Digital Commons Network^™

Control Is A Double-Edged Sword, And One Edge Is Sharper, Omri Rachum-Twaig

University of Illinois Journal of Law, Technology & Policy

In her book Talent Wants to Be Free, Lobel suggests a new, behavioral-economics, paradigm to employment intellectual property (EIP) law. Lobel describes a dynamic model to EIP control mechanisms such as non-competes, trade secrets and invention assignments, and argues that loosening them will create positive externalities to employers that will make such a shift economically justified. I first discuss the content of the book and the journey Lobel is guiding us through trying to emphasize the important notions in it and taking them a step forward towards a more "radical" suggestion. I argue that the utilitarian debate over EIP controls …

The Abundance And Diversity Of Intestinal Trematodes Collected From Blue Winged Teal And Ring-Neck Ducks Inhabiting Lake Winnibigoshish, Minnesota, Omolayo Ogunnowo

Journal of Undergraduate Research at Minnesota State University, Mankato

This study investigated the abundance and diversity of parasites residing in the digestive tracts of blue winged teal and ring-necked ducks collected at Lake Winnibigoshish, MN. The trematode parasites we focused on in this study were removed from the anterior-most, 15cm segment of the small intestine of 10 individuals of each bird species. The parasites were initially stored in 10% formalin and were subsequently stained with Schneider’s aceto carmine, then mounted on microscope slides for diagnostic purposes. A total of 1605 trematodes were recovered from the birds. We found that blue wing teal and ring-necked ducks tended to contain different …

Female Athletes And Their Journey, Emily Youngs

Sport Management Undergraduate

Female athletes have gained their role in sports, and now female athletes are expressing their journey as a female athlete. Looking at female athletes and their journey of becoming a college athlete, researchers can find motivation, self-efficacy, and early specialization. Past research on the 3 factors has been done prior to this research. The relationship between self-efficacy, motivation and early specialization was examined. The data was obtained through interviews from 5 college student athletes using qualitative research. The findings showed a significantly positive relationship between self-efficacy and these athletes, however there was a considerably negative finding in athletes and early …

Cryopreservation Of Hepatocyte (Hepg2) Cell Monolayers: Impact Of Trehalose, Blake Stokich, Quinn Osgood, David Grimm, Shhyam Moorthy, Nilay Chakraborty, Michael A. Menze

Faculty Research & Creative Activity

A simple method to cryogenically preserve hepatocyte monolayers is currently not available but such a technique would facilitate numerous applications in the field of biomedical engineering, cell line development, and drug screening. We investigated the effect of trehalose and dimethyl sulfoxide (Me2SO) in cryopreservation of human hepatocellular carcinoma (HepG2) cells in suspension and monolayer formats. HepG2 cell monolayers were incubated for 24 h at varying concentrations of trehalose (50–150 mM) prior to cryopreservation to identify the optimum concentration for such preincubation. When trehalose alone was used as the cryoprotective agent (CPA), cells in monolayer format did not survive freezing while …

Kcnj10 Determines The Expression Of The Apical Na-Cl Cotransporter (Ncc) In The Early Distal Convoluted Tubule (Dct1), Chengbiao Zhang, Lijun Wang, Junhui Zhang, Xiao-Tong Su, Dao-Hong Lin, Ute I. Scholl, Gerhard Giebisch, Richard P. Lifton, Wen-Hui Wang

NYMC Faculty Publications

The renal phenotype induced by loss-of-function mutations of inwardly rectifying potassium channel (Kir), Kcnj10 (Kir4.1), includes salt wasting, hypomagnesemia, metabolic alkalosis and hypokalemia. However, the mechanism by which Kir.4.1 mutations cause the tubulopathy is not completely understood. Here we demonstrate that Kcnj10 is a main contributor to the basolateral K conductance in the early distal convoluted tubule (DCT1) and determines the expression of the apical Na-Cl cotransporter (NCC) in the DCT. Immunostaining demonstrated Kcnj10 and Kcnj16 were expressed in the basolateral membrane of DCT, and patch-clamp studies detected a 40-pS K channel in the basolateral membrane of the DCT1 of …

