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White Blood Cell Counts, Parasite Prevalence, And Plasma Cortisol Levels Of Dogs In A County Animal Shelter: Changes Over Days And Impact Of A Program Of Repeated Human Interaction, Emily S. Dudley

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Animal shelter housing is highly stressful for a dog, compromising welfare and leading to undesirable behaviors and unknown health consequences. We documented the changes in circulating numbers of white blood cells, plasma cortisol, and fecal parasite shedding of dogs housed for 10 days at a county animal shelter. White blood cell changes were most prominent on Day 10 after arrival to the shelter. Changes included increased total leukocytes, mature neutrophils, and lymphocytes, with less consistent increases in monocytes and neutrophil to lymphocyte ratio (N:L). Fecal parasite shedding was elevated and not affected by day. Cortisol levels of shelter dogs declined …

Exploring How Middle School Students' Epistemologies In Practice Change Across Time With Varying Content Areas And Knowledge Product Contexts, Mackenzie Evan English

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Recently, the National Research Council developed A Framework for K-12 Science Education (NRC, 2012), to support a new vision of science education. The Framework (2012) focuses on three integrated dimensions--disciplinary core ideas, crosscutting concepts, and scientific and engineering practices which is different than traditional ways of learning science. I focused on students' engagement in scientific practices, attention to epistemological practices (EIP) that guide students' construction, evaluation and revision of knowledge products. I examined how students EIP's changed over time and across contexts with respect to different knowledge product types (models and explanations). I present data from 103, 6th grade students …

Evaluation Of Functional Near Infrared Spectroscopy (Fnirs) For Assessment Of The Visual And Motor Cortices In Adults, Brenna Giacherio

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Introduction: Functional near-infrared spectroscopy (fNIRS) is a relatively young technique in the field of medical imaging. As such, it has yet to be widely implemented for clinical use, despite its promising advantages. However, unlike fMRI-its much bulkier and costly counterpart-fNIRS has yet to be proven as a standalone imaging tool within a clinical setting, particularly that of ophthalmology or physical therapy.

Methods: Ten healthy young adults (23.8 ± 4.8 years) participated in the study. Activation of the visual cortex was achieved utilizing various reversing checkerboard stimuli across three data collection sessions for each participant. Further, activation of the motor cortex …

Effects Of Delayed Pharmacological Treatment And Limb Rehabilitation On Infarct Size And Functional Recovery After Stroke, Maria Helen Harley Balch

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Previous studies show a fluoxetine/simvastatin drug combination successfully reduced infarct size and increased functional recovery when administered 20-26 hours post stroke. This project tested the hypothesis that earlier drug delivery at 6-12 hours post stroke will improve functional recovery and decrease infarct size, and that limb rehabilitation will improve functional recovery.

Pre-stroke function was determined in rats, a stroke was induced, and daily treatment began 6-12 hours post stroke. Baseline functional deficit was established, and additional testing over 90 days monitored functional recovery. Limb rehabilitation was provided for designated animals, and brain analysis measured infarct size.

In animals with no …

Stop Cheating!: An Evaluation Of A Scientific Integrity Writing Strategy In General Chemistry I, Michelle L. Edwards

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Cheating in America has become an epidemic, which has unfortunately spread to academia. Researchers have long been interested in the trends in cheating behavior and the factors that influence these trends among undergraduate college students. Though cheating can take on many forms, in science, there is a deep concern about scientific misconduct related to research. Because training for future scientists begins in undergraduate courses, this study investigated the use of scientific integrity writing strategy in General Chemistry I at Wright State University. The goal of the study was to determine if providing scientific integrity and ethics training, while teaching students …

Routes To N-Heterocycle Functionalized Poly(Arylene Ether Sulfone)S, Jesse L. Picker

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The synthesis of poly(arylene ether sulfone)s, with a pendant aryl iodide, was achieved via nucleophilic aromatic substitution (NAS) polycondensation of 3-iodo-3',5'-difluoro-diphenylsulfone. The polymer series was subjected to amino acid promoted, copper catalyzed coupling reactions with various N-heterocycles. The resulting polymers became crosslinked and insoluble in any organic solvents. The iodo monomer was then subjected to an amino acid promoted, copper catalyzed coupling reaction with carbazole. The successful synthesis of 3'-(9-carbazole) 3,5-difluorodiphenylsulfone is reported. A series of PAES containing a carbazole substituent were synthesized and characterized. The polymers were characterized by a combination of NMR spectroscopy, SEC, TGA, DSC, UV-Vis spectroscopy. …

Assortative Fertilization In The Elegans-Group Of Caenorhabditis, Sara Rose Seibert

