Digital Commons Network^™

Solubility Enhancement Via Melt Extrusion: Drug-Polymer Solubility, Physicochemical Characterization And Quality By Design, Ketaki Patwardhan

Electronic Theses and Dissertations

Many new drugs developed face oral delivery challenges and absorption due to poor biopharmaceutical properties. Formation of solid dispersions is a very widely applied technique for solubility enhancement of water insoluble drugs. In order to form stable solid dispersions it is important to select appropriate excipients that will maintain the drug in its amorphous form for an extended period of time. Selection of appropriate excipients is critical during the development of stable amorphous solid dispersions. The solubility parameter concept has been explored for theoretically identifying the excipients that will be suitable based on the structure of the active. In this …

Understanding How White Allies In The Struggle Against Racism Unveil And Deconstruct Whiteness, Kim N. Sexton-Lewter

Dissertations

Despite claims of a post-racial society, racism is still alive and well in America and whiteness remains invisible or unseen (Delgado & Stefanic, 2012). To a great extent the invisibility of whiteness serves to preserve and perpetuate racism in our society (Wildman, 2005). Efforts to eradicate racism need to shift from focusing on people of color to the task of unveiling and calling out whiteness. Doing away with norms that traditionally benefit White people and disenfranchise people of color could prove productive in combatting socio-cultural patterns and conditions that maintain White privilege and racial inequalities (Peterson & Hamrick, 2009). This …

2014 - 2015 Undergraduate Catalog, Armstrong State University

Armstrong Office of the Registrar: Undergraduate Catalogs (Archived)

Academic catalog for Armstrong State University.

Manage Research Workflows With Open Science Framework And Digital Commons, Data Management Services, Zach S. Henderson Library

University Libraries: Instructional Resources (Archived)

Presentation slides on using Open Science Framework and Digital Commons for research data.

Expanding Understanding Of Public Policy As A Complex And Pluri-Disciplinary System: Illustrating Possibilities Of Epistemic Pluralism, Cynthia Cors

Theses and Dissertations

Science, and especially the social sciences, has developed as distinct territories, each with its own vocabulary and language-game (Wittgenstein, 1945/1958). Yet understanding and explaining science as a complex and pluri-disciplinary system has important practitioner-oriented as well as research-oriented and other benefits, benefits that can be enhanced through the use of cloud-based technologies. Understanding and explaining public policy in particular as complex can inform and transform the way problems are approached. This is particularly important for an action subject like public policy and administration that can be considered as having been influenced by many disciplines. Public administration (PA) through multiple perspectives, …

Evaluation Of Upper Extremity Movement Characteristics During Standardized Pediatric Functional Assessment With A Kinect®-Based Markerless Motion Analysis System, Jacob R. Rammer, Joseph J. Krzak, Susan A. Riedel, Gerald F. Harris

Biomedical Engineering Faculty Research and Publications

A recently developed and evaluated upper extremity (UE) markerless motion analysis system based on the Microsoft® Kinect® has potential for improving functional assessment of patients with hemiplegic cerebral palsy. 12 typically-developing adolescents ages 12-17 were evaluated using both the Kinect-based system and the Shriners Hospitals for Children Upper Extremity Evaluation (SHUEE), a validated measure of UE motion. The study established population means of UE kinematic parameters for each activity. Statistical correlation analysis was used to identify key kinematic metrics used to develop automatic scoring algorithms. The Kinect motion analysis platform is technically sound and can be applied to standardized task-based …

Arabidopsis Msl10 Has A Regulated Cell Death Signaling Activity That Is Separable From Its Mechanosensitive Ion Channel Activity, Kira M. Veley, Grigory Maksaev, Elizabeth M. Frick, Emma January, Sarah C. Kloepper, Elizabeth S. Haswell

Biology Faculty Research

Members of the MscS superfamily of mechanosensitive ion channels function as osmotic safety valves, releasing osmolytes under increased membrane tension. MscS homologs exhibit diverse topology and domain structure, and it has been proposed that the more complex members of the family might have novel regulatory mechanisms or molecular functions. Here, we present a study of MscS-Like (MSL)10 from Arabidopsis thaliana that supports these ideas. High-level expression of MSL10-GFP in Arabidopsis induced small stature, hydrogen peroxide accumulation, ectopic cell death, and reactive oxygen species- and cell death-associated gene expression. Phosphomimetic mutations in the MSL10 N-terminal domain prevented these phenotypes. The phosphorylation …

