Digital Commons Network^™

Group Behavior Among Model Bacteria Influences Particulate Carbon Remineralization Depths, K. A. S. Mislan, Charles A. Stock, John P. Dunne, Jorge L. Sarmiento

Journal of Marine Research

Organic particles sinking from the sunlit surface are oases of food for heterotrophic bacteria living in the deep ocean. Particle-attached bacteria need to solubilize particles, so they produce exoenzymes that cleave bonds to make molecules small enough to be transported through bacterial cell walls. Releasing exoenzymes, which have an energetic cost, to the external environment is risky because there is no guarantee that products of exoenzyme activity, called hydrolysate, will diffuse to the particle-attached bacterium that produced the exoenzymes. Strategies used by particle-attached bacteria to counteract diffusive losses of exoenzymes and hydrolysate are investigated in a water column model. We …

Simple Models For The Heat Flux From The Atlantic Meridional Overturning Cell To The Atmosphere, M. Behl, D. Nof, S. Van Gorder

Journal of Marine Research

It has been suggested that a slowdown of the Atlantic meridional overturning cell (AMOC) would cause the Northern Hemisphere to cool by a few degrees. We use a sequence of simple analytical models to show that due to the nonlinearity of the system, the simplified heat flux from the modeled AMOC to the atmosphere above is so robust that even changes of as much as 50% in the present AMOC transport are not enough to significantly change the temperature of the outgoing warmed atmosphere (i.e., the fraction of the atmosphere warmed by the AMOC). Our most realistic model (which is …

Stephen H. Webb, Jesus Christ, Eternal God: Heavenly Flesh And The Metaphysics Of Matter, Reviewed By Adam S. Miller

Mormon Studies Review

No abstract provided.

The Rising Incidence Of Small Endocrine Cancers In The United States: Effects On Surgical Therapy In An Age Of Imaging, Eric Kuo

Yale Medicine Thesis Digital Library

The increasing utilization of imaging technology has led to the diagnosis of cancers earlier in their clinical course. When small tumor size is coupled with relatively indolent histology, excellent oncologic outcomes require the risks of surgery to be carefully considered. However, characteristics and outcomes of small cancers of the thyroid and endocrine pancreas remain poorly defined, and evidence to guide their management is sparse.

Patients with tall cell (mTCV) and diffuse sclerosing (mDSV) variants of papillary thyroid microcarcinoma (mPTC), follicular (mFTC) and Hurthle cell microcarcinoma (mHCC), parathyroid carcinoma (PC) and pancreatic neuroendocrine tumors (PNETs) ≤ 2 cm in size were …

An Overview Of The Evidence For Tuberculosis From Ancient Egypt, Lisa Sabbahy Dr.

Faculty Book Chapters

The study of human remains from ancient Egypt and Nubia has captured the imagination of many people for generations, giving rise to the discipline of palaeopathology and fostering bioarchaeological research. This book contains 16 papers that cover material presented at a workshop entitled 'Palaeopathology in Egypt and Nubia: A Century in Review,' held at the Natural History Museum, London (August 29-30, 2012), which formed part of a three-year research project, 'Sir Grafton Elliot Smith: Palaeopathology and the Archaeological Survey of Nubia.' The papers explore the subject of palaeopathology from its beginnings in the early 1900s through to current research themes …

Contributions To An Arthropod Inventory Of Santa Cruz Island, California, Ida Naughton, Michael S. Caterino, Cause Hanna, David Holway

Publications

Arthropods have been understudied on Santa Cruz Island, resulting in an incomplete understanding of these diverse and ecologically important members of island ecosystems. To enhance the current understanding of Santa Cruz Island biodiversity, we sampled arthropods in 2 native plant habitats: island scrub oak (Quercus pacifica) woodland and patches of island morning glory (Calystegia macrostegia ssp. macrostegia). We used 4 standardized sampling techniques to sample arthropods in 16 Q. pacifica woodland plots. We sampled arthropods associated with C. macrostegia by pan trapping within 1 m of blooming morning glory individuals. In total, we sampled over 18,000 …

An Analysis Of Arthropod Interceptions By Aphis-Ppq And Customs And Border Protection In Puerto Rico, David A. Jenkins, Russell F. Mizell, Skip Van Bloem, Stefanie Whitmire, Leyinska Wiscovitch, Crystal Zaleski, Ricardo Goenaga

