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2014

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Young, Southern Women's Perceptions Of Stem Careers: Examining Science, Technology, Engineering And Mathematics As A Gendered Construct, Jessica Elizabeth Quinton Dec 2014

Young, Southern Women's Perceptions Of Stem Careers: Examining Science, Technology, Engineering And Mathematics As A Gendered Construct, Jessica Elizabeth Quinton

Theses and Dissertations

Career interests develop over a lifetime and tend to solidify during late adolescence and early adulthood (Lent, Brown, and Hackett, 2002). The primary purpose of the present qualitative study, which is framed in Feminist Standpoint Theory (Haraway, 1988; Harding, 2007; Naples, 2007; Richardson, 2007), is to understand how eighthgrade, young women in a suburban, public, southern, middle school the South Carolina County School District (CCSD) (pseudonym) perceive their accessibility to Science, Technology, Engineering, and Mathematics (STEM) courses and careers. The secondary purpose is to understand these young women’s “perceptions and unconscious beliefs about gender in science and mathematics” and how …

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Determinants Of Product Upgrading In The Argentine Wine Industry, Lucas Marc Cyr Dec 2014

Determinants Of Product Upgrading In The Argentine Wine Industry, Lucas Marc Cyr

Theses and Dissertations

In this thesis, I examine the impact that a firm's connections and internal resources has on the firm's ability to develop new products. The capability to make improvements to products is crucial to the long term success and growth of a firm. By using structural equation modeling, I take a different approach to network analysis to analyze data from the Argentine wine industry. While I did not find strong evidence to support the hypothesis that the combination of external networks and internal knowledge are key drivers to product upgrading, there was strong evidence to support each individual determinant’s impact on …

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Design And Development Of A Novel Class Of Cell Cycle Cdk Inhibitors Targeting The Cyclin Binding Groove Utilizing The Replace Strategy, Padmavathy Nandha Premnath Dec 2014

Design And Development Of A Novel Class Of Cell Cycle Cdk Inhibitors Targeting The Cyclin Binding Groove Utilizing The Replace Strategy, Padmavathy Nandha Premnath

Theses and Dissertations

Inhibition of CDK2 activity in G1 and S phases of the cell cycle can promote selective apoptosis of cancer cells through the E2F1 pathway. Currently available CDK inhibitors target the ATP binding pocket and result in lack of specificity for the cell cycle vs. the transcriptional CDKs. It has been shown that a peptide HAKRRLIF derived from the tumor suppressor p21 binds to the cyclin binding groove (CBG) and selectively inhibits cell cycle CDKs (CDK2/Cyclin A, CDK2/Cyclin E and CDK4/Cyclin D). The CBG is unique to cell cycle CDKs hence targeting this site avoids the inhibition of transcriptional CDKs can …

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Universal Two-Electron Correlation Operator On Excited States, Bryan Thomas Nichols Dec 2014

Universal Two-Electron Correlation Operator On Excited States, Bryan Thomas Nichols

Theses and Dissertations

Excited states of chemical systems are extremely important in understanding spectra, chemical phenomena, as well as how a particular compound behaves in reactions. Computationally, excited states are normally very expensive to calculate. The difficulty in calculating these states with wavefunction based methods can be mainly attributed to the calculation of large multi-determinant wavefunctions. One reason to use a complicated multi-determinant wavefunction is to include some of the effects of correlation energy. The quantity of correlation energy can most simply be defined as the reduction in energy caused by any two or more electrons trying to avoid each other. The most …

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Analysis Of Hurricane Preparedness Levels And Evacuation Intent For South Carolina Coastal Residents, Wesley Chad Seigler Dec 2014

Analysis Of Hurricane Preparedness Levels And Evacuation Intent For South Carolina Coastal Residents, Wesley Chad Seigler

Theses and Dissertations

Many communities across the nation, especially those in coastal areas, are experiencing extensive growth and expansion. This growth and the associated need for additional infrastructure, goods and services, and basic human needs often place people and the things they value in harm’s way due to the threat of a natural disaster. In order to properly prepare and mitigate disaster impacts, individuals and communities must view disasters as events that will likely occur at least once during their lifetime rather than simply outside possibilities. Residents of coastal communities must prepare for potential impacts from hurricanes and resulting storm surges and must …