Origins Of The Classical Gene Concept, 1900–1950: Genetics, Mechanistic, Philosophy, And The Capitalization Of Agriculture, Garland E. Allen

Biology Faculty Research

In the period of “classical genetics” (roughly 1915–1950), the common view of the gene was mechanistic—that is, genes were seen as individual, atomistic units, as material components of the chromosomes. Although it was recognized early on that genes could interact and influence each other’s expression, they were still regarded as individually functioning units, much like the chemists’ atoms or molecules. Although geneticists in particular knew the story was more complex, the atomistic gene remained the central view for a variety of reasons. It fit the growing philosophy of mechanistic materialism in the life sciences, as biologists tried to make their …

Simultaneous Robotic Manipulation And Functional Magnetic Resonance Imaging: Feasibility In Children With Autism Spectrum Disorders, Nicole M.G. Salowitz, Bridget Dolan, Rheanna Remmel, Amy V. Van Hecke, Kristine M. Mosier, Lucia Simo, Robert A. Scheidt

Biomedical Engineering Faculty Research and Publications

An unanswered question concerning the neural basis of autism spectrum disorders (ASD) is how sensorimotor deficits in individuals with ASD are related to abnormalities of brain function. We previously described a robotic joystick and video game system that allows us to record functional magnetic resonance images (FMRI) while adult humans make goal-directed wrist motions. We anticipated several challenges in extending this approach to studying goal-directed behaviors in children with ASD and in typically developing (TYP) children. In particular we were concerned that children with autism may express increased levels of anxiety as compared to typically developing children due to the …

Submovements During Reaching Movements After Stroke, Lucia S. Simo, Davide Piovesan, Jozsef Laczko, Claude Ghez, Robert A. Scheidt

Biomedical Engineering Faculty Research and Publications

Neurological deficits after cerebrovascular accidents very frequently disrupt the kinematics of voluntary movements with the consequent impact in daily life activities. Robotic methodologies enable the quantitative characterization of specific control deficits needed to understand the basis of functional impairments and to design effective rehabilitation therapies. In a group of right handed chronic stroke survivors (SS) with right side hemiparesis, intact proprioception, and differing levels of motor impairment, we used a robotic manipulandum to study right arm function during discrete point-to-point reaching movements and reciprocal out-and-back movements to visual targets. We compared these movements with those of neurologically intact individuals (NI). …

Age-Related Differentiation Of Sensorimotor Control Strategies During Pursuit And Compensatory Tracking, Megan L. Heenan, Robert A. Scheidt, Scott A. Beardsley

Biomedical Engineering Faculty Research and Publications

Motor control deficits during aging have been well-documented. Various causes of neuromotor decline, including both peripheral and central neurological deficits, have been hypothesized. Here, we use a model of closed-loop sensorimotor control to examine the functional causes of motor control deficits during aging. We recruited 14 subjects aged 19-61 years old to participate in a study in which they performed single-joint compensatory and pursuit tracking tasks with their dominant hand. We found that visual response delay and visual noise increased with age, while reliance on visual feedback, especially during compensatory tracking decreased. Increases in visual noise were also positively correlated …

The Arm Motion (Amd) Detection Test, Maria C. Bengston, Leigh A. Mrotek, Tina M. Stoeckmann, Claude Ghez, Robert A. Scheidt

Biomedical Engineering Faculty Research and Publications

Stroke can lead to sensory deficits that impair functional control of arm movements. Here we describe a simple test of arm motion detection (AMD) that provides an objective, quantitative measure of movement perception related proprioceptive capabilities in the arm. Seven stroke survivors and thirteen neurologically intact control subjects performed the AMD test. In a series of ten trials that took less than 15 minutes to complete, participants used a two-button user interface to adjust the magnitude of hand displacements produced by a horizontal planar robot until the motions were just perceptible (i.e. on the threshold of detection). The standard deviation …

