Digital Commons Network^™

John F. Boynton: Forgotten Apostle, Wendy Woodfield, Dr. Alex Baugh

Journal of Undergraduate Research

Brigham Young, Parley P. Pratt, and nearly all of the original twelve apostles of the Church of Jesus Christ of Latter-day Saints are familiar names in the homes of many church members. Their memories have lived on to our day through the many publications of church historians. However, one of these original church leaders seems to have faded from memory due to a lack of information. John F. Boynton also served as one of the original twelve apostles, impacted the lives of early church leaders, and was an outstanding advocate for the church during his years of missionary service. Andrew …

The Collegian (2014-01-27), Cleiri Quezada

UTB/TSC Archives - The Collegian [Newspaper]

Vol. 66, No. 17

Regio- And Stereoselective Photochemical [2+2] Cycloaddition Between 4-Hydroxycoumarin And Alkenes, Scott Henneman, Dr. Steven A. Fleming

Journal of Undergraduate Research

Recent photochemical research has proven helpful in understanding the regio- and stereoselective mechanism of four-member ring formation. When compounds cycloadd— combine either inter- or intramolecularly to form rings—a broad assortment of isomers are generally formed. However, the regio- and stereoselectivity of the cycloaddition process—the tendency of the compounds to combine in specific ways, i.e. the preference for one product over another—can be greatly enhanced through the utilization of a tether group. This tether group can be anything used to control the reacting molecular components involved in a cycloaddition towards combination in a specific orientation. The regio- and stereoselectivity of the …

Abundance And Distribution Of Major And Understudied Archaeal Lineages At Globally Distributed Deep-Sea Hydrothermal Vents, Alexander Fenner Rutherford

Dissertations and Theses

Deep-sea hydrothermal vents are some of the most biologically productive ecosystems on Earth, yet receive little to no input of photosynthetically derived organic matter. The trophic system at hydrothermal vents is based primarily on the reduction-oxidation (redox) of inorganic chemicals by Bacteria and Archaea. However, the distributional patterns of the microorganisms that colonize deep-sea hydrothermal vent deposits and their link to the geologic setting are still not deeply understood.

The goal of the studies presented in this thesis was to quantify the abundance, and distribution of major and understudied vent colonizing archaeal groups from globally distributed and geochemically distinct hydrothermal …

Daily Eastern News: January 27, 2014, Eastern Illinois University

January

No abstract provided.

The Bg News January 27, 2014, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. January 27, 2014. Volume 93-Issue 57.

The P53 Mutation/Deletion Profile In A Small Cohort Of The Omani Population With Diffuse Large B-Cell Lymphoma, Yahya Tamimi, Sheikha Al-Harthy, Ibrahim Al-Kindi, Mohammed, Hamza Babiker, Mansour Al-Moundhri, Ikram Burney

Sultan Qaboos University Medical Journal

Objectives: Mutations/deletions affecting the TP53 gene are considered an independent marker predicting a poor prognosis for patients with diffuse large B-cell lymphoma (DLBCL). A cohort within a genetically isolated population was investigated for p53 mutation/deletion status. Methods:Deoxyribonucleic acid (DNA) samples were extracted from 23 paraffin-embedded blocks obtained from DLBCL patients, and subjected to polymerase chain reaction (PCR) amplification and sequencing of exons 4–9 of the p53 gene. Results: While 35% of patients analysed displayed allelic deletions (P<0.01), immunohistochemical analysis revealed a mutation rate of 69.5%. It is noteworthy that the rate of p53 mutations/deletions in this small cohort was found to be higher than that previously reported in the literature. Interestingly, patients with p53 mutations displayed a better overall survival when compared to those without. The survival of patients treated with rituximab-containing combination chemotherapy was significantly better than those who did not receive rituximab (P <0.05). Furthermore, a modelling analysis of the deleted form of p53 revealed a huge structural change affecting the DNA-binding domain. Conclusion: The TP53 mutation/deletion status plays a role in mechanism(s) ruling the pathogenesis of DLBCL and may be useful for stratifying patients into distinct prognostic subsets.

