Digital Commons Network^™

Nack Is An Integral Component Of The Notch Transcriptional Activation Complex And Is Critical For Development And Tumorigenesis, Kelly L Weaver, Marie-Clotilde Alves-Guerra, Ke Jin, Zhiqiang Wang, Xiaoqing Han, Prathibha Ranganathan, Xiaoxia Zhu, Thiago Dasilva, Wei Liu, Francesca Ratti, Renee M Demarest, Cristos Tzimas, Meghan Rice, Rodrigo Vasquez-Del Carpio, Nadia Dahmane, David J Robbins, Anthony J Capobianco

Rowan-Virtua School of Osteopathic Medicine Departmental Research

The Notch signaling pathway governs many distinct cellular processes by regulating transcriptional programs. The transcriptional response initiated by Notch is highly cell context dependent, indicating that multiple factors influence Notch target gene selection and activity. However, the mechanism by which Notch drives target gene transcription is not well understood. Herein, we identify and characterize a novel Notch-interacting protein, Notch activation complex kinase (NACK), which acts as a Notch transcriptional coactivator. We show that NACK associates with the Notch transcriptional activation complex on DNA, mediates Notch transcriptional activity, and is required for Notch-mediated tumorigenesis. We demonstrate that Notch1 and NACK are …

Analysis Of Alternative Captive Bat Management Strategies In Response To White-Nose Syndrome, Mary Parkin, Robert Tawes, Lori Pruitt, Noelle Rayman, Richard Stark, Robyn Niver, Susi Von Oettingen, Barbara Douglas, Paul Mckenzie, Jeremy Coleman, Aaron Valenta

United States Fish and Wildlife Service: Publications

This report describes the process and presents the results of a structured decision making effort that was initiated by the U.S. Fish and Wildlife Service in November 2010. This initiative addressed the potential efficacy of captive bat management to as one means of addressing white-nose syndrome for seven species of concern. This was done by comparing alternative management strategies against identified objectives, and by comparing captive management against no captive management. Expert elicitation was used to conduct the analyses, which concluded in 2012. Afterwards, the team of U.S. Fish and Wildlife biologists that was convened for the decision making effort …

Linfield University Catalog, 2014-2015, Linfield Archives

Student Course Catalogs

No abstract provided.

Medicinal History Of North American Veratrum, Christopher M. Chandler, Owen M. Mcdougal

Chemistry and Biochemistry Faculty Publications and Presentations

Plants belonging to the genus Veratrum have been used throughout history for their medicinal properties. During the nineteenth and twentieth centuries, phytochemical investigations revealed a host of steroidal alkaloids in Veratrum species, some of which are potent bioactives. This review discusses Veratrum species that grow in North America with a focus on the medicinal history of these plants and the steroidal alkaloids they contain. While significant reviews have been devoted to singularly describing the plant species within the genus Veratrum (botany), the staggering breadth of alkaloids isolated from these and related plants (phytochemistry), and the intricacies of how the various …

Economics And Genocide: Choices And Consequences, Jurgen Brauer, Charles Anderton

Economics Department Working Papers

Professional economists rarely write on questions of genocide. This surprises because a workhorse tool of the economics discipline concerns the analysis of behavior that takes place under constraints. All parties in genocide—perpetrators, victims, and third parties—face cost and resource constraints subject to which they seek to achieve their objectives, be it killing, surviving, or intervening. This essay characterizes and illustrates economic thinking about objectives, costs, and resources for each of the three groups. There is potentially much that economics can contribute to genocide studies and, vice versa, much that genocide scholars may learn from welcoming an economic perspective.