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Assortative fertilization refers to the species-specific interactions between sperm and oocytes that affect the success of fertilization. One type of interaction is chemotaxis of sperm to oocytes. In Caenorhabditis elegans, amoeboid sperm must crawl along the uterine lining towards the spermathecae in response to oocyte-derived prostaglandin signals for fertilization. This chemotactic signaling system likely operates in other species of the Elegans-Group of Caenorhabditis as sperm of C. briggsae and C. remanei do localize to the C. elegans spermathecae. In this project the impacts of species-specific chemotaxis on fertilization and female fecundity were assessed. To accomplish this, the localization of …

Investigating Anatomical And Molecular Aspects Of Proprioceptive Sensory Neuron Diversity Using A Transgenic Mouse Model, Martha Jean Sonner

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Muscle spindles (MS) and Golgi tendon organs (GTOs) are encapsulated, stretch-activated sensory receptors housed within skeletal muscles, yet their functional contributions to proprioceptive monitoring of limb movements are quite different. For example, MS are responsible for detecting stretch of muscle fibers, and GTOs provide feedback regarding muscle tension during contraction. Peripheral axons extending from proprioceptive sensory neurons (PSNs) in the dorsal root ganglia supply MS and GTOs. MS are innervated by Group Ia and II sensory fiber endings, while GTOs are innervated by a single Group Ib sensory fiber. The developmental processes guiding axons from PSNs to their targets and …

Biogeochemistry Of Sulfur Isotopes In Crystal Lake, Clark County, West-Central Ohio, Amanda Lynn Meyer

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Crystal Lake showed distinct biogeochemical patterns, which were governed by thermal stratification, photosynthesis, and sulfur redox processes. Field parameter measurements and water and Planktothrix rubescens samples were collected in May, August, and October, 2013 at the deepest point in the lake, to better understand these processes. At the metalimnion-hypolimnion boundary, P. rubescens produced chlorophyll and turbidity maxima. Photosynthesis produced oxygen-rich and nutrient-poor surface waters. The decay of organic matter produced anoxic, nutrient-rich water in the hypolimnion. Sulfate concentrations were high in the epilimnion and metalimnion, with a maximum at the layer of P. rubescens, and decreased with depth in the …

Mercury Distributions And Cycling In The North Atlantic And Eastern Tropical Pacific Oceans, Katlin L. Bowman

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The distribution of mercury (Hg) in the ocean is complex as a result of in situ chemical transformations and inputs from natural and anthropogenic sources. Within the ocean, inorganic Hg is methylated to monomethylmercury (MMHg), which bioaccumulates and biomagnifies in marine food webs and poses a health risk to humans who eat fish. The biogeochemistry of Hg in the ocean has been studied for decades, however, recently improved sampling and analytical techniques have allowed for an enhanced understanding of global distributions of different Hg species. This dissertation uses a newly developed method for the analysis of MMHg that improves detection …

Environmental Factors Affecting Methylmercury In Fish Of The Laurentian Great Lakes Region, Joel Harvey

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Monomethylmercury (MMHg) can accumulate in fish to concentrations that pose a threat to the health of fish, piscivorous organisms, and humans who eat fish. A variety of environmental factors have been hypothesized to influence either the methylation of inorganic Hg or the bioaccumulation and magnification of MMHg. This study investigates the influence of selected environmental factors on MMHg concentrations in freshwater fish across a regional scale, most of the U.S. portion of Laurentian Great Lakes region. Fish MMHg was correlated with proton deposition, sulfate deposition, nitrate deposition, mercury deposition, pH, watershed area, and Secchi depth. Only proton deposition was positively …

Expression, Characterization, Cloning And Functional Impact Of Slc12a5 In The Endocrine Pancreas, Shams Kursan

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The Slc12a5 gene encodes the neuron-specific electroneutral K+Cl- cotransporter-2 (KCC2), a constitutively active Cl- extruder. In mature neurons, KCC2 functionally predominates over other members of the Slc12a family, particularly the Na+K+2Cl- cotransporter-1 (NKCC1), a ubiquitous Cl- loader. Therefore, KCC2 keeps and maintains the intracellular chloride concentration ([Cl-]i) below values predicted by thermodynamic equilibrium and in doing so, KCC2 plays a key role in neuron physiology: it makes possible the inhibitory action of neurotransmitters such as gamma-aminobutyric acid (GABA) and glycine. Neurons and insulin-secreting pancreatic ß-cells share many genes and functions. Indeed, neuron-specific genes have been also found in ß-cells whereas …