A Modular Low-Clearance Wrist Orthosis For Improving Wrist Motion In Children With Cerebral Palsy, Devon Holley, Michelle Johnson, Gerald F. Harris, Scott A. Beardsley

Biomedical Engineering Faculty Research and Publications

Children with Cerebral Palsy (CP) often exhibit impairments in the coordination of the grip and lift phases of arm movements that directly impact their ability to perform activities of daily living (ADLs). The application of assistive robotic therapy to children with spastic hemiplegic CP has shown that augmented movement training can lead to improved functional outcomes and improved arm kinematics. Assistive robotic therapy of the wrist has been shown to help improve motor skills in stroke patients, but the devices employed are often large and obtrusive, focusing on a repeated motion rather than a task-based itinerary. Here, we propose a …

Evaluation Of Ceramic Coaxial Cable Sensors For Long-Term In-Situ Monitoring Of Geologic Co₂ Injection And Storage, Yurong Li

Masters Theses

"Monitoring is an essential component of CO₂ injection and storage projects in order to manage the injection process, identify leakage risks, provide early failure warnings, determine the movement of CO₂ plume and provide input into reservoir models. In-situ monitoring provides critical and direct data points that can be used to fulfill the above objectives. However, downhole sensors that can withstand the harsh conditions and run over decades of the project life cycle remain unavailable. A new idea of ceramic coaxial cable temperature, pressure and strain sensor has recently been put forward and the sensors are under development.

A high pressure …

Workplace Sleepiness: Causes, Consequences And Countermeasures, Neda Khalafi

Masters Theses

"Sleep deprivation is an epidemic problem in our society that adversely affects the quality and safety of our daily lives. At home and on the job, inadequate sleep is associated with considerable social, financial, and health-related costs, due to instability of waking functions. Research has shown that, sleep deprivation among workers, whether from sleep disorders, lifestyle or shift work, can hinder the proper performance, and in extreme cases may pose hazard to the workers themselves and their environment. Deficits in daytime performance can have profound effects in the processing industry where workers are often required to perform monotonous tasks that …

Gold-Magnetite Nanoparticle-Biomolecule Conjugates: Synthesis, Properties And Toxicity Studies, Akshay Pariti

Masters Theses

"This thesis study focuses on synthesizing and characterizing gold-magnetite optically active magnetic nanoparticle and its conjugation with biomolecules for biomedical applications, especially magnetic fluid hyperthermia treatment for cancerous tissue. Gold nanoparticles have already displayed their potential in the biomedical field. They exhibit excellent optical properties and possess strong surface chemistry which renders them suitable for various biomolecule attachments. Studies have showed gold nanoparticles to be a perfect biocompatible vector. However, clinical trials for gold mediated drug delivery and treatment studied in rat models identified some problems. Of these problems, the low retention time in bloodstream and inability to maneuver externally …

Microwave Assisted Reconstruction Of Optical Interferograms For Distributed Fiber Optics Sensing & Characterization Of Pcb Dielectric Properties Using Two Striplines On The Same Board, Lei Hua

Masters Theses

"A new concept, the microwave-assisted reconstruction of an optical interferogram for distributed sensing, was developed to resolve both the position and reflectivity of each sensor along an optical fiber. This approach involves sending a microwave-modulated optical signal through cascaded fiber optic interferometers. The optical spectrum of each sensor can be reconstructed by sweeping the optical wavelength and detecting the modulation signal. A series of cascaded fiber optic extrinsic Fabry-Perot interferometric sensors was used to prove the concept. The microwave-reconstructed interferogram matched well with those recorded individually from a traditional optical spectrometer. The application of distributed strain measurement was also investigated. …

Experimental Investigation Of The Pebble Bed Structure By Using Gamma Ray Tomography, Fadha Shakir Ahmed

Masters Theses

"Pebble Bed Reactors offer a future for new nuclear energy plants. They are small, inherently safe, and can be competitive with fossil fuels. The fuel forms a randomly stacked pebble with non-uniform fuel densities. The thermal-mechanical behavior of pebble bed reactor core is depends strongly on the spatial variation of packing fraction in the bed and in particular on the number of contacts between pebbles, and between the pebbles and the blanket walls. To investigate these effects, experimental data to characterize bed structure are needed along with other numerical simulation and computational tools for validation.

