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Immature Myeloid Cells Promote Tumor Formation Via Non-Suppressive Mechanism, Myrna Lillian Ortiz

USF Tampa Graduate Theses and Dissertations

ABSTRACT

Although there is ample evidence linking chronic inflammation with cancer, the cellular mechanisms involved in early events leading to tumor development remain unclear. Myeloid cells are an intricate part of inflammation. They consist of mature cells represented by macrophages, dendritic cells and granulocytes and a population of Immature Myeloid Cells (IMC), which in healthy individuals are cells in transition to mature cells. There is a substantial expansion of IMC in cancer and many other pathological conditions which is associated with pathologic activation of these cells. As a result, these cells acquire the ability to suppress immune responses and are …

Faculty Senate Bill Fsb-2014-02-17-02-Gac: Graduate Affairs Committee, Armstrong Atlantic State University

Armstrong Faculty Senate: Bills, Motions & Resolutions (Archived)

Faculty Senate Bill FSB-2014-02-17-02-GAC: Graduate Affairs Committee

7th Annual Research Week- Event Proceedings, Office Of Research Development

Excellence Summit (Research Week) Archived Proceedings

7th Annual Research Week

One Step At A Time: A Journey Of Hope, Inspiration, And Determination, Melinda Hermanns, Barbara K. Haas

The Qualitative Report

Approximately three million persons in the United States face the challenge of living with Parkinson's Disease (PD). In spite of medical and surgical interventions, the disease progresses, resulting in bradykinesia, rigidity and postural instability that impair functional ability and quality of life. The purpose of this case study is to illuminate the impact an exercise program may have on an individual with PD. A single case study design was used to explore the effect of exercise on the quality of life of a 73-year old gentleman with advanced PD. Interviews and field observations of the client, wife, and staff at …

Georgia Southern University,Cosm News, Georgia Southern University

College of Science & Mathematics: News & Publications (2012-2022)

• COSM Undergrad presents at 46th Annual Southeastern Undergraduate Regional Conference (SURC)
• Physics Professor and Student’s Work Featured on the Cover of Nature

Newsroom, Georgia Southern University

Newsroom (2006-2023)

• Georgia Southern University Selects 2014 SOAR Leaders
• Symphonic Wind Ensemble Invited To Perform At Conference

February 17, 2014 Aasu Faculty Senate Minutes, Armstrong State University

Armstrong Faculty Senate: Minutes (Archived)

February 17, 2014 AASU Faculty Senate Minutes

February 17, 2014 Aasu Faculty Senate Agenda, Armstrong State University

Armstrong Faculty Senate: Armstrong Faculty Senate Agenda (Archived)

February 17, 2014 AASU Faculty Senate Agenda

February 17, 2014, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

In Territorio Veritas? Bringing Geographical Coherence Into The Ambiguous Definition Of Geographical Indications Of Origin, Irene Calboli

Faculty Scholarship

In this article, I touch upon a topic that remains highly controversial in international intellectual property law—the legal protection of geographical indications of origin (GIs): Chianti wine, Champagne sparkling wine, Gorgonzola cheese, Parma ham, Darjeeling tea, Colombian coffee, and other terms that indicate (or are supposed to indicate, as I will develop in this article) the geographical origin of the products they identify. In line with the theme of this special issue of the WIPO Journal, I focus on the requirement of “geographical origin” upon which the protection of GIs has been historically built and is generally justified. In particular, …

Targeted Drug Delivery System For Kidney And Liver Failure Patients Using Human Serum Albumin, Sara Gertsch, Sean Bedingfield, Stephanie Lawanto

Undergraduate Research and Creative Opportunities (URCO) Grant Program

Due to kidney or liver failure, normally harmless doses of prescription drugs can have toxic effects leading to further medical complications (Ing, 1979). Those suffering from kidney and liver failure frequently suffer related and unrelated ailments, but are restricted on the medications and the amounts thereof. Site-‐ specific ailments such as arthritis, localized viral infections, neuropathic pain, and other illnesses could be treated with smaller doses if the treating drug were only made available at the targeted site. The project goal is to develop a drug delivery system using human serum albumin (HSA) as a carrier for anti-‐ inflammatory, antibiotic, …

The Ipocamp Pressure Incubator For Deep-Sea Fauna, Bruce Shillito, Françoise Gaill, Juliette Ravaux

