Digital Commons Network^™

Ept7 Influences Estrogen Action In The Pituitary Gland And Body Weight Of Rats, Scott G. Kurz, Kirsten L. Mcfee, Nyssa Becker Samanas, Maureen Peters Hickman, Quincy A. Eckert, Tiffany L. Walker, Andrea S. Cupp, James D. Shull

Department of Animal Science: Faculty Publications

Estrogens control many aspects of pituitary gland biology, including regulation of lactotroph homeostasis and synthesis and secretion of prolactin. In rat models, these actions are strain specific and heritable, and multiple quantitative trait loci (QTL) have been mapped that impact the responsiveness of the lactotroph to estrogens. One such QTL, Ept7, was mapped to RNO7 in female progeny generated in an intercross between BN rats, in which the lactotroph population is insensitive to estrogens, and ACI rats, which develop lactotroph hyperplasia/adenoma and associated hyperprolactinemia in response to estrogen treatment. The primary objective of this study was to confirm the …

The Price Of Justice: Deferred Prosecution Agreements In The Context Of Iranian Sanctions, Kristie Xian

Notre Dame Journal of Law, Ethics & Public Policy

No abstract provided.

Encountering Metronormativity: Geographies Of Queer Visibility In Central New York, Sean H. Wang

Wagadu: A Journal of Transnational Women's & Gender Studies

This article uses metronormativity to discuss queer visibility and political organizing in central New York. It critically reviews the geography of sexuality literature and – through a vignette – illustrates how metronormative politics impacts service providers. It ends by suggesting that the Marxist concept of ordinary may offer an alternative to metronormativity.

Gene Patents And The Public Interest: Litigating Association For Molecular Pathology V. Myriad Genetics And Lessons Moving Forward, Sandra S. Park

North Carolina Journal of Law & Technology

No abstract provided.

Educators' Positive Stress Responses: Eustress And Psychological Capital, Karen Bradley

College of Education Theses and Dissertations

This study contributes qualitative support for the Positive Psychology concepts of Psychological Capital and eustress in the field of education. The research questions ask how stressors inherent in public education today may positively influence the meaning-making teachers engage in. The constructs of Psychological Capital (hope, self-efficacy, resilience, and optimism) are explored viewing their relationship to positive meaning-making for these individuals.

The study is based on life history interviews with six teachers identified as being positively oriented in their outlook. The career trajectory of each was discussed, along with identification of successes and challenges in being a public school teacher at …

Effects Of Ovariectomy And Anatomical Position On The Compact Bone As Seen In Three Month Summer Ovine Model, Bryan C. Kraft

Master's Theses

The purpose of this study is to characterize the compact-bone remodeling response to an ovariectomy model of human postmenopausal osteoporosis. Animal models are a beneficial practice allowing for the evaluation of the effectiveness of medical therapies and devices on diseases. The ovine model was chosen for this study due to its large size, similar bone remodeling to humans, and cost effectiveness. The main obstacle to overcome with the use of the ovine model was the lack of natural menopause experienced by this species. To overcome this, it was necessary to perform an ovariectomy to create estrogen depletion and artificially induce …

An Investigation Of Poly(N-Isopropylacrylamide) For Applications With Microfluidic Paper-Based Analytical Devices, Haydn Thomas Mitchell

Master's Theses

N,N′-methylenebisacrylamide-crosslinked poly(N-isopropylacrylamide), also known as P(NIPAM), was developed as a fluid delivery system for use with microfluidic paper-based analytical devices (microPADs). MicroPADs are postage-stamp-sized devices made out of paper that can be used as platforms for low-cost, simple-to-use point-of-care diagnostic assays. P(NIPAM) is a thermally responsive polymer that absorbs aqueous solutions at room temperature and will expel the solutions to microPADs when heated. The fluid delivery characteristics of P(NIPAM) were assessed, and P(NIPAM) was able to deliver multiple solutions to microPADs in specific sequences or simultaneously in a laminar-flow configuration. P(NIPAM) was then shown to be suitable …

Cayucos Community Health Plan, Jennifer Joyce Franich

Master's Theses

Recent, mounting research shows that chronic disease, the leading causes of death and primary driver of health care costs, cannot be effectively addressed through education or preventative health alone. A physical environment that promotes health—through access to healthy food, opportunities for physical activity, quality housing, transportation options, and safe schools—is an integral part of making our communities healthier. This research and accompanying Healthy Community Plans will serve as a way for the County to begin looking in-depth at the ways the built environment (our streets, parks, and neighborhoods) contribute or detract from the health of the community. Though the creation …