Publications

USDA Animal Plant Health Inspection Service Plant Protection and Quarantine (APHIS-PPQ) and Customs and Border Protection (CBP) inspect traffic entering the United States for arthropods posing a threat to national agriculture or ecosystems. We analyzed interceptions made by these agencies in Puerto Rico and the U.S. Virgin Islands between October 2006 and December 2009 for patterns with regard to the frequency of interceptions, origins of interceptions, and the taxa intercepted. 6,952 arthropods were intercepted in freight or luggage entering Puerto Rico and the U.S. Virgin Islands from foreign countries and 9,840 arthropods were intercepted from freight or luggage leaving Puerto …

Ua68/1/3 Potter College Of Arts & Letters Dean, Assistant Deans, Committees Publications, Wku Archives

WKU Archives Collection Inventories

Publications created by the Potter College of Arts & Letters Dean, regarding the administration of Potter College.

Contact was a Potter College newsletter about funding opportunities, including grants, for faculty projects and research in the 1970s.

The Forum was a Potter College newsletter for faculty to share information about professional activities and discuss intellectual items of interest in the 1970s.

Potter College Potpourri was a newsletter for faculty, staff, and students that was available in print and online in the late 1990s. It included recent happenings, a frequently asked questions section, and brief departmental updates.

Arts & Letters is the …

Ua45 2014-2015 Four-Year Degree Paths, Wku Registrar

WKU Administration Documents

An addendum to the 2014-2015 Undergraduate Catalog

The purpose of the Four-Year Degree Path is to assist undergraduate students in determining a timeline for completion of their undergraduate degree program. Each path displayed within this website provides students with the anticipated order in which a degree would typically be completed in a timely fashion at Western Kentucky University.

The Degree Paths show appropriate timing and spacing of general education, core course requirements, elective suggestions, prerequisites and displays how each of these requirements may be met during a four-year time frame.

The Degree Path is simply a guideline and might not …

Do You Believe He Can Fly? Royce White And Reasonable Accommodations Under The Americans With Disabilities Act For Nba Players With Anxiety Disorder And Fear Of Flying, Michael Mccann

Law Faculty Scholarship

This Article examines the legal ramifications of Royce White, a basketball player with general anxiety disorder and obsessive compulsive disorder, playing in the NBA. White's conditions cause him to have a fear of flying, thus making it difficult to play in the NBA. This subject is without precedent in sports law and, because of the unique aspects of an NBA playing career, lacks clear analogy to other employment circumstances. This dispute also illuminates broader legal and policy issues in the relationship between employment and mental illness.

This Article argues that White would likely fail in a lawsuit against an NBA …

Volume 68 Issue 1 (Spring/Summer 2014)

Utah Science

2 Growing Risk for Alzheimer’s Alzheimer’s disease is more than just forgetfulness. It robs people of their abilities to think, remember, reason and control their behavior. A combination of genetic and environmental factors contributes to the disease’s development, but the process may begin decades before symptoms appear. Researchers are working to discover what those factors might be and how people might decrease their risk of developing the disease.

8 Measuring Quality in Baby Steps Each day thousands of children in Utah spend part of their day in the care of someone other than their parents. The quality of daycare affects …

Seattle Pacific University Catalog 2014-2015, Seattle Pacific University

Seattle Pacific Catalogs

No abstract provided.

Cascaded Plasmon Resonances For Enhanced Nonlinear Optical Response, Seyfollah Toroghi

Electronic Theses and Dissertations

The continued development of integrated photonic devices requires low-power, small volume all-optical modulators. The weak nonlinear optical response of conventional optical materials requires the use of high intensities and large interaction volumes in order to achieve significant light modulation, hindering the miniaturization of all-optical switches and the development of lightweight transmission optics with nonlinear optical response. These challenges may be addressed using plasmonic nanostructures due to their unique ability to confine and enhance electric fields in sub-wavelength volumes. The ultrafast nonlinear response of free electrons in such plasmonic structures and the fast thermal nonlinear optical response of metal nanoparticles, as …

Yale School Of Medicine Facts & Figures 2014-2015, Yale School Of Medicine Office Of Communications

Facts & Figures – annual Yale School of Medicine numbers

Provided by the Office of Communications, the Facts and Figures brochure is produced annually as a way to provide a snapshot of key facts and data related to the School of Medicine as well as the Medical Campus. This includes enrollment data, research activity, financial summaries, and more.

