Digital Commons Network^™

Gleason Score At The Margin Can Predict Biochemical Recurrence After Radical Prostatectomy, In Addition To Preoperative Psa And Surgical Margin Status, Sidika Şeyma Özkanli, Itir Ebru Zemheri̇, Asif Yildirim, Hati̇ce Deni̇z Gür, Mevlana Derya Balbay, Serkan Şenol, Ahmet Oğuz Özkanli, Erdal Alkan, Tülay Zengi̇nki̇net, Abdullah Aydin, Turhan Çaşkurlu

Turkish Journal of Medical Sciences

To evaluate the relation between biochemical recurrence (BCR) of prostate cancer and the extent of positive surgical margins (PSMs), Gleason score (GS) of the tumor at the margins, and preoperative prostate-specific antigen (PSA) levels. Materials and methods: A total of 94 patients who underwent radical prostatectomy were recruited for this study and received postoperative follow-up care for 2 years. All specimens were evaluated for surgical margin status, PSM length, GS at positive margin, size of tumor, multifocality, invasion of seminal vesicle, lymphovascular invasion, and perineural invasion. PSM was defined as a prostate tumor. Results: Out of 94 patients, 34 patients …

Effects Of Whole-Body Vibration On Plasma Sclerostin Level In Healthy Women, Muharrem Çi̇dem, Yunus Karakoç, Hakan Ekmekçi̇, Suat Hayri̇ Küçük, Murat Uludağ, Kerem Gün, Şafak Sahi̇r Karamehmetoğlu, İlhan Karacan

Turkish Journal of Medical Sciences

To determine whether plasma sclerostin levels are affected by applying whole-body vibration treatments. Materials and methods: Following a pilot study, the present prospective, randomized, controlled single-blind study was performed on 16 healthy volunteer women (ages 20 to 40 years). Subjects were randomly divided into 2 groups, and whole-body vibration was applied to the treatment group but not to the controls. The plasma sclerostin levels were measured before the treatment and at the 10th minute after whole-body vibration on the 1st, 2nd, and 5th days of application. Results: The plasma sclerostin level measured at 10 min after the whole-body vibration treatment …

Resistin Predicts Ischemia In Myocardial Perfusion Scintigraphy, Mustafa Yildirim, Meli̇h Engi̇n Erkan, Muhammet Aşik, Taner Uçgun, Ayşe Yilmaz, Huri̇ Ti̇lla İlçe, Yusuf Aslantaş, Ramazan Memi̇şoğullari, Serkan Bulur, Ahmet Semi̇h Doğan

Turkish Journal of Medical Sciences

Resistin plays a role in the pathogenesis of coronary artery disease and is related to mortality and morbidity through a number of mechanisms. We hypothesize that plasma resistin levels are increased in the presence of ischemia, as measured by GATED single-photon emission computed tomography myocardial perfusion scintigraphy (SPECT MPS), in comparison with nonischemic subjects. Materials and methods: Fasting intravenous blood samples of patients were drawn before a stress test. An ELISA kit was used for the assays. All patients underwent a technetium 99m-sestamibi GATED SPECT MPS study with a 1-day stress-rest protocol. Images were analyzed visually and patients were assessed …

Prevalence Of Blabstractp And Blavim Gene Carriage In Metallo-\Beta-Lactamase-Producing Burn Isolates Of Pseudomonas Aeruginosa In Tehran, Fatemeh Salimi, Fereshteh Eftekhar

Turkish Journal of Medical Sciences

To study the prevalence of bla_{VIM} and bla_{IMP} genes in metallo-\beta-lactamase (MBL)-producing burn isolates of Pseudomonas aeruginosa in relation with AmpC and extended-spectrum \beta-lactamase (ESBL) production. Materials and methods: Thirty-two carbapenem-resistant MBL-producing P. aeruginosa burn isolates from Shahid Motahari Burn Hospital in Tehran were employed. Antibiotic susceptibility was determined to 13 antibiotics including imipenem and meropenem by disk diffusion. AmpC and ESBL production was detected by the AmpC disk test and combined disk diffusion assay, respectively. bla_{IMP} and bla_{VIM} gene carriage was shown by polymerase chain reaction and type-specific primers. Results: AmpC production was observed in 81% and ESBL production …

