Digital Commons Network^™

Reduction In Toxicity Of Doxorubicin By Á-Tocopherol Succinate (Vitamin E) And Ascorbic Acid (Vitamin C) In Human Adenocarcinoma Cells, Christie Michaud, Dr. Byron Murray

Journal of Undergraduate Research

Colorectal cancer is the second leading cause of cancer deaths in the United States and doxorubicin, is one of the more widely chemotherapeutic treatments for this disease. This study investigated the possibility of exposing adenocarcinoma cells to vitamin C/vitamin E (VC/VE) combinations as a means to reduce toxicity associated with doxorubicin (DXR) treatment.

Hepatic Oval Cells: A Potential Source Of Cartilage, Chris Meinhart, Dr. Laura C. Bridgewater

Journal of Undergraduate Research

Damage to articular cartilage found in synovial joints can occur both by trauma and disease processes. Cartilage, because of its avascular nature and low cellularity, has very poor regeneration capabilities. It is therefore important to explore new and effective cellular therapies to facilitate the repair of diseased or otherwise damaged cartilage.

Identification Of A Novel Positive Cis-Acting Element In The First Intron Of The Mouse Col11a2 Gene, Steven Alan Smith, Dr. Laura Bridgewater

Journal of Undergraduate Research

Three chondrocyte-specific enhancer elements were previously identified in the mouse type XI collagen gene, Col11a2 (1-3). Enhancer elements are base pair sequences of DNA to which proteins bind enhancing expression of a particular gene. One of these enhancers, called F/G, is located in the first intron of that gene (3). This work has revealed the likely presence of additional positive cis-acting (enhancer) elements in the first intron, and one of those elements has been identified.

Fdc As An Hiv Reservoir: Dna Sequence Analysis Of Hiv Isolated From Fdc And Cd4+ T Cells Of Infected Patient, Trever Bradley Burgon, Dr. Gregory F. Burton

Journal of Undergraduate Research

Human Immunodeficiency Virus (HIV), the retrovirus that causes Acquired Immunodeficiency Syndrome (AIDS), has infected over 60 million people and become what the Joint United Nations Program on HIV/AIDS calls: “the most devastating disease mankind has ever faced” (8). Current treatment, known as HAART (highly active antiretroviral therapy), is able to reduce HIV in the blood to undetectable levels but it cannot completely block replication nor remove HIV from the body. When patients stop taking HAART, their viral load (the quantity of virus detected in their blood) and symptoms quickly return to pretreatment levels. This viral rebound is caused by latent …

The Inkwell, Armstrong Atlantic State University

The Inkwell

No abstract provided.

Effects Of Storytelling In Advertising On Consumers` Empathy, Myung Jin Park, Doo Hee Lee

Asia Marketing Journal

Differentiated positioning becomes increasingly difficult when brand salience weakens. Also, the daily increase in new media use and information load has led to a social climate that regards advertising stimuli as spamming. For these reasons, the focus of advertisement-related communication is shifting from persuading consumers through the direct delivery of information to an emphasis on appealing to their emotions using matching stimuli to enhance persuasion effects. Recently, both academia and industry have increasingly shown an interest in storytelling methods that can generate positive emotional responses and attitude changes by arousing consumers` narrative processing. The purpose of storytelling is to elicit …

Area Students Tours With Illinois Wesleyan Collegiate Choir, Kathy Thilmany

News and Events (Discontinued Series)

No abstract provided.

Weighted Inverse Weibull Distribution: Statistical Properties And Applications, Valeriia Sherina, Broderick O. Oluyede

Mathematical Sciences: Faculty Publications

In this paper, the weighted inverse Weibull (WIW) class of distributions is proposed and studied. This class of distributions contains several models such as: length-biased, hazard and reverse hazard proportional inverse Weibull, proportional inverse Weibull, inverse Weibull, inverse exponential, inverse Rayleigh, and Fr´echet distributions as special cases. Properties of these distributions including the behavior of the hazard function, moments, coefficients of variation, skewness, and kurtosis, R´enyi entropy and Fisher information are presented. Estimates of the model parameters via method of maximum likelihood (ML) are presented. Extensive simulation study is conducted and numerical examples are given.