Nasal Allergy And Otitis Media : A Real Correlation?, Desiderio Passali, Giulio C. Passali, Maria Romano, Antonio, Luisa Bellussi, Francesco M. Passali

Sultan Qaboos University Medical Journal

Objectives: The correlation between middle ear pathology and nasal allergy has been debated for almost 30 years. This study aimed to evaluate the relationship between otitis media with effusion (OME) and persistent allergic rhinitis symptoms versus intermittent rhinitis in children. Methods: The study included 100 atopic children (52 boys, 48 girls) aged 5‒9 years with otological symptoms who were patients of the University of Siena Hospital, Italy. Ear, nose and throat evaluations, tympanometry, skin prick tests (SPTs), mucociliary transport time (MCTt) and Eustachian tube function tests were performed. Results: The SPTs revealed 50 children sensitised to Dermatophagoides pteronyssinus, 34 to …

Faculty Senate Bill Fsb-2014-01-27-01a: University Curriculum Committee, Armstrong Atlantic State University

Armstrong Faculty Senate: Bills, Motions & Resolutions (Archived)

Faculty Senate Bill FSB-2014-01-27-01a: University Curriculum Committee

The Free Press Vol 45 Issue 13, 01-27-2014, Kirsten Sylvain

Free Press, The

University oversight of fraternities questioned--Students stand in solidarity against pipeline--Lab supplies combust, igniting in an empty room--USM hires new associate provost--Study finds link between income and achievement

Tocotrienol-Rich Fraction From Palm Oil Prevents Oxidative Damage In Diabetic Rats, Fatmah A. Matough, Siti B. Budin, Zariyantey A. Abdul-Rahman, Mariati, Nasar Al-Wahaibi, Jamaludine Mohammed

Sultan Qaboos University Medical Journal

Objectives: This study was carried out to determine the effects of tocotrienol-rich fraction (TRF) (200 mg/Kg) on biomarkers of oxidative stress on erythrocyte membranes and leukocyte deoxyribonucleic acid (DNA) damage in streptozotocin (STZ)-induced diabetic rats. Methods: Male rats (n = 40) were divided randomly into four groups of 10: a normal group; a normal group with TRF; a diabetic group, and a diabetic group with TRF. Following four weeks of treatment, fasting blood glucose (FBG) levels, oxidative stress markers and the antioxidant status of the erythrocytes were measured. Results: FBG levels for the STZ-induced diabetic rats were significantly increased (P <0.001) when compared to the normal group and erythrocyte malondialdehyde levels were also significantly higher (P <0.0001) in this group. Decreased levels of reduced glutathione and increased levels of oxidised glutathione (P <0.001) were observed in STZ-induced diabetic rats when compared to the control group and diabetic group with TRF. The results of the superoxide dismutase and glutathione peroxidase activities were significantly lower in the STZ-induced diabetic rats than in the normal group (P <0.001). The levels of DNA damage, measured by the tail length and tail moment of the leukocyte, were significantly higher in STZ-induced diabetic (P <0.0001). TRF supplementation managed to normalise the level of DNA damage in diabetic rats treated with TRF. Conclusion: Daily supplementation with 200 mg/Kg of TRF for four weeks was found to reduce levels of oxidative stress markers by inhibiting lipid peroxidation and increasing the levels of antioxidant status in a prevention trial for STZ-induced diabetic rats.

The Legacy Of Robert Koch : Surmise, Search, Substantiate, Ritu Lakhtakia

Sultan Qaboos University Medical Journal

No abstract provided.

The Cytotoxicity Of Aflatoxin B1 In Human Lymphocytes, Suleiman Al-Hammadi, Farida Marzouqi, Aysha Shahin, Allen, Mariam Al-Shamsi, Eric Mensah-Brown, Abdul-Kader Souid

Sultan Qaboos University Medical Journal

Objectives: Aflatoxin B1 (AFB1) is a naturally occurring carcinogenic and immunosuppressive compound. This study was designed to measure its toxic effects on human peripheral blood mononuclear cells (PBMC). Methods: The study recruited 7 healthy volunteers. PBMC were isolated and cellular respiration was monitored using a phosphorescence oxygen analyser. The intracellular caspase activity was measured by the caspase-3 substrate N-acetyl-asp-glu-val-asp-7-amino-4-methylcoumarin. Phosphatidylserine exposure and membrane permeability to propidium iodide (PI) were measured by flow cytometry. Results: Cellular oxygen consumption was inhibited by 2.5 μM and 25 μM of AFB1. Intracellular caspase activity was noted after two hours of incubation with 100 μM …

Frequency Of Glomerular Dysfunction In Children With Beta Thalassaemia Major, Basma A. Ali, Ahmed M. Mahmoud

Sultan Qaboos University Medical Journal

Objectives: This study investigated the frequency of glomerular dysfunction in children with beta thalassaemia major (β-TM) by using different markers and correlating them with serum ferritin and iron chelation therapy. Methods: The study, carried out between August 2011 and May 2012, included 100 patients with β-TM, in two groups. Group Ia (n = 62) received chelation therapy (deferoxamine). Group Ib (n = 38) received followup care at the Pediatric Hematology Outpatient Clinic, Minia University Children’s Hospital, Egypt. Group II included 50 apparently healthy controls, age- and sex-matched to Group I. All patients underwent a thorough history-taking, clinical examination and laboratory …