Water And Nutrient Recycling In High Rate Algae Ponds Fed In Primary Treated Municipal Wastewater, Michael Field Chang

Master's Theses

Algal biofuels present a promising future alternative to petroleum based fuels. Water nutrient recycling is a key step to increase the sustainability of algae biofuel production facilities. This thesis discusses the process of nutrient and water recycling in high rate algae raceway ponds (HRAP) fed primary treated municipal wastewater. Research was conducted primarily at the San Luis Obispo Water Resource Reclamation Facility (SLOWRRF). Nine 30 m², 0.3 m deep HRAP’s were operated continuously from June 1, 2013 to April 17, 2014. The ponds were arranged in three sets of triplicate ponds, with two pond sets run on 3-day …

University Square Development Proposal, Tom Gregory Van Pelt

Master's Theses

The University Square Development Proposal (USDP) explores the redevelopment of the underutilized University Square site (the Site) in the City of San Luis Obispo (the City.) The Sites proximity to California Polytechnic State University, San Luis Obispo (Cal Poly), a university with significant student housing needs, makes it an ideal location for student housing. The City has also expressed interest in the Site, having identified it in the General Plan Land Use and Circulation Element (LUCE) update as a “Special Planning Area”. The LUCE proposes a new mixed-use typology on the Site that may include a mixture of multi-family housing, …

Juiciness In Citizen Science Computer Games: Analysis Of A Prototypical Game, Eric D. Ebucktha Buckthal

Master's Theses

Incorporating the collective problem-solving skills of non-experts could ac- celerate the advancement of scientific research. Citizen science games leverage puzzles to present computationally difficult problems to players. Such games typ- ically map the scientific problem to game mechanics and visual feed-back helps players improve their solutions. Like games for entertainment, citizen science games intend to capture and retain player attention. “Juicy” game design refers to augmented visual feedback systems that give a game personality without modi- fying fundamental game mechanics. A “juicy” game feels alive and polished. This thesis explores the use of “juicy” game design applied to the citizen …

Pump Station Calculations And Irrigation System Evaluation For Trestle Vineyard, Linda Bushey

BioResource and Agricultural Engineering

No abstract provided.

2014-15 Key Strategic Issues List, John F. Troxell Professor

Articles & Editorials

December 9 - Part II of the Key Strategic Issues List has been updated once again and is available for online viewing: 2014-15 KSIL

For several years, the Strategic Studies Institute (SSI) has annually published the Key Strategic Issues List (KSIL). The purpose of this document is to make students and other researchers aware of strategic topics that are of special interest to the U.S. Army. Part I of KSIL is entitled "Army Priorities for Strategic Analysis" (APSA) and is a list of high-priority topics organized to support the Army's five strategic objectives as identified in the "2014 Army Strategic …

Finding Of Widespread Viral And Bacterial Revolution Dsdna Translocation Motors Distinct From Rotation Motors By Channel Chirality And Size, Gian Marco De-Donatis, Zhengyi Zhao, Shaoying Wang, Lisa P. Huang, Chad T. Schwartz, Oleg V. Tsodikov, Hui Zhang, Farzin Haque, Peixuan Guo

Nanobiotechnology Center Faculty Publications

BACKGROUND: Double-stranded DNA translocation is ubiquitous in living systems. Cell mitosis, bacterial binary fission, DNA replication or repair, homologous recombination, Holliday junction resolution, viral genome packaging and cell entry all involve biomotor-driven dsDNA translocation. Previously, biomotors have been primarily classified into linear and rotational motors. We recently discovered a third class of dsDNA translocation motors in Phi29 utilizing revolution mechanism without rotation. Analogically, the Earth rotates around its own axis every 24 hours, but revolves around the Sun every 365 days.

RESULTS: Single-channel DNA translocation conductance assay combined with structure inspections of motor channels on bacteriophages P22, SPP1, HK97, T7, …

Myriad After Myriad: The Proprietary Data Dilemma, John M. Conley, Robert Cook-Deegan, Gabriel Lazaro-Munoz

North Carolina Journal of Law & Technology

No abstract provided.