Identification Of The Sites Of Action Of Inhibitors Of Mammalian Phospholipase D2 (Pld2) And The Role Of Interacting Protein Partners, Ramya Ganesan

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Phospholipase D (PLD) is a key enzyme for the remodeling of phospholipids in the cell membrane. PLD has been implicated in many physiological functions such as chemotaxis and phagocytosis as well as pathological functions such as ischemia/reperfusion and cancer metastasis. Several small molecule inhibitors of PLD have been recently developed to overcome these pathological effects. We have concentrated on 5-Fluoro-2-Indolyl des-Chlorohalopemide (FIPI) which is an indole derivative of halopemide that inhibits the two mammalian isoforms PLD1 and PLD2. We also concentrate on N-[2-[1-(3-Fluorophenyl)-4-oxo-1,3,-8-triazaspiro[4.5]dec-8-yl]ethyl]-2-naphthalenecarboxamide (NFOT) and N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4,5]dec-8-yl)ethyl]-2-naphthalenecarboxamide (NOPT) that are specific inhibitors of the PLD2 isoform. In spite of knowing their …

Finite Element Simulation Of Skull Fracture Evoked By Fall Injuries, Anthony Vicini

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This study presents novel predictive equations for von Mises stresses and deflection of bones in the frontal and lateral regions of the skull. The equations were developed based on results of a finite element model developed here. The model was validated for frontal and lateral loading conditions with input values mimetic to fall scenarios. Using neural network processing of the information derived from the model achieved R2 values of 0.9990 for both the stress and deflection. Based on the outcome of the fall victims, a threshold von Mises stress of 40.9 to 46.6 MPa was found to indicate skull fracture …

Use Of Vibrotactile Feedback And Stochastic Resonance For Improving Laparoscopic Surgery Performance, Robert Douglas Hoskins

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Vibrotactile feedback, used as sensory substitution for loss of haptic feedback, has been utilized to improve performance in manual control, teleoperation and during minimally invasive surgical tasks. Stochastic resonance (SR), introduced into the human control system as white noise at a sub-threshold level, has shown promise to improve the sensitivity of tactile receptors resulting in enhancement of performance for a variety of manual tracking and sensorimotor tasks. The purpose of this study was to determine if SR could improve performance (accuracy, speed) in a simulated laparoscopic palpation task and to compare it to vibrotactile feedback (VIB). It was hypothesized that …

Asymmetrical Interference Effects Between Two-Dimensional Geometric Shapes And Their Corresponding Shape Words, Bradley R. Sturz, Joshua E. Edwards, Ty W. Boyer

Psychology: Faculty Publications

Nativists have postulated fundamental geometric knowledge that predates linguistic and symbolic thought. Central to these claims is the proposal for an isolated cognitive system dedicated to processing geometric information. Testing such hypotheses presents challenges due to difficulties in eliminating the combination of geometric and non-geometric information through language. We present evidence using a modified matching interference paradigm that an incongruent shape word interferes with identifying a two-dimensional geometric shape, but an incongruent two-dimensional geometric shape does not interfere with identifying a shape word. This asymmetry in interference effects between two-dimensional geometric shapes and their corresponding shape words suggests that shape …

Group Via Calcium-Independent Phospholipase A2 Regulates Bcl-Xl Protein Levels In Mice Lung, Sang-Jin Nam

Theses and Dissertations

With previous indication of the Group VIA phospholipase A2 (iPLA2β) enzyme regulating ER-stress induced apoptosis in β-cells by regulating the anti-apoptotic protein Bcl-xL via alternative splicing, our lab postulated iPLA2β to be utilizing a similar mechanism to regulate apoptosis in mice lung. Our previous lab work has shown implications of lung function compromise in iPLA2β-/- mice, and we speculated the cause to be due altered lung architecture stemming from the attenuation of apoptosis. The western blot analysis in this study suggested that iPLA2β is involved in the regulation of Bcl-xL, but the mRNA ratios of the splice variants suggested that …

Persecuting Alex Rodriguez: Race, Money And The Ethics Of Reporting The Performance-Enhancing Drug Scandal, Bonnie Brennen, Rick Brown

College of Communication Faculty Research and Publications

This qualitative textual analysis considers the US press coverage of Alex Rodriguez for his alleged use of performance-enhancing drugs. It evaluates nearly 500 newspaper, magazine and broadcast reports from 2007 to 2014 on Rodriguez, as well as reader and journalistic responses, and finds issues of overt and inferential racism, stereotyping and symbolic impurity, and a crude emphasis on money in the coverage. This research considers the ethics of the press coverage through a framework of Critical Race Theory and suggests an approach rooted in communitarian ethics to foster greater social justice and balance in sports media coverage.