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Advanced Digital Signal Processing Based Redefined Power Quality Indices, And Their Applications To Wind Power, Md Moinul Islam Dec 2014

Advanced Digital Signal Processing Based Redefined Power Quality Indices, And Their Applications To Wind Power, Md Moinul Islam

Theses and Dissertations

This dissertation proposes a time-frequency distribution (TFD) based new method to redefine the power quality (PQ) indices for the assessment of PQ disturbances typically present in electric power systems. The redefined PQ indices are applied to various types of synthetic and real-world PQ disturbances in order to verify the efficacy and applicability of the proposed method. The case studies show that the proposed method provides actual results with respect to the existing TFD-based transient PQ indices, and provides much more accurate results than the traditional fast Fourier transform (FFT) based PQ indices under stationary and nonstationary PQ disturbances. In addition, …

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The Role Of Lis1 In Adult Mammalian System, Xu Gao Dec 2014

The Role Of Lis1 In Adult Mammalian System, Xu Gao

Theses and Dissertations

Lis1 haploinsufficiency in humans results in a “smooth brain” phenotype called lissencephaly, and also causes severe cognitive and motor impairments and epilepsy. Seizure severity and frequency typically worsens with time; patients often die within the first decade due to seizure-induced aspiration and pneumonia. Various mouse models have been used to examine the role of Lis1 during brain development, and it is clear that Lis1 regulates a microtubule motor, cytoplasmic dynein. Intriguingly, Lis1 expression remains high in adult brains indicating that it plays a role in mature systems. Indeed, our group found that Lis1 and several related proteins regulate dynein-dependent axon …

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Early Screening And Identification Of Preschool Children Affected By Serious Emotional Disorders, Cathy Renee Robey-Williams Dec 2014

Early Screening And Identification Of Preschool Children Affected By Serious Emotional Disorders, Cathy Renee Robey-Williams

Theses and Dissertations

Mental illness has surpassed physical health problems as the leading cause for morbidity and mortality in American children. National prevalence of serious emotional disorders in the 0-5 age group has ranged from 9.5% to 14.2%. Of the 15 million children affected by mental illness, less than 20- 25% receive any treatment. Nationwide, early screening, identification, and treatment of preschoolers with emotional or behavioral disorders have become a critical priority in order to reduce the increasing burden of healthcare costs for mental illness and psychiatric care. The purpose of this study was to test the feasibility of a screening process for …

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Innovation Among Georgian Journalism Educators: A Network Analysis Perspective, Ana Keshelashvili Dec 2014

Innovation Among Georgian Journalism Educators: A Network Analysis Perspective, Ana Keshelashvili

Theses and Dissertations

Rapid developments in technology in recent years have disrupted the media’s traditional role as a main informer for citizens. The changes have challenged journalism educators worldwide, pushing them to innovate and experiment. One purpose of this dissertation is to examine adoption of innovations by journalism educators in Georgia, a small post-Soviet country with partly free media and lack of professional outlets, that has been and still is a beneficiary of Western aid for media development. Employing innovation diffusion theory and the network analysis perspective, this dissertation uses a census of journalism educators and journalism program leaders in Georgia to understand …

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Leadership Perspectives On International Education For Public School Students In South Carolina: Two Case Studies, Frederick Eugene Brown Dec 2014

Leadership Perspectives On International Education For Public School Students In South Carolina: Two Case Studies, Frederick Eugene Brown

Theses and Dissertations

This study explores how two rural public school districts in South Carolina conceptualize and implement an international education, according to the perspectives of administrators and teachers. This comparative case study of two public school districts spans the districts’ elementary, middle, high and career center schools and seeks to understand how the presence of a major multinational corporation influences school internationalization. The data on their perspectives on internationalization were drawn from interviews. I interviewed the school principal and teachers involved in internationalizing the curriculum, policy and practice in each of the ten schools. In addition to school level personnel, I interviewed …

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Single Nucleotide Polymorphisms In Dna Repair And Oxidative Stress Genes, And Their Interaction With Antioxidants On Prostate Cancer Aggressiveness, Samuel Antwi Dec 2014