The Significance Of Matrix Metalloproteinases In The Immunopathogenesis And Treatment Of Multiple Sclerosis, Abbas Mirshafiey, Babak Asghari, Ghasem Jadidi-Niaragh, Farhad, Gholamreza Azizi

Sultan Qaboos University Medical Journal

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). The major pathological outcomes of the disease are the loss of blood-brain barrier (BBB) integrity and the development of reactive astrogliosis and MS plaque. For the disease to occur, the non-resident cells must enter into the immune-privileged CNS through a breach in the relatively impermeable BBB. It has been demonstrated that matrix metalloproteinases (MMPs) play an important role in the immunopathogenesis of MS, in part through the disruption of the BBB and the recruitment of inflammatory cells into the CNS. Moreover, MMPs can also enhance the cleavage …

Two Distinct Dynamic Modes Subtend The Detection Of Unexpected Sounds, Jean-Rémi King, Alexandre Gramfort, Aaron Schurger, Lionel Naccache, Stanislas Dehaene

Psychology Faculty Articles and Research

The brain response to auditory novelty comprises two main EEG components: an early mismatch negativity and a late P300. Whereas the former has been proposed to reflect a prediction error, the latter is often associated with working memory updating. Interestingly, these two proposals predict fundamentally different dynamics: prediction errors are thought to propagate serially through several distinct brain areas, while working memory supposes that activity is sustained over time within a stable set of brain areas. Here we test this temporal dissociation by showing how the generalization of brain activity patterns across time can characterize the dynamics of the underlying …

Faculty Senate Bill Fsb-2014-01-27-01b: University Curriculum Committee, Armstrong Atlantic State University

Armstrong Faculty Senate: Bills, Motions & Resolutions (Archived)

Faculty Senate Bill FSB-2014-01-27-01b: University Curriculum Committee

January 27, 2014 Aasu Faculty Senate Agenda, Armstrong State University

Armstrong Faculty Senate: Armstrong Faculty Senate Agenda (Archived)

January 27, 2014 AASU Faculty Senate Agenda

Interview Sue Williams Spurlock: Collegiate Oral History Interview, Christy L. Spurlock

Faculty/Staff Personal Papers

Interview with Sue Williams Spurlock about her college experience at Western Kentucky University in the late 1950s early 1960s.

Report For Nmdgf Permit: 3518, 2013, Jeff Winstead

Natural Heritage New Mexico Documents

Document from New Mexico Department of Game & Fish Scientific permit.

The Multiscale Backbone Of The Human Phenotype Network Based On Biological Pathways, Christian Darabos, Marquitta J. White, Britney E. Graham, Derek N. Leung, Scott M. Williams, Jason H. Moore

Dartmouth Scholarship

Background:

Networks are commonly used to represent and analyze large and complex systems of interacting elements. In systems biology, human disease networks show interactions between disorders sharing common genetic background. We built pathway-based human phenotype network (PHPN) of over 800 physical attributes, diseases, and behavioral traits; based on about 2,300 genes and 1,200 biological pathways. Using GWAS phenotype-to-genes associations, and pathway data from Reactome, we connect human traits based on the common patterns of human biological pathways, detecting more pleiotropic effects, and expanding previous studies from a gene-centric approach to that of shared cell-processes.

Results:

The resulting network has a …

Development And Validation Of A Rubric For Diagnosing Students' Experimental Design Knowledge And Difficulties, Annwesa Dasgupta, Trevor R. Anderson, Nancy Pelaez

PIBERG Publications

It is essential to teach students about experimental design, as this facilitates their deeper understanding of how most biological knowledge was generated and gives them tools to perform their own investigations. Despite the importance of this area, surprisingly little is known about what students actually learn from designing biological experiments. In this paper, we describe a rubric for experimental design (RED) that can be used to measure knowledge of and diagnose difficulties with experimental design. The development and validation of the RED was informed by a literature review and empirical analysis of undergraduate biology students’ responses to three published assessments. …

A Phylogenetic Examination Of The Primary Anthocyanin Production Pathway Of The Plantae, James Campanella, John V. Smalley, Maureen E. Dempsey

