Digital Commons Network^™

Stochastic Data Assimilation Approaches For Magnetic Resonance Temperature Imaging, Joshua P. Yung

Dissertations and Theses (Open Access)

During magnetic resonance (MR)-guided thermal therapies, proton resonance frequency shift (PRFS) based MR temperature imaging can quantitatively monitor tissue temperature changes. It is widely known that the PRFS technique is easily perturbed by tissue motion, tissue susceptibility changes, magnetic field drift, and modality–dependent applicator induced artifacts. Due to recent advances in computational algorithms and hardware, much more powerful statistical analysis methods are becoming realizable in the real-time processing environment. To this end, my dissertation research focused on the development, validation, and implementation of stochastic data-driven processing techniques to increase the robustness of MR temperature monitoring during thermal therapies. MR temperature …

Energy Stress Causes Chaperones To Assemble Into Cytoplasmic Complexes, Kimberly J. Cope

Dissertations and Theses (Open Access)

The majority of proteins require molecular chaperones to assist their folding into tertiary and quaternary structures. Certain stresses can compromise the weak hydrophobic forces responsible for these structures and lead to protein unfolding, misfolding, and aggregation. Aggregates of proteins are hallmarks of devastating diseases such as Alzheimer’s, Parkinson’s, and Huntington’s diseases. Fortunately, bacteria, plants, and fungi have a potent disaggregase, named Hsp104 in Saccharomyces cerevisiae. Recently, heat-induced aggregates, termed Q-bodies, were found to contain three molecular chaperones: Hsp70, Hsp104, and Hsp42. Their coalescence from small puncta into larger inclusions required Hsp104. During glucose deprivation, a stress that isn’t known to …

Build-And-Fill Development Of Lower Ismay (Middle Pennsylvanian Paradox Formation) Phylloid-Algal Mounds Of The Paradox Basin, Southeastern Utah, Lincoln H. Reed

Theses and Dissertations

Phylloid-algal mounds form heterogeneous hydrocarbon reservoirs in the southeastern portion (Blanding sub-basin) of the Paradox Basin. Well-studied Lower Ismay mounds exposed along walls of the San Juan River gorge in the vicinity of Eight Foot Rapids, the west limb of the Raplee Anticline, and at the classic Honaker Trail locality (southwestern Paradox Basin) have often been cited as outcrop analogs of productive subsurface mounds. Until now, however, there has not been a complete description of the distribution, size, and spacing of outcropping algal mounds at the classic Eight Foot Rapids locality. The Lower Ismay sequence was analyzed in the context …

Energy And Climate Change: A Climate Prediction Market, Michael P. Vandenbergh, Kaitlin T. Raimi, Jonathan M. Gilligan

Vanderbilt Law School Faculty Publications

Much of energy policy is driven by concerns about climate change. Views about the importance of carbon emissions affect debates on topics ranging from the regulation of electricity generation and transmission to the need for incentives to develop emerging technologies. Government efforts to fund and communicate climate science have been extraordinary, but recent polling suggests that roughly half of the American population is unsure or does not believe that anthropogenic climate change is occurring. Among some populations, belief in climate change is declining even as the climate science becomes more certain. Much of the doubt occurs among individuals who support …

Genetic Analysis Of Ancient Human Remains From The Early Bronze Age Cultures Of The North Pontic Steppe Region, Jeff Pashnick

Masters Theses

During the Neolithic transition into the Early Bronze Age (EBA) in the North Pontic steppe region (NPR), people, cultures, and technologies were rapidly changing. Farming was on the decline and Indo-European languages were spreading through the region along with pastoralist way of life. In this study we used mitochondrial DNA (mtDNA) haplotyping to study the people living in the NPR during these times. Additionally, we used next-generation sequencing (NGS) technologies in attempts to develop novel methods to assess the degradation of ancient DNA (aDNA). We extracted ancient mtDNA from remains of 11 individuals belonging to late Neolithic and EBA populations …

Developing A Predictive Model Of Heart Wall Motion In Fluoroscopic Images, Christopher Hawkins