Rapid Identification Of A Novel Complex I Mt-Nd2 M.10134c>A Mutation In A Leigh Syndrome Patient, David K. Miller, Minal J. Menezes, Cas Simons, Lisa G. Riley, Sandra T. Cooper, Sean M. Grimmond, David R. Thorburn, John Christodoulou, Ryan J. Taft

Genomics and Precision Medicine Faculty Publications

Leigh syndrome (LS) is a rare progressive multi-system neurodegenerative disorder, the genetics of which is frequently difficult to resolve. Rapid determination of the genetic etiology of LS in a 5-year-old girl facilitated inclusion in Edison Pharmaceutical’s phase 2B clinical trial of EPI-743. SNP-arrays and high-coverage whole exome sequencing were performed on the proband, both parents and three unaffected siblings. Subsequent multi-tissue targeted high-depth mitochondrial sequencing was performed using custom long-range PCR amplicons. Tissue-specific mutant load was also assessed by qPCR. Complex I was interrogated by spectrophotometric enzyme assays and Western Blot. No putatively causal mutations were identified in nuclear-encoded genes. …

New Seminar Explores Careers In Science Communications, Clinton Colmenares

Browse All News

No abstract provided.

Silica Cycling In The Ultra-Oligotrophic Eastern Mediterranean Sea, M. D. Krom, N. Kress, Kent A. Fanning Ph.D.

Marine Science Faculty Publications

Although silica is a key plant nutrient, there have been few studies aimed at understanding the Si cycle in the eastern Mediterranean Sea (EMS). Here we use a combination of new measurements and literature values to explain the silicic acid distribution across the basin and to calculate a silica budget to identify the key controlling processes. The surface water concentration of ∼1 μM, which is unchanging seasonally across the basin, was due to the inflow of western Mediterranean Sea (WMS) water at the Straits of Sicily. It does not change seasonally because there is only a sparse population of diatoms …

Flavonoid Treatment Of Glycogen Synthase Kinase-Based Disease, Jun Tan, Doug Shytle, Kavon Rezai-Zadeh

USF Patents

The flavonoid luteolin reduces amyloid-β peptide (Aβ) generation. Luteolin is also a selective GSK-3 inhibitor that 1) decreases amyloidogenic γ-secretase APP processing, and 2) promotes presenilin 1 (PS1) carboxyl-terminal fragment (CTF) phosphorylation. GSK-3α activity is essential for both PS1 CTF phosphorylation states and PS1-APP interaction. These findings were validated in vivo, using a Tg2576 Alzheimer's Disease model system. Luteolin treatment decreased soluble Aβ levels, reduced GSK-3 activity, and disrupted PS1-APP association. In addition, Tg2576 mice treated with diosmin, a glycoside of a flavone structurally and functionally similar to luteolin (diosmetin), displayed significantly reduced Aβ pathology as well.

Materials And Methods For Prevention And Treatment Of Rna Viral Diseases, Shyam S. Mohapatra, Aruna K. Behera

USF Patents

The subject invention concerns a method of inhibiting an RNA virus infection within a patient by increasing the amount of 2-5 oligoadenylate synthetase (2-5 AS) activity within the patient. Preferably, the preventative and therapeutic methods of the present invention involve administering a nucleotide encoding 2-5 AS, or at least one catalytically active fragment thereof, such as the p40, p69, p100 subunits, to a patient in need thereof. The present inventors have determined that overexpression of 2-5AS causes a reduction in epithelial cell damage, reduction in infiltration of mononuclear cells in the peribronchiolar and perivascular regions, and reduction in thickening of …

Method For The Treatment Of Malignancies, Richard Heller, Loree C. Heller

USF Patents

A method of treating cancerous tumors is presented herein. The method includes injecting an effective dose of a plasmid encoded for IL-12, B7-1 or IL-15 into a cancerous tumor and subsequently administering at least one high voltage, short duration pulse to the tumor. The electroporation pulses may be administered at least 700V/cm for a duration of less than 1 millisecond. The intratumor treatments with electroporation may be administered in at least a two-treatment protocol with the time between treatments being about 7 days. The intratumor treatments with electroporation may be administered in a three-treatment protocol with a time of four …

Placental Fkbp5 Genetic And Epigenetic Variation Is Associated With Infant Neurobehavioral Outcomes In The Richs Cohort, Alison G. Paquette, Barry M. Lester, Devin C. Koestler, Corina Lesseur, David A. Armstrong, Carmen J. Marsit

