Digital Commons Network^™

Design And Synthesis Of Pyrimidine Fused Heterocycles As Single Agents With Combination Chemotherapy Potential, Roheeth Pavana

Electronic Theses and Dissertations

This dissertation describes the design, synthesis and biological evaluation of pyrimidine fused heterocycles as single agents with combination chemotherapy potential. Major limitations of cancer chemotherapy include dose limiting toxicities of clinically used agents and the development of multidrug resistance by the tumor. Agents that interfere with microtubules are important antitumor agents. Tumor angiogenic mechanisms that are vital for tumor growth and metastasis are targeted by antiangiogenic agents. Antiangiogenic agents are usually not tumoricidal but are mainly cytostatic. Combination chemotherapy with antiangiogenic and cytotoxic agents have shown significant promise and several studies with such combinations are in progress in the clinic. …

The Coordination Chemistry Of Dithione Ligands: Design, Syntheses, Characterization And Reactivity Study Of Molybdenum And Select First Row Transition Metal Complexes, Benjamin Mogesa

Electronic Theses and Dissertations

The coordination chemistry of dithiolene complexes has attracted enormous interest by inorganic chemists due to their presence in biological systems and possible applications in material science. Dithiolene units have been identified at the active site of metalloenzymes, containing molybdenum and tungsten. Model complexes have played a significant role in understanding the structural and reactivity of the active site of these enzymes.

In Chapter 2, we report the synthesis of a series of molybdenum complexes, MoIVO(p-SC6H4X)2(R2Dt0), where R = iPr or Me and X = H, Cl, CF3, Me, OMe and tBu, to serve as model complexes for the active site …

Dopamine Transporter (Dat), Nicotinic Acetylcholine Receptor (Nachr), And Metabotropic Glutamate Receptor 2 (Mglu2) Irreversible Probes For Identifying Anti-Psychostimulant Therapeutics, Shaili Aggarwal

Electronic Theses and Dissertations

Numerous in vitro and in vivo studies implicate that certain ligands that interact with DAT, nAChRs, and mGlu2 have tremendous potential as anti-addiction therapeutics. However, understanding how these promising anti-addiction compounds interact with their major drug targets at the molecular level is limited because of the absence of human DAT, nAChRs, and mGlu2 x-ray crystal structures. This knowledge gap is important towards rationally designing new therapeutics for psychostimulant abuse and addiction. The objective of this research was to develop irreversible chemical probes based on promising anti-addiction lead compounds (i.e., pyrovalerone, bupropion, BINA, etc) to map their binding sites and poses …

Graduate Students' Perception Of Curriculum-Based Efficacy Of The Acquisition Of Multicultural Counseling Skills, Demond Ethridge Bledsoe

Electronic Theses and Dissertations

The United States is undergoing a period in which the demographics of the population are shifting drastically. The profession of counseling is tasked with providing services to diverse groups of clients, many of whom may have experienced racism, prejudice, and oppression as a result of their cultural or ethnic identity. Literature suggests that cultural and ethnic minority clients have poorer outcomes than their majority counterparts, and a significant factor in gaining positive treatment outcomes is the multicultural skill development in the clinician; however, little research focusing on effective delivery methods for multicultural skill development in counselor trainees has been conducted. …

Dopamine Transporter (Dat) And Metabotropic Glutamate Receptor 5 (Mglu5) Irreversible Probes For Identifying Anti-Psychostimulant Therapeutics, Ranganadh Velagaleti

Electronic Theses and Dissertations

Numerous behavioral studies indicate that dopamine transporter (DAT) inhibitors and metabotropic glutamate receptor 5 (mGlu5) negative allosteric modulators (NAMs) possess promising anti-addiction therapeutic properties. However, the lack of human DAT (hDAT) and mGlu5 X-ray crystal structures makes it difficult to understand how these promising anti-addiction compounds interact with their major drug targets at the molecular level. This knowledge gap represents an important problem towards rationally designing new therapeutics for numerous addiction disorders. The objective of this research was to develop irreversible chemical probes based on select DAT inhibitors and mGlu5 NAMs in order to map the corresponding binding sites and …

Factors Influencing Nurses' Intentions To Provide Weight Management Education To Hospitalized Obese Adults, Milissa Volino

Electronic Theses and Dissertations

Obesity is a sensitive, global health problem that impacts individuals of all ages and places individuals at risk for various chronic health problems. Nurses caring for hospitalized obese clients are in a prime position to provide them with timely information on weight management. This study utilized an exploratory sequential mixed method design to examine medical-surgical nurses' intentions to provide weight management education to hospitalized obese adults and the factors that influence nurses' intentions.

In phase 1, a focus group interview guide and nurse demographic form (NDF) were developed. Focus groups were conducted and analysis resulted in the creation of 15 …

The Race For Privilege In Blackness: Transformative Leadership In Traversing Space In Search Of Black Queer Cool, Tiffany Wilkins

Electronic Theses and Dissertations

This portraiture project, incorporating auto-ethnographic elements, investigating how African American educational systems became systems of oppression faced by lesbian, gay, bisexual, transgender and questioning (LGBTQ) youth of color, intentionally blends artist in creative glance with researcher in systemic inquiry and knowledge gathering (Lawrence-Lightfoot & Hoffman-Davis, 1997; Ellis et al., 2011).

