Digital Commons Network^™

Effect Of Macromolecular Crowding On The Electrostatic Interaction Of Barnase-Barstar: Initial Steps Using An Explicit Solvent Model, Helena Qi

Honors Thesis Collection

No abstract provided.

Constructing Enantioselectivity Using Asymmetric Michael Additions, Elizabeth Mcloughlin

Honors Thesis Collection

No abstract provided.

Janus Devices For Gastrointestinal Drug Delivery, Young-Ah Lee

Honors Thesis Collection

No abstract provided.

An Intensive Examination Of Chloroplast Movement And Npq In Arabidopsis Thaliana Wild Type And Mutants Grown Under Different Light Conditions., Andrea Bae

Honors Thesis Collection

No abstract provided.

Monoclonal Antibody Targeted Delivery Of Boron Loaded Gold Nanoparticles To Pancreatic Cancer Cells For Boron Neutron Capture Therapy., Sara Martin

Honors Thesis Collection

No abstract provided.

The Role Of The Hedgehog Signaling Pathway In The Regulation Of Larval And Adult Appendage Patterning In The Flour Beetle, Tribolium Castaneum, Karin Darakananda

Honors Thesis Collection

No abstract provided.

Édouard Vuillard: Painting Disease And Infirmity In Fin-De-Siècle Paris, Michaela Haffner

Honors Thesis Collection

No abstract provided.

Distinguishing Proximal And Distal Sources Of Sandstone By Combining U-Pb Age, And Geochemical Signatures Of Detrital Zircon Populations: An Example From The Permian Brushy Canyon Formation, West Texas, Sarah George

Honors Thesis Collection

No abstract provided.

The Characterization Of The Interaction Between Phosphodiesterase 3a And Compound 1b, A Novel Selective Cytotoxic Agent, Lara Gechijian

Honors Thesis Collection

No abstract provided.

Haptic Interaction In 3d Stereoscopic User Interfaces, Heather Petrow

Honors Thesis Collection

Haptic feedback is an area of technology that utilizes the sense of touch, by providing tactile interaction. It has been integrated into gaming consoles and mobile devices, and has been researched for its potential in programs that range from medical training simulations to collaborative workspaces. 3D stereo display is another growing facet of technology that is reexamining the possibilities of the user experience. The zSpace system is a computing hardware platform that simulates realistic, holographic, 3D stereoscopic vision. Using this system, this research project aimed to study how haptic feedback can enhance the user interface and understanding of 3D virtual …

Evaluation Of Phosphodiesterase 3a As A Biomarker And Target For A Novel Cytotoxic Agent, Miryam Saad

Honors Thesis Collection

No abstract provided.

Investigating The Role Of Ventral Veins Lacking In The Endocrine Regulation Of Metamorphic Timing, Amy Ko

Honors Thesis Collection

No abstract provided.

Educating For Femininity? Reform Of Working And Middle Class Girls' Education In Victorian England, Daisy Dowdall

Honors Thesis Collection

Working and middle-class girls’ education underwent significant reform in Victorian England. These reforms have been widely studied, with scholars divided into two broad historiographical schools: one that emerged in the late 1970s and places emphasis on the theory behind the reform to argue that little changed, and one that developed around 1990 and focuses on tangible practical change to demonstrate that a transformation did indeed occur.

The purpose of this thesis is to bridge the gap between these two bodies of scholarship, examining the significance of girls’ educational reform from the subjective positions of some working-class and middle-class girls, as …

From Theory To Post-Theory And Beyond: Politics & Film, Ana Lomtadze

Honors Thesis Collection

This thesis explores film theory’s two modes of existence as conceptualized by Theorists and Post-Theorists. While the former sees film as primarily an ideological apparatus and the audience as its passive or resistant consumer, the latter regards film as an empirical object and conceptualizes spectators from a cognitivist standpoint. I engage critically with various texts from Theory and Post-Theory to ask larger metatheoretical questions about film theory’s ontological character. In particular, I reflect on its nature and function through two angles—film theory’s relationship with politics and engagement with individual films.

No Leper Left Behind: Kinship, Identity, And Modernity In An Indian Leprosy Colony, Heather M. Pearson

Honors Thesis Collection

No abstract provided.

Synthesis And Evaluation Of A Series Of Novel Isoprenylated Coumarins As Potential Anti-Pancreatic Cancer Agents, Katherine Eyring

Honors Thesis Collection

No abstract provided.

The Dark Matter Time Projection Chamber 4shooter Directional Dark Matter Detector: Calibration In A Surface Laboratory, James B.R. Battat, Cosmin Deaconu, Richard Eggleston, Peter Fisher, Pietro Giampa, Vincent Gregoric, Shawn Henderson, Igal Jaegle, Jay Lawhorn, Jeremy P. Lopez, Jocelyn Monroe, Gabriela Druitt, Kristen A. Recine, Adam Strandberg, Hidefumi Tomita, Sven Vahsen, Hermann Wellenstein

Faculty Research and Scholarship

The 4Shooter is a prototype dark matter detector built by the Dark Matter Time Projection Chamber (DMTPC) collaboration. The aim of the collaboration is to observe dark matter with directional sensitivity by measuring the recoil directions of nuclei struck by dark matter particles. The 4Shooter is a single time projection chamber containing CF₄ gas, with both optical (CCD and photomultiplier tube) and charge readout. This paper describes the 4Shooter and presents results from the commissioning of the detector in a surface laboratory.

