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Pre-Service Teachers’ Use Of Visualizations In The Science Classroom: A Case Study, Brooke A. Whitworth, Jennifer L. Chiu

Publications

Scientific visualizations of phenomena can enhance the way learners understand scientific concepts (Honey & Hilton, 2011). Scientific concepts can be abstract and difficult for students to understand and visualizations can help make these abstract concepts more concrete for students. For example, chemistry students often struggle with understanding how atoms bond since they cannot directly see atoms. Using a visualization to show students how the electrons are shared or transferred can help students understand these abstract concepts. In addition, many visualizations are freely available online and can be a key element to maintain quality science instruction with limited resources.

Fda Involvement In Off-Label Use: Debate Between Richard Epstein And Ryan Abbott, Richard A. Epstein, Ryan Abbott

Faculty Articles

Before a drug can be sold legally in the United States, the Food and Drug Administration (FDA) must approve it as safe and effective for a particular indication or use — the use then appears on the drug's label. Federal law, however, allows doctors to prescribe drugs that the FDA has approved for one indication for any other indication, even though the FDA never evaluated the safety or efficacy of the drug for that use. Off-label prescribing is an integral part of modern-day medicine. Patients may benefit when they receive drugs or devices in contexts not approved by the FDA. …

Quantifying Regulatory Benefits, Richard L. Revesz

Faculty Articles

This Essay makes three principal claims. First, it shows that breakeven analysis is a useful technique for adding structure to costbenefit analysis when a regulatory benefit has not been quantified. In particular, breakeven analysis can sometimes address the judicial hostility to using nonquantified benefits as trumps. But it is a secondbest approach because actually quantifying the benefit can provide far more useful information to the regulatory process. Second, the Essay argues that the categories of “quantifiable” and “nonquantifiable” benefits are not immutable. “Unquantifiable” benefits are simply benefits that have not yet been quantified. Over the last few decades, important categories …

Cura Personalis: A Healthcare Delivery Quandary At The End Of Life, George P. Smith Ii

Saint Louis University Journal of Health Law & Policy

Holistic Medicine traces its provenance to the foundational value or chrism of the Society of Jesus of cura personalis which directs respect be given to all individuals and to their souls — especially whenever medical healing is required. Today, the notion of best patient care should include not merely attention to somatic issues of refractory pain management but, equally, to non-somatic or existential suffering. It is at the end-stage of life that palliative — as opposed to curative — care must be provided. When a condition is seen as medically futile, this Article advocates palliative or deep sedation — when …

The Inclusion Of Pregnant Women In Clinical Research, Barbara A. Noah

Saint Louis University Journal of Health Law & Policy

In the past three decades, there has been unprecedented growth in medical research utilizing human subjects, with much promise for new treatments that extend life, improve quality of life, and prevent disease and disability. Safe prescribing of drug therapies requires that researchers design clinical trials to test products for the benefit of all persons who are likely to utilize them, not just a limited population. For this reason, it is essential that clinical trials include women, pregnant women, children, and racial minorities, as appropriate, because these populations sometimes exhibit different patterns of response or adverse reactions.

Despite some significant progress …

Patient Registries: Patient Consent When Children Become Adults, Leslie P. Francis

Saint Louis University Journal of Health Law & Policy

No abstract provided.

Mobile Medical App Regulation: Preventing A Pandemic Of “Mobilechondriacs”, Nathaniel R. Carroll

Saint Louis University Journal of Health Law & Policy

No abstract provided.

Selections On The Empirical And Theoretical Investigations Of Behavioral Variability: An Introduction To The Special Issue, W. David Stahlman, Aaron P. Blaisdell

Psychological Science Articles

The study of behavioral variability continues to grow in importance and gather interest. A thorough understanding of the fundamental processes by which variation is generated and by which it is adaptive is potentially important to our understandings of a whole host of phenomena, including all types of learning, from basic skills to language and thought (Bateson & Martin, 2013) as well as the antifragility of complex systems (Taleb, 2012). This issue represents a brief look into an important scientific enterprise, extraordinarily vast in scope and implications (Brembs, 2010). Even if we accept a fundamental unpredictability to animal behavior, this does …

2013-2014 Faculty Senate Annual Report, University Of South Carolina

Faculty Senate

The primary file includes the 2013-2014 Athletic Advisory Committee Annual Report. Additional annual reports are attached.