Resurrectionists' Excursions: Evidence Of Postmortem Dissection From The Spring Street Presbyterian Church, Shannon A. Novak, Wesley Willoughby

Northeast Historical Archaeology

In this paper we contextualize two unique individuals recovered from the historic Spring Street Presbyterian Church burial vaults in lower Manhattan (ca. 1820-1846). The crania of one adolescent and one infant display clear evidence of a craniotomy. Both had complete circumferential incisions to remove the calvarium for internal examination. Both crania were sectioned using a saw, though the adolescent underwent further postmortem preparation: thin scalpel marks indicate defleshing, and metal pins embedded in the frontal and occipital bones would have facilitated disarticulation and rearticulation of the vault, presumably for teaching. By the early 19th century, the illicit exhumation of graves …

The Children Of Spring Street: Rickets In An Early Nineteenth-Century Congregation, Meredith A. B. Ellis

Northeast Historical Archaeology

This paper examines the prevalence of rickets, or vitamin D deficiency, in the subadult skeletal remains from the burial vaults of the Spring Street Presbyterian Church of New York City. The burial vaults of the church were active from approximately 1820–1846 and contain the remains of at least 86 subadults (minimum number of individuals count [MNI] of left tibiae). Over 34% of the subadult tibiae in this collection display pathology consistent with vitamin D deficiency. Since vitamin D is acquired through access to sunlight and specific foods, a high rate of rickets can give clues about living conditions, parenting strategies, …

Archaeologies Of Disease And Public Order In Nineteenth-Century New York: The View From Spring And Varick, William Werner, Shannon A. Novak

Northeast Historical Archaeology

The authors situate evidence of disease among the burial population of the Spring Street Presbyterian Church within evolving attitudes towards public health and civic order in 19th-century Manhattan. Two personal vignettes illustrate how individuals interacted with the physical space of the church’s vicinity at different moments in the history of municipal reform. The first, a 16-year-old girl named Louisa, was virtually absent from the historical record until the recovery and analysis of her skeletal remains from the church burial vaults. Her skeletal biography conveys the cosmopolitan nature of Manhattan social relations in the early 19th century and the complex ways …

"That Class Of Person Who Cannot Afford A Pew": Analysis Of The Human Remains From The Spring Street Presbyterian Church Burial Vaults, Thomas A. Crist

Northeast Historical Archaeology

The analysis of the skeletal remains of 85 people interred between ca. 1820 and 1846 in the vaults of the abolitionist Spring Street Presbyterian Church provides unique insights regarding the biological history of antebellum New York City unavailable from other sources. Even though the sample size is small, the remains reflect the prevalence of infectious diseases, metabolic disorders, nutritional deficiencies, premature deaths, and high infant mortality that characterized the rapidly industrializing city. Among the most remarkable discoveries were a rare case of abdominal cancer; a mother and her full-term fetus in utero buried together; two autopsied children; and a dental …

The Bates Student - Volume 143 Number 12 - January 29, 2014, Bates College

The Bates Student

No abstract provided.

Banner News, Lester K. Mwirichia, Trevor Gutknecht, Keith Taylor Jr., Julie Roosa, Nick Hamden

Banner News

No abstract provided.

2014 January 29 -- Agenda And Attachments

Agendas and Minutes

No abstract provided.