The Pou Factor Ventral Veins Lacking/Drifter Directs The Timing Of Metamorphosis Through Ecdysteroid And Juvenile Hormone Signaling, Cece Cheng, Amy Ko, Leila Chaieb, Takashi Koyama, Prioty Sarwar, Christen K. Mirth, Wendy A. Smith, Yuichiro Suzuki

Faculty Research and Scholarship

Although endocrine changes are known to modulate the timing of major developmental transitions, the genetic mechanisms underlying these changes remain poorly understood. In insects, two developmental hormones, juvenile hormone (JH) and ecdysteroids, are coordinated with each other to induce developmental changes associated with metamorphosis. However, the regulation underlying the coordination of JH and ecdysteroid synthesis remains elusive. Here, we examined the function of a homolog of the vertebrate POU domain protein, Ventral veins lacking (Vvl)/Drifter, in regulating both of these hormonal pathways in the red flour beetle, Tribolium castaneum (Tenebrionidae). RNA interference-mediated silencing of vvlexpression led to both precocious …

Breaking Constraint: Axial Patterning In Trichechus (Mammalia: Sirenia), Emily A. Buchholtz, Kaisa L. Wayrynen, Iris W. Lin

Faculty Research and Scholarship

Meristic variation is often limited in serially homologous systems with high internal differentiation and high developmental modularity. The mammalian neck, an extreme example, has a fixed (at seven) count of diversely specialized segments. Imposition of the mammalian cervical constraint has been tentatively linked to the origin of the diaphragm, which is muscularized by cells that migrate from cervical somites during development. With six cervical vertebrae, the genus Trichechus (manatee) has apparently broken this constraint, although the mechanism of constraint escape is unknown. Hypotheses for the developmental origin of Trichechus cervical morphology include cervical rib 7 repatterning, a primaxial/abaxial patterning shift, …

Functionalizing Silica Coated Iron Oxide Nanoparticles For Imaging And Targeted Treatment Of Pancreatic Cancer, Raji Nagalla

Honors Thesis Collection

No abstract provided.

A Critique Of Postmodern Feminism: The Theoretical, Pedagogical, And Real-World Limitations Of Liberation From Essence Ideology, Marilynn Willey

Honors Thesis Collection

No abstract provided.

Preparation Of Analogs Of The Glp-1 Receptor Inverse Agonist, T-0632, Emily Wilson

Honors Thesis Collection

No abstract provided.

Altruism: A Natural Thought History Of An Idea, Caroline Golub

Honors Thesis Collection

This thesis explores the numerous definitions and ideas surrounding the term altruism, tracking it from its origins in sociology, to the ways in which it has been interpreted across disciplines.

Differentially Expressed Pr-A And Pr-B Are Co-Localized With Src-1 And Src-2 In The Female Mouse Hypothalamus, Sarah Finkelstein

Honors Thesis Collection

No abstract provided.

Investigation Of Reductive Amination In The Synthesis Of T-0632, Julie Kwon

Honors Thesis Collection

No abstract provided.

Wellesley Magazine Fall 2014, Wellesley College Alumnae Association

Wellesley Magazine (Alumnae Association)

Featured in this issue:

Wendy Posts It / by Sarah Ligon ’03

Blue on the Red Planet / by Lisa Scanlon Mogolov ’99

Rewriting the Book on Clapp Library / by Catherine O'Neill Grace

Wellesley Magazine Winter 2014, Wellesley College Alumnae Association

Wellesley Magazine (Alumnae Association)

Featured in this issue:

The Night That Changed Wellesley:

-- Up in Flames / by Lisa Scanlon Mogolov ’99

-- College Hall and Everything After / by Helen Lefkowitz Horowitz ’63

The Grand Experiment / by Sarah Ligon ’03

Chasing the Next Big Idea / by Melissa Ludtke ’73

Phenoxybenzamine Is Neuroprotective In A Rat Model Of Severe Traumatic Brain Injury, Thomas Rau, Aakriti Kothiwal, Annela Rova, Joseph F. Rhoderick, David J. Poulsen

Biomedical and Pharmaceutical Sciences Faculty Publications

Phenoxybenzamine (PBZ) is an FDA approved α-1 adrenergic receptor antagonist that is currently used to treat symptoms of pheochromocytoma. However, it has not been studied as a neuroprotective agent for traumatic brain injury (TBI). While screening neuroprotective candidates, we found that phenoxybenzamine reduced neuronal death in rat hippocampal slice cultures following exposure to oxygen glucose deprivation (OGD). Using this system, we found that phenoxybenzamine reduced neuronal death over a broad dose range (0.1 μM–1 mM) and provided efficacy when delivered up to 16 h post-OGD. We further tested phenoxybenzamine in the rat lateral fluid percussion model of TBI. When administered …

Progressive Education In Context, I-Iv, Bank Street School For Children

Progressive Education in Context

Contains current articles that highlight aspects of the educational vision, mission, and values of the Bank Street School for Children.

Cardiovascular Sonography Course Entering Class 2014-Tampa Regional Campus, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.