A Phenomenological Exploration Of Teacher Experiences In Creating And Teaching A Senior Year English Transition Course, Kimberly Kaye Parsons

Theses and Dissertations--Curriculum and Instruction

The purpose of this qualitative transcendental phenomenological study is to describe a particular phenomenon: the lived experiences of high school teachers who were responsible for creating and teaching a senior-year English Transition Course. Moustakas’ methods, framework and data analysis guidelines, coupled with interviews using Seidman’s three-interview process, is the best procedure for achieving the research aim. Thus, the study is based upon the results of interviews of 10 high school teachers from schools within a specific geographic region who collaborated with four English faculty members from a comprehensive four-year institution within the same region, over a period of three years. …

Frostpaw Addresses Global Warming, William Snape

PEEL Faculty Scholarship

Climate change impacts the law on many levels and in many ways. This Article asks a threshold question: what legal structures will most effectively reduce growing levels of anthropogenic greenhouse pollution? The answer is that an existing U.S. statute-the Clean Air Act-not only possesses clear commands to ratchet down greenhouse pollutants domestically, but also provides explicit authority to negotiate concomitant air pollution reduction with countries around the planet in a fair, transparent, and reciprocal fashion. Further, application of the Clean Air Act is consistent with other legal and policy tools to address global warming. This statute-based solution, while facially simple, …

“They Can Only Do So Much:” Use Of Family While Coping With Rural Homelessness, Deanna L. Trella, Timothy P. Hilton

Contemporary Rural Social Work Journal

This research explores individual and family reliance on non-homeless family members in coping with homelessness in a rural area. Drawing on 114 in-depth, semi-structured interviews with homeless adults and families in Michigan’s Upper Peninsula, we found that almost all participants relied on non-homeless family members for assistance, but with variation in the amount of help sought and received. Some participants displayed high thresholds for help-seeking, only relying on family under extreme circumstances and generally asking for modest assistance. This was common among childless single homeless adults who often had different support. Other participants displayed low thresholds for help-seeking, frequently asking …

Differences Between Children With Fetal Alcohol Spectrum Disorders And Attention Deficit Hyperactivity Disorders: Rural Social Work Implications For Prevention, Assessment, And Treatment, Susan M. Ryan, George S. Leibowitz, Jeanne M. Nauheimer, Paul Force-Emery Mackie

Contemporary Rural Social Work Journal

This literature review examined nine quantitative research studies published between 1992-2013 that compared children with Fetal Alcohol Spectrum Disorders (FASD) and Attention Deficit Hyperactivity Disorder (ADHD) to identify: (a) the differences between these children (e.g., intellectual, behavioral); and (b) the diagnostic tools that may be used to distinguish between them, thereby providing a differential diagnosis. Special focus was placed on rural treatment implications. These studies revealed differences between the intellectual, executive functioning, adaptive behavior, motor, and behavioral skills of children with FASD and ADHD. This review identified neurodevelopmental assessments used in these nine research studies that appear to support learning …

Iterative Ethical Discussion In Hybridized Practice Classes, Michelle Emery Blake Mssw, Ph.D., Mary Fran Davis

Contemporary Rural Social Work Journal

An increasing number of social work programs at both the bachelor’s and master’s levels utilize online or hybridized instruction, including practice courses. These courses may be of particular advantage to students in rural communities by minimizing commute times and making social work education more available. However, a concern is whether these venues allow essential content, such as the development of professional ethics, to be adequately addressed. This teaching note is based on the authors’ experiences with conducting online ethics discussions and provides suggestions for incorporating online scenarios that reflect practice dilemmas, which students must consider critically before responding to posted …

Using Phylogenetically-Informed Annotation (Pia) To Search For Light-Interacting Genes In Transcriptomes From Non-Model Organisms, Daniel I. Speiser, M. Sabrina Pankey, Alexander K. Zaharoff, Barbara A. Battelle, Heather D. Bracken-Grissom, Jesse W. Breinholt, Seth M. Bybee, Thomas W. Cronin, Anders Garm, Annie R. Lindgren, Nipam H. Patel, Megan L. Porter, Meredith E. Protas, Anja S. Rivera, Jeanne M. Serb, Kirk S. Zigler, Keith A. Crandall, Todd H. Oakley

Collected Faculty Scholarship

Background: Tools for high throughput sequencing and de novo assembly make the analysis of transcriptomes (i.e. the suite of genes expressed in a tissue) feasible for almost any organism. Yet a challenge for biologists is that it can be difficult to assign identities to gene sequences, especially from non-model organisms. Phylogenetic analyses are one useful method for assigning identities to these sequences, but such methods tend to be time-consuming because of the need to re-calculate trees for every gene of interest and each time a new data set is analyzed. In response, we employed existing tools for phylogenetic analysis to …

The Periodical Winter 2014, Southern Adventist University

the Periodical – Chemistry Department Newsletter

Volume 1, issue 1 of the Periodical includes articles about Rhonda Scott's time as chair of the department, faculty news, a pictorial directory of 2014 graduates, an alumni spotlight, and Chemistry Club news.