Epidemiology Of Malaria In A Village In The Rufiji River Delta, Tanzania: Declining Transmission Over 25 Years Revealed By Different Parasitological Metrics, Anna Färnert, Victor Yman, Manijeh Vafa Homann, Grace Wandell, Leah Mhoja, Marita Johansson, Salome Jesaja, Johanna Sandlund, Kazuyuki Tanabe, Ulf Hammar, Matteo Bottai, Zul Premji, Anders Björkman, Ingegerd Rooth

Pathology, East Africa

Background: Assessments of the epidemiology of malaria over time are needed to understand changes in transmission and guide control and elimination strategies.

Methods: A longitudinal population study was established in 1985 in Nyamisati village in the Rufiji River Delta, Tanzania. A physician and research team lived in the village 1984–2000. Parasite prevalence by microscopy and two PCR methods, spleen rates and haemoglobin levels were measured in repeated cross-sectional surveys between 1985 and 2010. Passive surveillance of malaria cases was maintained until end 1999. Bed nets were distributed after the surveys 1993, 1999 and 2010.

Results: In 1985, overall parasite prevalence …

Uchunguzi (Journal Watch/Montre De Journal) April 2014, Benjamin Wachira

Family Medicine, East Africa

Content: If you want to know how we practised medicine 5 years ago, read a textbook. If you want to know how we practised medicine 2 years ago, read a journal. If you want to know how we practise medicine now, go to a (good) conference. If you want to know how we will practise medicine in the future, listen in the hallways and use FOAM (Joe Lex, 2012). FOAM is free, open-access medical education. As stated in the Hippocratic Oath: “…and to teach them this art – if they desire to learn it – without fee and covenant”, the …

Exposure To Multiple Parasites Is Associated With The Prevalence Of Active Convulsive Epilepsy In Sub-Saharan Africa, Gathoni Kamuyu, Christian Bottomley, James Mageto, Brett Lowe, Patricia Wilkins, John C. Noh, Thomas B. Nutman, Anthony Ngugi, Rachael Odhiambo, Ryan Wagner, Angelina Kakooza-Mwesige, Seth Owusu-Agyei, Kenneth Ae-Ngibise, Honorati Masanja, Faith Osier, Peter Odermatt, Charles Newton

Family Medicine, East Africa

Background: Epilepsy is common in developing countries, and it is often associated with parasitic infections. We investigated the relationship between exposure to parasitic infections, particularly multiple infections and active convulsive epilepsy (ACE), in five sites across sub-Saharan Africa.

Methods and Findings: A case-control design that matched on age and location was used. Blood samples were collected from 986 prevalent cases and 1,313 age-matched community controls and tested for presence of antibodies to Onchocerca volvulus, Toxocara canis, Toxoplasma gondii, Plasmodium falciparum, Taenia solium and HIV. Exposure (seropositivity) to Onchocerca volvulus (OR = 1.98; 95%CI: 1.52-2.58, p

Conclusion: This study investigates how …

18fdg Synthesis And Supply: A Journey From Existing Centralized To Future Decentralized Models, Maseeh Uz Zaman, Nosheen Fatima, Zafar Sajjad, Unaiza Zaman, Rabia Tahseen, Areeba Zaman

Department of Radiology

Positron emission tomography (PET) as the functional component of current hybrid imaging (like PET/ CT or PET/MRI) seems to dominate the horizon of medical imaging in coming decades. 18Flourodeoxyglucose (18FDG) is the most commonly used probe in oncology and also in cardiology and neurology around the globe. However, the major capital cost and exorbitant running expenditure of low to medium energy cyclotrons (about 20 MeV) and radiochemistry units are the seminal reasons of low number of cyclotrons but mushroom growth pattern of PET scanners. This fact and longer half-life of 18F (110 minutes) have paved the path of a centralized …