Dartmouth Scholarship

Adverse maternal environments can lead to increased fetal exposure to maternal cortisol, which can cause infant neurobehavioral deficits. The placenta regulates fetal cortisol exposure and response, and placental DNA methylation can influence this function. FK506 binding protein (FKBP5) is a negative regulator of cortisol response, FKBP5 methylation has been linked to brain morphology and mental disorder risk, and genetic variation of FKBP5 was associated with post-traumatic stress disorder in adults. We hypothesized that placental FKBP5 methylation and genetic variation contribute to gene expression control, and are associated with infant neurodevelopmental outcomes assessed using the Neonatal Intensive Care Unit (NICU) Network …

Methods And Compositions For Inhibiting The Proliferation Of Cancer Cells (Div), Ratna Chakrabarti

UCF Patents

A method of decreasing the expression of LIM kinase 1 in a cancer cell comprising; providing an oligonucleotide consisting of the sequence of SEQ ID NO: 1; providing a cancer cell comprising an mRNA encoding LIM kinase 1; and introducing the oligonucleotide into the cancer cell, wherein the oligonucleotide decreases the expression of LIM kinase 1 in the cancer cell. The method also provides compositions of an antisense RNA LIM kinase 1 that can be administered to an individual for the purpose of inhibiting a protein kinase pathway and which further comprises methods for treating and monitoring the proliferation and …

Senyawa Hasil Isolasi Dari Tumbuhan Ki Encok (Plumbago Zeylanica) Yang Beraktivitas Antibakteri Penyakit Mulut Dan Gigi, Euis Julaeha, Tati Herlina, Tri Mayanti, Aditya Seiza Wibisono, Riza Yulisar, Ajeng Diantini

Chimica et Natura Acta

Plumbago zeylanica (Ki Encok) merupakan salah satu tumbuhan obat multifungsi yang banyak ditemukan di Indonesia. Daun dan akarnya berkhasiat sebagai obat pada berbagai penyakit termasuk anti jamur dan anti bakteri. Penelitian ini dilakukan untuk mengetahui senyawa bioaktif antibakteri yang dapat digunakan untuk mengobati penyakit gigi dan mulut. Dari hasil pemisahan dan pemurn fraksi aktif, tiga senyawa telah berhasil diisolasi dari ekstrak n-heksana dan etilasetat daun Ki Encok (Plumbago zeylamica), yaitu 3β-galaktosasitosterol (1), epi-isoshiolon (2), dan metil 2,4-dihidroksibenzoat (3). Ketiga senyawa tersebut telah diuji aktivitasnya terhadap bakteri untuk penyakit mulut dan gigi yaitu Streptococcus mutan dan Streptococcus sanguinis. Hasilnya, diameter zona …

Trophic Cascade Effects Of Deer Overabundance On Connecticut's Native Vegetation And Small Mammal Populations, Megan A. Floyd

Master's Theses

No abstract provided.

Conservation Of Bridle Shiner (Notropis Bifrenatus) In Connecticut: Issues In Detecting An Elusive Species, Kasey C. Pregler

Master's Theses

Bridle Shiner (Notropis bifrenatus) is apparently declining over most of its range and is currently listed as a species of concern in Connecticut. Using an occupancy modeling framework in program PRESENCE, my study compared seining and electrofishing backpack unit detection probabilities of Bridle Shiner. This research indicated the apparent decline of Bridle Shiner in the state was in part due to changes in sampling gear used for statewide surveys. Seining used 50 years ago was demonstrably more effective at capturing Bridle Shiner than the currently favored and more frequently used electrofishing gear. In light of this recent finding, …

Toward Image-Based Three-Dimensional Reconstruction From Cubesats: Impacts Of Spatial Resolution And Snr On Point Cloud Quality, Jordyn Stoddard

Theses

The adoption of cube-satellites (cubesats) by the space community has drastically lowered the cost of access to space and reduced the development lifecycle from the hundreds of millions of dollars spent on traditional decade-long programs. Rapid deployment and low cost are attractive features of cubesat-based imaging that are conducive to applications such as disaster response and monitoring. One proposed application is 3D surface modeling through a high revisit rate constellation of cubesat imagers. This work begins with the characterization of an existing design for a cubesat imager based on ground sampled distance (GSD), signal-to-noise ratio (SNR), and smear. From this …