Comparison Of Tree Condition And Value For City Parks And Stephen F. Austin State University In Nacogdoches, Texas, U.S., David Kulhavy, Daniel Unger, I-Kuai Hung, Di Wu, Jianghua Sun

Faculty Publications

Trees in landscapes are valued for physical as well as aesthetic benefits and biodiversity. Trees on a university campus and in city parks also help to provide an environment in which students and visitors can study and relax. A critical decision facing urban foresters, arborists, and planners involves deciding when an existing tree should be removed and replaced; it is a decision often based on an evaluation of the tree’s health, condition, and safety concerns. This project surveyed a total of 3,335 trees with 79 species on the campus of Stephen F. Austin State University (Nacogdoches, Texas, U.S.) and 1,572 …

Computational Analysis Of Transcriptional Circuitries In Human Embryonic Stem Cells Reveals Multiple And Independent Networks, Xiaosheng Wang, Chittibabu Guda

Journal Articles: Genetics, Cell Biology & Anatomy

It has been known that three core transcription factors (TFs), NANOG, OCT4, and SOX2, collaborate to form a transcriptional circuitry to regulate pluripotency and self-renewal of human embryonic stem (ES) cells. Similarly, MYC also plays an important role in regulating pluripotency and self-renewal of human ES cells. However, the precise mechanism by which the transcriptional regulatory networks control the activity of ES cells remains unclear. In this study, we reanalyzed an extended core network, which includes the set of genes that are cobound by the three core TFs and additional TFs that also bind to these cobound genes. Our results …

Choline Kinase Beta Is Required For Normal Endochondral Bone Formation, Zhuo Li, Gengshu Wu, Roger B. Sher, Zohreh Khavandgar, Martin Hermansson, Gregory A. Cox, Michael R. Doschak, Monzur Murshed, Frank Beier, Dennis E. Vance

Paediatrics Publications

Background Choline kinase has three isoforms encoded by the genes Chka and Chkb. Inactivation of Chka in mice results in embryonic lethality, whereas Chkb-/- mice display neonatal forelimb bone deformations. Methods To understand the mechanisms underlying the bone deformations, we compared the biology and biochemistry of bone formation from embryonic to young adult wild-type (WT) and Chkb-/- mice. Results The deformations are specific to the radius and ulna during the late embryonic stage. The radius and ulna of Chkb-/- mice display expanded hypertrophic zones, unorganized proliferative columns in their growth plates, and delayed formation of primary ossification centers. The differentiation …

Neonatal Morbidity Associated With Late Preterm And Early Term Birth: The Roles Of Gestational Age And Biological Determinants Of Preterm Birth, Hilary K. Brown, Kathy Nixon Speechley, Jennifer Macnab, Renato Natale, M. Karen Campbell

Paediatrics Publications

Background: The aim of this study was to elucidate the role of gestational age in determining the risk of neonatal morbidity among infants born late preterm (34-36 weeks) and early term (37-38 weeks) compared with those born full term (39-41 weeks) by examining the contribution of gestational age within the context of biological determinants of preterm birth.Methods: This was a retrospective cohort study. The sample included singleton live births with no major congenital anomalies, delivered at 34-41 weeks of gestation to London-Middlesex (Canada) mothers in 2002-11. Data from a city-wide perinatal database were linked with discharge abstract data. Multivariable models …

A Retinoblastoma Allele That Is Mutated At Its Common E2f Interaction Site Inhibits Cell Proliferation In Gene-Targeted Mice, Matthew J. Cecchini, Michael J. Thwaites, Srikanth Talluri, James I. Macdonald, Daniel T. Passos, Jean Leon Chong, Paul Cantalupo, Paul M. Stafford, M. Teresa Sáenz-Robles, Sarah M. Francis, James M. Pipas, Gustavo Leone, Ian Welch, Frederick A. Dick