Strategies For Overcoming Common Obstacles In The Online Environment: Issues In Virtual School Teaching, Michael K. Barbour, Kelly L. Unger

Education Faculty Publications

K-12 online learning or virtual schooling has seen substantial growth in the United States over the past two decades. While the practice of virtual schooling has exploded, the availability of research-based best practices to guide teachers working in these environments is lacking. This chapter presents four cases from Michigan Virtual School (MVS) teachers that examine a variety of issues that virtual school teachers face when facilitating K-12 student learning in the online environment, including strategies to provide substantive feedback in English Language Arts, methods for addressing the demonstration of mathematical computations, using Web 2.0 tools to increase interaction in an …

Folk Food Webs And The Role Of Praxis In Substantive Ecological Knowledge, Yancey Orr, Brian Hallmark

Environmental Science and Policy: Faculty Publications

In the second half of the 20th century, investigations of indigenous environmental knowledge have been the subject of broader anthropological debates over how knowledge and experience are formed. Many such approaches have focused on environmental nomenclature and taxonomy, or what Roy Ellen has called "formal lexical knowledge" (1999). Such knowledge is readily available to an ethnographer and also more easily transmitted through language between subjects. These characteristics of formal lexical knowledge have led to considerable attention given to differences in environmental knowledge between cultures and have possibly resulted in the inflation of the efficacy of language in forming knowledge. However, …

Disturbed Waters – A Montana Chemist Searches For The Source Of A Persistent Poison, Kindra Mcquillan

Graduate Student Theses, Dissertations, & Professional Papers

In December 2008, when Montana's great Clark Fork River tested its historic banks for the first time in 100 years, a crowd of hundreds gathered to watch the removal of Milltown Dam at the confluence of the river with the Big Blackfoot. After a century of pollution from Butte's copper mines, the river was undergoing the nation's largest­yet restoration project, the Upper Clark Fork River Superfund Complex.

But in a windowless laboratory a mile away, University of Montana chemist Heiko Langner had troubling news. Toxic methylmercury flowed through the river at concentrations of concern, undetected and undermining the project. It …

Effects Of Road-Stream Crossings On Populations Of The Idaho Giant Salamander (Dicamptodon Aterrimus), Richard K. Honeycutt

Graduate Student Theses, Dissertations, & Professional Papers

Habitat disturbances affect wildlife populations through numerous mechanisms, and determining specific components of habitat disturbances affecting those populations is challenging. For example, a single disturbance can both change local habitat conditions and impose limitations on dispersal of animals. Both of these components can negatively affect biological responses, such as body condition, local movement patterns, or survival. Culverts are a habitat disturbance having both of these components. Culverts affect local habitat conditions by increasing sediment levels in downstream reaches, negatively affecting animals downstream of culverts. Culverts also impose limits on dispersal by blocking passage of stream organisms to upstream reaches, negatively …

An Environmental Toxic Model Of Parkinson's Disease: The Fruit Fly, Jennene Lyda

Graduate Student Theses, Dissertations, & Professional Papers

Parkinson’s disease (PD) is the second most common neurodegenerative disorder with no known specific cause; although genetic risk factors and/or environmental exposure are thought to be involved. The etiology of PD is currently unknown, although the combination of non-genetic components such as environmental exposures, the accumulation of exposure, and gene-environment interactions are thought to play a major role. However, despite this knowledge it is important to develop better models that parallel PD pathophysiology to further understand the mechanisms underlying dopaminergic neuron (DaN) damage. The use of mammalian models to study the degenerative processes in PD has been the most common …

Proactive Management Of Pneumonia Epizootics In Bighorn Sheep In Montana, Sarah N. Sells

Graduate Student Theses, Dissertations, & Professional Papers

Pneumonia epizootics are a major challenge for management of bighorn sheep (Ovis canadensis), often causing high mortality and subsequent long-term impacts that may continue for decades. There have been at least 22 epizootics in herds in Montana from 1979‒2013, including 1 that led to a herd’s extirpation, several that appear to be affecting herds up to 3 decades later, and 11 in the last 6 years. The disease is complex and associated risk factors are poorly understood. A lack of tools to help predict and proactively manage risk of pneumonia epizootics in attempt to prevent die-offs has led …