What Is The Effect Of Radioiodine Therapy On Helicobacter Pylori Infection?, Celi̇l Alper Usluoğullari, Eda Demi̇r Önal, Eli̇f Özdemi̇r, Sedat Caner, Osman Ersoy, Reyhan Ersoy, Beki̇r Çakir

Turkish Journal of Medical Sciences

Helicobacter pylori is an important human pathogen associated with gastric and duodenal ulcers, gastric mucosa-associated lymphoid tissue lymphoma, and adenocarcinoma. Radioiodine (RAI) treatment plays an important role in the management of differentiated thyroid cancer and primary hyperthyroidism. It is known that during RAI treatment, a considerable amount is absorbed by the stomach as well. In this study we aimed to reveal any therapeutic impact of RAI on H. pylori infections. Materials and methods: Eighty-seven patients who were hospitalized for RAI treatment were consecutively included in this study. Of those, 76 patients had differentiated thyroid cancer and 11 had primary hyperthyroidism. …

การผลิตไบโอบิวทานอลจากการย่อยสลายของเปลือกถั่วเหลือง, มานพ บุญเจริญ

Chulalongkorn University Theses and Dissertations (Chula ETD)

งานวิจัยนี้ทำการศึกษาการย่อยสลายเปลือกถั่วเหลืองด้วยกรดเพื่อใช้เป็นสารตั้งต้นในการผลิตอะซิโตน เอทานอล และบิวทานอล ด้วยเชื้อ Clostridium saccharobutylicum ATCC BAA 117 การย่อยสลายทำในหม้อนึ่งไอน้ำความดันสูงที่ความเข้มข้น อัตราส่วนของแข็งต่อของเหลว และเวลาในการทำปฏิกิริยาที่ค่าต่างๆ สภาวะที่ดีที่สุดสำหรับการผลิตน้ำตาลรีดิวซ์ที่สูงและสารยับยั้งที่ต่ำ มีดังนี้ ความเข้มข้นกรดร้อยละ 5 โดยปริมาตร อัตราส่วนของแข็งต่อของเหลว 1 ต่อ 5 เวลาการย่อยสลาย 15 นาที น้ำตาลไฮโดรไลเซทประกอบด้วยน้ำตาลรีดิวซ์รวม 31.86 กรัมต่อลิตร รวมทั้งเฟอร์ฟูรัล 0.66 กรัมต่อลิตร และไฮดรอกซีเมทิลเฟอร์ฟูรัล 0.059 กรัมต่อลิตร เฟอร์ฟูรัลที่ความเข้มข้น 0.05 กรัมต่อลิตร ได้แสดงฤทธิ์ยับยั้งการเจริญเติบโตของ C. saccharobutylicum ATCC BAA 117 แต่ไฮดรอกซีเมทิลเฟอร์ฟูรัลไม่มีผลกระทบ การบำบัดโดยใช้ Overliming ด้วยแคลเซียมไฮดรอกไซด์ และการดูดซับด้วยเรซิน XAD-4 และถ่านกัมมันต์ ช่วยปรับปรุงน้ำตาลไฮโดรไลเซทให้สามารถใช้ในการหมักได้อย่างมีนัยสำคัญ การหมักแบบกะที่อุณหภูมิ 35 องศาเซลซียส ค่าความเป็นกรดด่าง 5.5 เมื่อใช้น้ำตาลไฮโดรไลเซท (30-65 กรัมต่อลิตร) ที่ชนิดแหล่งและความเข้มข้นแหล่งไนโตรเจนต่างๆ การผลิตตัวทำละลายที่เหมาะสมจะได้รับจากที่สภาวะอุณหภูมิ 35 องศาเซลเซียส ค่าความเป็นกรดด่าง 5.5 ในอาหารน้ำตาลไฮโดรไลเซทที่ประกอบด้วยน้ำตาลรีดิวซ์ 65 กรัมต่อลิตร ยีตส์สกัด แอมโมเนียมอะซิเตทและน้ำแช่ข้าวโพด ตัวทำละลายรวมมีค่า 15.69 กรัมต่อลิตร ประกอบด้วยอะซิโตน บิวทานอล และเอทานอลเท่ากับ 12.15, 15.69 และ 2.39 กรัมต่อลิตร ตามลำดับ มีผลได้ตัวทำละลายเท่ากับ 0.46 และอัตราการผลิตตัวทำละลาย 0.37 กรัมต่อลิตรต่อชั่วโมง ในงานวิจัยนี้แสดงให้เห็นว่าเปลือกถั่วเหลืองสามารถใช้เป็นแหล่งคาร์บอนที่มีศักยภาพสำหรับการหมักเพื่อผลิตอะซิโตน เอทานอล และบิวทานอล