All Theses

Image guided surgery (IGS) is an integral part of minimally invasive surgery. IGS combines pre- and perioperative images acquired from different imaging modalities to give the surgeon a more complete view of the internal organs. These modalities include computed tomography, magnetic resonance imaging, and fluoroscopy, to name a few. Fluoroscopy is also known as video x-ray and is becoming increasingly popular in procedures around the heart. Unfortunately, this increase in fluoroscopy use also brings an increase in exposure to ionizing radiation for the patient and the surgeon. This radiation can lead to increased cancer risk and a number of other …

Evaluation Of 2,4-D And Dicamba Based Herbicide Programs For Weed Control In Tolerant Soybean, Dwayne Joseph

All Theses

Weeds are the most limiting factor on soybean yields in South Carolina. With their early emergence and rapid growth, weeds compete with crops for resources. The recent evolution of herbicide resistant weeds has made it increasingly difficult for growers to actively control weeds in fields. Glyphosate and ALS-resistant Palmer amaranth (Amaranthus palmeri S. Watson) biotypes have spread rapidly throughout South Carolina, especially in areas where resistance management isn't practiced. In the near future, soybean varieties will be introduced with tolerance to 2,4-D (Dow AgroSciences) and dicamba (Monsanto Company). Field and greenhouse experiments were conducted at Edisto Research and Education Center …

Modeling And Design Strategy Of Online Advertising Ecosystem, Qiuchen Wang

All Theses

Internet has undoubtedly become a major and effective medium for advertising, and it will soon replace traditional advertising media. Online advertising ecosystem is consisted of thousands of agents, which can be divided into three types: users, advertisers and publishers. Each type of the agents plays an important role in the ecosystem. However, it is generally very difficult to model such a complex and large-scale system, not to mention the design of suitable strategies for the ecosystem. On the other side, replicator-mutator (RM) dynamics combine tools from evolutionary dynamics of populations, complex networks, and control theory to study evolution of behavior …

Felt Stigma From Medical Professionals: Effects Of Body Mass Index On Medical Use, Adam Yates

All Theses

This thesis examines the relationship between body mass index (BMI) and perceived discrimination, using the frequency of routine medical care as a proxy for discrimination using waves I (1995) and II (2005) of the Midlife in the U.S (MIDUS) survey. This thesis examines stigma and discrimination of the obese in medical care using the theoretical framework of Felt Stigma and Identity Theory. This thesis addresses 5 research questions: (1) What effect does body mass index have on health usage patterns? (2) What effect does gender have on the relationship between body mass index and health usage patterns? (3) What effect …

Understanding Public Perceptions About Beach Nesting Shorebirds And Habitat Management On Cape Cod, Massachusetts, Marla Hamilton

All Dissertations

Coastline habitats along the eastern seaboard of North America serve as prime locations for beachfront development and consumptive and non-consumptive recreational opportunities. Many of these areas are also globally important nesting and wintering areas for threatened and endangered shorebirds (primarily species belonging to the order Charadriiformes). Across the span of their hemispheric ranges, shorebirds face significant threats due to increases habitat loss, human disturbance, and illegal hunting practices. With coastline use increasing human-wildlife interactions, positive public input and interaction is needed to mitigate negative consequences to wildlife. Although many techniques have been employed to discourage beach users from practicing recreational …

Synthesis, Design, And Environmental Fate Of Metallic Nanoparticles, Ashley E. Hart

All Dissertations

Rational design of nanoparticle surface chemistry offers the ability to control nanoparticle characteristics such as size, polydispersity, shape, dispersibility in various solvents, functionality and end fate. Ligand exchange has proved to be is a versatile method for modifying the surface of plasmonic nanoparticles. Ligand exchange has provided a “green” alternative to traditional biphasic syntheses that require large amounts of phase transfer catalysts. Ligand exchange can also be used to reduce the amount of post synthesis processing and waste when it is conducted on nanoparticles that have been synthesized with a method that affords control over nanoparticle size and polydispersity. Ligand …

Optical Forces In Nanophotonic Structures, Chenguang Huang

All Dissertations

Nowadays, optical forces are widely used to control or measure the position of micrometer- to nanometer-sized particles, such as living cells, DNA and bacteria. Two major categories of optical forces are discussed here: gradient or dipole force and scattering force. The gradient force is originated from the fact that a polarizable micro-particle placed in a laterally varying optical field will experience different forces in the positively and negatively charged sides. In this thesis, we investigate the optical gradient force in 2D hybrid and plasmonic waveguides. Compared to the conventional dielectric waveguides, we show that the optical force can be enhanced …