Lowveld Practices In Mahenye, Zimbabwe: A Critical Analysis Of Resilience In A Marginalized Southern African Community, Scott Byington

Graduate Student Theses, Dissertations, & Professional Papers

The concept of resilience has been developed by scholars in the social-ecological systems resilience and community resilience/disaster literature. While initially a descriptive model, the framework of resilience has since integrated both literatures and become a prescriptive tool for sustainable development initiatives. Political ecologists critically argue that the current conceptualization of resilience is problematic given resilience scholars’ lack of engagement with situational social complexities related to power and knowledge. They also argue that mainstream resilience literature is devoid of cultural, historical and political analysis. As such, individuals and communities at the margins of power may vulnerable to the application of resilience …

When The Sap Flows: Affection And Industry In The Maple Woods, Nicholas R. Littman

Graduate Student Theses, Dissertations, & Professional Papers

This thesis arises from my time waiting for, collecting, and boiling sap from maple trees into syrup. I spent four months in the Adirondack Mountains of upstate New York working for a modern commercial sugaring operation and sugaring in the old-fashioned manner—with buckets and a wood-fired evaporator.

The narrative follows my journey as a lifelong Westerner traveling east to learn an old tradition with my hands. Instead of observing how the warmth of a changing climate was affecting maple sugaring, I was thrust into a landscape defined by cold, during one of the coldest winters on record in the Northeast. …

The Effects Of Intimate Relationship Education On University Students' Attachment Security, Meredith Hood

Graduate Student Theses, Dissertations, & Professional Papers

For several decades, a variety of interventions have been utilized in an effort to improve the likelihood that individuals will attain a stable and satisfying marriage. Historically, these interventions have taken place when individuals are already partnered and challenging relationship dynamics are already established. More recently, however, many relationship experts have established a more proactive approach to prevent marital decline. Adults with secure attachment feel comfortable with closeness and interdependence in relationships. Similarly, they believe they are worthy of love and see others as trustworthy and dependable. In contrast, adults with insecure attachment tend to struggle more in close relationships. …

The Impacts Of Removing Wildfire On Pinus Ponderosa Resistance Against Dendroctonus Ponderosae, Sharon Metzger Hood

Graduate Student Theses, Dissertations, & Professional Papers

Disturbance and disturbance interactions drive multiple ecosystem processes over multiple spatial and temporal scales. I studied the role of frequent, low-severity fire in Pinus ponderosa (ponderosa pine) forests in altering the success of the irruptive insect Dendroctonus ponderosae (mountain pine beetle (MPB)). I had three overarching research questions: (1) What are the best predictors of ponderosa pine resin flow, a trait related to MPB attack success, and how do these predictors relate to tree growth?; (2) Are predictors of resin flow also predictors of MPB attack success and are they affected by changes to wildfire disturbance regimes?; (3) How do …

The Synthesis And Study Of Heterocyclic, Dimeric And Chiral Ligands For The Multidrug-Resistance Transporter, Scott Steiger

Graduate Student Theses, Dissertations, & Professional Papers

The development of multidrug resistance in tumor cells has been recognized as a major obstacle to successful cancer treatment. Tumor cells in vitro and in vivo can develop multidrug resistance (MDR) to the lethal effects of the cytotoxic drugs used to treat them, with about 40% of cancers going on to develop MDR. There are multiple factors that lead to MDR but the factor that we will be exploring in this dissertation is the expression of multiple drug resistance gene 1 and the over expression of multi drug resistance protein 1(MDR1, also known as P-glycoprotein or P-gp). MDR1 has also …

Stigma Perceptions Of Adolescents With Emotional And/Or Behavioral Difficulties, Camille Barraclough