Weekly News Digest 01/29/2014, Jenna Ray

Weekly Bulletin Archive

In this issue:

● French Film Festival Continues with Couleur de peau: Miel

● Alumna Keni Zenner ’12 Gives Back to the Community

● Morris Named a 2014 Second Nature Climate Leadership Finalist

● Jake Grussing ’05 Featured in the Minneapolis StarTribune

The Anchor, Volume 127.15: January 29, 2014, Hope College

The Anchor: 2014

The Anchor began in 1887 and was first issued weekly in 1914. Covering national and campus news alike, Hope College’s student-run newspaper has grown over the years to encompass over two-dozen editors, reporters, and staff. For much of The Anchor's history, the latest issue was distributed across campus each Wednesday throughout the academic school year (with few exceptions). In recent years The Anchor moved to monthly print issues and a more frequently updated website. The Anchor is now published in print twice per academic semester. Occasionally, the volume and/or issue numbering is irregular.

We Are...Marshall, January 29, 2014, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

Ecolunch | Reconstructing The Brains Of Extinct Archosaur, Jan 29, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Physics Colloquium | Transient Astronomy And The Violent Deaths Of Star, Jan 29, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Testing The Prognostic Accuracy Of The Updated Pediatric Sepsis Biomarker Risk Model, Hector R. Wong, Scott L. Weiss, John S. Giuliano Jr., Mark S. Wainwright, Robert J. Freishtat, +20 Additional Authors

Pediatrics Faculty Publications

Background

We previously derived and validated a risk model to estimate mortality probability in children with septic shock (PERSEVERE; PEdiatRic SEpsis biomarkEr Risk modEl). PERSEVERE uses five biomarkers and age to estimate mortality probability. After the initial derivation and validation of PERSEVERE, we combined the derivation and validation cohorts (n = 355) and updated PERSEVERE. An important step in the development of updated risk models is to test their accuracy using an independent test cohort.

Objective

To test the prognostic accuracy of the updated version PERSEVERE in an independent test cohort.

Methods

Study subjects were recruited from multiple pediatric intensive …

Polymeric Monolithic Stationary Phases For Capillary Reversed-Phase Liquid Chromatography Of Small Molecules, Kun Liu

Theses and Dissertations

Highly cross-linked monoliths prepared from single cross-linking monomers were found to increase surface area and stability. Therefore, seven cross-linking monomers, i.e., 1,3-butanediol dimethacrylate (1,3-BDDMA), 1,4-butanediol dimethacrylate (1,4-BDDMA), neopentyl glycol dimethacrylate (NPGDMA), 1,5-pentanediol dimethacrylate (1,5-PDDMA), 1,6-hexanediol dimethacrylate (1,6-HDDMA), 1,10-decanediol dimethacrylate (1,10-DDDMA), and 1,12-dodecanediol dimethacrylate (1,12-DoDDMA), were used to synthesize highly cross-linked monolithic columns in 75-µm i.d. capillaries by one-step UV-initiated polymerization using dodecanol and methanol as porogens for reversed-phase liquid chromatography (RPLC) of small molecules. Selection of porogen type and concentration was investigated in detail. Isocratic elution of alkylbenzenes at a flow rate of 300 nL/min was conducted for all of …

Spectrum, Volume 32, Issue 1, Sacred Heart University

Newspapers (Obelisk & Spectrum)

Highlights include: New Year New SHU -- Father Jerry Announces Retirement -- US Officials Cite Security Steps for Sochi Games -- Senior Nostalgia -- Students comment on fitness trends -- Editorials -- Alternative Winter Break

Understanding Sexual Abstinence Among Adolescent Males, David William Haas, Dr. Renata Forste

Journal of Undergraduate Research

Adolescent sexual activity is an important social issue because it is associated with other high-risk behaviors such as alcohol and substance abuse. Past studies have generally examined factors related to the initiation of sexual activity among youth, rather than modeling the factors predictive of sexual abstinence. Early sexual activity places youth at risk of premarital pregnancy and sexually transmitted disease. In addition, first intercourse is influential in redefining a youth’s identity and attitudes, and is an important factor in the transition from adolescence to adulthood (Upchurch, Levy-Storms, Sucoff, & Aneheshensel, 1998). The present study of teen sexual behavior models the …

Educational Attainment And Parity Among Mormons And Non- Mormons In Utah, William J. Jensen, Dr. Ray M. Merrill

Journal of Undergraduate Research

In recent decades, a common view arose that increased educational attainment led to less religious commitment and in views counter to spiritual growth but that encouraged scientific and intellectual accomplishments. 1234 Turning away from spiritual to secular explanations of life has received considerable attention (Stark 1998).

