Digital Commons Network^™

Gambaran Sistem Penyelenggaraan Makanan Di Pondok Pesantren Hubulo Gorontalo, Sitti Aisyah Taqhi

Media Kesehatan Masyarakat Indonesia

Penyelenggaraan makanan adalah rangkaian kegiatan mulai dari perencanaan menu sampai dengan pendistribusian makanan kepada konsumen dalam rangka pencapaian status kesehatan yang optimal melalui pemberian makanan yang tepat dan termasuk kegiatan pencatatan, pelaporan, dan evaluasi. Penelitian ini bertujuan me-ngetahui gambaran sistem penyelenggaraan makanan di Pondok Pesantren Hubulo Gorontalo yang meliputi input, proses, dan output. Jenis penelitian yang digunakan adalah kualitatif dengan pendekatan deskriptif yang menggunakan data primer dan sekunder. Informan penelitian adalah pimpinan pondok pesantren, koordinator bagian keuangan, dan kepala dapur. Pengolahan dan analisis data menggunakan content analysis dan disajikan dalam bentuk teks naratif. Hasil penelitian diperoleh bahwa dari segi input …

Pola Makan Dengan Kadar Gula Darah Pasien Dm Tipe 2, Andi Mardhiyah Idris, Nurhaedar Jafar, Rahayu Indriasari

Media Kesehatan Masyarakat Indonesia

Pola makan yang salah dapat menyebabkan kenaikan kadar gula darah pada pasien diabetes mellitus tipe 2. Penelitian ini bertujuan mengetahui hubungan pola makan dengan kadar gula darah pasien diabetes mellitus tipe 2 di wilayah kerja puskesmas Kota Makassar. Desain penelitian yang digunakan adalah survei analitik dengan pendekatan studi cross-sectional, dilaksanakan pada bulan April-Mei 2014 di wilayah kerja Puskesmas Batua Raya dan Bara-barayya. Populasi penelitian, yaitu rata-rata jumlah pasien yang berkunjung perbulan di Puskesmas Batua Raya dan Bara-barayya, yaitu 67 orang. Pengambilan sampel dilakukan dengan menggunakan purposive sampling dengan jumlah sampel 46 orang. Instrumen penelitian adalah kuesioner identitas diri, food recall …

Evaluasi Pla (Participatory Learning And Action) Malaria, Nurwati Nurwati

Media Kesehatan Masyarakat Indonesia

Salah satu upaya yang dilakukan oleh Pemerintah Kabupaten Halmahera Selatan untuk mengendalikan malaria dengan melibatkan partisipasi masyarakat dengan pendekatan PLA (Participatory Learning and Action) yang merupakan kegiatan pembelajaran ke masyarakat untuk dapat mengambil tindakan dalam pengendalian malaria. Penelitian ini bertujuan mendapatkan informasi dalam mengevaluasi pelaksanaan Participatory Learning and Action malaria di Desa Bori Kecamatan Bacan Timur Kabupaten Halmahera Selatan. Penelitian ini adalah penelitian kualitatif dengan pendekatan fenomenologi. Informan penelitian terdiri dari 6 orang, yaitu pengelola malaria, kepala desa, kader malaria desa, petugas polindes dan tokoh masyarakat.Pengumpulan data dilakukan dengan cara wawancara mendalam dan observasi. Hasil penelitian ini menunjukkan bahwa fasilitasi …

Obesitas, Asupan Natrium Dan Kalium Terhadap Tekanan Darah, Fatimah Kautsar, Aminuddin Syam, Abdul Salam

Media Kesehatan Masyarakat Indonesia

Hipertensi adalah penyakit yang terjadi akibat peningkatan tekanan darah yang bisa menyebabkan berbagai komplikasi terhadap beberapa penyakit lain, bahkan penyebab timbulnya penyakit jantung, stroke, dan ginjal. Tujuan penelitian ini adalah mengetahui hubungan obesitas asupan natrium dan kalium dengan tekanan darah pada mahasiswa Universitas Hasanuddin angkatan 2013 dengan menggunakan desain cross sectional. Populasi dalam penelitian ini, yaitu mahasiswa Unhas dengan berat badan berlebih yang berjumlah 411 orang. Teknik pengambilan sampel menggunakan teknik purposive sampling. Hasil penelitian diperoleh 46,5% responden menderita hipertensi (tekanan darah tinggi). Hasil penelitian yang dilakukan terhadap obesitas (berdasarkan IMT) dengan tekanan darah diperoleh p=0,030. Hal ini menunjukkan ada …

Aeroponic/Hydroponic Growth Module, Sean Marrs, Joshua Moreno

Mechanical Engineering

No abstract provided.