Chiasmic Rhetoric: Alan Turing Between Bodies And Words, Patricia Fancher

All Dissertations

This Dissertation analyzes the life and writing of inventor and scientist Alan Turing in order to identify and theorize chiasmic relations between bodies and texts. Chiasmic rhetoric, as I develop throughout the Dissertation, is the dynamic processes between materials and discourses that interact to construct powerful rhetorical effect, shape bodies, and also compose new knowledges. My research here extends our knowledge of the rhetoric of science by demonstrating the ways that Alan Turing's embodied experiences shape his rhetoric. Turing is an unusual figure for research on bodily rhetoric and embodied knowledge. He is often associated with disembodied knowledge and as …

South Atlantic Stream Fish Assemblages: Multi-Scale Structuring Factors, Trait Associations And Channelization, And Responses To Dam Removal, Cathy Marion

All Dissertations

South Atlantic coastal plain wadeable streams are unique and understudied freshwater environments that provide crucial habitats for a wide range of aquatic taxa. In Chapter 1, we investigated patterns in fish assemblages across South Carolina's coastal plain, and developed statistical models to identify the dominant multi-scale abiotic environmental factors that influence assemblage structure. Our analyses indicated the presence of four predominant fish assemblages that commonly occur in the coastal plain, which we termed the: 1) fluvial, 2) eastern mudminnow, 3) centrarchid, and 4) non-fluvial assemblages. Natural geographic gradients and instream habitat parameters associated with velocity, channel form, stream size, and …

The Avian Thrombocyte Is A Specialized Immune Cell, Farzana Ferdous

All Dissertations

Thrombocytes are the most abundant circulating cells next to red blood cells in avian blood. Avian thrombocytes are homologous in function to mammalian platelets. Avian thrombocytes and the mammalian platelet are widely recognized contributors to inflammatory responses upon stimulation with various microbial stimulants. However, some observed responses of the avian thrombocyte depart from a standardized model ascribed to innate cells. To help unravel the role of thrombocytes in innate immunity, and possibly adaptive immunity, first we examined the surface features of chicken thrombocytes. Chicken thrombocytes constitutively express transcripts for different Toll-like receptors (TLRs) that are crucial for the innate immune …

Synthesis And Characterization Of Nanoscale Polymer Films Grafted To Metal Surfaces, Yuriy Galabura

All Dissertations

Anchoring thin polymer films to metal surfaces allows us to alter, tune, and control their biocompatibility, lubrication, friction, wettability, and adhesion, while the unique properties of the underlying metallic substrates, such as magnetism and electrical conductivity, remain unaltered. This polymer/metal synergy creates significant opportunities to develop new hybrid platforms for a number of devices, actuators, and sensors. This present work focused on the synthesis and characterization of polymer layers grafted to the surface of metal objects. We report the development of a novel method for surface functionalization of arrays of high aspect ratio nickel nanowires/micronails. The polymer 'grafting to' technique …

Novel Optical Microresonators For Sensing Applications, Hanzheng Wang

All Dissertations

Optical microresonators have been proven as an effective means for sensing applications. The high quality (Q) optical whispering gallery modes (WGMs) circulating around the rotationally symmetric structures can interact with the local environment through the evanescent field. The high sensitivity in detection was achieved by the long photon lifetime of the high-Q resonator (thus the long light-environment interaction path). The environmental variation near the resonator surface leads to the effective refractive index change and thus a shift at the resonance wavelength. In this Dissertation, we present our recent research on the development of new optical microresonators for sensing applications. Different …

Mechanical Properties Of Low Dimensional Materials, Deepika Saini

All Dissertations

Recent advances in low dimensional materials (LDMs) have paved the way for unprecedented technological advancements. The drive to reduce the dimensions of electronics has compelled researchers to devise newer techniques to not only synthesize novel materials, but also tailor their properties. Although micro and nanomaterials have shown phenomenal electronic properties, their mechanical robustness and a thorough understanding of their structure-property relationship are critical for their use in practical applications. However, the challenges in probing these mechanical properties dramatically increase as their dimensions shrink, rendering the commonly used techniques inadequate. This Dissertation focuses on developing techniques for accurate determination of elastic …