Graduate Student Theses, Dissertations, & Professional Papers

The current study sought to better understand how adolescents with serious mental health problems participating in inpatient psychiatric treatment experience self- and perceived public stigma, using demographic and clinical factors to help further explain adolescents' experience of self- and perceived public stigma. Participants reported moderate levels of both self- and perceived public stigma, though these adolescents did not report significantly higher levels of self- or perceived public stigma than community/outpatient based samples. Although neither the three demographic nor three clinical factors were able to account for a significant amount of reported self- or perceived public stigma, the current research examined …

Dielectric Characterization Of Coastal Cartilage Chondrocytes, Michael W. Stacey, Ahmet C. Sabuncu, Ali Beskok

Bioelectrics Publications

BACKGROUND: Chondrocytes respond to biomechanical and bioelectrochemical stimuli by secreting appropriate extracellular matrix proteins that enable the tissue to withstand the large forces it experiences. Although biomechanical aspects of cartilage are well described, little is known of the bioelectrochemical responses. The focus of this study is to identify bioelectrical characteristics of human costal cartilage cells using dielectric spectroscopy.

METHODS: Dielectric spectroscopy allows non-invasive probing of biological cells. An in house computer program is developed to extract dielectric properties of human costal cartilage cells from raw cell suspension impedance data measured by a microfluidic device. The dielectric properties of chondrocytes are …

Characterization Of Rift Valley Fever Virus Nucleocapsid Protein-Rna Binding Interactions And Development Of A High-Throughput Screening Assay For Identification Of N-Rna Binding Inhibitors, Mary Lee Ellenbecker

Graduate Student Theses, Dissertations, & Professional Papers

Rift Valley fever virus (RVFV) is an emerging infectious pathogen that causes severe disease in humans and livestock and has the potential for global spread. Currently, there is no treatment for RVFV infection and there is no proven safe and effective vaccine. Inhibition of RNA binding to RVFV nucleocapsid (N) protein represents an innovative antiviral therapeutic strategy because several essential steps in the RVFV replication cycle involve N binding to viral RNA. The overall goals of our research are to better understand how RVFV N protein interacts with RNA, to develop a high-throughput drug screening assay for identification of compounds …

Glutamate Transporter Modulation Of Ambient And Synaptic Glutamate Levels, Weinan Sun

Graduate Student Theses, Dissertations, & Professional Papers

Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system. An accurate spatial and temporal glutamate concentration profile during signaling is crucial for reliable neural computation. In these studies, we investigated the roles of glutamate transporters in controlling both ambient glutamate levels and dynamic glutamate concentrations profiles during synaptic transmission. Using the Xenopus oocyte expression system, we demonstrated that glutamate transporters act as an effective sink and are capable of maintaining >200 fold glutamate concentration gradient between the bath and cell surface when expressed at levels corresponding to physiological transporter densities in the CNS. We also characterized the …

The Development And Study Of Surface Bound Ruthenium Organometallic Complexes, Geoffrey Reuben Abbott

Graduate Student Theses, Dissertations, & Professional Papers

The focus of this project has been on the use of mono-diimine ruthenium organometallic complexes, of the general structure [H(Ru)(CO)(L)2(L’)2][PF6] (L=PPh3, DPPENE and L’=Bpy, DcBpy, MBpyC, Phen, AminoPhen) bound to surfaces as luminescent probes. Both biological and inorganic/organic hybrid surfaces have been studied. The complexes were characterized both bound and unbound using standard analytical techniques such as NMR, IR and X-ray crystallography, as well as through several photophysical methods as well.

Initially the study focused on how the photophyscial properties of the complexes were affected by incorporation into biological membranes. It was found that by conjugating the probes to a …

The Identity Of Upholding Indigenous Lifeways, Sean Falcon Chandler

Graduate Student Theses, Dissertations, & Professional Papers

This qualitative study examined the role of Native Lifeways in tribal colleges as perceived by their presidents and other influential leaders on the campuses of three tribal colleges. Tribal colleges were founded in part to support and promote Native Lifeways, as demonstrated within their respective mission statements. Given the fact that TCUs are at the forefront of the defense of Native Lifeways, they continue to be in a state of endangerment as a result of the history of U.S. Indian Policy.

Data was acquired from the face-to-face interviews of 15 leaders within the three tribal colleges located in northwest United …