Digital Commons Network^™

Chronic Allergic Contact Dermatitis Promotes Skin Cancer, Shadmehr Demehri, Trevor J. Cunningham, Eva A. Hurst, Andras Schaffer, David M. Sheinbein, Wayne M. Yokoyama

Open Access Publications

No abstract provided.

Reassessing The Impact Of Smoking On Preeclampsia/Eclampsia: Are There Age And Racial Differences?, Jen Jen Chang, Jerome F. Strauss Iii, Jon P. Deshazo, Fidelma B. Rigby, David P. Chelmow, George A. Macones

Open Access Publications

No abstract provided.

Extensive Error In The Number Of Genes Inferred From Draft Genome Assemblies, James F. Denton, Jose Lugo-Martinez, Abraham E. Tucker, Daniel R. Schrider, Wesley C. Warren, Matthew W. Hahn

Open Access Publications

No abstract provided.

Pathogen Reduction In Human Plasma Using An Ultrashort Pulsed Laser, Shaw-Wei D. Tsen, David H. Kingsley, Karen Kibler, Bert Jacobs, Sara Sizemore, Sara M. Vaiana, Jeanne Anderson, Kong-Thon Tsen, Samuel Achilefu

Open Access Publications

No abstract provided.

A Rare Sequence Variant In Intron 1 Of Thap1 Is Associated With Primary Dystonia, Joel S. Perlmutter, Brad A. Racette, Randal C. Paniello, Et Al

Open Access Publications

No abstract provided.

Glycosylation Variants Of A Β-Glucosidase Secreted By A Taiwanese Fungus, Chaetomella Raphigera, Exhibit Variant-Specific Catalytic And Biochemical Properties, Aki Yoneda, Hsion-Wen David Kuo, Mayumi Ishihara, Parastoo Azadi, Su-May Yu, Tuan-Hua David Ho

Open Access Publications

No abstract provided.

Α2Β1 Integrin, Gpvi Receptor, And Common Fcrγ Chain On Mouse Platelets Mediate Distinct Responses To Collagen In Models Of Thrombosis, Robin J. Marjoram, Zhengzhi Li, Li He, Douglas M. Tollefsen, Thomas J. Kunicki, S. Kent Dickeson, Samuel A. Santoro, Mary M. Zutter

Open Access Publications

No abstract provided.

Joint Testing Of Genotypic And Gene-Environment Interaction Identified Novel Association For Bmp4 With Non-Syndromic Cl/P In An Asian Population Using Data From An International Cleft Consortium, Qianqian Chen, Hong Wang, Holger Schwender, Tianxiao Zhang, Jacqueline B. Hetmanski, Yah-Huei Wu Chou, Xiaoqian Ye, Vincent Yeow, Samuel S. Chong, Bo Zhang, Ethylin Wang Jabs, Margaret M. Parker, Alan F. Scott, Terri H. Beaty

Open Access Publications

No abstract provided.

Optimal Body Weight For Health And Longevity: Bridging Basic, Clinical, And Population Research, Luigi Fontana, Frank B. Hu

Open Access Publications

No abstract provided.

Dendritic Cells In Dengue Virus Infection: Targets Of Virus Replication And Mediators Of Immunity, Michael A. Schmid, Michael S. Diamond, Eva Harris

Open Access Publications

No abstract provided.

Antisense Reduction Of The Protein Tau Attenuates Neuronal Hyper-Excitability And Permits Clearance Of Intraneuronal Tau Accumulations In Vivo, Sarah Devos

Open Access Publications

No abstract provided.

Targeting An Ikbke Cytokine Network Impairs Triple-Negative Breast Cancer Growth, Thanh U. Barbie, Shunqiang Li, Xiuli Zhang, John Herndon, Timothy Fleming, Matthew J. Ellis, William E. Gillanders, Et Al

Open Access Publications

No abstract provided.

Phylogenomics And The Dynamic Genome Evolution Of The Genus Streptococcus, Vincent P. Richards, Sara R. Palmer, Paulina D. Pavinski Bitar, Xiang Qin, George M. Weinstock, Sarah K. Highlander, Christopher D. Town, Robert A. Burne, Michael J. Stanhope

Open Access Publications

No abstract provided.

