Of Mtor Inhibitors And Ampk Activators In Non-Small Cell Lung Cancer., Grinal Corriea

Theses and Dissertations

Pemetrexed (PTX), an antifolate drug, has been approved by the US FDA for first line therapy of mesothelioma and non-small cell lung cancer. In addition to its primary site of action on thymidylate synthase (TS), PTX also inhibits the second folate-dependent enzyme of purine biosynthesis aminoimidazolecarboxamide ribonucleotide formyltransferase (AICART). The accumulation of the substrate for AICART, ZMP, in PTX-inhibited cancer cells leads to activation of AMP-activated protein kinase (AMPK) with subsequent inhibition of mammalian target of rapamycin (mTOR) and hypophosphorylation of its downstream targets responsible for protein synthesis and cell proliferation. Inhibitors of mTORC1 like Rapamycin and its analogs (rapalogs) …

Development Of A Compact, Low-Cost Wireless Device For Biopotential Acquisition, Graham Kelly

Theses and Dissertations

A low-cost circuit board design is presented, which in one embodiment is smaller than a credit card, for biopotential (EMG, ECG, or EEG) data acquisition, with a focus on EEG for brain-computer interface applications. The device combines signal conditioning, low-noise and high-resolution analog-to-digital conversion of biopotentials, user motion detection via accelerometer and gyroscope, user-programmable digital pre-processing, and data transmission via Bluetooth communications. The full development of the device to date is presented, spanning three embodiments. The device is presented both as a functional data acquisition system and as a template for further development based on its publicly-available schematics and computer-aided …

Evaluation Of The Physiological Effects Of Reduced Hydroxocobalamin On Acute Carbon Monoxide Toxicity, Alden Newcomb

Theses and Dissertations

Carbon monoxide (CO) poisoning represents a global health threat responsible for hundreds of thousands of hospital visits and tens of thousands of deaths annually. Oxygen therapy is the only current approved treatment for CO poisoning. Previous work published in the 1970’s and research conducted in the VCURES lab group has indicated that a reduced form of vitamin B12, hydroxocobalamin (B12r), can potentially serve as an antidote for CO poisoning by converting CO bound to hemoglobin to carbon dioxide (CO2) and mitigating the deleterious neurological effects of CO poisoning. For the first time in documented literature we successfully used a Clark-type …

Modulation Of Cns Neurotransmitter Levels And Associated Behaviors In Organic Anion Transporter 1 (Slc22a6) And Organic Anion Transporter 3 (Slc22a8) Knockout Mice, Christine Farthing

Theses and Dissertations

According to the World Health Organization, mental disorders represent the leading cause of disability in the US generating ~58 billion dollars in medical costs annually. Additionally, among the US population, ~40 million adults suffer from an anxiety disorder and ~14 million suffer from a major depressive disorder. The association between the persistence of these neurobehavioral conditions and central nervous system (CNS) levels of biogenic amines and metabolites has been studied for half a century. Further, a number of drugs interfering with neurotransmission/metabolism are used clinically for treatment of these disorders. Recently, some members of the solute carrier (SLC) superfamily, the …

An Investigation Of Nurbs-Based Deformable Image Registration, Travis J. Jacobson

Theses and Dissertations

Deformable image registration (DIR) is an essential tool in medical image processing. It provides a means to combine image datasets, allowing for intra-subject, inter-subject, multi-modality, and multi-instance analysis, as well as motion detection and compensation. One of the most popular DIR algorithms models the displacement vector field (DVF) as B-splines, a sum of piecewise polynomials with coefficients that enable local shape control. B-splines have many advantageous properties in the context of DIR, but they often struggle to adequately model steep local gradients and discontinuities. This dissertation addresses that limitation by proposing the replacement of conventional B-splines with a generalized formulation …

Transformational Directing: An Analysis On How Leadership Affects The Creative Process, James Clayton Winters

Theses and Dissertations

Leadership is often ascribed as a quality one either possess or doesn’t. We often hear phrases like “She is born leader” or “All eyes are on you”, these are thrown around without discretion in the classroom, conference rooms, social gatherings, and business meetings. This work contends that leadership and in particular leadership that grows and transforms its participants is less an inherent character trait, than an outlook and set of core principles that lead to transformation. Through the application of current and developing business leadership theory and its effect on creativity and a cross analysis of “Best in Class” theatre …