Paediatrics Publications

The retinoblastoma protein (pRB) is best known for regulating cell proliferation through E2F transcription factors. In this report, we investigate the properties of a targeted mutation that disrupts pRB interactions with the transactivation domain of E2Fs. Mice that carry this mutation endogenously (Rb1δG) are defective for pRB-dependent repression of E2F target genes. Except for an accelerated entry into S phase in response to serum stimulation, cell cycle regulation in Rb1δG/δG mouse embryonic fibroblasts (MEFs) strongly resembles that of the wild type. In a serum deprivation-induced cell cycle exit, Rb1δG/δG MEFs display a magnitude of E2F target gene derepression similar to …

Rac1 Signaling Is Critical To Cardiomyocyte Polarity And Embryonic Heart Development, Carmen Leung, Xiangru Lu, Murong Liu, Qingping Feng

Paediatrics Publications

Background-Defects in cardiac septation are the most common form of congenital heart disease, but the mechanisms underlying these defects are still poorly understood. The small GTPase Rac1 is implicated in planar cell polarity of epithelial cells in Drosophila; however, its role in mammalian cardiomyocyte polarity is not clear. We tested the hypothesis that Rac1 signaling in the second heart field regulates cardiomyocyte polarity, chamber septation, and right ventricle development during embryonic heart development. Methods and Results-Mice with second heart field-specific deficiency of Rac1 (Rac1SHF) exhibited ventricular and atrial septal defects, a thinner right ventricle myocardium, and a bifid cardiac apex. …

Adaptive Mechanisms Controlling Uterine Spiral Artery Remodeling During The Establishment Of Pregnancy, Michael J. Soares, Damayanti Chakraborty, Kaiyu Kubota, Stephen J. Renaud, M. A. Karim Rumi

Paediatrics Publications

Implantation of the embryo into the uterus triggers the initiation of hemochorial placentation. The hemochorial placenta facilitates the acquisition of maternal resources required for embryo/fetal growth. Uterine spiral arteries form the nutrient supply line for the placenta and fetus. This vascular conduit undergoes gestation stage-specific remodeling directed by maternal natural killer cells and embryo-derived invasive trophoblast lineages. The placentation site, including remodeling of the uterine spiral arteries, is shaped by environmental challenges. In this review, we discuss the cellular participants controlling pregnancy-dependent uterine spiral artery remodeling and mechanisms responsible for their development and function. © 2014 UBC Press.

An Unbiased Proteomic Screen Reveals Caspase Cleavage Is Positively And Negatively Regulated By Substrate Phosphorylation, Jacob P. Turowec, Stephanie A. Zukowski, James D.R. Knight, David M. Smalley, Lee M. Graves, Gary L. Johnson, Shawn S.C. Li, Gilles A. Lajoie

Paediatrics Publications

Post-translational modifications of proteins regulate diverse cellular functions, with mounting evidence suggesting that hierarchical cross-talk between distinct modifications may fine-tune cellular responses. For example, in apoptosis, caspases promote cell death via cleavage of key structural and enzymatic proteins that in some instances is inhibited by phosphorylation near the scissile bond. In this study, we systematically investigated how protein phosphorylation affects susceptibility to caspase cleavage using an N-terminomic strategy, namely, a modified terminal amino isotopic labeling of substrates (TAILS) workflow, to identify proteins for which caspase-catalyzed cleavage is modulated by phosphatase treatment. We validated the effects of phosphorylation on three of …

Linkage Analysis And Exome Sequencing Identify A Novel Mutation In Kctd7 In Patients With Progressive Myoclonus Epilepsy With Ataxia, Sali M.K. Farhan, Lisa M. Murphy, John F. Robinson, Jian Wang, Victoria M. Siu, C. Anthony Rupar, Asuri N. Prasad, Kym Boycott, Jan Friedman, Jacques Michaud, Francois Bernier, Michael Brudno, Bridget Fernandez, Bartha Knoppers, Mark Samuels, Steve Scherer, Robert A. Hegele

Paediatrics Publications

Epilepsy affects approximately 1% of the world's population. Genetic factors and acquired etiologies, as well as a range of environmental triggers, together contribute to epileptogenesis.Wehave identified a family with three daughters affected with progressive myoclonus epilepsy with ataxia. Clinical details of the onset and progression of the neurologic presentation, epileptic seizures, and the natural history of progression over a 10-year period are described. Using autozygosity genetic mapping, we identified a high likelihood homozygous region on chromosome 7p12.1-7q11.22. We subsequently applied whole-exome sequencing and employed a rare variant prioritization analysis within the homozygous region. We identified p.Tyr276Cys in the potassium channel …