Digital Commons Network^™

Modulation Of Cholera Toxin Structure And Function By Host Proteins, Helen Burress

Electronic Theses and Dissertations

Cholera toxin (CT) moves from the cell surface to the endoplasmic reticulum (ER) where the catalytic CTA1 subunit separates from the holotoxin and unfolds due to its intrinsic thermal instability. Unfolded CTA1 then moves through an ER translocon pore to reach its cytosolic target. Due to the instability of CTA1, it must be actively refolded in the cytosol to achieve the proper conformation for modification of its G protein target. The cytosolic heat shock protein Hsp90 is involved with the ER-to-cytosol translocation of CTA1, yet the mechanistic role of Hsp90 in CTA1 translocation remains unknown. Potential post-translocation roles for Hsp90 …

A Human-Centric Approach To Data Fusion In Post-Disaster Managment: The Development Of A Fuzzy Set Theory Based Model, Mubarak Banisakher

Electronic Theses and Dissertations

It is critical to provide an efficient and accurate information system in the post-disaster phase for individuals' in order to access and obtain the necessary resources in a timely manner; but current map based post-disaster management systems provide all emergency resource lists without filtering them which usually leads to high levels of energy consumed in calculation. Also an effective post-disaster management system (PDMS) will result in distribution of all emergency resources such as, hospital, storage and transportation much more reasonably and be more beneficial to the individuals in the post disaster period. In this Dissertation, firstly, semi-supervised learning (SSL) based …

Appropriation Without Representation? The Limited Role Of Indigenous Groups In Wipo's Intergovernmental Committee On Intellectual Property And Genetic Resources, Traditional Knowledge, And Folklore, Veronica Gordon

Vanderbilt Journal of Entertainment & Technology Law

The World Intellectual Property Organization's (WIPO) Intergovernmental Committee on Intellectual Property and Genetic Resources, Traditional Knowledge, and Folklore (IGC) is currently engaged in text-based negotiations to develop an international legal instrument, or set of instruments, that will effectively protect traditional knowledge, traditional cultural expressions, and genetic resources. Yet, the people who will arguably be most affected by the ultimate instrument(s)--indigenous peoples and local communities--are not able to fully participate in these negotiations. Instead, WIPO deems them "Observers." They cannot formally present proposals, amendments, or motions, and cannot vote at IGC sessions. Thus, their limited influence implicates questions of equity, sovereignty, …

An Exploration Of Mutation Effect Sizes In The Nematode Caenorhabditis Elegans, Melody Dossey

EWU Masters Thesis Collection

Mutation rates vary within and among species, in part reflecting the variable input of the two main sources of mutation, DNA replication errors and DNA damage. In somatic tissues, oxidative damage resulting from free radical attacks on DNA is an important and well-characterized cause of mutation, contributing to many diseases and to the aging process. In contrast, it is not known whether oxidative damage can lead to heritable mutations in germline (sperm and egg) DNA. In a previous study, the germline mutation rate was estimated from a mutation accumulation study in two strains of rhabditid nematode (Caenorhabditis elegans), the N2 …

3d Image Acquisition System For Facial Recognition, James E. Pearson

EWU Masters Thesis Collection

Identification of an individual has been a long standing problem in human existence. It is clear from the rising rates of identity theft and misappropriation of services that current methods employed to identify individuals is ineffectual. The most common way people identify other individuals is via recognition of the subjects face. The speed and accuracy with which one person can identify another person is uncanny leading to the development automated facial recognition systems. The vast majority of these systems use two-dimensional (2D) images imagery to perform facial recognition with limited success. The use of 2D imagery has limitations which cannot …

The Effects Of Emotional Interrupt On Reaction Times In Primary And Secondary Psychopathy, Megan N. Korst

EWU Masters Thesis Collection

The emotional interrupt task is presented as a motor response task that is bracketed by emotional images. The motor response task, in this study, is presented as a reaction time task. The participants either choose the left or right finger as a response to the circle or square on the screen, respectively. The emotional images that are presented before and after the motor response task are presented as either negative, neutral or positive images, known as interrupt conditions. The reaction time that occurs during each of the interrupt conditions are affected by personality traits of each participant. This study focused …