Journal of Marine Science and Technology–Taiwan

Animal Biology studies have always benefited from the achievement of experiments on live animals, which obviously provide data on dynamic aspects of physiology. When it comes to deep-sea fauna, in vivo experiments are impaired, and in some cases impossible, due to the severe and often lethal stress experienced by animals throughout the sampling process. However, freshly collected deep fauna may be maintained alive and in good condition, by using specific aquaria which restore environmental conditions prevailing at depth in situ. Here we describe the pressure device named “Incubateur Pressurisé pour l’Observation et la Culture d’Animaux Marins Profonds”, or IPOCAMP, and …

Climate- And Eustasy-Driven Cyclicity In Pennsylvanian Fusulinid Assemblages, Donets Basin (Ukraine), Rimma R. Khodjanyazova, Vladimir I. Davydov, Isabel P. Montañez, Mark D. Schmitz

Geosciences Faculty Publications and Presentations

A model of cyclic recurrence (~ 0.6–1.2 myr) of three fusulinid assemblages in the Middle Pennsylvanian siliciclastic–carbonate succession of the Donets Basin is proposed. Each cycle records progressive turnover of assemblages in shallow marine environments in response to sea-level and regional climate change. A Hemifusulina-assemblage (A), adapted to cooler and reduced salinity seawater records the onset of sea level rise accompanied by humid climatic conditions. Sea level high stand is captured by the Beedeina–Neostaffella–Ozawainella–Taitzehoella (or Beedeina-dominated) assemblage (B), characteristic of relatively deeper-water environments. The B assemblage is successively replaced by the most …

Capillary Electrophoresis-Based Assay Of Phosphofructokinase-1, Andrew Malina, Sherrisse K. Bryant, Simon H. Chang, Grover L. Waldrop, S. Douglass Gilman

Faculty Publications

An assay was developed for phosphofructokinase-1 (PFK-1) using capillary electrophoresis (CE). In the glycolytic pathway, this enzyme catalyzes the rate-limiting step from fructose-6-phosphate and magnesium-bound adenosine triphosphate (Mg-ATP) to fructose-1,6-bisphosphate and magnesium-bound adenosine diphosphate (Mg-ADP). This enzyme has recently become a research target because of the importance of glycolysis in cancer and obesity. The CE assay for PFK-1 is based on the separation and detection by ultraviolet (UV) absorbance at 260 nm of Mg-ATP and Mg-ADP. The separation was enhanced by the addition of Mg 2+ to the separation buffer. Inhibition studies of PFK-1 by aurintricarboxylic acid and palmitoyl coenzyme …

Functionally Diverse Biotin-Dependent Enzymes With Oxaloacetate Decarboxylase Activity, Adam D. Lietzan, Martin St. Maurice

Biological Sciences Faculty Research and Publications

Biotin-dependent enzymes catalyze carboxylation, decarboxylation and transcarboxylation reactions that participate in the primary metabolism of a wide range of organisms. In all cases, the overall reaction proceeds via two half reactions that take place in physically distinct active sites. In the first half-reaction, a carboxyl group is transferred to the 1-N′ of a covalently tethered biotin cofactor. The tethered carboxybiotin intermediate subsequently translocates to a second active site where the carboxyl group is either transferred to an acceptor substrate or, in some bacteria and archaea, is decarboxylated to biotin and CO₂ in order to power the export of sodium …

Neuronal Growth Cones And Regeneration: Gridlock Within The Extracellular Matrix, Diane M. Snow

Spinal Cord and Brain Injury Research Center Faculty Publications

The extracellular matrix is a diverse composition of glycoproteins and proteoglycans found in all cellular systems. The extracellular matrix, abundant in the mammalian central nervous system, is temporally and spatially regulated and is a dynamic "living" entity that is reshaped and redesigned on a continuous basis in response to changing needs. Some modifications are adaptive and some are maladaptive. It is the maladaptive responses that pose a significant threat to successful axonal regeneration and/or sprouting following traumatic and spinal cord injuries, and has been the focus of a myriad of research laboratories for many years. This review focuses largely on …