Group Home Care: The Influence Of Positive Youth Development Factors And Social Capital On Youth Outcomes, Sundonia J. Wonnum

Theses and Dissertations

This study examined the influence of positive youth development factors and social capital on outcomes among youth in group home care. One of the major assumptions of this study was that existing research is deficit-focused and provides little evidence of what practices are linked to positive outcomes among youth residing in and exiting group homes. A conceptual model was developed to depict the influence of predictors (derived from the Positive Youth Develop Framework and Social Capital Theory) on youth outcomes – change in psychosocial problem severity and prosocial behavior, living environment, school involvement, employment, delinquency, and extracurricular activity. An exploratory …

Investigating The Role Of The Synaptic Transcriptome In Ethanol-Responsive Behaviors, Megan A. O'Brien

Theses and Dissertations

Alcoholism is a complex neurological disorder characterized by loss of control in limiting intake, compulsion to seek and imbibe ethanol, and chronic craving and relapse. It is suggested that the characteristic behaviors associated with the escalation of drug use are caused by long-term molecular adaptations precipitated by the drug’s continual administration. These lasting activity-dependent changes that underlie addiction-associated behavior are thought, in part, to depend on new protein synthesis and remodeling at the synapses. It is well established that mRNA can be transported to neuronal distal processes, where it can undergo localized translation that is regulated in a spatially restricted …

Clusters Bridging Disciplines, Swayamprabha Behera

Theses and Dissertations

Clusters constitute an intermediate state of matter between molecules and solids whose properties are size dependent and can be tailored. In recent years, cluster science has become one of the most exciting areas of research since their study can not only bridge our understanding between atoms and their bulk but also between various disciplines. In addition, clusters can serve as a source of new materials with uncommon properties. This dissertation deals with an in-depth study of clusters as a bridge across physics, chemistry, and materials science and provides a fundamental understanding of the structure-property relationships by focusing on three different …

Expanding Understanding Of Public Policy As A Complex And Pluri-Disciplinary System: Illustrating Possibilities Of Epistemic Pluralism, Cynthia Cors

Theses and Dissertations

Science, and especially the social sciences, has developed as distinct territories, each with its own vocabulary and language-game (Wittgenstein, 1945/1958). Yet understanding and explaining science as a complex and pluri-disciplinary system has important practitioner-oriented as well as research-oriented and other benefits, benefits that can be enhanced through the use of cloud-based technologies. Understanding and explaining public policy in particular as complex can inform and transform the way problems are approached. This is particularly important for an action subject like public policy and administration that can be considered as having been influenced by many disciplines. Public administration (PA) through multiple perspectives, …

Structural Studies Of Interferon Regulatory Factor 4: A Molecular Perspective Of Its Regulatory Mechanism, Soumya Govinda Remesh

Theses and Dissertations

Interferon (IFN) regulatory factor family member 4 (IRF4) is a transcription factor that serves specific roles in transcriptional regulation of IFN responsive genes and is indispensable in B- & T-cell differentiation. IRF4 like the other members of the family has two major domains- the N-terminal DNA binding domain (DBD) essential for its recognition and binding to the Interferon Stimulated Response Element DNA sequence and a C-terminal Interferon activation domain (IAD) thought to maintain IRF4 in an auto-inhibited inactive state and is also critical in its activation. A putative unstructured linker connects the DBD and IAD. Activation in most members of …

Analysis Of The Role Of Astrocyte Elevated Gene-1 In Normal Liver Physiology And In The Onset And Progression Of Hepatocellular Carcinoma, Chadia L. Robertson

Theses and Dissertations

First identified over a decade ago, Astrocyte Elevated Gene-1 (AEG-1) has been studied extensively due to early reports of its overexpression in various cancer cell lines. Research groups all over the globe including our own have since identified AEG-1 overexpression in cancers of diverse lineages including cancers of the liver, colon, skin, prostate, breast, lung, esophagus, neurons and neuronal glia as compared to matched normal tissue. A comprehensive and convincing body of data currently points to AEG-1 as an essential component, critical to the progression and perhaps onset of cancer. AEG-1 is a potent activator of multiple pro-tumorigenic signal transduction …