Hearing Loss And The Structure Of The Ear, Molly Rannebarger

A with Honors Projects

This is a PowerPoint presentation given by a student on the structure of the ear, causes of hearing loss and available solutions.

Redefining Medical Necessity: A Consumer-Driven Solution To The U.S. Health Care Crisis, Ryan Abbott, Carl Stevens

Loyola of Los Angeles Law Review

The American health care system is plagued by high costs and poor public health outcomes, due in part to the overuse of costly diagnostic tests and treatments. In 2009, the Institute of Medicine estimated that unnecessary care wastes $750 billion, equivalent to about 30 percent of health care spending. Moreover, overtreatment can directly harm patients as a result of surgical complications, drug toxicity, and hospital-acquired infections. Yet while the problem of medical waste has long been recognized, solving the problem has proven elusive. In part, this difficulty is due to perverse economic incentives for physicians and hospitals, which still primarily …

The Genome Sequence Of A Widespread Apex Predator, The Golden Eagle (Aquila Chrysaetos), Jacqueline M. Doyle, Todd E. Katzner, Peter H. Bloom, Yanzhu Ji, Bhagya K. Wijayawardena, J Andrew Dewoody

Faculty & Staff Scholarship

Biologists routinely use molecular markers to identify conservation units, to quantify genetic connectivity, to estimate population sizes, and to identify targets of selection. Many imperiled eagle populations require such efforts and would benefit from enhanced genomic resources. We sequenced, assembled, and annotated the first eagle genome using DNA from a male golden eagle (Aquila chrysaetos) captured in western North America. We constructed genomic libraries that were sequenced using Illumina technology and assembled the high-quality data to a depth of ∼40x coverage. The genome assembly includes 2,552 scaffolds >10 Kb and 415 scaffolds >1.2 Mb. We annotated 16,571 genes that are …

Matrix Models For Size-Structured Populations: Unrealistic Fast Growth Or Simply Diffusion?, Nicolas Picard, Jingjing Liang

Faculty & Staff Scholarship

Matrix population models are widely used to study population dynamics but have been criticized because their outputs are sensitive to the dimension of the matrix (or, equivalently, to the class width). This sensitivity is concerning for the population growth rate () because this is an intrinsic characteristic of the population that should not depend on the model specification. It has been suggested that the sensitivity of to matrix dimension was linked to the existence of fast pathways (i.e. the fraction of individuals that systematically move up a class), whose proportion increases when class width increases. We showed that for matrix …

Higher Education, Higher Costs: An Income-Contingent Approach, Catherine Hensly

Undergraduate Research Awards

An examination of different methods of paying for higher education with an emphasis on an income-contingent approach. The paper applies this method to a real-world institution, Radford University in Virginia. The limitations of this method and gender disparities in higher education are also considered. The author's entry essay for the 2014 Undergraduate Research Awards is included.