Cal Poly India Project, Derek Babine, Austen Hibler, Alex Hernandez

Mechanical Engineering

This report documents the research, ideation, and development of a solution, implemented by the Cal Poly India Sanitation Team per the request of Mr. Harish Bhutani, to solve the problem of hazardous human waste management in poor villages in India. The sponsor envisioned a universal design that would give each household in those villages access to a private toilet system because the current solution is open defecation in water sources and farming fields. The initial constraints required the project be low cost, not use of electricity or water, have the ability to cater to an 8-10 person household, and be …

Temperature Controlled Packaging Container For Biologics And Pharmaceuticals, Melinda Phan, Yufay Chow-Yee, Abraham Ho

Mechanical Engineering

Clinical Supplies Management, Inc. (CSM) provides clinical trial services to biotechnology and pharmaceutical companies by shipping pharmaceuticals to clinics and other patients. In winter 2014, CSM presented a temperature control packaging project to the Cal Poly Senior Project class. As a result, three Cal Poly Mechanical Engineering Students were tasked to design, manufacture, and qualify a shipping container that would maintain ten 10 mL vials between 2-8°C for 96 hours. The final product would have to cost less to ship than the Credo Cube, CSM’s current temperature control packaging product. After considerable research and analysis on possible temperature control technologies, …

Fresh Bytes - Connected Hydroponics For Small-Scale Growing, Jack Bowen

Liberal Arts and Engineering Studies

Many users are now transitioning to small-scale hydroponics and aquaponics at home. There can be a barrier to entry with these systems as there is a delicate balance of chemicals, pH, etc. that must be maintained. There are sensors for these various components but they are either aimed at commercial production or are un-automated. Fresh Bytes is a microcomputer with sensors to detect all of these unseen components in a hydroponic system. A prototype of this microcomputer is produced along with CAD plans for more professional versions of it. The sensors are verified and future development is contemplated.

Compositing Brought To Life, Anika Morris

Liberal Arts and Engineering Studies

No abstract provided.

Aquaponics Art, Alexander Horton

Liberal Arts and Engineering Studies

Aquaponics has enormous potential to change the way we farm. I wanted to connect more people to Cal Poly's first aquaponics club by creating a functioning aquaponics art installation that allows people to plant their own plants. This paper is catalog of the design process as a reflection of what this project hopes to accomplish.

Intention Tremor And Deficits Of Sensory Feedback Control In Multiple Sclerosis: A Pilot Study, Megan Heenan, Robert A. Scheidt, Douglas Woo, Scott A. Beardsley

Biomedical Engineering Faculty Research and Publications

Background

Intention tremor and dysmetria are leading causes of upper extremity disability in Multiple Sclerosis (MS). The development of effective therapies to reduce tremor and dysmetria is hampered by insufficient understanding of how the distributed, multi-focal lesions associated with MS impact sensorimotor control in the brain. Here we describe a systems-level approach to characterizing sensorimotor control and use this approach to examine how sensory and motor processes are differentially impacted by MS.

Methods

Eight subjects with MS and eight age- and gender-matched healthy control subjects performed visually-guided flexion/extension tasks about the elbow to characterize a sensory feedback control model that …

Reversible Blockade Of Complex I Or Inhibition Of Pkcβ Reduces Activation And Mitochondria Translocation Of P66Shc To Preserve Cardiac Function After Ischemia, Meiying Yang, David F. Stowe, Kenechukwu B. Udoh, James S. Heisner, Amadou K.S. Camara

Biomedical Engineering Faculty Research and Publications

Aim

Excess mitochondrial reactive oxygen species (mROS) play a vital role in cardiac ischemia reperfusion (IR) injury. P66^Shc, a splice variant of the ShcA adaptor protein family, enhances mROS production by oxidizing reduced cytochrome c to yield H₂O₂. Ablation of p66^Shc protects against IR injury, but it is unknown if and when p66^Shc is activated during cardiac ischemia and/or reperfusion and if attenuating complex I electron transfer or deactivating PKCβ alters p66^Shc activation during IR is associated with cardioprotection.