Proteoglycans: Road Signs For Neurite Outgrowth, Justin A. Beller, Diane M. Snow

Spinal Cord and Brain Injury Research Center Faculty Publications

Proteoglycans in the central nervous system play integral roles as "traffic signals" for the direction of neurite outgrowth. This attribute of proteoglycans is a major factor in regeneration of the injured central nervous system. In this review, the structures of proteoglycans and the evidence suggesting their involvement in the response following spinal cord injury are presented. The review further describes the methods routinely used to determine the effect proteoglycans have on neurite outgrowth. The effects of proteoglycans on neurite outgrowth are not completely understood as there is disagreement on what component of the molecule is interacting with growing neurites and …

Marine Invertebrate Larval Distribution At The Hydrothermal Vent Site Of Gueishandao, Hans-Uwe Dahms, Li-Chun Tseng, Jiang-Shiou Hwang

Journal of Marine Science and Technology–Taiwan

Scientists remain uncertain about numerous aspects of hydrothermal vent (HV) ecology, including the reproductive biology of their biota, as well as their recruitment and dispersal during larval stages (meroplankton) in the plankton above the HV sites. We studied the meroplankton from a shallow HV site off the northeastern coast of Taiwan, in the northwest Pacific Ocean. Our findings potentially explain how fauna endemic to HVs persist at specific HV sites. With the exception of some damaged Cnidaria and Ctenophora, the plankton net catches were in good condition and sufficient for identification.

Less Cookbook And More Research! Synthetic Efforts Toward Jbir-94 And Jbir-125: A Student-Designed Research Project In A Sophomore Organic Chemistry Lab, Mike A. Christiansen, C. L. Crawford, C. D. Mangum

Chemistry and Biochemistry Faculty Publications

In light of the meaningful learning gains that can be obtained through a genuine research experience, chemistry educators have had a longstanding interest in making teaching labs less “cookbook-like” and more research-driven [1]. With this mindset, we recently restructured our two-semester sophomore organic chemistry lab course to include a synthesis project that was chosen, designed, and carried out by students. This led to progress toward the syntheses of JBIR-94 and JBIR-125, two antioxidative/anticancer natural products that have yet to be assembled through organic chemistry. The major drawback of our course redesign is that it requires close supervision by an instructor …

Sequence Diversity Of Ammonium Transporter Genes In Cultured And Natural Species Of Marine Phytoplankton, Lee-Kuo Kang, Jeng Chang

Journal of Marine Science and Technology–Taiwan

The sequence database of ammonium transporter (Amt1) genes in eukaryotic phytoplankton was expanded by obtaining new sequences from cultured strains and natural populations collected in the East China Sea (ECS). From unialgal cultures, 6 new Amt1 sequences belonging to the Bacillariophyceae, Dinophyceae, and Prasinophyceae were obtained. A phylogenetic analysis revealed that AMT1s of higher plants were most closely related to those in green algae. In addition, haptophyte and diatom AMT1s formed distinct monophyletic clades. Diatom AMT1s were further divided into 3 orthologous subclasses, and active gene duplications were observed in subclass III. As for mixed-species sequencing using ECS samples, 78 …

Shrimp Immune System -Special Focus On Penaeidin, Yen-Ling Song, Ching-Yu Li

Journal of Marine Science and Technology–Taiwan

In this review paper, we summarize the immune system of penaeid shrimp. This review includes the clotting system comprising clot protein and clotting enzyme (transglutaminase II), as well as the prophenoloxidase (proPO) activation system including proPO-activating enzyme (PPAE), proPO and clip domain serine protease homolog (c-SPH). In addition, several shrimp cytokines or cytokine-like molecules found in tiger shrimp Penaeus monodon participating in the defense responses are also discussed. C-SPH could enhance hemocyte adhesion. Shrimp astakine promoted hemocyte proliferation in the hematopoietic tissues and could be down-regulated at the post-transcriptional level by the binding of intracellular molecules such as transglutaminase I …

Evolution Of Vacuolar Pyrophosphatases And Vacuolar H+-Atpases In Diatoms, Adrien Bussard, Pascal Jean Lopez