Application Of Ce-Qual-W2 On Tigris River In Iraq, Muhanned Al-Murib

Civil and Environmental Engineering Master's Project Reports

The Tigris River is the eastern member of the two great rivers in Iraq. Two big rivers pass through Iraq, Mesopotamia. Tigris and Euphrates Rivers with their tributaries form a major river system in the Middle East. Four riparian countries, Turkey, Syria, Iran, and Iraq, share the Tigris River basin area and Iraq has the majority of this basin area. The total length of the Tigris is 1850 km from which 1418 km is within Iraq. A study area of 880 km from Mosul dam to Kut barrage is modeled using a water quality CE-QUAL-W2 model. CE-QUAL-W2 is a two-dimensional …

Should All Drugs Be Patentable?: A Comparative Perspective, Cynthia M. Ho

Faculty Publications & Other Works

Although there has been substantial discussion of the proper scope of patentable subject matter in recent years, drugs have been overlooked. This Article begins to address that gap with a comparative perspective. In particular, this Article considers what is permissible under the Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS), as well as how India and Canada have utilized TRIPS flexibilities in different ways to properly reward developers of valuable new drugs, while also considering the social harm of higher prices beyond an initial patent term on drugs.

This Article brings valuable insight into this area at a critical …

A Mixed-Methods Comparison Of Standards-Based And Traditional Gradebooks In One High School, Kevin P. Mabie

Dissertations

Online gradebooks have gradually become a staple of schools in the 21st century. Students and parents have immediate access to grades, and the composition of these grades is transparent. While the purpose of the online gradebook may have initially been for the conveniences such systems offer the school and its stakeholders, it has also served as a catalyst for gradebook reform. Gradebook construction strategies have been called into question, and solutions which allow gradebooks to provide more accurate and specific information have been developed. This study explored student learning growth through the use of two different online gradebooks: a traditionally …

Biological Aging And Peer Victimization: The Role Of Social Support In Telomere Length And Health Outcomes, Maria Elizabeth Guarneri-White

Psychology Theses - Archive

The health benefits of social support have been well documented in the literature (Baumeister & Leary, 1995; Newman & Roberts, 2013), as have the somatic and psychological outcomes of being the victim of bullying (Wang, Nansel, & Iannotti, 2011; Knack, Jensen-Campbell, & Baum, 2011). Recent research has looked at the separate role each of these interpersonal processes play in cellular aging via the study of telomeres, which are the protective caps on the ends of chromosomes that shorten with each cell division (Epel, 2009). Data indicate that stress can accelerate this shortening, leading to premature cell death and a shortened …

Abortion, Religion, And The Accusation Of Establishment: A Critique Of Justice Stevens’ Opinions In Thornburgh, Webster, And Casey, John M. Breen

Faculty Publications & Other Works

It is commonplace to characterize legal arguments in favor of protecting the human embryo or fetus as “inherently religious” such that laws embodying this point of view constitute an establishment of religion in violation of the First Amendment. The practical effect of this argumentative strategy is to foreclose substantive debate on the issue of the legal status of the unborn – to preclude from consideration an entire point of view and so win an argument without ever really having one.

This claim has a long pedigree, tracing back to the founding of NARAL and Lawrence Lader’s “Catholic strategy.” Its most …

Vanadium Complexes Are In Vitro Inhibitors Of Leishmania Secreted Acid Phosphatases, Richard Mendez, Benjamin M. Dorsey, Craig C. Mclauchlan, Matt Beio, Timothy L. Turner, Victoria H. Nguyen, Alexander Su, William Beynon, Jon A. Friesen, Marjorie A. Jones

Faculty Publications – Chemistry

Leishmaniasis is a parasitic disease caused by the protozoa Leishmania. These organisms secrete acid phosphatases during their growth cycle as an important part of cell targeting to host macrophage cells thus allowing for a successful infection. Secreted acid phosphatases (SAP) are reported to play a significant role in the survival of Leishmania cells, thus evaluation of these enzymes is of interest. The inhibition of SAP can be the focus of a new drug therapy. We tested for SAP activity from Leishmania tarentolae following the addition of a series of vanadium complexes including decavanadate. Cell cultures at different stages in their …