Methods

Isolated guinea pig hearts were perfused and subjected to increasing periods …

Developing A Tool For Site-Specific Gene Inactivation In Chlamydia, Cayla Marie Johnson

Theses

Chlamydia trachomatis is an obligate intracellular bacterial pathogen that infects both humans and domestically important animals. Research in the field has until more recently been hindered by a lack of genetic tools. We have modified Sigma's TargeTron^TM Gene Knockout System, which utilizes a mobile group II intron for site-specific insertion and gene inactivation, for use in C. trachomatis. As proof of principle, we used the system to inactivate incA, creating mutant strains DFCT3 and DFCT4 (independent clones both carrying incA::GII[bla]). IncA is a chlamydial inclusion membrane protein involved in homotypic fusion of inclusions when cells are infected with more …

Fate Control And Human Rights: The Policies And Practices Of Local Governance In America's Arctic, Mara Kimmel

ISER Articles

The loss of territoriality over lands conveyed under the Alaska Native Claims Settlement Act had adverse impacts for Alaskan tribal governance. Despite policy frameworks that emphasize the value of local governance at an international, regional, and statewide level, Alaskan tribes face unique obstacles to exercising their authority, with consequences for both human development and human rights. This Article examines how territoriality was lost and analyzes the four major effects of this loss on tribal governance. It then describes two distinct but complimentary strategies to rebuilding tribal governance authority that rely on both territorial and non-territorial authority.

Functional Morphology Of The Connective Tissue Of The Clavicular System Of The Domestic Cat, Felis Catus, Amanda N. Cooper

Honors Capstones

No abstract provided.

Associations Between Pqct-Based Fat And Muscle Area And Density And Dxa-Based Total And Leg Soft Tissue Mass In Healthy Women And Men, Vanessa D. Sherk, Robert S. Thiebaud, Zhaojing Chen, Murat Karabulut, So Jung Kim, Debra A. Bemben

Health & Biomedical Sciences Faculty Publications

Peripheral Quantitative Computed Tomography (pQCT) can be used for muscle and fat area and density assessments. These may independently influence muscle and fat mass measurements from Dual Energy X-ray Absorptiometry (DXA).

Objective: To determine associations between pQCT-derived soft tissue density and area measures and DXA-derived soft tissue mass.

Methods: Linear regression models were developed based on BMI and calf fat and muscle cross-sectional area (FCSA and MCSA) and density measured by pQCT in healthy women (n=76) and men (n=82) aged 20-59 years. Independent variables for these models were leg and total bone-free lean mass (BFLM) and fat mass (FM) measured …

An Exploration Of Cell Cycle Regulation In Arabidopsis Thaliana Trichomes, Ashley Willis

Honors Capstones

No abstract provided.

The Influence Of White-Tailed Deer On Plant Communities In West Virginia And Stakeholder Attitudes Toward Deer Management With Respect To Plant Conservation, Kelley Lynne Flaherty

Graduate Theses, Dissertations, and Problem Reports (ETD)

White-tailed deer (Odocoileus virginianus) may impact plant species by reducing individual survival or reduce reproductive potential by feeding on flowering parts or seeds. Herbivory may benefit plant populations by increasing dispersal of seeds. The combination of these factors may influence the composition of native plant communities. The recovery of deer populations from near extirpation was seen as a wildlife management success story. However, the maintenance of abnormally high deer density levels over many years may have taken a toll on plant communities. Some biologists now question whether or not white-tailed deer could be considered overabundant in some parts of their …

Synergistic Inhibition Of Cyclooxygenases And Monoacylglycerol Lipase In Neuropathic Pain, Molly S. Crowe

Graduate Theses, Dissertations, and Problem Reports (ETD)

Neuropathic pain is caused by altered nerve function that often presents as allodynia, which is the painful perception of typically non-noxious stimuli. Neuropathic pain is commonly treated with GABA analogues, steroids, or non-steroidal anti-inflammatory drugs (NSAIDs). NSAIDs inhibit one or more cyclooxygenase (COX) enzymes and are effective, commonly used analgesics that have relatively fewer side effects than other treatments. However, chronic cyclooxygenase inhibition also causes gastrointestinal inflammation and increased risk of cardiac events. Like NSAIDs, cannabinoids have analgesic and anti-inflammatory properties and reduce neuropathic pain in preclinical models. The present study investigated the analgesic effects of inhibiting both monoacylglycerol lipase …