Single Nucleotide Polymorphisms In Dna Repair And Oxidative Stress Genes, And Their Interaction With Antioxidants On Prostate Cancer Aggressiveness, Samuel Antwi

Theses and Dissertations

Prostate cancer is the leading invasive malignancy and the second most common cause of cancer death among American men. Despite compelling evidence that oxidative stress, ineffective DNA damage repair, and habitually low antioxidants intake may act in tandem to influence prostate carcinogenesis, few studies have examined gene-diet interactions involving these risk factors. Even fewer studies have examined such interactions in relation to prostate cancer aggressiveness. This study investigated whether single nucleotide polymorphisms (SNPs) in DNA repair- and oxidative stress-related genes modulated associations between antioxidant intake and prostate cancer aggressiveness. We utilized data from the North Carolina-Louisiana Prostate Cancer Project (PCaP) …

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Novel Biofabrication Technologies To Recapitulate In Vivo Geometries In Collagen Hydrogels, Veronica Rodriguez-Rivera Dec 2014

Novel Biofabrication Technologies To Recapitulate In Vivo Geometries In Collagen Hydrogels, Veronica Rodriguez-Rivera

Theses and Dissertations

Tissue engineering and regenerative medicine aims to restore form and function to tissues that have been lost or damaged due to disease, congenital defect, or trauma. Biomaterials suitable to restore these complex tissues need to provide a balance between chemical and mechanical properties, providing accurate cell-matrix interaction and induce in vivo behaviors such as proliferation, differentiation and migration. It also requires that physical and chemical cues be presented to the body in the proper temporal and spatial pattern. The extracellular matrix exerts forces that are transmitted through focal adhesion causing changes in the cell behavior. The hypothesis for this dissertation …

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Low Reynolds Number Turbulence: Mechanisms And Applications, Wei Zhao Dec 2014

Low Reynolds Number Turbulence: Mechanisms And Applications, Wei Zhao

Theses and Dissertations

Turbulence, as one of "the most important unsolved classical problem in physics" (R. Feynman, 1932), has been investigated for more than 130 years. Conventionally, turbulence is believed to be a phenomenon of high Reynolds numbers (Re). However, we find that turbulence can also be achieved at low Re by proper external forcing, either in macroflows or in microflows. In macroflows, the characteristics of high Re turbulence can be achieved in confined flows, when the bulk flow Re is around 400, by external forcing at its optimal frequency (Wang 2003; Wang 2006). Interestingly, the optimal narrow band of frequency is fixed …

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Surface Modification Of Nanoplatelets In Polymer Nanocomposites, Shailesh K. Shori Dec 2014

Surface Modification Of Nanoplatelets In Polymer Nanocomposites, Shailesh K. Shori

Theses and Dissertations

In polymer nanocomposites (PNCs), it is very important that the nanofiller (typically an inorganic) is well-dispersed in an organic polymer matrix. Optimal compatibility results in end-use products such as packaging materials with enhanced properties. In practice, however, this is challenging to achieve because “ideal” dispersions require the complete uniform separation, termed exfoliation, of the nanofiller within the matrix. As a result, different nanofillers including calcium niobate (CN) and montmorillonite (MMT) are first studied for their ability to exfoliate in aqueous suspensions by measuring the organic cation uptake. The cation exchange capacity, or CEC, determined that CN needs further work before …

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Gestational Weight Gain, Pregnancy Outcomes, And Use Of Perinatal Health Services, Lujing Zhan Dec 2014

Gestational Weight Gain, Pregnancy Outcomes, And Use Of Perinatal Health Services, Lujing Zhan

Theses and Dissertations

This dissertation consists of three studies that were undertaken to better understand 1) the role of gestational weight gain (GWG) during early pregnancy on subsequent blood pressure changes and the risk of pregnancy-induced hypertension (PIH), 2) the causal effect of GWG in both early and mid-late pregnancy on the subtypes of preterm births, and 3) the impact of personal capital on the use of perinatal health services (i.e., prenatal care use and preconception care counseling). The first two studies were based on the data from the 1988 National Maternal and Infant Health Survey and the third study employed the data …