In this study, a powerful …

Ecology Of A Declining Great Plains Fish, Fundulus Sciadicus, In The Missouri Ozarks, Gregory Travis Thompson

Masters Theses

"Anthropogenic habitat disturbances are of growing concern due to their impacts on native biota, especially in freshwater ecosystems. Damming, channelization, urbanization, wetland draining, and non-native fish introductions all play large roles in habitat homogeneity, fragmentation, and species competition. This has negative effects on native fish and invertebrate species. In the Midwestern United States, the plains topminnow (Fundulus sciadicus) has been declining across its range, to the point of becoming a species of special concern in Missouri. This is possibly due to a combination of the above anthropogenic habitat disturbances. To better understand the ecology of the plains topminnow …

Simultaneous Robotic Manipulation And Functional Magnetic Resonance Imaging: Feasibility In Children With Autism Spectrum Disorders, Nicole Marie Gregor Salowitz, Bridget K. Dolan, Rheanna Remmel, Amy V. Van Hecke, Kristine M. Mosier, Lucia S. Simo, Robert A. Scheidt

Biomedical Engineering Faculty Research and Publications

An unanswered question concerning the neural basis of autism spectrum disorders (ASD) is how sensorimotor deficits in individuals with ASD are related to abnormalities of brain function. We previously described a robotic joystick and video game system that allows us to record functional magnetic resonance images (FMRI) while adult humans make goal- directed wrist motions. We anticipated several challenges in extending this approach to studying goal-directed behaviors in children with ASD and in typically developing (TYP) children. In particular we were concerned that children with autism may express increased levels of anxiety as compared to typically developing children due to …

Streaming Computations With Precise Control, Peng Li, Kunal Agrawal, Jeremy Buhler, Roger Chamberlain

All Computer Science and Engineering Research

No abstract provided.

Understanding The Times: A Causal/Comparative Study Of The Effectiveness Of A Christian Worldview Curriculum In Helping Students Develop A Christian Worldview, Donald Barrows

Doctoral Dissertations and Projects

Christian educators are concerned about the development of a Christian worldview in their students. They also desire that their students maintain that worldview after graduation. In this study, the author attempts to determine the effectiveness of the Understanding the Times Christian worldview curriculum in helping students develop a Christian worldview. To do this, a causal/comparative research design was used as participants took a worldview test to determine the extent to which their worldviews compared with biblical teachings. The researcher sampled a random sample of Christian high school graduates who have taken the yearlong Understanding the Times Christian worldview course at …

The Perceptions Of Caucasian Female Elementary Teachers And The Overrepresentation Of African-American Males In Special Education, Thomas Seaberry

Doctoral Dissertations and Projects

There is a disproportionate amount of African-American males in special education programs. Several factors have been offered by researchers as to why this phenomenon continues to be a problem throughout the county. The purpose of this study was to understand how Caucasian female teachers' perceptions of African-American male students might influence their overrepresentation in special education. This qualitative study employed an ethnographic case study method, and relied primarily on a pilot study and teacher interviews to obtain data related to this phenomenon. Using this research design, the researcher established six themes related to the research phenomenon: (1) cultural discontinuity between …

Exploring Intrinsic Value Of Educating Military Planners In Design Thinking: A Case Study, John Mangold

Doctoral Dissertations and Projects

The purpose of this qualitative single instrumental, exploratory, theory-building, holistic researcher case study was to explore a novel approach to military transformation; a prototype of a problem solving methodology that accounts for an inescapable reality in the current and future operational environment: complexity and uncertainty. Design thinking was used as an essential component supporting a theoretical framework to explore the process of solving complex, ill-structured problems. Fifteen participants from a senior U.S. military service college were studied using observations, interviews, and site documents. The data analyzed used the systematic, analytic procedures of Stake (1995, 2008) and Merriam, (1998, 2009) whereby …

Women In Science 2014, Clark Science Center's Summer Research Fellows Program

SURF Abstracts (Women in Science)

Women in Science 2014 summarizes research done by Smith College’s Summer Research Fellowship (SURF) Program participants. Ever since its 1967 start, SURF has been a cornerstone of Smith’s science education. In 2014, 150 students participated in SURF (141 hosted on campus and nearby eld sites), supervised by 61 faculty mentor-advisors drawn from the Clark Science Center and connected to its eighteen science, mathematics, and engineering departments and programs and associated centers and units. At summer’s end, SURF participants were asked to summarize their research experiences for this publication.