The Effects Of Parturition On Pelvic Age Indicators, Rosanne Bongiovanni

Graduate Student Theses, Dissertations, & Professional Papers

Estimating age from skeletal remains provides a critical component of the biological profile of an individual. To date, there are different methods used on select parts of the skeleton to assess the age of the individual, and currently, the pelvis is relied upon heavily to obtain accurate and reliable age ranges (Berg 2008; Brooks and Suchey 1990; Buckberry and Chamberlain 2002). Many have stated that age related changes follow different trends in males and females, with parity presented as one of the possible causes for such differences (Berg 2008; Meindl and Lovejoy 1989; Resnick and Niwayama 1998; Suchey and Katz …

Effects Of Individual-Oriented Relationship Education On University Students' Knowledge, Beliefs, And Attitudes, Sara Polanchek

Graduate Student Theses, Dissertations, & Professional Papers

This quasi-experimental, exploratory study adds important empirical research to the relatively new field of individual-oriented relationship education. It describes the extent to which specific relationship beliefs and attitudes are held, and evaluates the impact of an undergraduate, semester-long Intimate and Family Relationships course on these beliefs. Utilizing data collected over two semesters at the University of Montana, this study compared 356 student responses at the beginning and end of the semester on three separate scales designed to quantify select measures of specific constraint beliefs and attitudes: Attitudes About Romance and Mate Selection (AARMS), the Parental Authority Questionnaire (PAQ), and the …

Nets Or Vaccines: Malaria Vaccine Research, David Ernenwein

Pepperdine Policy Review

The global battle against malaria has seen many victories in the developed world but the undeveloped world and particularly Africa continue to suffer from this disease. The development of the RTS,S vaccine and ongoing research into additional vaccines have been touted as the solution to the crisis. However, the news of the successful RTS,S trial should be viewed with caution. Concerns over the effectiveness of the existing vaccine and the cost of further development may not be justified, especially given the known effectiveness of current treatment methods. This research must be watched carefully lest the allure of the vaccine blind …

Much Ado About Cyber-Space: Cyber-Terrorism And The Reformation Of The Cyber-Security, Christian Pedersen

Pepperdine Policy Review

The threats residing in cyber-space are becoming well understood by policymakers and security experts alike. However, cyber-security defenses and strategies cannot solely be directed towards nation states, as non-governmental actors – such as transnational crime groups and terrorist organizations are becoming increasingly reliant upon internet technologies. Attacks on the digital components of the critical infrastructure, have the potential to unleash devastation on the United States. In a time when reliability and ethnicity of the National Security Administration, the Nation’s leading digital intelligence organization, are becoming increasingly questioned; defensive measures need to be improved to prevent future attacks and improve the …

Agricultural Patenting: A Case Study Of Monsanto, Shannon Moran

Pepperdine Policy Review

In 2012, genetically-modified crops reached 170 million hectares around the globe. The ability to patent basic forms of life such as plant properties and the legal history of those intellectual property rights gives biotechnological companies such as Monsanto immense power in the vital agricultural sector. This article outlines the concerns over genetically-modified products and the implications for follow-on advancements within biotechnology by using Monsanto as a case study. The article finds that patent policies similar to those within the United States severely restrict competition and stifle innovation in not only the agricultural sector but also within research and humanitarian projects. …

Federal V. State Effectiveness: An Analysis Of The Endangered Species Act And Current Potential Attempts At Reform, Nicholas Primo

Pepperdine Policy Review

In November 2013, several Congressional leaders drafted a new bill to reform the Endangered Species Act of 1973 (ESA). While the Endangered Species Management Self-Determination Act (ESMSDA) was the first major attempt at updating the crucial U.S. environmental policy in decades, it also inflamed environmentalist defenders of the original bill. More importantly, it raised several questions as to whether state or federal-oriented approaches to endangered species protection and environmental policy more broadly is ultimately more effective. This article analyzes the original 1973 ESA, followed by an analysis of the ESMSDA currently being considered. It will discuss the various strengths and …