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Applications Of Advanced Imaging Methods: Macro-Scale Studies Of Woven Composites And Micro-Scale Measurements On Heated Ic Packages, Siming Guo Dec 2014

Applications Of Advanced Imaging Methods: Macro-Scale Studies Of Woven Composites And Micro-Scale Measurements On Heated Ic Packages, Siming Guo

Theses and Dissertations

As a representative advanced imaging technique, the digital image correlation (DIC) method has been well established and widely used for deformation measurements in experimental mechanics. This methodology, both 2D and 3D, provides qualitative and quantitative information regarding the specimen’s non-uniform deformation response. Its full-field capabilities and non-contacting approach are especially advantageous when applied to heterogeneous material systems such as fiber-reinforced composites and integrated chip (IC) packages. To increase understanding of damage evolution in advanced composite material systems, a series of large deflection bending-compression experiments and model predictions have been performed for a woven glass-epoxy composite material system. Stereo digital image …

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Diversity, Genetics, And Health Benefits Of Sorghum Grain, Davina Rhodes Dec 2014

Diversity, Genetics, And Health Benefits Of Sorghum Grain, Davina Rhodes

Theses and Dissertations

Staple cereal crops provide the majority of nutrients to the world's population, and thus, can significantly impact human nutrition and health. Phenotypic and genetic diversity within a crop can be useful for biofortification and crop improvement, but quantitative phenotyping is needed to identify varieties with high or low concentrations of a nutrient of interest, and to identify alleles responsible for quantitative trait variation of the nutrient. Sorghum [Sorghum bicolor (L.) Moench] is a diverse and widely adapted cereal crop that provides food for more than 500 million people in sub-Saharan Africa and Asia, and is becoming increasingly popular in specialty …

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Thermal Ecology And Physiology Of An Intertidal Predator-Prey System: Pisaster Ochraceus And Mytilus Californianus, Cristian J. Monaco Dec 2014

Thermal Ecology And Physiology Of An Intertidal Predator-Prey System: Pisaster Ochraceus And Mytilus Californianus, Cristian J. Monaco

Theses and Dissertations

Untangling natural systems’ complexity requires understanding the mechanisms responsible for organisms’ responses to environmental change. Recently, significant advances have been made by recognizing the relevance of direct and indirect effects, which take place when multiple biotic and abiotic factors influence each other. I examined potential direct effects of environmental variables on a predator-prey interaction, as well as potential indirect effects of these variables on the interaction itself. I placed emphasis on behavioral and physiological adaptations, which would potentially contribute/modify these effects. My study system was comprised of a rocky intertidal keystone predator, the sea star Pisaster ochraceus, and its main …

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A Three-Dimensional-Engineered Matrix To Study The Microenvironment Of Cancer Stem Cells, Samaneh Kamali Sarvestani Dec 2014

A Three-Dimensional-Engineered Matrix To Study The Microenvironment Of Cancer Stem Cells, Samaneh Kamali Sarvestani

Theses and Dissertations

Maintenance of cancer stem cells (CSCs) is regulated by their microenvironment. As cancer cells are affected by many factors in their microenvironment, a major challenge is to isolate the effect of a specific factor on CSCs while keeping other factors unchanged. We developed a synthetic inert 3D Poly Ethylene Glycol Di-Acrylate (PEGDA) gel culture system as a unique tool to study the effect of microenvironmental factors on CSCs response. Synthetic hydrogels provide the flexibility to design three-dimensional (3D) matrices to isolate and study individual factors in the tumor microenvironment. The first objective of this work was to investigate the effect …

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Effects Of Sight Singing Using Moveable-Do Solmization On The Transposition Performance Of Undergraduate Group Piano Students, Michelle Irene Wachter Dec 2014

Effects Of Sight Singing Using Moveable-Do Solmization On The Transposition Performance Of Undergraduate Group Piano Students, Michelle Irene Wachter

Theses and Dissertations

The purpose of this study was to examine the effects of sight singing, using moveable-do solmization, on the keyboard transposition performance of undergraduate group piano students. Thirty-nine (N = 39) undergraduate non-keyboard music majors enrolled in three intact sections of first-semester group piano courses participated in this quantitative study. Students completed an individual pretest and posttest consisting of a videotaped sight-reading and transposition performance and a pretest and posttest questionnaire. Throughout the six-week treatment period, all students received sight-reading and transposition instruction using identical musical examples. A control group sight read and transposed examples without singing, while students in two …