Bkca Channel Inhibitor Modulates The Tumorigenic Ability Of Hormone-Independent Breast Cancer Cells Via The Wnt Pathway, Brandon M. Schickling, Sarah K. England, Nukhet Aykin-Burns, Lyse A. Norian, Kimberly K. Leslie, Victoria P. Frieden-Korovkina

Open Access Publications

No abstract provided.

Psychiatric Correlates Of Snuff And Chewing Tobacco Use, Qiang Fu, Michael G. Vaughn, Li-Tzy Wu, Andrew C. Heath

Open Access Publications

No abstract provided.

Genetic Analysis Of Circadian Responses To Low Frequency Electromagnetic Fields In Drosophila Melanogaster, Giorgio Fedele, Mathew D. Edwards, Supriya Bhutani, John M. Hares, Manuel Murbach, Edward W. Green, Stephane Dissel, Michael H. Hasting, Ezio Rosato, Charalambos P. Kyriacou

Open Access Publications

No abstract provided.

A Clathrin Coat Assembly Role For The Muniscin Protein Central Linker Revealed By Talen-Mediated Gene Editing, Perunthottathu K. Umasankar, Li Ma, James R. Thieman, Anupma Jha, Balraj Doray, Simon C. Watkins, Linton M. Traub

Open Access Publications

No abstract provided.

Structure Of Cellular Escrt-Iii Spirals And Their Relationship To Hiv Budding, Anil G. Cashikar, Soomin Shim, Robyn Roth, Michael R. Maldazys, John E. Heuser, Phyllis I. Hanson

Open Access Publications

No abstract provided.

Nextgen Sequencing Reveals Short Double Crossovers Contribute Disproportionately To Genetic Diversity In Toxoplasma Gondii, Asis Khan, Jahangheer S. Shaik, Michael Behnke, Qiuling Wang, Jitender P. Dubey, Hernan A. Lorenzi, James W. Ajioka, Benjamin M. Rosenthal, L. David Sibley

Open Access Publications

No abstract provided.

Invariance And Plasticity In The Drosophila Melanogaster Metabolomic Network In Response To Temperature, Ramkumar Hariharan, Jessica M. Hoffman, Ariel S. Thomas, Quinlyn A. Soltow, Dean P. Jones, Daniel E.L. Promislow

Open Access Publications

No abstract provided.

Comparative Analyses Of Proteins From Haemophilus Influenzae Biofilm And Planktonic Populations Using Metabolic Labeling And Mass Spectrometry, Deborah Mb Post, Jason M. Held, Margaret R. Ketterer, Nancy J. Phillips, Alexandria Sahu, Michael A. Apicella, Bradford W. Gibson

Open Access Publications

No abstract provided.

Conserved Syntenic Clusters Of Protein Coding Genes Are Missing In Birds, Peter V. Lovell, Morgan Wirthlin, Larry Wilhelm, Patrick Minx, Nathan H. Lazar, Lucia Carbone, Wesley C. Warren, Claudio V. Mello

Open Access Publications

No abstract provided.

Risk-Stratified Patients With Resectable Soft Tissue Sarcoma Benefit From Epirubicin-Based Adjuvant Chemotherapy, Aaron D. Schenone, Jingqin Luo, Luke Montgomery, Daniel Morgensztern, Douglas R. Adkins, Brian A. Van Tine

Open Access Publications

No abstract provided.

Nanotechnology And Its Implication In Medical Science, Syed Ahsan Ali, M. Tariq

Department of Medicine

No abstract provided.