Queer Alchemies: Radical Futurity In The Shell Of The Now, Elizabeth R. Canfield

Theses and Dissertations

This work operates at the intersection of academics, art, and activism. Within queer studies there is a tension between assimilation and liberation, sometimes situated as between pragmatism and utopia. This work re-examines Frankfurt school Marxist views of utopia through a queer theoretical lens in order to employ the radical imagination and queer futurity to examine new ways of practicing liberation. Drawing from theorists like Judith Butler, Jose Esteban Munoz, and Gloria Anzaldua, this work uses art (film, writing, zine-making, and sound) as a way to envision and enact a better world situated in the present.

Detection And Rapid Recovery Of The Sutter’S Mill Meteorite Fall As A Model For Future Recoveries Worldwide, Marc Fries, Lucille Le Corre, Mike Hankey, Jeff Fries, Robert Matson, Jake Schaeffer, Vishnu Reddy

United States National Aeronautics and Space Administration: Publications

The Sutter’s Mill C-type meteorite fall occurred on 22 April 2012 in and around the town of Coloma, California. The exact location of the meteorite fall was determined within hours of the event using a combination of eyewitness reports, weather radar imagery, and seismometry data. Recovery of the first meteorites occurred within 2 days and continued for months afterward. The recovery effort included local citizens, scientists, and meteorite hunters, and featured coordination efforts by local scientific institutions. Scientific analysis of the collected meteorites revealed characteristics that were available for study only because the rapid collection of samples had minimized terrestrial …

The Seasonal Cycle Of Satellite Chlorophyll Fluorescence Observations And Its Relationship To Vegetation Phenology And Ecosystem Atmosphere Carbon Exchange, J. Joiner, Y. Yoshida, A. P. Vasilkov, K. Schaefer, M. Jung, L. Guanter, Y. Zhang, S. Garrity, E. M. Middleton, K. F. Huemmrich, L. Gu, L. Belelli Marchesini

United States National Aeronautics and Space Administration: Publications

Mapping of terrestrial chlorophyll fluorescence from space has shown potential for providing globalmeasurements related to gross primary productivity (GPP). In particular, space-based fluorescence may provide information on the length of the carbon uptake period. Here, for the first time we test the ability of satellite fluorescence retrievals to track seasonal cycle of photosynthesis as estimated from a diverse set of tower gas exchange measurements from around the world. The satellite fluorescence retrievals are obtained using new observations near the 740 nm emission feature from the Global Ozone Monitoring Experiment 2 (GOME-2) instrument offering the highest temporal and spatial resolution of …

Impacts Of Disturbance History On Forest Carbon Stocks And Fluxes: Merging Satellite Disturbance Mapping With Forest Inventory Data In A Carbon Cycle Model Framework, Christopher A. Williams, G. James Collatz, Jeffrey Masek, Chengquan Huang, Samuel N. Goward

United States National Aeronautics and Space Administration: Publications

Forest carbon stocks and fluxes are highly dynamic following stand-clearing disturbances from severe fire and harvest and this presents a significant challenge for continental carbon budget assessments. In this work we use forest inventory data to parameterize a carbon cycle model to represent post-disturbance carbon trajectories of carbon pools and fluxes for specific forest types growing in high and low site productivity class settings. We then apply these trajectories to landscapes and regions based on forest age distributions derived from either the FIA data or from Landsat time series stacks (1985–2006) for 54 representative scenes throughout most of the conterminous …

Estimation Of Vegetation Photosynthetic Capacity From Space-Based Measurements Of Chlorophyll Fluorescence For Terrestrial Biosphere Models, Yongguang Zhang, Luis Guanter, Joseph A. Berry, Joanna Joiner, Christiaan Van Der Tol, Alfredo Huete, Anatoly Gitelson, Maximilian Voigt, Philipp Köhler

United States National Aeronautics and Space Administration: Publications

Photosynthesis simulations by terrestrial biosphere models are usually based on the Farquhar’s model, in which the maximum rate of carboxylation (V_cmax) is a key control parameter of photosynthetic capacity. Even though V_cmax is known to vary substantially in space and time in response to environmental controls, it is typically parameterized in models with tabulated values associated to plant functional types. Remote sensing can be used to produce a spatially continuous and temporally resolved view on photosynthetic efficiency, but traditional vegetation observations based on spectral reflectance lack a direct link to plant photochemical processes. Alternatively, recent space-borne measurements …

The New Stem Faculty Profile: Balancing Family And Dual Careers, Patricia Wonch Hill, Mary Anne Holmes, Julia Mcquillan

Department of Earth and Atmospheric Sciences: Faculty Publications

Purpose — This chapter contrasts “ideal worker” with “real worker” characteristics among STEM faculty in gendered organizations. The gap between the two reveals the need for academic institutions to revise the notion of and the policies for typical faculty members.