Influence Of Marianismo On Colorectal Cancer Screening Behavior Among Hispanic Women In The United States, Robin Thompson

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second leading cause of cancer death in the United States (U.S).1 Although early detection and treatment can reduce CRC-related morbidity and mortality, almost twothirds of patients are diagnosed with advanced stage disease indicating non-adherence to recommended screening guidelines.1 Indeed, less than half of individuals over 50 years of age get screened at recommended intervals.2 More specifically, lower rates of CRC screening exist among these groups: those identifying as being of Hispanic origin, the uninsured, disabled individuals, and women.3 In a 2011 report from the National Center on Health …

Association Of Hiv Testing, Educational Attainment, And Age Among Black And Non-Black Men, Ashley N. Martell

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Human Immunodeficiency Virus (HIV) infection can lead to a chronic condition, Acquired Immunodeficiency Syndrome (AIDS), but can be well managed with a combination of medications, treatments, and remedies.1 The emergence of HIV in the United States in 1981 created an atmosphere unlike any other at that time. Overtime, the science community has worked diligently to combat this disease through research, practice, and intervention. Although many efforts have been put forth over the past thirty years, millions of Americans still remain infected with HIV.2 Among those who are infected with HIV/AIDS we see disproportionate rates among specific races and gender. Research …

Investigations Of Laser-Based Repulsive Axonal Guidance And Other Novel Biophysical Applications Of Laser Microbeams, Bryan James Black

Physics Dissertations - Archive

Over the past 30 years, the properties of light have been increasingly exploited to probe and manipulate biological samples. The subsequent techniques and technologies, combined with the broadening optical characterization of biological samples (from cells to single molecules), have had a revolutionary impact on the fields of biophysics, bioengineering, chemistry, and molecular biology. Light is now known to be capable of manipulating biological samples with high spatial and temporal precision, and minimal invasiveness. Herein, we offer the findings of several novel, light-based studies as well as novel applications which exploit a laser microbeam as either a potential gradient, a cutting …

Contents, North Carolina Journal Of Law & Technology

North Carolina Journal of Law & Technology

No abstract provided.

Reproduction-Powered Industry: Coordinating Agency Regulations For Synthetic Biology, Brendan Parent

North Carolina Journal of Law & Technology

No abstract provided.

Faults Identification In Three-Phase Induction Motors Using Support Vector Machines, Rama Hammo

Master of Technology Management Plan II Graduate Projects

Induction motor is one of the most important motors used in industrial applications. The operating conditions may sometime lead the machine into different fault situations. The main types of external faults experienced by these motors are over loading, single phasing, unbalanced supply voltage, locked rotor, phase reversal, ground fault, under voltage and over voltage. The machine should be shut down when a fault is experienced to avoid damage and for the safety of the workers. Computer based relays monitor the machine and disconnect it during the faults. The relay logic used to identify these faults requires sophisticated signal processing techniques …

Natural Transformation Of Thermotoga Sp. Strain Rq7, Dongmei Han, Hui Xu, Rutika Puranik, Zhaohui Xu

Biological Sciences Faculty Publications

Background

Thermotoga species are organisms of enormous interest from a biotechnological as well as evolutionary point of view. Genetic modifications of Thermotoga spp. are often desired in order to fully release their multifarious potentials. Effective transformation of recombinant DNA into these bacteria constitutes a critical step of such efforts. This study aims to establish natural competency in Thermotoga spp. and to provide a convenient method to transform these organisms.