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Going Up The Country: A Comparison Of Elite Ceramic Consumption Patterns In Charleston And The Carolina Frontier, Rebecca E. Shepherd Dec 2014

Going Up The Country: A Comparison Of Elite Ceramic Consumption Patterns In Charleston And The Carolina Frontier, Rebecca E. Shepherd

Theses and Dissertations

The 18th century colonial world is characterized by a dramatic increase in the consumption of goods identified as the “consumer revolution.” During this period fashionable material culture and the social performances associated with their use became universally recognized symbols of group membership. This thesis uses archaeological evidence to explore variation in the degree of participation in the consumer revolution between urban and rural settings in late eighteenth-century South Carolina. The data used for this research will be taken from excavated ceramic assemblages of two domestic archaeological sites, both of which were homes owned consecutively by the wealthy Brewton and Motte …

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Measurement Of Polarization Observables PZ, PSZ, And PCZ In Double-Pion Photoproduction Off The Proton, Yuqing Mao Dec 2014

Measurement Of Polarization Observables PZ, PSZ, And PCZ In Double-Pion Photoproduction Off The Proton, Yuqing Mao

Theses and Dissertations

Meson production from excited nucleons is important in the study of baryon resonances and pion photoproduction is attracting much attention. To date a rather large amount of unpolarized cross-section measurements have been reported for both single- and double-pion photoproduction. However, polarization observables provide complementary information as they probe different combinations of transition amplitudes. The database for polarization observables remains quite sparse. Double-pion photoproduction have been studied in Hall B at Jefferson Lab with linearly polarized tagged photon beams incident on longitudinally polarized protons. The experiment covered center-of-mass energies between 1.4 GeV and 2.3 GeV. The target was a FROzen Spin …

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A Phenomenological Study Of Student Engagement In United States History Classrooms, Emily Louvette Manigault Dec 2014

A Phenomenological Study Of Student Engagement In United States History Classrooms, Emily Louvette Manigault

Theses and Dissertations

The purpose of this phenomenological study is to explore the relationship between student engagement and the perception of academic achievement (learning) by teachers and students in an urban high school social studies course. Over the past several years, educational leaders and researchers have tried to find a cause for a number of issues in public education, including low academic achievement, increasing student drop-out rates and the decline of positive perceptions of schools in general. As a result, there has been increasing research done on the level of engagement that students experience during their schooling. Much of the research has focused …

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Semiparametric Regression Analysis Of Bivariate Interval-Censored Data, Naichen Wang Dec 2014

Semiparametric Regression Analysis Of Bivariate Interval-Censored Data, Naichen Wang

Theses and Dissertations

Survival analysis is a long-lasting and popular research area and has numerous applications in all fields such as social science, engineering, economics, industry, and public health. Interval-censored data are a special type of survival data, in which the survival time of interest is never exactly observed but is known to fall within some observed interval. Interval-censored data arise commonly in real-life studies, in which subjects are examined at periodical or irregular follow-up visits. In this dissertation, we develop efficient statistical approaches for regression analysis of bivariate intervalcensored data, in which the two survival times of interest are correlated and both …

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Virtual High Schools Versus Brick And Mortar High Schools: An Analysis Of Graduation Rates For Low Socio-Economic Students In South Carolina, Alice Denise Montgomery Dec 2014

Virtual High Schools Versus Brick And Mortar High Schools: An Analysis Of Graduation Rates For Low Socio-Economic Students In South Carolina, Alice Denise Montgomery

Theses and Dissertations

The No Child Left Behind Act (NCLB) in 2001 was designed to ensure that all students are receiving an appropriate education. All states were mandated to implement state-wide assessments to monitor student achievement. With the identification of student needs that came from the results of state-wide assessments, leaders at both the state and district levels began to develop programs to address these needs. The virtual high school is one of the alternative settings for education that came out of this movement. Full-time virtual high schools have a growing enrollment every year. However, the progress these schools are making in the …