Department of Biology Faculty Scholarship and Creative Works

Background: Anthocyanin pigments aid in reproduction and provide ultraviolet protection to land plants. We have examined the phylogenetic relationships among the five primary enzymes responsible for producing anthocyanin pigment in its three major forms. Dihydroflavonol 4-reductase (DFR), anthocyanidin synthase (ANS), Flavonoid 3'glucosyltransferase (F3GT), flavonoid 3'hydroxylase (F3'H), and flavonoid 3'5' hydroxylase (F3'5'H) are responsible for the final steps in anthocyanin pigment production. Results: We were interested in how conserved the anthocyanin pathway genes may be among land plants, and evolutionarily how far back into the plant lineage anthocyanin production may be traced. The DFR, ANS, F3GT, and F3'H genes date back …

Bargaining Market Equity Adjustments By Rank And Discipline, Jonathan P. Blitz, Jeffrey F. Cross

Journal of Collective Bargaining in the Academy

Faculty contract negotiations generally include wages, hours, and other conditions of employment as well as mutually agreed non-mandatory subjects of bargaining. Negotiators typically address wages in terms of across-the-board increases, promotion in rank, merit increases, and one-time signing bonuses. Less typically, faculty salary negotiations include various forms of equity adjustments and salary increases linked to the underlying market and social forces and to salary compression that may, or may not, be related to these forces. The authors describe how they negotiated differential discipline-specific target salaries based in part on College and University Personnel Association faculty salary data.

The Virtual Research Lab: Research Outcomes Expectations, Lee Stadtlander, Martha Giles, Amy Sickel

Journal of Educational Research and Practice

This paper examines the complexities of working with student researchers in a virtual lab setting, logistics, and methods to resolve issues. To demonstrate the feasibility of a virtual lab, a mixed method study consisting of quantitative surveys and qualitative data, examined changes in doctoral students’ confidence as measured by research outcome expectations and changes in a self-assessment of research knowledge and skills test in a three quarter virtual psychology research lab. In the lab, 10 doctoral students conducted a faculty-designed project, analyzed data, and co-wrote a literature review. Findings indicate lab students’ research knowledge and research outcome expectations improved significantly …

Crew Resource Management Application In Commercial Aviation, Frank Wagener, David C. Ison

Journal of Aviation Technology and Engineering

The purpose of this study was to extend previous examinations of commercial multi-crew airplane accidents and incidents to evaluate the Crew Resource Management (CRM) application as it relates to error management during the final approach and landing phase of flight. With data obtained from the Federal Aviation Administration (FAA) and the National Transportation Safety Board (NTSB), a x² test of independence was performed to examine if there would be a statistically significant relationship between airline management practices and CRM-related causes of accidents/incidents. Between 2002 and 2012, 113 accidents and incidents occurred in the researched segments of flight. In total, …

Estimating Temperature Fields From Modis Land Surface Temperature And Air Temperature Observations In A Sub-Arctic Alpine Environment, Scott N. Williamson, David S. Hik, John A. Gamon, Jeffrey L. Kavanaugh, Gwenn E. Flowers

School of Natural Resources: Faculty Publications

Spatially continuous satellite infrared temperature measurements are essential for understanding the consequences and drivers of change, at local and regional scales, especially in northern and alpine environments dominated by a complex cryosphere where in situ observations are scarce. We describe two methods for producing daily temperature fields using MODIS ―clear-sky‖ day-time Land Surface Temperatures (LST). The Interpolated Curve Mean Daily Surface Temperature (ICM) method, interpolates single daytime Terra LST values to daily means using the coincident diurnal air temperature curves. The second method calculates daily mean LST from daily maximum and minimum LST (MMM) values from MODIS Aqua and Terra. …

A Joint Model For Multistate Disease Processes And Random Informative Observation Times, With Applications To Electronic Medical Records Data, Jane M. Lange, Rebecca A. Hubbard, Lurdes Y. T. Inoue, Vladimir Minin

UW Biostatistics Working Paper Series

Multistate models are used to characterize individuals' natural histories through diseases with discrete states. Observational data resources based on electronic medical records pose new opportunities for studying such diseases. However, these data consist of observations of the process at discrete sampling times, which may either be pre-scheduled and non-informative, or symptom-driven and informative about an individual's underlying disease status. We have developed a novel joint observation and disease transition model for this setting. The disease process is modeled according to a latent continuous time Markov chain; and the observation process, according to a Markov-modulated Poisson process with observation rates that …

Academic Affairs Division Newsletter, January 2014, San Jose State University

Academic Affairs Division Newsletter

No abstract provided.

The Tiger Vol. 108 Issue 2 2014-01-24, Clemson University

Tiger Newspapers

No abstract provided.