Environmental Aquatic Resource Sensing: Basic Sciences, Business Education, And Outreach, Laura G. Leff, Darren L. Bade, Jonathan Scaffidi, Craig E. Williamson, Chris Woolverton

Journal of Contemporary Water Research and Education

Freshwater resources are critical features of the landscape and are threatened by many phenomena (e.g., eutrophication, invasive species, climate change, acid rain). The importance of fresh waters requires that scientists continually improve their tactics and technologies for broader understanding. Increasing use of automated sensors to collect environmental data creates a need for training of environmental scientists. In this paper, we present case studies based on a doctoral training program. For each case study presented, the goals and overall recommendations for adaptation to other programs are discussed. Case studies were selected based on recommendations of external evaluators of the program, the …

An "Igert" Model For Interdisciplinary Doctoral Education In Water-Related Science And Policy, Nicholas Pinter, Sara Baer, Lizette Chevalier, Rhonda Kowalchuk, Christopher Lant, Matt Whiles

Journal of Contemporary Water Research and Education

Most doctoral programs in the U.S. remain “stove-piped” in traditional single-discipline fields, while scientific progress increasingly occurs at the boundaries between multiple disciplines. In response, the U.S. National Science Foundation has been funding projects in Integrative Graduate Education, Research, and Training (IGERT) to train a new generation of interdisciplinary scientists. The IGERT Ph.D. program in “Watershed Science and Policy” at Southern Illinois University (SIU) builds each year's student class as a diverse “cadre” who work intensively together on one hot-button river basin. The structure of these projects, and other program elements, are reviewed here along with successes and challenges to …

Does Respiratory Response At Altitude Lead To A Variation In Blood Oxygen Concentrations Among Individuals, Robert Adams, Dr. Robert Conlee

Journal of Undergraduate Research

Oxygen is the essential element in the air we breathe. The concentration of oxygen is constant in the atmosphere at approximately 21%. However barometric pressure is not constant throughout the atmosphere. The barometric pressure measures the amount of pressure the particles in the atmosphere exert and varies depending on altitude and weather. At sea level the barometric pressure is 760mmHg. The oxygen molecules accessible for respiration exert 21% of that pressure. The pressure of these oxygen molecules is 160mmHg and is referred to as the partial pressure of oxygen. As the altitude increases the total barometric pressure decreases from 760mmHg …

Terry Nails The Sale: Senior Narrative Film Project, Dustin Condren, Stan Ferguson

Journal of Undergraduate Research

After filming my third-year narrative film project, I felt ready for a significant change. Everything that I had done up until that point had consisted of stories of college-age men struggling to come to terms with their own weaknesses and desires. Essentially they were all “inner-struggle” pieces. The project that I had just completed was good, but I wanted something else. Something real, something that told a story, and would allow me as a director to explore dramatic structures.

Quantitative Mri Analysis Of The Cingulate Gyrus, Corpus Callosum, And Thalamus Following Carbon Monoxide Poisoning, Adam G. Bergeson, Dr. Ramona O. Hopkins

Journal of Undergraduate Research

Carbon monoxide (CO) exposure is the most common cause of poisoning death in the United States.1 The cellular damage due to CO poisoning is observed in organ systems with high oxygen utilization such as the cardiovascular system and central nervous system. Neuropathological changes that occur due to CO exposure result from a number of biological mechanisms and underlie the development of neuroanatomical abnormalities that occur following CO poisoning.2 Neuroanatomical changes following CO poisoning can be seen using a variety of neuroimaging techniques, including, Magnetic Resonance Imaging (MRI), Quantitative MRI (QMRI), and Computed Tomography (CT). Findings include fornix atrophy, increased ventricle-to-brain …