An aspiring African American, gender non-conforming, lesbian leader is an auto-ethnographic portraiture exemplar: a counter-narrative of transcending obstacles overshadowing accessing college, graduate school, career success in education; doctoral ambitions with audacity within classes of pervasive racism, heterosexism and homophobia. Parallel instances of critical confrontations in predominantly Black secondary schools and …

Moving To A New Paradigm: A Reflection On Ethics, Sara Bajor '15

Richard T. Schellhase Essay Prize in Ethics

No abstract provided.

Marx Wartofsky, Tom Leddy

Faculty Publications

Marx W. Wartofsky was born in Brooklyn and received his bachelor’s, master’s, and doctoral degrees at Columbia University. He was a professor at Boston University (where he taught for twenty-six years) and then at Baruch College and the Graduate Center of the City University of New York. He was long-time editor of the Philosophical Forum, which he founded in 1970. He also co-founded with Robert Cohen the Boston University Center for Philosophy and History of Science in 1960. He wrote three books: Conceptual Foundations of Scientific Thought (1968), Feuerbach (1977), and Models: Representation and the Scientific Understanding (1979), the last …

The Effect Of Multiple Single Nucleotide Polymorphisms In The Folic Acid Pathway Genes On Homocysteine Metabolism, Shuang Liang, Yuanpeng Zhou, Huijun Wang, Yanyan Qian, Duan Ma, Weidong Tian, Vishwani Persaud-Sharma, Chen Yu, Yunyun Ren, Shufeng Zhou, Xiaotian Li

Pharmacy Faculty Publications

Objective. To investigate the joint effects of the single nucleotide polymorphisms (SNPs) of genes in the folic acid pathway on homocysteine (Hcy) metabolism. Methods. Four hundred women with normal pregnancies were enrolled in this study. SNPs were identified by MassARRAY. Serum folic acid and Hcy concentration were measured. Analysis of variance (ANOVA) and support vector machine (SVM) regressions were used to analyze the joint effects of SNPs on the Hcy level. Results. SNPs of MTHFR (rs1801133 and rs3733965) were significantly associated with maternal serum Hcy level. In the different genotypes of MTHFR (rs1801133), SNPs of RFC1 (rs1051266), …

Sequential Activation Of Elk-1/Egr-1/Gadd45Α By Arsenic, Qiwen Shi, Vijaykumar Sutariya, Anupam Bishayee, Deepak Bhatia

Pharmacy Faculty Publications

Long-term exposure to arsenic, an environmental contaminant, leads to increased risks of cancers. In the present study, we investigated the sequential regulation of Elk-1 and Egr-1 on As3+-induced GADD45α, an effector of G2/M checkpoint. We found that As3+ transcriptionally induced both Elk-1 and Egr-1, and NF-κB binding site was necessary for As3+-induced Egr-1 promoter activity. However, specific inhibition of JNK, ERK, and Elk-1 inhibited Egr-1 induction. Furthermore, silencing of Egr-1 downregulated As3+-induced expression of GADD45α and ChIP assay confirmed the direct binding of Egr-1 to GADD45α promoter. Taken together, our data indicated that the increase of GADD45α in response to …

Mir-382 Inhibits Tumor Growth And Enhance Chemosensitivity In Osteosarcoma, Meng Xu, Hua Jin, Cheng-Xiong Xu, Bo Sun, Zhi Mao, Wen-Zhi Bi, Yan Wang

Pharmacy Faculty Publications

Dysregulation of miRNAs is involved in osteosarcoma (OS). Here, we demonstrate that miR-382 is decreased in specimens of OS patients with a poor chemoresponse compared to those with a good chemoresponse. In addition, our clinical data show that decreased miR-382 was associated with poor survival in OS patients. Overexpression of miR-382 inhibited cell growth and chemoresistance by targeting KLF12 and HIPK3, respectively. In contrast, inhibition of miR-382 or overexpression of target genes stimulated OS cell growth and chemoresistance both in vitro and in vivo. Taken together, these findings suggest that miR-382 is a tumor suppressor miRNA and induction of …

Multiscale Design Of Cell-Type–Specific Pharmacokinetic/Pharmacodynamic Models For Personalized Medicine: Application To Temozolomide In Brain Tumors, A. Ballesta, Q. Zhou, X. Zhang, H. Lv, J. M. Gallo