Journal of Marine Science and Technology–Taiwan

To cope with changing environments and maintain optimal metabolic conditions, the control of the intracellular proton gradients has to be tightly regulated. Among the important proton pumps, vacuolar H+ -ATPases (V-ATPases) and H+ - translocating pyrophosphatases (H+ -PPases) were found to be involved in a number of physiological processes, and shown to be regulated at the expression level and to exhibit specific sub-cellular localizations. Studies of the role of these transporters are relatively scarce in algae and nearly absent in diatoms. Phylogenetic analyses disclose that diatoms, with both K+ -dependent and K+ -independent membrane integral pyrophosphatases, including proteins with high …

Polychaetes As Annelid Models To Study Ecoimmunology Of Marine Organisms, Virginie Cuvillier-Hot, Céline Boidin-Wichlacz, Aurélie Tasiemski

Journal of Marine Science and Technology–Taiwan

Annelids are among the first coelomates and are therefore of special phylogenetic interest. They constitute an important part of the biomass of the seashore, estuaries, fresh water and terrestrial soils. Moreover, they occupy a central position in the trophic networks, as a major food source for fishes, birds and terrestrial fauna. Among Annelids, the large majority of polychaetes is restricted to the marine domain. This report gives an overview of the immune strategies developed by polychaetes to fight pathogens. The potential and interest to use these worms as biomarkers to monitor the influence of environmental perturbation on the immunity of …

Neurogenesis In Cephalopods: "Eco-Evo-Devo" Approach In The Cuttlefish Sepia Officinalis (Mollusca-Cephalopoda), Sandra Navet, Sébastien Baratte, Yann Bassaglia, Aude Andouche, Auxane Buresi, Laure Bonnaud

Journal of Marine Science and Technology–Taiwan

Cephalopods are new evolutionary and ecological models. By their phylogenetic position (Lophotrochozoa, Mollusca), they provide a missing master piece in the whole puzzle of neurodevelopment studies. Their derived and specific nervous system but also their convergence with vertebrates offer abundant materials to question the evolution and development of the nervous system of Metazoa (evo-devo studies). In addition, their various adaptions to different modes of life open new fields of investigation of developmental plasticity according to ecological context (eco-evo-devo approach). In this paper, we review the recent works on cephalopod nervous developmental investigations. We show how cephalopods, and especially Sepia officinalis, …

Traditional Vs New Approaches For Assessing Coral Health: A Global Overview And The Paradigm Of French Polynesia, Laetitia Hédouin, Véronique Berteaux-Lecellier

Journal of Marine Science and Technology–Taiwan

Today, there is increasing concern regarding the capacity of Scleractinian corals to sustain the growing number of insults associated with global and local changes (e.g. global warming, ocean acidification, pollution). If corals are to exist, there is an urgent need to use indicators of coral health that provide insight into early sub lethal shifts in corals before the irreversible effects of exposure manifest at the population and community levels. This paper will provide an overview of the most relevant and appropriate indicators of coral health currently used in traditional monitoring programs (traditional approach) or those that could be used in …

Assessing The Potential Bacterial Origin Of The Chemical Diversity In Calcareous Sponges, Elodie Quévrain, Mélanie Roué, Isabelle Domart-Coulon, Marie-Lise Bourguet-Kondracki

Journal of Marine Science and Technology–Taiwan

The chemodiversity and cultivable bacterial diversity of temperate calcareous sponges were investigated in a time series of collection of two sponges, Leuconia johnstoni (Baerida, Calcaronea) collected from the northeastern Atlantic Ocean and Clathrina clathrus (Clathrinida, Calcinea) collected from the northwestern Mediterranean Sea, using combined chemical and microbiological approaches. Bacteria were visualized in tissue sections of these sponges with Gram staining and in situ hybridization. The sponge crude extracts revealed annually persistent biological activities against reference human pathogen strains: L. johnstoni extracts displayed antimicrobial activity against a Gram positive Staphylococcus aureus strain; C. clathrus extracts displayed a broad spectrum of antimicrobial …

Diversity Of Bacterial Communities On Sunken Woods In The Mediterranean Sea, Sandrine Bessette, Sonja K. Fagervold, Chiara Romano, Daniel Martin, Nadine Le Bris, Pierre E Galand

Journal of Marine Science and Technology–Taiwan

Sunken woods are very rich and diverse ecosystems supporting large macrofaunal diversity and representing a source of carbon and energy for any heterotrophic organism able to consume plant material, and those relying on specialized microbial taxa. However, relatively little is known about the microbial communities that degrade sunken woods and produce reduced compounds that serve as energy sources for chemosynthetic lifestyles. The purpose of this study was to explore the bacterial diversity developing on and within sunken woods in a NW Mediterranean submarine canyon and its adjacent slope by using 16S rRNA genes survey. We described communities from Pine wood …