Clarissa's Suffering: Theorizing Sympathy And Physical Pain In The Eighteenth Century, Audrey Hungerpiller

Theses and Dissertations

This thesis examines theories of pain in the eighteenth century, and what it meant to sympathize with the pain of another. I begin briefly with the theories of Descartes and his adherents before focusing on David Hartley and John Locke. Physicians and natural philosophers of the period understood pain as a pure mechanism of the nervous system, confined to the tubelike fibers that run through the body. Naturally everyone feels pain by some means, whether illness or injury, so men ought to be able to sympathize with the afflictions of others. Yet, according to Adam Smith in The Theory of …

Phenotypes And Variants In Cases Submitted For X-Linked Intellectual Disability (Xlid) Gene Panel Testing, Michael J. Friez

Theses and Dissertations

Intellectual disability (ID) refers to reduced cognitive function, apparent before the age of 18, that negatively affects a person's learning and adaptive capacity. Approximately 1-3% of the population is affected with ID, males more than females, and most in the mild-to-moderate range. ID creates financial, logistical and psychosocial challenges for affected persons and their families and caregivers. It is estimated that up to 50% of ID has a genetic cause. Molecular genetic diagnosis may help in obtaining services and has important implications for family members, but can be elusive. Genes causing ID are known to be over-represented on the X …

The Effects Of Aeration On Phytoplankton Community Composition And Primary Production In Stormwater Detention Ponds Near Myrtle Beach, Sc, Lauren Hehman

Theses and Dissertations

Stormwater detention ponds are a common approach to managing stormwater runoff in coastal South Carolina. While effective at preventing flooding, they can be sites of intense phytoplankton blooms that result from excess nutrients inputs. This can lead to water quality degradation within ponds from oxygen depletion, fish kills, health concerns from harmful algal blooms (HABs), and water quality deterioration in adjacent coastal waters when pond discharges. The most common management practice to rid the ponds of excess phytoplankton biomass is the addition of copper-based algaecides. While temporarily effective, these algaecides require regular re-application and lead to artificial cycles of productivity …

The Comparative Effectiveness Of Group Prenatal Care On Women's Psychosocial Health, Emily Heberlein

Theses and Dissertations

Background: High rates of adverse birth outcomes persist in the United States despite increased access to individual prenatal care (IPNC). Psychosocial factors influence birth outcomes and affect infant and child development and maternal functioning. Group prenatal care (GPNC) combines individual physical assessments and facilitated group education and support. Studies of GPNC show promising results, including lowered preterm birth rates, but the GPNC psychosocial mechanisms influencing birth outcomes are unclear.

Methods: Surveys at study enrollment (N=248), late pregnancy, and six weeks postpartum assessed psychosocial effects of each PNC model. Multiple regression models and planned moderator analyses tested whether GPNC participants had …

Anthropogenic Ecological Impacts Of 17th And 18th Century Chickasaw Through A Study Of Faunal Remains, Marybeth Harte

Theses and Dissertations

A diachronic analysis of five faunal assemblages from Chickasaw sites is carried out to evaluate their anthropogenic ecological impacts during the colonial time period (A.D. 1650-1750). Change in faunal exploitation, diversity measures and disturbance taxa frequencies are analyzed to gauge these impacts. A comparison with late Mississippian period faunal use provides a benchmark to examine how shifts in the cultural system initiated new ecological impacts. Results from the faunal analysis are also compared with reports of faunal utilization and landscape management practices in the historical record. These reports provide a basis for assessing change in prey preferences according to the …