Studies Of The Middle Class, Scott S. Stanard

Theses and Dissertations

I create oil paintings and drypoints that bring attention to scenes of American middle class life. I present crowds of people engaged in community activities and festivals. This enables me to depict a cross section of the residents of a given region. I also create a counterpoint to these peopled gatherings by painting and drawing the exteriors of middle class homes. In my work, I attempt to imbue a sense of intrigue and pathos.

I work from candid photos that I take of people and their living spaces. In these photos, I modify and delete elements to optimize narrative and …

Thermal Tuning Of Mems Buckled Membrane Actuator Stiffness, Robert A. Lake, Kyle K. Ziegler, Ronald A. Coutu Jr.

Electrical and Computer Engineering Faculty Research and Publications

The thermal tuning characteristics of a microelectromechanical systems (MEMS) buckled membrane exhibiting regions of both positive and negative stiffness is examined and analyzed using finite element method (FEM) simulation and through experimentation. The membranes are fabricated by releasing a silicon/silicon dioxide (Si/SiO₂) laminated membrane from a silicon on insulator (SOI) wafer. The difference in thermal expansion coefficients between Si and SiO2 induces a compressive stress in the SiO₂ layer causing out-of-plane buckling of the membrane. This structure is found to have positive and negative stiffness regions when actuated with a transverse force. It is demonstrated that the …

Sildenafil And Celecoxib Interact To Kill Breast Cancer Cells, Brittany Binion

Theses and Dissertations

Breast cancer is the second most commonly diagnosed cancer among American women and is responsible for the second highest number of cancer-related deaths. Targeted therapeutic agents sildenafil, a phosphodiesterase type 5 inhibitor, and celecoxib, a cyclooxygenase-2 inhibitor, have been used individually in conjunction with other chemotherapeutic agents to enhance cell killing in a variety of cancers. Sildenafil when combined with traditional chemotherapeutic drugs, such as the taxanes and anthracyclines, or celecoxib combined with traditional hormone therapies have been used to increase cytotoxicity and cell killing. The data presented here demonstrates that the novel combination of sildenafil and celecoxib work together …

Adaptive Radiation Therapy For Lung Cancer, Christian W. Dial

Theses and Dissertations

Prognosis for lung cancer patients remains poor. For those receiving radiation therapy, local control and survival have been shown to improve with increased doses; however, deliverable dose is often limited by associated toxicity. Therefore, methods that reduce dose to normal tissues and allow isotoxic escalation are desirable. Adaptive radiation therapy seeks to improve treatment by modifying the initial plan throughout delivery, and has been shown to decrease normal tissue dose. Studies to date suggest a trend of increasing benefit with increases in replanning frequency; however, replanning is costly in terms of workload and past studies implement at most weekly adaptation. …

Seeing The Sausage Made: How Compromise Works In Large Groups And Representative Bodies, James E. Crawford Jr.

Theses and Dissertations

Inspired by the lack of Congressional compromise during the 2013 federal shutdown, I explore how compromise works in large groups and representative bodies. An on-line survey, personal interviews, and a discourse analysis of the Congressional Record yield a diverse collection of data, including personal and public stories of compromise. I examine the stories and other data through an eclectic mix of contemporary scholarship, borrowing literary theory from the Russian critic Mikhail Bakhtin, socio-linguistic concepts from American linguist James Paul Gee, and moral philosophy from Israeli thinker Avishai Margalit. I also incorporate the work of political scientists Amy Gutmann and Dennis …

Can Using The Internal Audit Function As A Training Ground For Management Deter Internal Auditor Fraud Reporting?, Christopher K. Eller

Theses and Dissertations

This study examines the effects of using the internal audit function as a training ground for management and fraud magnitude on internal auditor fraud reporting decisions. Using a 2x2 between-participants experiment, the current study manipulates the use of the internal audit function as a management training ground (used as a training ground vs. not used as a training ground) and fraud magnitude (large fraud, defined as 30 percent of net income vs. small fraud, defined as one percent of net income). The results indicate that internal auditors may be less likely to report a fraud to their superior when the …