The Expanding Use Of Genetic And Psychological Evidence: Finding Coherence In The Criminal Law? , Michael Vitiello

Nevada Law Journal

No abstract provided.

Title Vii And Diversity, Kingsley R. Browne

Nevada Law Journal

No abstract provided.

Probability Of Regenerating A Normal Limb After Bite Injury In The Mexican Axolotl (Ambystoma Mexicanum), Sierra Thompson, Laura Muzinic, Christopher Muzinic, Matthew L. Niemiller, S. Randal Voss

Biology Faculty Publications

Multiple factors are thought to cause limb abnormalities in amphibian populations by altering processes of limb development and regeneration. We examined adult and juvenile axolotls (Ambystoma mexicanum) in the Ambystoma Genetic Stock Center (AGSC) for limb and digit abnormalities to investigate the probability of normal regeneration after bite injury. We observed that 80% of larval salamanders show evidence of bite injury at the time of transition from group housing to solitary housing. Among 717 adult axolotls that were surveyed, which included solitary-housed males and group-housed females, approximately half presented abnormalities, including examples of extra or missing digits and …

Multipolarity, Intellectual Property, And The Internationalization Of Public Health Law, Sam F. Halabi

Michigan Journal of International Law

The cause of global health today is arguably the most influential human rights movement ever seen, mobilizing vast flows of direct and indirect aid to the developing world to fight disease and build health care infrastructure; prompting the establishment of international organizations like UNAIDS and the Global Fund to fight AIDS, Tuberculosis and Malaria (Global Fund); including global health as a priority in major diplomatic summits; and driving the formation and implementation of international agreements to address global health threats. Champions of this movement claim that the diverse and influential state and non-state actors participating in the development of the …

Smooth Muscle Cell Organization In The Stem Region Of The Gracilis Collateral Circulation, Amanda Krall

Biomedical Engineering

Many patients who suffer from the ischemic Peripheral Arterial Occlusive Disease (PAOD) experience intermittent claudication, which can be attributed to impaired vasodilation. Collateral vessels are the primary site of resistance to blood flow downstream; therefore maximizing vasodilation in collaterals is crucial for efficient circulation. Collaterals function as natural bypasses around the occluded arteries and the increase in flow into these vessels causes them to outwardly remodel into conduit vessels. However, functional vasodilation in the stem region of collateral vessels is impaired at day 7 following femoral ligation, which can be attributed to smooth muscle cell malfunction. However, the increase in …

Environmentally Persistent Free Radicals Inhibit Cytochrome P450 Activity In Rat Liver Microsomes, James R. Reed, George F. Cawley, Taylor G. Ardoin, Barry Dellinger, Slawomir M. Lomnicki, Farhana Hasan, Lucy W. Kiruri, Wayne L. Backes

Faculty Publications

Combustion processes generate particulate matter that affects human health. When incineration fuels include components that are highly enriched in aromatic hydrocarbons (especially halogenated varieties) and redox-active metals, ultrafine particulate matter containing air-stable, environmentally persistent free radicals (EPFRs) is generated. The exposure to fine EPFRs (less than 2.5. μm in diameter) has been shown to negatively influence pulmonary and cardiovascular functions in living organisms. The goal of this study was to determine if these EPFRs have a direct effect on cytochrome P450 function. This was accomplished by direct addition of the EPFRs to rat liver microsomal preparations and measurement of several …

Granite State College, University System Of New Hampshire 2014-2015 Catalog, Undergraduate, Granite State College

Granite State College Catalogs

No abstract provided.

Mcnair Scholars Smartnews, June 2014, Mcnair Scholars Program

EMU McNair Challenger

No abstract provided.

The Development Of Sleep-Wake Rhythms And The Search For Elemental Circuits In The Infant Brain, Mark S. Blumberg, Andrew J. Gall, William D. Todd

Faculty Publications

Despite the predominance of sleep in early infancy, developmental science has yet to play a major role in shaping concepts and theories about sleep and its associated ultradian and circadian rhythms. Here we argue that developmental analyses help us to elucidate the relative contributions of the brainstem and forebrain to sleep-wake control and to dissect the neural components of sleep-wake rhythms. Developmental analysis also makes it clear that sleep-wake processes in infants are the foundation for those of adults. For example, the infant brainstem alone contains a fundamental sleep-wake circuit that is sufficient to produce transitions among wakefulness, quiet sleep, …