Design — All STEM faculty at a Midwestern research intensive university were asked to participate in a mail and web-based survey to study faculty experiences within departments. The response rate was 70%. Faculty were then categorized by their employment, education, and parent status, and by the work status of their spouse/partner, to assess how closely the faculty matched the ideal …

Architecture, Heterogeneity, And Origin Of Late Miocene Fluvial Deposits Hosting The Most Important Aquifer In The Great Plains, Usa, R. Matthew Joeckel, Steve R. Wooden Jr., Jesse T. Korus, Jon Garbisch

Department of Earth and Atmospheric Sciences: Faculty Publications

The Ash Hollow Formation (AHF) of the Ogallala Group is an important sedimentary archive of the emergence of the Great Plains and it contains major groundwater resources. Stratal patterns of constituent alluvial lithofacies demonstrate that the AHF is much more heterogeneous than is commonly assumed. Very fine- to fine-grained sandstone dominate overall, chiefly lithofacies Sm (massive to locally stratified sandstone). Stacked, thin sheets of Sm with accretionary macroform surfaces are common, indicating that many sandstone architectural elements originated as compound-bar deposits in dominantly sand-bed streams. Channel forms are difficult to identify and steep cutbanks are absent. Multiple units of lithofacies …

A 60,000-Year Record Of Hydrologic Variability In The Central Andes From The Hydrogen Isotopic Composition Of Leaf Waxes In Lake Titicaca Sediments, Kyrstin L. Fornace, Konrad A. Hughen, Timothy M. Shanahan, Sherilyn C. Fritz, Paul A. Baker, Sean P. Sylva

Department of Earth and Atmospheric Sciences: Faculty Publications

A record of the hydrogen isotopic composition of terrestrial leaf waxes (δDwax) in sediment cores from Lake Titicaca provides new insight into the precipitation history of the Central Andes and controls of South American Summer Monsoon (SASM) variability since the last glacial period. Comparison of the δDwax record with a 19-kyr δD record from the nearby Illimani ice core supports the interpretation that precipitation δD is the primary control on δDwax with a lesser but significant role for local evapotranspiration and other secondary influences on δDwax. The Titicaca δDwax record con-firms overall wetter conditions in the Central Andes during the …

The Evaluation And Diagnosis Of Dementia And Alzheimer’S Disease: The Update, Kongkiat Kulkantrakorn

Asian Medical Journal and Alternative Medicine

Dementia is a common condition in clinical practice. Its prevalence has been on the rise, due to the rapidincrease of elderly population. Alzheimer’s disease is the most common cause of dementia. Patients always had cognitiveimpairment in many aspects which impact their daily livings. Therefore, proper evaluation and diagnosis are very important inthe patient’s care. Certain systemic and psychiatric diseases need to be excluded prior the diagnosis of neurodegenerativedisease. Further investigation is often needed for specific diagnosis according to the standard criteria for each disease.During the past decade, the criteria have been changed significantly due to better understandings in their pathophysiology.Biological …

Investigating The Role Of The Synaptic Transcriptome In Ethanol-Responsive Behaviors, Megan A. O'Brien

Theses and Dissertations

Alcoholism is a complex neurological disorder characterized by loss of control in limiting intake, compulsion to seek and imbibe ethanol, and chronic craving and relapse. It is suggested that the characteristic behaviors associated with the escalation of drug use are caused by long-term molecular adaptations precipitated by the drug’s continual administration. These lasting activity-dependent changes that underlie addiction-associated behavior are thought, in part, to depend on new protein synthesis and remodeling at the synapses. It is well established that mRNA can be transported to neuronal distal processes, where it can undergo localized translation that is regulated in a spatially restricted …

The Origin Of Parental Rights: Labor, Intent, And Fathers, Dara Purvis

Faculty Scholarship

Most theories of parentage fail to explain the genesis of the right to parent - for example, why does a biological relationship generate parental rights? This Article shows that the law of parental rights mirrors theories of acquiring property, and that the law has shifted over time, from favoring a property right based in genetics to a Lockean theory of property rights earned through labor. The growth of Lockean labor-based theories is epitomized in reforms to parentage laws that incorporate functional theories of parenting, meaning that adults who perform caretaking work that creates a significant relationship with children are recognized …

A Troublesome Right: The Law In Dworkin's Treatment Of Law And Religion A Symposium On Ronald Dworkin's Religion Without God, Paul Horwitz

Articles

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