Acute Sleep Organization Following Unanesthetized Circumcision Of Neonates, Margeaux M. Gray

Graduate Theses, Dissertations, and Problem Reports (ETD)

Sleep changes in response to environmental pressures and the needs of individuals. The adaptability of sleep is noticeable following largely stressful or adverse events, and is understood to facilitate recovery. Rapid changes in sleep occur in-utero, during the days following birth, and across the first few postnatal years. These rapid changes are considered adaptive and indicative of normal and healthy development. Elective surgical intervention, such as circumcision, may influence the organization and quality of sleep during this developmentally sensitive period. Neonates undergoing circumcision, a prevalent procedure in the U.S. (American Academy of Pediatrics Circumcision Policy Statement [AAP], 1999, 2005, 2012), …

Lkb1 Deficient Non-Small Cell Lung Cancer Cells Are Vulnerable To Energy Stress Induced By Atp Depletion, Chao Yang

Dissertations and Theses (Open Access)

Lung cancer is the second most frequent cancer in United States, which represents about 13.5% of new cancer cases every year. It accounts for about 27.2% of all cancer related deaths, which is more than the sum of deaths caused by prancretic, breast and colorectal. On average, only about 16% of lung cancer patients survive beyond 5 years. LKB1 is the third most mutated gene in lung cancer. It has been shown that LKB1 is mutated in at least 15% to 30% of NSCLC. Tumor with LKB1 mutation is associated with poor differentiation, high metastasis and worse response to chemotherapy. …

Swarna Ramaswamy_Thesis, Swarna S. Ramaswamy

Dissertations and Theses (Open Access)

STRUCTURAL INVESTIGATIONS OF LIGAND GATED ION CHANNELS

Swarna Ramaswamy, B.S

Advisor: Vasanthi Jayaraman, Ph.D.

Ion channels form an integral part of membrane proteins. In the nervous system including the central and the peripheral nervous system, ligand gated ion channels form a very important part of intercellular communications. They receive chemical signals and convert them to electrical signal, mainly by allowing ion passage across the cell membrane. Ion passage also translates into downstream signaling events. Faithful translation of these signals and transmittance is crucial for several physiological functions, implying that irregular ion channel function could lead to serious consequences.

This thesis …

The Role Of Mir-34a In Inhibition Of Prostate Tumor Growth In The Bone And Induction Of Autophagy, Sanchaika Gaur

Dissertations and Theses (Open Access)

Prostate cancer (PCa) is the second leading cause of cancer-related deaths in men in the United States, with most deaths occurring from bone metastasis. Several new therapies have been FDA approved for bone-metastatic PCa, but patient survival has only marginally improved due to therapy resistance, which often arises from constitutive activation of compensatory signaling pathways. This dissertation work focused on a mechanistic understanding of how cross talk between tyrosine kinase receptors contributes to therapy resistance, and how this may be overcome by downregulating expression of these receptors. In PCa cell lines and xenograft models, I demonstrated that activation of IGF-1R …

Sox2-Dependent Transcriptional Control Of Airway Differentiation In The Mouse Lung, Belinda J. Hernandez

Dissertations and Theses (Open Access)

The lung is a highly branched tree-like tubular system that results from more than 20 generations of the conducting airways and consists of 300 million alveoli for gas exchange. Airway branches form via branching morphogenesis and then mature into conducting airways, in which the number and distribution of different cell types need to be precisely controlled. The conducting airways contain four lung cell types: club cells, ciliated cells, basal cells, and neuroendocrine cells.SOX2 is a well-known conducting airway marker. SOX2 is a transcription factor that is known to be important in embryonic development and induction of pluripotent stem cells. We …

Investigating Checkpoint Kinases 1/2 As Novel Therapeutic Targets In Head And Neck Squamous Cell Carcinoma, Mayur Arvind Gadhikar

Dissertations and Theses (Open Access)