Crustacean Hyperglycemic Hormone: Structural Variants, Physiological Function, And Cellular Mechanism Of Action, Chi-Ying Lee, Kuo-Wei Tsai, Wei-Shiun Tsai, Jia-Ying Jiang,, Yan-Jhou Chen

Journal of Marine Science and Technology–Taiwan

Crustacean hyperglycemic hormone (CHH) is a peptide hormone originally identified in the X-organ/sinus gland (XO/ SG) complex of the eyestalks. It belongs to the CHH family which also includes molt-inhibiting hormone (MIH), vitellogenesis-inhibiting hormone (VIH), and mandibular organinhibiting hormone (MOIH), and ion transport peptide (ITP). Multiple molecular variants of CHH are generated by both post-transcriptional and post-translational mechanisms. In addition to the XO/SG complex, CHH gene is widely expressed in many extra-eyestalk tissues. Functionally, available data indicate that CHH is involved with the regulation of carbohydrate metabolism and stress-induced hyperglycemia. Several other physiological processes, including molting, ion and water balance, …

Hydrothermal Vent Effluents Affect Life Stages Of The Copepod Tisbe Sp, Hans-Uwe Dahms, Li-Chun Tseng, Derek Moo-Chul Shim, Jiang-Shiou Hwang

Journal of Marine Science and Technology–Taiwan

We examined the environmental effects of various concentrations of hydrothermal vent (HV) effluents on growth, reproduction, and survivorship of the Tisbe sp. harpacticoid copepod that were retrieved from localities near the vent. Developmental stages (nauplii and copepodids) were exposed to various concentrations of HV effluents in a static renewal culture system. In the survivorship experiments, we tested 3 distinct developmental phases in HV effluent dilutions from 50% to 1%. The HV effluents considerably reduced the survivorship of the naupliar stages at concentrations of >1% (P < 0.05); all nauplii died at concentrations of 25% and 50%. The copepodids were considerably affected at concentrations of >1% in Tisbe sp. (P < 0.05), and no copepodid survived at 50% (P < 0.01). The adult females died at a 50% concentration in Tisbe sp. The developmental duration was not considerably affected in the naupliar or copepodid phases; however, it exhibited a trend of developmental delay. The naupliar development of Tisbe sp. was substantially delayed at a concentration of 10% (P < 0.01), whereas copepodids and adults only exhibited a trend of delayed development with increasing HV concentration. The endpoint mortality exhibited a greater sensitivity to chemical exposure than the endpoint development time. The early developmental stages of Tisbe sp. in both traits were more sensitive to HV effluents than advanced stages. Mortality was a useful toxicological endpoint compared that of developmental duration. We demonstrated that Tisbe sp. may be used in the monitoring of acute and life cycle effects of natural marine pollution caused by HV effluents.

Integrated Guidance On The Care Of Familial Hypercholesterolaemia From The International Fh Foundation., Gerald F Watts, Samuel Gidding, Anthony S Wierzbicki, Peter P Toth, Rodrigo Alonso, W Virgil Brown, Eric Bruckert, Joep Defesche, Khoo Kah Lin, Michael Livingston, Pedro Mata, Klaus G Parhofer, Frederick J Raal, Raul D Santos, Eric J G Sijbrands, William G Simpson, David R Sullivan, Andrey V Susekov, Brian Tomlinson, Albert Wiegman, Shizuya Yamashita, John J P Kastelein

Division of Cardiology Faculty Papers

Familial hypercholesterolaemia (FH) is a dominantly inherited disorder present from birth that markedly elevates plasma low-density lipoprotein (LDL) cholesterol and causes premature coronary heart disease. There are at least 20million people with FH worldwide, but the majority remain undetected and current treatment is often suboptimal. To address this major gap in coronary prevention we present, from an international perspective, consensus-based guidance on the care of FH. The guidance was generated from seminars and workshops held at an international symposium. The recommendations focus on the detection, diagnosis, assessment and management of FH in adults and children, and set guidelines for clinical …