The Social Evolution Of Terror And Genocide Across Time And Geographic Space: Perspectives From Evolutionary Game Theory, Charles Anderton

Economics Department Working Papers

This article uses evolutionary game theory to reveal the interpersonal and geographic characteristics of a society that make it vulnerable to a conquest from within by terrorist organizations and genocide architects. Under conditions identified in the space-less version of the model, entrepreneurs of violence can create the social metamorphosis of a peaceful people group into one that supports or does not resist violence against an out-group. The model is extended into geographic space by analyzing interactions among peaceful and aggressive phenotypes in Moore and von Neumann neighborhoods. The model also reveals policy interventions in which the social evolution of aggression …

Humoral And Cellular Immunotherapy In All In Children, Adolescents, And Young Adults, Jessica Hochberg, Nader Kim El-Mallawany, Mitchell S. Cairo

NYMC Faculty Publications

Although the event-free survival for children and adolescents with acute lymphoblastic leukemia (ALL) has dramatically improved over the past half century, it has plateaued over the past decade. Children and adolescents with refractory/relapsed ALL continue to have a dismal prognosis with hematopoietic stem cell transplant being their most viable option for cure. There is an obvious need for the development of novel agents to further enhance overall outcomes. In this review we focus on the development of humoral and cellular immunotherapeutic agents in the treatment of childhood, adolescent, and young adult ALL. Immunotherapy in various forms has shown immense promise. …

Stress And Health Behaviors: Zoe Transformation Challenge Findings, Jeana Handley

Graduate Research Projects

No abstract provided.

Metabolomics Characterization Of U.S. And Japanese F-15 And C-130 Flight Line Crews Exposed To Jet Fuel Volatile Organic Compounds And Aerosols, Nicholas J. Delraso, David Mattie, Asao Kobayashi, Stephen W. Mitchell, Scott Dillard, Michael L. Raymer, Isaie Sibomana, Nicholas V. Reo

Computer Science and Engineering Faculty Publications

Air and ground crews transfer a significant amount of jet fuel, and as a result of transfers, breathe its volatile emission from residues. Working on the flight line also exposes maintainers to exhaust from the jet fuel as engines are tested or run before and after flight. Since little is known concerning level of exposure and the corresponding biological response associated with human jet fuel exposure, nuclear magnetic resonance (NMR)-based metabolomics analysis of human urine was utilized for characterization of metabolite profiles of flight line personnel for potential biomarker discovery. This project was a collaborative research effort between the US …

September 2014, Yolanda Carr, Diane Fitzsimmons

Office of Sponsored Programs

No abstract provided.

Combining Demographic And Genetic Factors To Assess Population Vulnerability In Stream Species, Erin Landguth, C. C. Muhlfeld, R. S. Waples, L. Jones, Winsor H. Lowe, Diane C. Whited, J. Lucotch, H. Neville, Gordon Luikart

Biological Sciences Faculty Publications

Accelerating climate change and other cumulative stressors create an urgent need to understand the influence of environmental variation and landscape features on the connectivity and vulnerability of freshwater species. Here, we introduce a novel modeling framework for aquatic systems that integrates spatially explicit, individual-based, demographic and genetic (demogenetic) assessments with environmental variables. To show its potential utility, we simulated a hypothetical network of 19 migratory riverine populations (e.g., salmonids) using a riverscape connectivity and demogenetic model (CDFISH). We assessed how stream resistance to movement (a function of water temperature, fluvial distance, and physical barriers) might influence demogenetic connectivity, and hence, …

Toward A New Theory Of Waste: From "Matter Out Of Place" To Signs Of Life , Joshua Reno

Anthropology Faculty Scholarship

This paper offers a counterpoint to the prevailing account of waste in the human sciences. This account identifies waste, firstly, as the anomalous product of arbitrary social categorizations, or ‘matter out of place’, and, secondly, as a distinctly human way of leaving behind and interpreting traces, or a mirror of culture. Together, these positions reflect a more or less constructivist and anthropocentric approach. Most commonly, waste is placed within a framework that privileges considerations of meaning over materiality and the threat of death over the perpetuity of life processes. For an alternative I turn to bio-semiotics and cross-species scholarship around …

Response Of Conifer-Encroached Shrublands In The Great Basin To Prescribed Fire And Mechanical Treatments, Richard F. Miller, Jaime Ratchford, Bruce A. Roundy, Robin J. Tausch, April Hulet, Jeanne C. Chambers