Framing The Prosecution, Daniel C. Richman

Faculty Scholarship

The enormous value of Dan Simon’s In Doubt lies not just in its nuanced exploration of the challenges to accurate criminal factfinding, but also in its challenge to us to rethink trials themselves. Even as we endeavor to give criminal defendants the means and license to raise reasonable doubts, we need to think more about when and how those doubts can be allayed. Just because most jurisdictions have not come out of the first round of play – the one in which defendants get the tools to poke holes in the cases against them – does not mean it is …

How To Improve The Financial Architecture And Its Resilience, Dirk Helbing, Eve Mitleton-Kelly, Jean-Philippe Bouchaud, Fabio Caccioli, J. Doyne Farmer, Steve Keen, Katharina Pistor, Dennis J. Snower, Olsen Richard, Angelo Ranaldo, Norbert Häring, Edward Fullbrook

Faculty Scholarship

This financial resilience survey was circulated on behalf of a working group of the Complexity Council of the World Economic Forum comprised of Prof. Eve Mitleton-Kelly of London School of Economics and Prof. Dirk Helbing at ETH Zurich's Risk Center. It was sent to a few dozens of financial experts with the aim to create an inventory of ideas of how the financial system might be improved and made more resilient. Unconventional ideas were also welcome.

Age-Related Differentiation Of Sensorimotor Control Strategies During Pursuit And Compensatory Tracking, Megan L. Heenan, Robert A. Scheidt, Scott A. Beardsley

Biomedical Engineering Faculty Research and Publications

Motor control deficits during aging have been well-documented. Various causes of neuromotor decline, including both peripheral and central neurological deficits, have been hypothesized. Here, we use a model of closed-loop sensorimotor control to examine the functional causes of motor control deficits during aging. We recruited 14 subjects aged 19-61 years old to participate in a study in which they performed single-joint compensatory and pursuit tracking tasks with their dominant hand. We found that visual response delay and visual noise increased with age, while reliance on visual feedback, especially during compensatory tracking decreased. Increases in visual noise were also positively correlated …

The Arm Motion (Amd) Detection Test, Maria C. Bengston, Leigh A. Mrotek, Tina M. Stoeckmann, Claude Ghez, Robert A. Scheidt

Biomedical Engineering Faculty Research and Publications

Stroke can lead to sensory deficits that impair functional control of arm movements. Here we describe a simple test of arm motion detection (AMD) that provides an objective, quantitative measure of movement perception related proprioceptive capabilities in the arm. Seven stroke survivors and thirteen neurologically intact control subjects performed the AMD test. In a series of ten trials that took less than 15 minutes to complete, participants used a two-button user interface to adjust the magnitude of hand displacements produced by a horizontal planar robot until the motions were just perceptible (i.e. on the threshold of detection). The standard deviation …

Characterization Of A Human Powered Nebulizer Compressor For Resource Poor Settings, Christopher J. Hallberg, Mary Therese Lysaught, Christopher E. Zmudka, William K. Kopesky, Lars E. Olson

Biomedical Engineering Faculty Research and Publications

Background

Respiratory disease accounts for three of the ten leading causes of death worldwide. Many of these diseases can be treated and diagnosed using a nebulizer. Nebulizers can also be used to safely and efficiently deliver vaccines. Unfortunately, commercially available nebulizers are not designed for use in regions of the world where lung disease is most prevalent: they are electricity-dependent, cost-prohibitive, and not built to be reliable in harsh operating conditions or under frequent use.

To overcome these limitations, the Human Powered Nebulizer compressor (HPN) was developed. The HPN does not require electricity; instead airflow is generated manually through a …

Which Design And Biomaterial Factors Affect Clinical Wear Performance Of Total Disc Replacements? A Systematic Review, Sai Y. Veruva, Marla J. Steinbeck, Jeffrey M. Toth, Dominik D. Alexander, Steven M. Kurtz

Biomedical Engineering Faculty Research and Publications

Background

Total disc replacement was clinically introduced to reduce pain and preserve segmental motion of the lumbar and cervical spine. Previous case studies have reported on the wear and adverse local tissue reactions around artificial prostheses, but it is unclear how design and biomaterials affect clinical outcomes.

Questions/purposes

Which design and material factors are associated with differences in clinical wear performance (implant wear and periprosthetic tissue response) of (1) lumbar and (2) cervical total disc replacements?

Methods

We performed a systematic review on the topics of implant wear and periprosthetic tissue response using an advanced search in MEDLINE and Scopus …