A Pilot Examination Of Self-Esteem, Depression, And Sleep In College Women, Jessica R. Conti, Sue K. Adams, Tiffani S. Kisler

Human Development and Family Science Faculty Publications

While sleep deficits in adulthood are common and worsening, college women experience significantly more sleep problems and depression than their male counterparts. In recent years, sleep has been investigated as one of the primary contributors to college functioning and GPA. No known study, however, has investigated the connection between self-esteem, depression and sleep. Questionnaire assessments were given to 43 female college juniors and seniors, including: demographic information, Rosenberg Self-esteem Scale, Beck Depression Inventory, and Pittsburg Quality Sleep Index. This pilot study investigates the relationship between college self-esteem and sleep quality, as mediated by depression. The results of the study indicate …

Complementary And Alternative Medicine Use And Adherence To Asthma Medications Among Latino And Non-Latino White Families, Elizabeth L. Mcquaid, David A. Fedele, Sue K. Adams, Daphne Koinis-Mitchell, Jessica Mithcell, Sheryl J. Kopel, Ronald Seifer, Barbara Jandasek, Gregory K. Fritz, Glorisa Canino

Human Development and Family Science Faculty Publications

Objective: The current study sought to evaluate patterns of complementary and alternative medicine (CAM) use in a sample of Latino and Non-Latino white (NLW) children with asthma, to determine whether parental beliefs about conventional medications and barriers to obtaining these medications were related to CAM use, and to assess whether CAM use was associated with decreased adherence to controller medications.

Methods: Participants included 574 families of children with asthma from Non-Latino White, Puerto Rican, and Dominican backgrounds from RI and from Island Puerto Rico. All parents completed a brief checklist of barriers to medication use and an assessment …

Maternal Anxiety During And After Pregnancy: Effects On Child Internalizing Behaviour, Sue K. Adams, Jennifer F. Daly, Kathleen N. Morgan

Human Development and Family Science Faculty Publications

Background: Anxiety during pregnancy can have significant effects on both a developing fetus and long-term developmental outcomes. In animal and human models, prenatal anxiety has been associated with characteristics of inhibited temperament in infants, which may be a precursor to later anxiety disorders. This pilot study examined if maternal report of anxiety during pregnancy differentially explained preschool-aged children’s internalizing behaviour over and above a mother’s trait anxiety. In addition, using multi-reporter methodology, the study examined if maternal anxiety during pregnancy predicted multiple reporters’ ratings of child internalizing behaviour.

Method: Participants in this pilot study included preschool-aged children, their …

Graduate Teaching Assistants; Critical Colleagues Or Casual Components In The Undergraduate Learning Laboratory? An Exploration Of The Role Of The Postgraduate Teacher In The Sciences., Barry Ryan

Articles

Laboratory training is key to many science subjects and those that teach the practical laboratory skills maintain a pivotal role in undergraduate science training. Graduate Teaching Assistants (GTAs) are regularly used in higher education institutes to teach these practical lab skills. The GTA can be involved in both laboratory teaching and assessing all levels of undergraduates. This varied and challenging role requires support from the institute and if appropriately provided the learning experience can be rewarding not only for the undergraduate, but also for the GTA. In this review, the critical role of the laboratory GTA will be examined, their …

New Inhibitors Of The Fvb2 Subunit From Mammalian Kv1 Potassium Channels, Barry Ryan, Gary Henehan, Alka Kumari, Oliver Dolly

Articles

The role of the redox state of KVB2 subunits in the modulation of Kv1 potassium channels has been well documented over the past few years. It has been suggested that a molecule that binds to or inhibits the aldo-keto reductase activity of KVB2 might affect the modulation of channel properties. Previous studies of possible modulators of channel activity have shown that cortisone and some related compounds are able to physically dissociate the channel components by binding to a site at the interface between � and � subunits. Herein, we describe some new inhibitors of rat brain KVB2, identified using an …

In Defense Of Emergent Individuals: A Reply To Moreland, Joshua Johnson

Faith and Philosophy: Journal of the Society of Christian Philosophers

No abstract provided.