Meal Pattern Of Male Rats Maintained On Amino Acid Supplemented Diets: The Effect Of Tryptophan, Lysine, Arginine, Proline And Threonine, Raghad Ayaso, Hala Ghattas Ph.D., Mohamad Abiad, Omar Obeid

Faculty Publications

The macronutrient composition of the diet has been shown to affect food intake, with proteins having distinct effects. The present study investigated the effect of diet supplementation with individual amino acids (tryptophan, lysine, arginine, proline and threonine) on meal pattern among male rats. Meal pattern and body weight were monitored for two weeks. Proline and threonine had minimal effects on meal pattern, while the most pronounced changes were observed in the tryptophan group. Both tryptophan and lysine decreased overall food intake, which was translated into a reduction in body weight. The reduced food intake of the tryptophan group was associated …

Recent Cropping Frequency, Expansion, And Abandonment In Mato Grosso, Brazil Had Selective Land Characteristics, Stephanie A. Spera, Avery S. Cohn, Leah K. Vanwey, Jack F. Mustard, Bernardo F.T. Rudorff, Marcos Adami

Geography and the Environment Faculty Publications

This letter uses satellite remote sensing to examine patterns of cropland expansion, cropland abandonment, and changing cropping frequency in Mato Grosso, Brazil from 2001 to 2011. During this period, Mato Grosso emerged as a globally important center of agricultural production. In 2001, 3.3 million hectares of mechanized agriculture were cultivated in Mato Grosso, of which 500 000 hectares had two commercial crops per growing season (double cropping). By 2011, Mato Grosso had 5.8 million hectares of mechanized agriculture, of which 2.9 million hectares were double cropped. We found these agricultural changes to be selective with respect to land attributes —significant …

Neuroevolutionary Feature Selection Using Neat, Soroosh Sohangir, Shahram Rahimi, Bidyut Gupta

Computer Science Publications

The larger the size of the data, structured or unstructured, the harder to understand and make use of it. One of the fundamentals to machine learning is feature selection. Feature selection, by reducing the number of irrelevant/redundant features, dramatically reduces the run time of a learning algorithm and leads to a more general concept. In this paper, realization of feature selection through a neural network based algorithm, with the aid of a topology optimizer genetic algorithm, is investigated. We have utilized NeuroEvolution of Augmenting Topologies (NEAT) to select a subset of features with the most relevant connection to the target …

Southern Alumni, Siu Alumni Association

SIU Alumni Magazine

No abstract provided.

Development And Application Of Novel Conformation-Specific Monoclonal Antibodies For Parkinson’S Disease Pathology., Nour Khaled Majbour

Accounting Dissertations

An abundance of genetic, biochemical and histopathological evidence suggests that the formartion of α-synuclein (α-syn) protein deposits is an important, and likely seminal, step in the development of several important neurodegenerative diseases, the so-called synucleinopathies, including Parkinson’s Disease (PD), intensive research, to date, the only accepted diagnosis for PD is based on clinical criteria. α-syn conversion from soluble monomers into oligomers or fibrils represents a crucial step in synucleinopathies pathogenesis; however, the exact mechanism underlying the cellular aggregation has not been fully elucidated. A growing body of evidence suggests that α-syn soluble oligomers, rather than mature fibrils, are the neurotoxic …

Estimating Bacterial Diversity In Scirtothrips Dorsalis (Thysanoptera: Thripidae) Via Next Generation Sequencing, Aaron M. Dickey, Andrew J. Trease, Antonella Jara-Cavieres, Vivek Kumar, Matthew K. Christenson, Lakshmi-Prasad Potluri, J. Kent Morgan, Robert G. Shatters Jr., Cindy L. Mckenzie, Paul H. Davis, Lance S. Osborne

Biology Faculty Publications

The last 2 decades have produced a better understanding of insect-microbial associations and yielded some important opportunities for insect control. However, most of our knowledge comes from model systems. Thrips (Thysanoptera: Thripidae) have been understudied despite their global importance as invasive species, plant pests and disease vectors. Using a culture and primer independent next-generation sequencing and metagenomics pipeline, we surveyed the bacteria of the globally important pest, Scirtothrips dorsalis Hood. The most abundant bacterial phyla identified were Actinobacteria and Proteobacteria and the most abundant genera were Propionibacterium, Stenotrophomonas, and Pseudomonas. A total of 189 genera of bacteria were identified. The …