Articles

In response to the recent expansion of piñon and juniper woodlands into sagebrush-steppe communities in the northern Great Basin region, numerous conifer-removal projects have been implemented, primarily to release understory vegetation at sites having a wide range of environmental conditions. Responses to these treatments have varied from successful restoration of native plant communities to complete conversion to nonnative invasive species. To evaluate the general response of understory vegetation to tree canopy removal in conifer-encroached shrublands, we set up a region-wide study that measured treatment-induced changes in understory cover and density. Eleven study sites located across four states in the Great …

2014 Annual Accountability Report, Clemson University

Accountability Reports

Clemson University's 2013-2014 Annual Accountability Report submitted to the South Carolina Budget and Control Board.

Comparing Moral Judgments Of Patients With Frontotemporal Dementia And Frontal Stroke, Sandra Baez, Blas Couto, Teresa Torralva, Luciano A. Sposato, David Huepe, Patricia Montañes, Pablo Reyes, Diana Matallana, Nora S. Vigliecca, Andrea Slachevsky, Facundo Manes, Agustin Ibanez

Anatomy and Cell Biology Publications

Importance Several clinical reports have stated that patients with prefrontal lesions or patients with the behavioral variant of frontotemporal dementia share social cognition impairments. Moral reasoning is impaired in both conditions but there have been few investigations that directly compare this domain in the 2 groups.

Observations This work compared the moral judgments of these patient groups using a task designed to disentangle the contributions of intentions and outcomes in moral judgment. For both disorders, patients judged scenarios where the protagonists believed that they would cause harm but did not as being more permissible than the control group. Moreover, patients …

Olanzapine-Induced Methylation Alters Cadherin Gene Families And Associated Pathways Implicated In Psychosis, Melkaye G. Melka, Christina A Castellani, Nagalingam Rajakumar, Richard O'Reilly, Shiva M Singh

Biology Publications

BACKGROUND: The complex aetiology of most mental disorders involves gene-environment interactions that may operate using epigenetic mechanisms particularly DNA methylation. It may explain many of the features seen in mental disorders including transmission, expression and antipsychotic treatment responses. This report deals with the assessment of DNA methylation in response to an antipsychotic drug (olanzapine) on brain (cerebellum and hippocampus), and liver as a non-neural reference in a rat model. The study focuses on the Cadherin/protocadherins encoded by a multi-gene family that serve as adhesion molecules and are involved in cell-cell communication in the mammalian brain. A number of these molecules …

Deaf Catholic Newsletter, Fall 2014

Deaf Catholic Newsletter

A newsletter published for Deaf Catholics in Philapelphia, PA

Deaf Catholic Newsletter Finding Aid

Diversity At 100: Women And Underrepresented Minorities In The Esa: Peer-Reviewed Letter, George Middendorf

Department of Biology Faculty Publications

No abstract provided.

Long-Term Cre-Mediated Retrograde Tagging Of Neurons Using A Novel Recombinant Pseudorabies Virus, Hysell V. Oviedo, Hassasna K. Oyibo, Petr Znamenskiy, Lynn W. Enquist, Anthony M. Zador

Publications and Research

Brain regions contain diverse populations of neurons that project to different long-range targets. The study of these subpopulations in circuit function and behavior requires a toolkit to characterize and manipulate their activity in vivo. We have developed a novel set of reagents based on Pseudorabies Virus (PRV) for efficient and long-term genetic tagging of neurons based on their projection targets. By deleting IE180, the master transcriptional regulator in the PRV genome, we have produced a mutant virus capable of infection and transgene expression in neurons but unable to replicate in or spread from those neurons. IE180-null mutants showed no cytotoxicity, …

Bioe 370.01: General Ecology, Erick P. Greene

University of Montana Course Syllabi

No abstract provided.

Biom 450.01: Microbial Physiology, James D. Driver

University of Montana Course Syllabi

No abstract provided.

Artz 106a.03: Visual Language- 2-D Foundations, Elizabeth J. Huhtala

University of Montana Course Syllabi

No abstract provided.