Book Review Of Gary Olson's "Empathy Imperiled: Capitalism, Culture And The Brain, Kris Franklin

Other Publications

No abstract provided.

Isamu Noguchi's Modernism: Negotiating Race, Labor, And Nation, 1930-1950, Stephanie Takaragawa

Sociology Faculty Articles and Research

In a study that combines archival research, a firm grounding in the historical context, biographical analysis, and sustained attention to specific works of art, Amy Lyford provides an account of Isamu Noguchi's work between 1930 and 1950 and situates him among other artists who found it necessary to negotiate the issues of race and national identity. In particular, Lyford explores Noguchi's sense of his art as a form of social activism and a means of struggling against stereotypes of race, ethnicity, and national identity. Ultimately, the aesthetics and rhetoric of American modernism in this period both energized Noguchi's artistic production …

All That Heaven Will Allow: A Statistical Analysis Of The Co-Existence Of Same Sex Marriage And Gay Matrimonial Bans, Deirdre Bowen

Faculty Articles

This article offers the first analysis to date of national data evaluating whether defense of marriage acts (mini or super-DOMAs) preserve and stabilize the family. After finding that they do not—just as same sex marriage does not appear to destabilize families—the article analyzes what variables are, in fact, associated with family stability. Specifically, those variables are: families below the poverty line; men and women married three or more times; religiosity; percent conservative versus liberal in a state; disposable income; percent with bachelor’s degree; and median age of first marriage. Next, the article applies the sociological concepts of moral entrepreneurism and …

Presumed Incompetent: Continuing The Conversation, Carmen Gonzalez, Angela P. Harris

Faculty Articles

On March 8, 2013, the Berkeley Journal of Gender, Law & Justice hosted an all-day symposium featuring more than forty speakers at the University of California, Berkeley School of Law to celebrate and invite responses to the book entitled, Presumed Incompetent: The Intersections of Race and Class for Women in Academia (Gabriella Gutiérrez y Muhs, Yolanda Flores Niemann, Carmen G. González & Angela P. Harris eds., 2012). Presumed Incompetent presents gripping first-hand accounts of the obstacles encountered by female faculty of color in the academic workplace, and provides specific recommendations to women of color, allies, and academic leaders on ways …

A Continuing Plague: Faceless Transactions And The Coincident Rise Of Food Adulteration And Legal Regulation Of Quality, Denis Stearns

Faculty Articles

Over two decades ago, the Jack in the Box E. coli outbreak, in which five victims died, and hundreds more were seriously injured, dramatically changed the way the world looked at food and food safety. Although deemed “trivial” by tort scholars, who nonetheless used legal doctrines first developed in food cases to justify the extension of strict liability to all products, this article uses the Jack in the Box outbreak as a point of departure for exploring not only the relationship between food, being, and knowledge, but to posit that commerce in food, and the inevitability of profit-motivated food adulteration, …

Bearing Children, Bearing Risks: Feminist Leadership For Progressive Regulation Of Compensated Surrogacy In The United States, Sara Ainsworth

Faculty Articles

Compensated surrogacy-an arrangement in which a woman carries and gives birth to a child for someone else in exchange for money-intimately affects women. Yet, feminist law reformers have not led efforts to regulate this practice in the United States. Their absence is notable given the significant influence of feminist lawmaking in a host of other areas where women's interests are at stake. This lack of feminist law reform leadership can be understood, however, in light of the complex issues that surrogacy raises-complexity that has long divided feminists. In response to efforts to pass surrogacy legislation in Washington State in 2010, …

“If They Hand You A Paper, You Sign It”: A Call To End The Sterilization Of Women In Prison, Sara Ainsworth, Rachel Roth