The Influence Of Dementia Caregiver Mental Health On Quality Of Care In Argentina, Alejandra Morlett Paredes

Theses and Dissertations

This study examined the connections between cognitive functioning in individuals with dementia and caregiver burden, burden and mental health, mental health and quality of care. One hundred two dementia caregivers from San Lucas, Argentina completed questionnaires assessing these constructs. Caregiver burden, depression, anxiety, and satisfaction with life explained 18.8% of the variance in quality of care – respect and 14.7% of the variance in quality of care – provide. An SEM with generally adequate fit indices uncovered that cognitive functioning in individuals with dementia was inversely associated with caregiver burden, caregiver burden was inversely associated with mental health, and mental …

Repetition, Betsy J. Yost

Theses and Dissertations

Artist Statement

My work is about memory, and my awareness of the repetition of large and small events in my life. In my paintings, drawings, and mixed media I create rhythmic patterns with images and colors to imply a sense of recurrence. I often repeat imagery such as paper dolls or geometric and organic shapes in my work. I choose and repeat shapes and colors that remind me of events in my childhood and in my life as an adult. I see these multiple images as symbolic self-portraits which prompt memories of recurring events, such as waking up each morning …

Regulation Of Pancreatic Α And Β Cell Function By The Bile Acid Receptor Tgr5, Divya Prasanna Kumar

Theses and Dissertations

The discovery that bile acids act as endogenous ligands of the membrane receptor TGR5 and the nuclear receptor FXR increased their significance as regulators of cholesterol, glucose and energy metabolism. Activation of TGR5, expressed on enteroendocrine L cells, by bile acids caused secretion of GLP-1, which stimulates insulin secretion from pancreatic β cells. Expression of TGR5 on pancreatic islet cells and the direct effect of bile acids on the endocrine functions of pancreas, however, are not fully understood. The aim of this study was to identify expression of TGR5 in pancreatic islet cells and determine the effect of bile acids …

Disparities In Adverse Childhood Experiences And Sexual Health In The Us: Results From A Nationally Representative Sample, Monique J. Brown

Theses and Dissertations

Background: Adverse childhood experiences (ACEs) are a major public health problem in the US, and have been linked to risky sexual behavior and psychopathology. However, studies examining the link between the wide range of ACEs and sexual health outcomes and behaviors, and the associated mediational role of psychopathology are lacking.

Objectives: The main objectives of this dissertation project were: 1) To determine the association between ACEs and sexual health outcomes and behaviors (early sexual debut, intimate partner violence (IPV) perpetration, and HIV/STIs); 2) To examine the disparities among selected populations; and 3) To assess the mediational role of psychopathology in …

Stress Management For Cancer Survivors Using A Technologically Adapted Psychosocial Intervention: A Randomized Trial Determining The Effect Of Expressive Writing On Psychoneuroimmunology Based Outcomes, Utkarsh B. Subnis

Theses and Dissertations

Patients with cancer transitioning from completing their final cancer treatments to survivorship are particularly at risk for experiencing psychosocial stress, and the Institute of Medicine (IOM) has referred to these cancer patients as “lost in transition.” In this study, patients with cancer in their transition phase after completing their final radiation treatment were defined as cancer survivors (CS). CS must deal with chronic stressors such as the fear of cancer recurrence as well as the resumption of their roles in their family and work lives. Chronic stress impacts the nervous system and increases secretion of stress hormones (e.g. cortisol) from …

Nonfiction, Documentary And Family Narrative: An Intersection Of Representational Discourses And Creative Practices, Kristine T. Weatherston

Theses and Dissertations

Nonfiction, Documentary, and Family Narrative:
 An Intersection of Representational Discourses and Creative Practices explores the role of personal memory, family history, and inter-generational storytelling as the basis for making a nonfiction film. The film, American Boy, tells the story of my mother’s immigration to the United States after the failed Hungarian Revolution of 1956, opening a discussion of four generations of my family life in the context of historical events, exile, self re-invention, and identity formation. As a media producer and nonfiction author, I narrate my understanding of these events to my infant son, as a way of communicating …