Evaluation Of The Functional Capabilities Of Fins And Limbs For Moving On Land: Insights Into The Invasion Of Land By Tetrapods, Sandy Kawano

All Dissertations

Transitions to novel habitats present different adaptive challenges, producing captivating examples of how functional innovations of the musculoskeletal system influence phenotypic divergence and adaptive radiations. One intriguing example is the transition from aquatic fishes to tetrapods. Recent technological advances and discoveries of critical fossils have catapulted our understanding on how fishes gave rise to terrestrial vertebrates. Considerable attention has been paid to legged locomotion on land, but given that the first tetrapods were aquatic, limbs did not evolve primarily for terrestriality. How, then, is the locomotor function of limbs different from fins? Extant amphibious fishes demonstrate that fins can be …

Microfluidic Particle And Cell Manipulation Using Reservoir-Based Dielectrophoresis, Saurin Patel

All Dissertations

Controlled manipulation of synthetic particles and biological cells from a complex mixture is important to a wide range of applications in biology, environmental monitoring, and pharmaceutical industry. In the past two decades microfluidics has evolved to be a very useful tool for particle and cell manipulations in miniaturized devices. A variety of force fields have been demonstrated to control particle and cell motions in microfluidic devices, among which electrokinetic techniques are most often used. However, to date, studies of electrokinetic transport phenomena have been primarily confined within the area of microchannels. Very few works have addressed the electrokinetic particle motion …

A Biophysical Understanding Of The Applications And Implications Of Nanomaterials, Nicholas Geitner

All Dissertations

The last few decades have seen an explosion in the study and application of nanomaterials that continues to grow at a dizzying pace. Despite exciting applications in nano-enabled electronics, materials, medicine, and environmental remediation, an understanding of the interactions of these materials with natural materials and systems and the resulting implications lags severely behind. The purpose of this Dissertation is to illuminate these interactions as well as develop novel environmental applications from a biophysical perspective. Following an introduction and literature review in Chapter 1, Chapters 2-4 will explore the application of dendritic polymers as novel and biocompatible oil dispersants for …

Venturing Through The Tall Grass: Experiencing The Manitoba Tall Grass Prairie Preserve, Christie L. Borkowsky, Erin Zahradka

The Prairie Naturalist

The Manitoba Tall Grass Prairie Preserve (hereafter the Preserve) was established in 1989 with a goal of protecting a vanishing habitat and to educate the general public of the importance of native grasslands (M. Latta, Nature Manitoba, personal communication). Starting in the early 1990s, an annual Prairie Day event was organized in early August to provide a means of interaction between prairie enthusiasts, the general public and local residents. Self-guiding interpretive trails with rustic amenities were established in 1996 and 2004. School programs, tours, and a simple two-page newsletter have been used to promote the Preserve and bring out visitors …

Project Prairie And Tallgrass Education On The Rice Lake Plains: A Journey From 1870 To Today And Beyond, Todd Farrell, Mark Rupke, Mark Stabb

The Prairie Naturalist

Project Prairie began in 2011 as a curriculum-linked integrated environmental studies program to showcase the Rice Lake Plains (RLP), a tallgrass prairie landscape of sandy rolling hills located at the eastern extent of the Oak Ridges Moraine in southern Ontario. Project Prairie provides educators both indoor and outdoor activities that support their curriculum and share the story of the RLP. Project Prairie provides teacher and student resources that focus on the RLP from the mid-nineteenth century to present day. Learning objectives of Project Prairie are developed from the subjects of science, social science, language arts, geography, history, and Aboriginal culture. …

Notes: Oriental Bittersweet In Grasslands Near Eastern Bluebird Nest Boxes, Neal D. Mundahl