Cryopreservation Of Hepatocyte (Hepg2) Cell Monolayers: Impact Of Trehalose, Blake Stokich, Quinn Osgood, David Grimm, Shhyam Moorthy, Nilay Chakraborty, Michael Menze

Faculty and Staff Scholarship

A simple method to cryogenically preserve hepatocyte monolayers is currently not available but such a technique would facilitate numerous applications in the field of biomedical engineering, cell line development, and drug screening. We investigated the effect of trehalose and dimethyl sulfoxide (Me2SO) in cryopreservation of human hepatocellular carcinoma (HepG2) cells in suspension and monolayer formats. HepG2 cell monolayers were incubated for 24 h at varying concentrations of trehalose (50–150 mM) prior to cryopreservation to identify the optimum concentration for such preincubation. When trehalose alone was used as the cryoprotective agent (CPA), cells in monolayer format did not survive freezing while …

Identifikasi Populasi Bakteri Dalam Spons Pencuci Piring Dengan Metode Pcr-Rflp, Shabarni Gaffar, Iman Permana Maksum, Euis Julaeha

Chimica et Natura Acta

Spons pencuci piring 200.000 kali lebih kotor dibanding dudukan toilet. Berbagai bakteri penyebab penyakit seperti Eschericia coli, Pseudomonas dan Staphylococcus, berkembang biak di permukaan yang basah. Selain itu, 500 ribu bakteri hidup di dalam saluran pembuangan bak cuci piring. Jika spons dalam kondisi tidak kering (lembab karena direndam), maka akan menjadi markas semua bakteri. Penelitian ini bertujuan untuk menentukan populasi bakteri yang terdapat pada spons cuci piring yang basah. Identifikasi dilakukan dengan metoda molekular berbasis DNA yaitu teknik PCR-RFLP gen 16s rDNA. Metoda PCR-RFLP merupakan genetik fingerprinting yang akurat, cepat dan sederhana. Koloni bakteri yang ditumbuhkan dari spons pencuci piring …

Pemanfaatan Asap Cair Kayu Putih (Malaleuca Cajuputi) Sebagai Antioksidan Dalam Pengolahan Ikan Tuna Asap, Daniel Ambrosius Nicolas Apituley, Jusuf Leiwakabessy, Esterlina Elizabeth Elsina Martha Loh

Chimica et Natura Acta

Asap cair mempunyai peluang untuk digunakan secara luas di Maluku karena ketersediaan bahan baku yang melimpah terutama bahan baku yang berasal dari limbah hasil pertanian maupun hasil pengolahan minyak kayu putih. Batang dan ranting kayu putih dapat digunakan sebagai bahan baku dalam pembuatan asap cair. Asap cair yang dibuat melalui pirolisis kayu putih tersebut mengandung komponen senyawa yang dapat berperan sebagai antioksidan yang dapat menghambat maupun mencegah terjadinya proses oksidasi. Penelitian ini bertujuan untuk mengkaji komponen kimia penyusun asap cair yang dapat berperan sebagai antioksidan serta kemampuannya dalam mencegah terjadinya kerusakan oksidatif pada ikan Tuna asap. Hasil analisis dengan GC-MS …

Genetic Variants In The Sorl1 Gene Are Associated With Age At Onset Of Alzheimer Disease: A Survival Analysis, Ke-Sheng Wang, Xuefeng Liu, Liang Wang, David Briones, Chun Xu

Health & Biomedical Sciences Faculty Publications

Few studies focused on the association of SORL1 with the age at onset (AAO) of Alzheimer disease (AD). This study investigated the association of 43 SNPs in SORL1 with the AAO of AD by using the Kaplan-Meier survival analysis and the Cox proportional hazards model in SAS version 9.2 and linear regression model in PLINK software (791 AD patients and 782 controls). Both logrank test and Cox regression model showed that five SNPs (rs1784934, rs676759, rs560573, rs593769, and rs11218313) were associated with the AAO of AD in the male sample, while one SNP (rs17125558) was associated with the AAO of …

Alumnus, Zookeeper Celebrates World Elephant Day At Memphis Zoo, Winthrop University

Winthrop News 2014

• Today marks World Elephant Day, an international project that raises awareness of the urgent plight of Asian and African elephants.
• Thomas Reid '10, a zookeeper at Memphis Zoo, cares for the zoo's three African elephants.