Results

Foreign DNA was found to be relatively stable in the supernatant of a Thermotoga culture for up to 6 hours. Adding donor DNA to T. sp. strain RQ7 at its …

What’S Love Got To Do With Lawyers? Thoughts On Relationality, Love, And Lawyers’ Work, Eli Wald, Russell G. Pearce

Faculty Scholarship

In a new and provocative book, Rob Vischer has challenged the neutral partisan conception of the lawyer and the legal profession’s reductive presumption that all clients wish to pursue atomistic self-interest irrespective of the consequences to others. Vischer’s use of the teachings of Martin Luther King, Jr. and of Christian theology as a foundation for an alternative, and richly relational, account of law practice is both inspiring and effective.

To debunk the presumption that clients seek narrow self-interest, which the book argues is a powerful component of the neutral partisan conception, Vischer compellingly asserts that clients are relational beings often …

Shadow Work In Support Of The Adult Developmental Journey, Robin Gregory Mclaughlin

Educational Studies Dissertations

In his book, In over our heads: the mental demands of modern life, Kegan (1994) has suggested that the average level of adults’ thinking is more complex today than at previous times in history. This is due, in part, to our increased lifespans, which have enabled complex thinking to evolve and emerge. However, Kegan has also suggested that the demands of the social environment are expanding much faster than the average complexity of adult thinking and learning. In Kegan’s terms, we are “in over our heads.” Using a semi-clinical, semi-structured, qualitative interview with twenty adult learners, this study investigated the …

Mechanomyographic Parameter Extraction Methods: An Appraisal For Clinical Applications, Morufu Olusola Ibitoye, Nur Azah Hamzaid, Jorge M. Zuniga, Nazirah Hasnan, Ahmad Khairi Abdul Wahab

Journal Articles

The research conducted in the last three decades has collectively demonstrated that the skeletal muscle performance can be alternatively assessed by mechanomyographic signal (MMG) parameters. Indices of muscle performance, not limited to force, power, work, endurance and the related physiological processes underlying muscle activities during contraction have been evaluated in the light of the signal features. As a non-stationary signal that reflects several distinctive patterns of muscle actions, the illustrations obtained from the literature support the reliability of MMG in the analysis of muscles under voluntary and stimulus evoked contractions. An appraisal of the standard practice including the measurement theories …

Novel Tuberculostatic Agents Suitable For Treatment Of Mycobacterium Tuberculosis Infections Of The Central Nervous System, Ronald Bartzatt, Preeti Sule, Suat L.G. Cirillo, Jeffrey D. Cirillo

Chemistry Faculty Publications

Aims: To demonstrate the efficacy of five small molecule compounds for inhibiting the growth of Mycobacterium tuberculosis. To present evidence that these compounds will penetrate into the central nervous system.

Study Design: Five small molecule compounds bearing a hydrazide group were synthesized utilizing microwave excitation. These compounds were then placed into tissue culture with Mycobacterium tuberculosis at various concentrations for evaluation of bacterial growth inhibition.

Place and Duration of Study: The compounds to be tested were prepared at the University of Nebraska Chemistry Department August 2013. The evaluation of antibacterial activity was determined at the Texas A&M Health Science …

Identifying Aging-Related Genes In Mouse Hippocampus Using Gateway Nodes, Kathryn Dempsey Cooper, Hesham Ali

Interdisciplinary Informatics Faculty Publications

Background: High-throughput studies continue to produce volumes of metadata representing valuable sources of information to better guide biological research. With a stronger focus on data generation, analysis models that can readily identify actual signals have not received the same level of attention. This is due in part to high levels of noise and data heterogeneity, along with a lack of sophisticated algorithms for mining useful information. Networks have emerged as a powerful tool for modeling high-throughput data because they are capable of representing not only individual biological elements but also different types of relationships en masse. Moreover, well-established graph …

Completions 2014-2015, Uno Office Of Institutional Effectiveness

IPEDS Completions

IPEDS Completions annual report contains the following information:

• Number of awards conferred by program, by level, and by race/ethnicity and gender of recipient
• Number of completers, separately by race/ethnicity, gender, age and level of award