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Climate-Induced Changes In The Germination Phenology Of Boechera Stricta, Samuel Johnson Dec 2014

Climate-Induced Changes In The Germination Phenology Of Boechera Stricta, Samuel Johnson

Theses and Dissertations

Climate change is having demonstrable, worldwide impacts on ecological systems in ways that have modified aspects of organism behavior. Plant phenologies have responded to warmer temperatures in a variety of ways that may have implications for long-term species survival. How germination phenology changes in response to warmer climate is a largely unexplored question yet the ability of a plant to advance or delay germination in unfavorable conditions is critical for survival. Knowing the relative success and timing of germination under different climate regimes is important in understanding whether species can keep pace with the rate of climate change via migration …

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Bio-Active Degradable Micellar Hydrogels For Osteogenic Differentiation Of Mesenchymal Stem Cells, Seyedsina Moeinzadeh Dec 2014

Bio-Active Degradable Micellar Hydrogels For Osteogenic Differentiation Of Mesenchymal Stem Cells, Seyedsina Moeinzadeh

Theses and Dissertations

A feasible approach to the restoration of injured bone tissue is the use of tissue engineering strategies to deliver mesenchymal stem cells (MSCs) to the site of regenration in degradable, in-situ gelling, bio-active hydrogels. Although inert Polyethylene glycol (PEG) hydrogels provide flexibility in controlling the cell microenvironment, their use for in vivo applications in tissue regeneration is limited by their persistence (nondegradability) in the site of regeneration. In an attempt to produce inert hydrolytically degradable matrices for encapsulation of MSCs, hydrogels based on star PEG macromonomers chain-extended with short hydroxy acid (HA) segments (SPEXA) were synthesized and characterized with respect …

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Automated Scratchpad Mapping And Allocation For Embedded Processors, Yang Gao Dec 2014

Automated Scratchpad Mapping And Allocation For Embedded Processors, Yang Gao

Theses and Dissertations

Embedded system-on-chip processors such as the Texas Instruments C66 DSP and the IBM Cell provide the programmer with a software controlled on-chip memory to supplement a traditional but simple two-level cache. By decomposing data sets and their corresponding workload into small subsets that fit within this on-chip memory, the processor can potentially achieve equivalent or better performance, power efficiency, and area efficiency than with its sophisticated cache. However, program controlled on chip memory requires a shift in the responsibility for management and allocation from the hardware to the programmer. Specifically, this requires the explicit mapping of program arrays to specific …

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Theoretical Investigation Of The Catalytic, Liquid-Phase Hydrodeoxygenation Of Organic Acids And Esters, Sina Behtash Dec 2014

Theoretical Investigation Of The Catalytic, Liquid-Phase Hydrodeoxygenation Of Organic Acids And Esters, Sina Behtash

Theses and Dissertations

With worldwide fossil fuel resources dwindling and greenhouse gas emissions rising, it is urgent to find renewable liquid fuel alternatives from e.g. biomass to meet the world’s growing energy demand. Lipid feedstocks and pyrolysis oils from woody biomass can be utilized for the production of second-generation biofuels via a catalytic hydrodeoxygenation (HDO) process. The conversion of fatty acids and esters plays an important role in the activity and selectivity of these processes. Understanding the HDO reaction mechanism of organic acids and esters on metal surfaces is a prerequisite for the rational design of new HDO catalysts specifically designed for upgrading …

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Understanding Geo-Social Network Patterns: Computation, Visualization, And Usability, Caglar Koylu Dec 2014

Understanding Geo-Social Network Patterns: Computation, Visualization, And Usability, Caglar Koylu

Theses and Dissertations

Geo-social networks are formed by flows of physical entities (e.g., humans, vehicles, sensors, animals), and communication (e.g., information, ideas, innovation) that connect places to places and individuals to individuals. Several major problems remain to be addressed for understanding the complex patterns in geo-social networks. This dissertation makes the following contributions to the theory and methodologies that aim at understanding complex geo-social data by integrating methods of computation, visualization and usability evaluation. Chapter 2 introduces a novel network-based smoothing approach that addresses the size-difference and small area problem in calculating and mapping locational (graph) measures in spatial interaction networks. The new …

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