The Under-Representation Of Minorities In Political Careers, Chelsea Barr, Ina Pae

Journal of Undergraduate Research at Minnesota State University, Mankato

Numerous studies have found that people of color, women, and those with physical challenges are significantly under-represented in political careers due to societal barriers. For example, women’s participation in politics shows some improvement while women occupy only 12% of the political careers. To explore whether students and professors interested in political careers have experienced under-representation of minorities, a mixed-method approach with both surveys and interviews of Minnesota State University, Mankato, students and professors from the departments of Government and Gender and Women’s Studies were utilized. These students were selected because both fields study political institutions, and are likely to seek …

08/11/2014 Obituary Records, Hawaii Obituaries

Obituaries

List of Obituaries for individuals who passed away on 08/11/2014. Scroll down to see the names and obituary description.

Culinary Internship And The European Mobility Action Plan: Part One, Frank Cullen

Articles

International mobility for work placement has experienced exponential growth over the past five years with the assistance of European Leonardo da Vinci and Erasmus funding for European internships. The main purpose behind the European Commission funding ventures for internship (experiential learning) is to enhance the students’ cultural awareness, cultivate their language skills and develop their professionalism in their field of study. It is generally accepted that experiential learning in the workplace provides many learning opportunities for students (Billett, 2001:121, Fuller and Unwin, 2003, Guile and Griffiths, 2001, Cullen, 2010a, Cullen, 2010b, Kristensen, 2004). In spite of acceptance that experiential learning …

Uab Researcher Obtains Grant To Study Protein Linked To Brain Cancer, Beena Thannickal

Browse All News

No abstract provided.

Presenting Problems And Treatment Expectations Among Service Users Accessing Psychiatric Outpatient Care: Are There Gender Differences?, Ora Nakash, Maayan Nagar, Itzhak Levav

School for Social Work: Faculty Publications

Background: Community-based studies have documented gender differences in mental health problems and service utilization. This mixed methods study explored gender differences in severity of emotional distress, referral paths, presenting problems and care expectations among service users upon accessing outpatient psychiatric care. Methods: Consecutive service users (N=284, 64% women) who presented for a new or repeated episode of care in adult outpatient clinics completed questionnaires on a measure of emotional distress, treatment history and referral path. These variables were quantitatively analyzed. Also, users completed two open-ended questionnaires on reasons for seeking care and expectations from the services. These variables were qualitatively …

Tombusvirus-Yeast Interactions Identify Conserved Cell-Intrinsic Viral Restriction Factors, Zsuzsanna Sasvari, Paulina Alatriste Gonzalez, Peter D. Nagy

Plant Pathology Faculty Publications

To combat viral infections, plants possess innate and adaptive immune pathways, such as RNA silencing, R gene and recessive gene-mediated resistance mechanisms. However, it is likely that additional cell-intrinsic restriction factors (CIRF) are also involved in limiting plant virus replication. This review discusses novel CIRFs with antiviral functions, many of them RNA-binding proteins or affecting the RNA binding activities of viral replication proteins. The CIRFs against tombusviruses have been identified in yeast (Saccharomyces cerevisiae), which is developed as an advanced model organism. Grouping of the identified CIRFs based on their known cellular functions and subcellular localization in yeast …

Epoxide-Mediated Differential Packaging Of Cif And Other Virulence Factors Into Outer Membrane Vesicles, A. E. Ballok, L. M. Filkins, J.. M. Bomberger, B. A. Stanton, George A. O'Toole

Dartmouth Scholarship

Pseudomonas aeruginosa produces outer membrane vesicles (OMVs) that contain a number of secreted bacterial proteins, including phospholipases, alkaline phosphatase, and the CFTR inhibitory factor (Cif). Previously, Cif, an epoxide hydrolase, was shown to be regulated at the transcriptional level by epoxides, which serve as ligands of the repressor, CifR. Here, we tested whether epoxides have an effect on Cif levels in OMVs. We showed that growth of P. aeruginosa in the presence of specific epoxi

From The Provost 2014-08-11, Richard Caulfield

From the Provost

No abstract provided.