Pharmacy Faculty Publications

Optimizing anticancer therapeutics needs to account for variable drug responses in heterogeneous cell populations within the tumor as well as in organs of toxicity. To address cell heterogeneity, we propose a multiscale modeling approach—from in vitro to preclinical and clinical studies—to develop cell-type–specific pharmacokinetic–pharmacodynamic (PK-PD) models. A physiologically based mechanistic modeling approach integrating data from aqueous solutions, U87 glioma cells, mice, and cancer patients was utilized to characterize the brain disposition of temozolomide (TMZ), the cornerstone of chemotherapy against glioblastoma multiforme. The final model represented intracellular normal brain and brain tumor compartments in which TMZ pH-dependent conversion to the DNA-alkylating …

Assessing The Impact Of Parental Depressive Symptoms On Offspring Temperament And Development In Infancy, Nancy Huynh, Jackie Finik, Jenny Ly, Yoko Nomura

Publications and Research

The study prospectively followed 135 women during their pregnancy and their offspring till 6 months of age, to examine the roles of maternal and paternal depression during pregnancy on offspring neurobehavioral development as measured by their early temperament. Maternal and paternal depression statuses were ascertained during the third trimester, and infant temperament was evaluated at 6 months, via mothers self-report. Multivariable general linear model was used to assess 1) the main effects of maternal and paternal depression on infant temperament and 2) the interaction effect between maternal and paternal depression on infant temperament. Results show that maternal depression, but not …

Brief Of Digital Humanities And Law Scholars As Amici Curiae In Support Of Defendant-Appellees And Affirmance, (The Authors Guild, Inc., Et Al., V. Google, Inc., Et Al.), Matthew L. Jockers, Matthew Sag, Jason Schultz

Copyright, Fair Use, Scholarly Communication, etc.

Amici are over 150 professors and scholars who teach, write, and research in computer science, the digital humanities, linguistics or law, and two associations that represent Digital Humanities scholars generally.2 Amici have an interest in this case because of its potential impact on their ability to discover and understand, through automated means, the data in and relationships among textual works. Legal Scholar Amici also have an interest in the sound development of intellectual property law. Resolution of the legal issue of copying for non-expressive uses has far-reaching implications for the scope of copyright protection, a subject germane to Amici’s professional …

Decision Making In The Picu: An Examination Of Factors Influencing Participation Decisions In Phase Iii Randomized Clinical Trials, Laura E. Slosky, Marilyn Stern, Natasha L. Burke, Laura A. Siminoff

Psychology Faculty Publications

Background. In stressful situations, decision making processes related to informed consent may be compromised. Given the profound levels of distress that surrogates of children in pediatric intensive care units (PICU) experience, it is important to understand what factors may be influencing the decision making process beyond the informed consent. The purpose of this study was to evaluate the role of clinician influence and other factors on decision making regarding participation in a randomized clinical trial (RCT). Method. Participants were 76 children under sedation in a PICU and their surrogate decision makers. Measures included the Post Decision Clinician Survey, …

Faculty Development 2013-2014 Final Year End Report, Faculty Development Committee

Faculty Development Committee (Inactive)

No abstract provided.

General Education Survey Of Graduating Seniors: Trends 2002-2013, University Of Minnesota, Morris Institutional Research

Assessment of Student Learning Reports

No abstract provided.

Assessment Report On Academic Programs And General Education, Assessment Of Student Learning Committee

Assessment of Student Learning Reports

No abstract provided.

Biology Discipline Assessment Plan 2014-2017, Biology Discipline

Assessment of Student Learning Reports

No abstract provided.

Undergraduate Symposium Abstracts

Journal of the Minnesota Academy of Science

No abstract provided.

Human Disturbance Of Snowy Plovers (Charadrius Nivosus) In Northwest Florida During The Breeding Season, Jonathan B. Cohen, Maureen M. Durkin, Margo Zdravkovic

Florida Field Naturalist

No abstract provided.

Status And Distribution Of Egyptian Geese (Alopochen Aegyptiaca) In Southeastern Florida, Bill Pranty, Valeri Ponzo

Florida Field Naturalist

No abstract provided.

Florida Burrowing Owl (Athene Cunicularia Floridana) Preys On Eurasian Collared-Dove (Streptopelia Decaocto), Ronald R. Bielefeld

Florida Field Naturalist

No abstract provided.

Front Cover, Florida Field Naturalist

Florida Field Naturalist

No abstract provided.

First Report Of Common Merganser (Mergus Merganser) For Cuba And The Greater Antilles, Alain Parada Isada, Odey Martínez Llanes, Lance J. Degnan

Florida Field Naturalist

No abstract provided.

Twenty-Second Report Of The Florida Ornithological Society Records Committee: 2012, Jon S. Greenlaw

Florida Field Naturalist

No abstract provided.

Front Cover, Florida Field Naturalist

Florida Field Naturalist

No abstract provided.

In The Urban Arena, Kim Hill, Danielle Kamp '15

Illinois Wesleyan University Magazine, 2002-2017

In bringing a new equestrian facility to the inner-city high school where she teaches, Maggie Kendall's lifelong love of horses gallops full circle.

University Of Texas Health Science Center At Tyler Catalog, 2014 - 2016, University Of Texas Health Science Center At Tyler

Catalogs

No abstract provided.