Biob 301.01: Developmental Biology, Ekaterina Voronina

University of Montana Course Syllabi

No abstract provided.

Fdi Effects On Economic Growth: The Role Of Natural Resource And Environmental Policy, Maryam Asghari, Nathalie Hilmi, Alain Safa

Topics in Middle Eastern and North African Economies

Foreign direct investment (FDI) is a crucial ingredient of the global economy. In the Persian Gulf, FDI is a major source of economic growth, employment, technology, and productivity. Because of these benefits, attracting FDI in the Persian Gulf region has become a key element of strategies promoting economic development. Natural resources and environmental policy in host countries may affect the FDIeconomic growth relationship. There has been much dispute as to whether economies that are open and those with more natural capital and lax environmental policy grow faster. This paper examines whether natural resources and environmental policy in Persian Gulf countries …

Statistical Signs Of Social Influence On Suicides, Hygor Piaget M. Melo, André A. Moreira, Élcio Batista, Hernán A. Makse, José S. Andrade

Publications and Research

By treating the suicide as a social fact, Durkheim envisaged that suicide rates should be determined by the connections between people and society. Under the same framework, he considered that crime is bound up with the fundamental conditions of all social life. The social effect on the occurrence of homicides has been previously substantiated, and confirmed here, in terms of a superlinear scaling relation: by doubling the population of a Brazilian city results in an average increment of 135% in the number of homicides, rather than the expected isometric increase of 100%, as found, for example, for the mortality due …

It's Just A Game: The Detriments Sport Has Forced Upon Masculinity, Michael Krug

Student Research and Creative Projects 2014-2015

No abstract provided.

Examination Of Isoprenoid Chain-Length Control In Corynebacterium Glutamicum, Kacie Nelson, Francis Mann

Student Research and Creative Projects 2014-2015

Prenyltransferases catalyze the polymerization condensation reaction of isopentenyl diphosphate (IPP) and allylic acceptors of varying lengths. Throughout the prenyltransferases enzymes found in the family, Actinobacteria, there exist two catalytic DDxxD motifs in the amino acid sequence. The 4th and 5th amino acid residues before the first motif classically determine chain length of the isoprenoid product and, through manipulation of those amino acids, the resulting chain length can be altered based on the size of the amino acid residue. Corynebacterium glutamicum contains the conserved DDxxD motifs, but the upstream amino acids vary across the three predicted prenyltransferases. Additionally, the presence of …

Legislative Reform For Coerced Sterilization In Minnesota, 1925-36, Ryan Lange

Student Research and Creative Projects 2014-2015

No abstract provided.

Winona Currents Magazine, University Advancement - Winona State University

Winona Currents

This magazine published by Winona State University’s University Advancement was intended to inform WSU Alumni, students, faculty, staff and the greater community about Alumni and the university. The cover theme is: Great Walls Come Down: Students discover selves & others on travel study.

Game Birds Of The World: A Catalog Of The Madson Collection, Paul A. Johnsgard, Eric Fowler, Michael Forsberg, Mary Bomberger Brown, Dee Ebbeka, Jacki Loomis, Patricia W. Freeman

Paul Johnsgard Collection

This remarkable collection of ornithological specimens is a gift of Everett C. Madson, M.D., a graduate of the University of Nebraska-Lincoln, to the University of Nebraska State Museum in honor of Paul Johnsgard, Ph.D., Professor Emeritus of the School of Biological Sciences.

Contents:

Foreword

Introduction

Biography - Paul A. Johnsgard

Biography - Everett C. Madson

Species Profiles and Photographs

Tinamous (Order Tinamiformes, Family Tinamidae)

Spotted Tinamou (Nothura maculosa)

Waterfowl (Order Anseriformes)

Ducks, Geese and Swans (Family Anatidae)

Whistling Ducks (Tribe Dendrocygnini)

White-faced Whistling Duck (Dendrocygna vidu

Geese and Swans (Tribe Anserini)

Black Swan (Cygnus atratus).

Tundra [Whistling] Swan (Cygnus columbianus) …