Perceptions Of And Implicit Attitudes Toward Women: The Influence Of Parental Status, Race, And Label Choice, Annalucia Bays

Theses and Dissertations

Previous research suggests that childfree and childless women are perceived more negatively than mothers. This study investigated attitudes based on parental status, race, and descriptive label. Undergraduate students (N = 386) were randomized to consider targets described as childless, childfree, or mothers/parents. Participants completed a personality characteristic rating scale, the competence and warmth scales of the Stereotype Content Model, an evaluation thermometer, a measure of pronatalism, and a Single Category Implicit Association Test. Childless and childfree women of all races were perceived more negatively than mothers, and women in all parental status groups were ambivalently stereotyped. Implicit attitudes favored …

Barriers And Facilitators To Infant Feeding Among Low-Income African American Women, Cecilia E. Barbosa

Theses and Dissertations

Objective The purpose of the mixed methods study was to compare barriers and facilitators encountered by low-income African American women who engaged in different infant feeding practices. Methods Using the positive deviance approach and modified Integrated Model as theoretical frameworks, the research began with a qualitative study that informed a survey examining intention, skills, and environmental factors differentiating women’s infant feeding practices. Results Twenty-eight and 190 low-income African American adult women participated in focus groups or interviews and a survey, respectively. In the qualitative study, positive deviants, who breastfed for at least four months, seemed to have stronger breastfeeding intentions, …

Enhancing Critical Thinking In Clinical Laboratory Students: A Multimodal Model, Denise Marie Juroske Short

Theses and Dissertations

The purpose of this study was to improve critical thinking skills in clinical laboratory technologists through the development, implementation, and assessment of a multimodal model targeting critical thinking skills. Clinical laboratory technologists influence patient care through the testing of laboratory samples. Employers of these entry level professionals identified a need for improved critical thinking skills. This quasi-experimental study aimed to design a multimodal critical thinking model, implement the model into the clinical laboratory educational curriculum, and assesses this skill set for students in a pre-test / post-test format. The model was delivered and assessed for 47 clinical laboratory students at …

The Effect Of Sleep Medication Use And Poor Sleep Quality On Risk Of Falls In Community-Dwelling Older Adults, Yaena Min

Theses and Dissertations

The work presented in this dissertation focuses on the association between sleep medication use, poor sleep, and falls in community-dwelling adults 65 years or older. Sleep complaints and the consumption of medications to aid sleep are common in older adults. Psychotropic medications, such as sedative hypnotics, are associated with risk of falls in older adults. However, very few studies have assessed the impact of poor sleep and sleep medication use on the risk of falls in community-dwelling older adults. In the first project, a cross-sectional analysis of the Health and Retirement Study (HRS) 2010 data was conducted to determine the …

Video Games: Their Effect On Society And How We Must Modernize Our Pedagogy For Students Of The Digital Age, Christopher J. Baker

Theses and Dissertations

This thesis aims to explore how video games have become an extremely beneficial tool in regards to education, art, medicine, psychology, economics, and beyond. Chapter 1 focuses on how ubiquitous video games have become in America, and what makes video games such a uniquely enjoyable experience to warrant such popularity. Chapter 2 explores how video games have become instrumental in various fields. Chapter 3 discusses the role that video games now play in the world of education; specifically how we, as educators, must adapt a modern pedagogy best suited to students who have grown up with video games, which have …

Why Female Suicide Bombers? A Closer Look At The Liberation Tigers Of Tamil Eelam And Chechen Separatists, Latisha T. Campbell

Theses and Dissertations

The central hypothesis of this study is that terrorist organizations choose to use females as suicide bombers not only as tactical innovation but also to “signal” or send a message to various audiences. In order to meet the research objectives of this study, two terrorist organizations—the Liberation Tigers of Tamil Eelam and the Chechen Separatists or those individuals associated with the Chechen Resistance—are examined in detail from their inception through 2013 using a structured focused comparison methodology.

Evidence is found to support both of the studies’ main hypotheses. First, female suicide bombers are used by terrorist organizations because they are …