Cisplatin, despite being the cornerstone chemotherapy for the treatment of head and neck squamous cell carcinoma (HNSCC), provides clinical benefits in just a subset of patients. This together with the lack of biomarkers predicting therapeutic responses, have led to unacceptably high rate of treatment failures in HNSCC. TP53 is the most frequently mutated gene in HNSCC, and the effect of p53 loss or mutation on cisplatin responses in HNSCC is poorly understood. In the current study, we hypothesized that HNSCC cells respond to cisplatin in a p53 dependent manner and unambiguously show that presence of wild-type TP53 (wtp53) confers sensitivity …

P120-Catenin Regulates Rest And Corest, And Modulates Mouse Embryonic Stem Cell Differentiation, Moonsup Lee

Dissertations and Theses (Open Access)

The canonical-Wnt pathway and beta-catenin have been extensively studied to determine their contributions to stem cell biology, but less is known about p120-catenin in the nuclear compartment. P120 is developmentally required as a consequence of its biochemical and functional interactions with cadherins, small-GTPases and transcriptional regulators. We report here that p120-catenin binds to and negatively regulates REST and CoREST, that others have indicated form a repressive complex having diverse key roles in developmental and pathologic gene regulation. We thus provide the first evidence for a direct upstream modulator of REST/CoREST function. Using mouse embryonic stem cells (mESCs), mammalian cell lines, …

Hypoxia Mediated Downregulation Of Mirna Biogenesis Leads To Increased Tumor Progression, Rajesha Rupaimoole

Dissertations and Theses (Open Access)

In recent years, there has been a growing recognition of the importance of tumor associated microenvironment in the initiation and progression of tumors. However, a mechanistic understanding of the complicated biological interplay between the stromal framework and malignant regions of the tumor remains incompletely understood. In this study, we address mechanisms by which hypoxia in the tumor microenvironment leads to attenuation of miRNA biogenesis by downregulation of two key enzymes, Drosha and Dicer in cancer cells. Previous data from our laboratory had shown the clinical relevance of downregulated Dicer and Drosha in ovarian and other cancer types, but a clear …

Role Of Phosphorylation Of Focal Adhesion Kinase At Tyrosine 861 In Prostate Cancer Metastasis, Tanushree Chatterji

Dissertations and Theses (Open Access)

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that mediates interactions between the extracellular matrix and intracellular signaling pathways critical in promoting numerous cellular functions including adhesion, proliferation, survival and migration. Most FAK functions result from phosphorylation by Src family kinases, which trigger numerous signaling cascades. Overexpression of FAK is associated with metastasis in many solid tumors, including prostate cancer. Hence, understanding the mechanisms by which FAK is regulated in prostate cancer will better elucidate its role in prostate cancer metastasis. Work in this dissertation tested the hypothesis that altered phosphorylation of FAK is critical for cell migration and …

Sustained Adrenergic Signaling Promotes Cervical Cancer Progression, Nouara C. Sadaoui

Dissertations and Theses (Open Access)

Background: Chronic stress and sustained adrenergic signaling are known to promote tumor progression. The underlying mechanisms behind this process are not well understood. We examined the effects of sustained adrenergic signaling on cervical cancer progression through increased expression of HPV oncogenes, E6 and E7.

Materials and Methods: ADRβ expression levels were examined in patient-derived cervical cancer samples. We used an orthotopic model of cervical cancer to investigate the effects of restraint stress on tumor growth and metastasis. We evaluated the in vivo effects of a β-blocker, propranolol, and HPV E6/E7 siRNA. In vitro, ADRβ positive cervical cancer cells were …

Mdm2-Mediated Degradation Of Sirt6 Phosphorylated By Akt1 Promotes Tumorigenesis And Trastuzumab Resistance In Breast Cancer, Umadevi Thirumurthi

Dissertations and Theses (Open Access)

Sirtuin6 (SIRT6) is one of the members of the Sirtuin family and functions as a longevity assurance gene by promoting genomic stability. It also regulates various cancer-associated pathways and was recently established as a bonafide tumor suppressor in colon cancer. This suggests that SIRT6 is an attractive target for pharmacological activation in cancer treatment, and hence, identification of potential regulators of SIRT6 would be an important and critical contribution towards cancer treatment. Here, we show that AKT1 phosphorylates SIRT6 at Ser³³⁸ and induces MDM2-SIRT6 interaction, priming SIRT6 for degradation via the MDM2-dependent ubiquitin-proteasome pathway. Blocking SIRT6 Ser³³⁸ phosphorylation …