Faculty Articles

The context in which the sterilization of incarcerated women takes place is a deeply coercive one. The practice of sterilizing incarcerated women, whether intentionally coerced or not, takes place against a backdrop of mass incarceration and the long and ignominious history of forced and coerced sterilizations directed at poor people and women of color in the United States. Professor Sara Ainsworth and Dr. Rachel Roth explore this backdrop, and the federal sterilization regulations that arose from this history and from women's activism to change it, in Part I. In Part II, they explain how the appallingly bad and often unconstitutional …

Taking The Tension Out Of Hypertension: A Prospective Study Of Psychological Well-Being And Hypertension, Claudia Trudel-Fitzgerald, Julia K. Boehm, Mika Kivimaki, Laura D. Kubzansky

Psychology Faculty Articles and Research

Background—Previous studies have shown that psychological well-being is associated with reduced risk of cardiovascular disease. However, whether well-being might be specifically associated with reduced risk of hypertension has not been rigorously investigated in prospective studies.

Objective—This study examined the prospective association between two measures of psychological well-being and incident hypertension.

Methods—Participants were 6,384 healthy British civil servants age 39 to 63 from the Whitehall II cohort. Psychological well-being (emotional vitality and optimism) and cardiovascular risk factors (demographic characteristics, health status, health behaviors, psychological ill-being) were assessed during the 1991-1994 baseline. Incident hypertension was defined by clinical measures …

Evaluation Of Foliar Sprays To Reduce Crop Damage By Canada Geese, Charles D. Dieter, Cody S. Warner, Curiong Ren

Human–Wildlife Interactions

South Dakota Department of Game, Fish and Parks annually spends >$500,000 managing crop damage caused by grazing Canada geese (Branta canadensis). Foliar applications of a chemical feeding deterrent could provide an effective alternative to the methods currently being used to reduce damage. In 2011 and 2012, we evaluated Rejex-It Migrate Turfguard®, Bird Shield®, Avian Control®, and Avipel® as grazing deterrents. We used a ground sprayer to apply the treatments every 7 days to plots in soybean fields in Day County, South Dakota. We monitored activity in the plots using time-lapse photography. We began treating the plots after geese …

Effects Of Removal On A Lightly Exploited Coyote Population In Eastern Nevada, Patrick J. Jackson

Human–Wildlife Interactions

Coyote (Canis latrans) removal is a common, yet controversial, management practice to increase game populations throughout the West. I studied the effect of removal on coyote populations in eastern Nevada from 2004 to 2008 and reviewed 27 available publications to determine the level of human exploitation on my study populations. Removals were performed by USDA Wildlife Services (WS) to benefit game populations and involved the use of trapping, neck snaring, and ground and aerial shooting. To determine if the removal had an effect on the coyote populations, I measured 3 parameters: the presence or absence of skewed sex …

Testing A Structural Equation Model Of Language-Based Cognitive Fitness, Elizabeth Ann Moxley-Paquette

Walden Dissertations and Doctoral Studies

The normative development of language is often taken for granted, yet problems with language development can result in stress for the individual and family. A challenge with these language development problems lies within the contemporary education system, which assumes that children have appropriate skills when they begin school. The purpose of the study was to test a theoretical model of language readiness known as language-based cognitive fitness, which includes measures associated with structural concepts of language involving receptive language, expressive language, spontaneous narrative speech, and writing fluency. The sample included children from a private school who received an extensive battery …

Institutionalization Of Children In The Czech Republic: A Case Of Path Dependency, Victoria Schmidt, Jo Daugherty Bailey

The Journal of Sociology & Social Welfare

Despite the development of alternative forms of care, international and domestic pressures for change, and over 20 years of efforts at deinstitutionalization, the Czech Republic has one of the highest rates of institutionalization of children in Europe (UNICEF, 2012). The continuing reliance upon residential care for children by the child protection system, particularly for children who are disabled or of Roma descent, demonstrates a case of path dependency in which a solidification of the system’s response is rooted in its past. Understanding the impact of historical precedence is key to reforming the current system.