The Prairie Naturalist

Oriental bittersweet (Celastrus orbiculatus Thunb.; hereafter OB) is an invasive, woody vine that has been expanding its range westward in North America since its introduction from East Asia in the mid-1700s for horticultural purposes (Albright et al. 2009, United States Department of Agriculture [USDA] 2012). Although typically a woodland problem in the United States (McNab and Meeker 1987), OB can invade grassland habitats (Fike and Niering 1999), likely sprouting from seeds dropped by birds and mammals (McNab and Meeker 1987, Greenberg et al. 2001, Sarver et al. 2008) and often developing into large, shrub-like tangles of intertwining stems (Fike …

Manitoba Tall Grass Prairie Preserve: Providing Habitat For Protected And Provincially Rare Species, Christie L. Borkowsky

The Prairie Naturalist

The establishment of the Manitoba Tall Grass Prairie Preserve in 1989 secured some of the largest and highest quality parcels of tall grass prairie remaining in the province. Shortly after securement by either Nature Manitoba (formerly Manitoba Naturalists Society) or Manitoba Habitat Heritage Corporation, seasonal staff from the Critical Wildlife Habitat Program (CWHP) began inventory efforts to document the various floral and faunal species occurring on these acquisitions. With the addition of the Nature Conservancy of Canada to the Preserve partnership, the Preserve has grown in size to nearly 5,000 ha. The list of species identified on the Preserve has …

Potential Impacts Of Bison Wallows On A Restored Tallgrass Prairie Community, Kimran Miller, Johanna Foster, Kristen Nielsen, Mary O'Loughlin

The Prairie Naturalist

When bison (Bos bison) repeatedly roll on the ground, they denude vegetation and create wallows (semi-permanent bare areas) that alter the native prairie plant community. Responses to these wallow-related disturbances are not as well documented in restored prairies. From 1 June to 1 September 2010 and from 3 June to 6 August 2011, we examined potential responses at Neal Smith National Wildlife Refuge, a restored prairie with resident bison. We hypothesized that plants and beetles would vary along a disturbance gradient. Our predictions were: (1) near wallows, plants with weedy lifestyles would have highest cover and biomass compared …

A Floristic Survey Of Selected Sites In The Loup River Valley, Nance County, Nebraska, Diane M. Flynn, Steven J. Rothenberger

The Prairie Naturalist

The Loup River Valley of Nebraska contains natural, undisturbed wet meadows with significant plant diversity. Even though these sites are infrequent and are often intermixed with heavily grazed pastures or cultivated fields, they support numerous plant and animal species that do not occur elsewhere. We surveyed three study sites (an ungrazed wet meadow; a grazed wet meadow; and a riparian area) that totaled approximately 68.8 ha during the 2010 and 2011 growing seasons. We compiled an annotated vascular plants checklist for the study area that included 244 plant species of which about 49% (119) were new county records. The mean …

Reproduction Of Copyrighted Works By Educators And Librarians, United States Copyright Office

Copyright, Fair Use, Scholarly Communication, etc.

Many educators and librarians ask about the fair use and photocopying provisions of the copyright law. The United States Copyright Office cannot give legal advice or offer opinions on what is permitted or prohibited. However, we have published in this circular basic information on some of the most important legislative provisions and other documents dealing with reproduction by librarians and educators.

The Subjects Covered in This Booklet

The documentary materials collected in this circular deal with reproduction of copyrighted works by educators, librarians, and archivists for a variety of uses, including:

• Reproduction for teaching in educational institutions at all …

My Church Loyalties, D. Stephen Long

Theology Faculty Research and Publications

No abstract provided.

Characterization Of A Putative Sir2 Like Deacetylase And Its Role In Sabp2 Dependent Salicylic Acid Mediated Pathways In Plant, Md I. Haq

Electronic Theses and Dissertations

Salicylic Acid Binding Protein2 (SABP2) is an enzyme known to play important role in SA mediated pathway. SBIP-428 (SABP2 Interacting Protein-428), a SIR2 like deacetylase, has been found to interact with SABP2. We demonstrate that SBIP-428 functions as a Sirtuin deacetylase. We show that SBIP-428 itself is lysine acetylated. Interactions of a SBIP-428 with SABP2 also raised the possibility of SABP2 itself being lysine acetylated. The recombinant purified SABP2 or native partially purified SABP2 displayed no acetylation. In response to TMV infection, the expression of SBIP-428 was down regulated at 48 hpi. In addition, SBIP-428 was up regulated in plant …