Digital Commons Network^™

Mcr-Miner: Maximal Confident Association Rules Miner Algorithm For Up/Down-Expressed Genes, Wael Zakaria, Yasser Kotb, Fayed Ghaleb

Applied Mathematics & Information Sciences

DNA microarrays allow simultaneous measurements of expression levels for a large number of genes across a number of different experimental conditions (samples). The algorithms for mining association rules are used to reveal biologically relevant associations between different genes under different experimental samples. This paper presents a new column-enumeration based method algorithm (abbreviated by MCR-Miner) for mining maximal high confidence association rules for up/down-expressed genes. MCR-Miner algorithm uses an efficient maximal association rules tree data structure (abbreviated by MAR-Tree). MAR-tree enumerates (lists) all genes with their binary representations, the binary representation of a gene saves the status (normal, up, and downexpressed) …

Off-Label Promotion After United States V. Caronia, Brian M. Blood

First Amendment Law Review

No abstract provided.

Genome Of The Human Hookworm Necator Americanus, Yat T. Tang, Xin Gao, Bruce A. Rosa, Sahar Abubucker, Kymberlie Hallsworth-Pepin, Peter J. Hotez, Jeffrey M. Bethony, +23 Additional Authors

Microbiology, Immunology, and Tropical Medicine Faculty Publications

The hookworm Necator americanus is the predominant soil-transmitted human parasite. Adult worms feed on blood in the small intestine, causing iron-deficiency anemia, malnutrition, growth and development stunting in children, and severe morbidity and mortality during pregnancy in women. We report sequencing and assembly of the N. americanus genome (244 Mb, 19,151 genes). Characterization of this first hookworm genome sequence identified genes orchestrating the hookworm's invasion of the human host, genes involved in blood feeding and development, and genes encoding proteins that represent new potential drug targets against hookworms. N. americanus has undergone a considerable and unique expansion of immunomodulator proteins, …

Detection And Antibiotic Treatment Of Mycoplasma Arginini Contamination In A Mouse Epithelial Cell Line Restore Normal Cell Physiology, Brianna Boslett, Subhra Nag, Andrew Resnick

Physics Faculty Publications

Mycoplasma contamination of cultured cell lines is difficult to detect by routine observation. Infected cells can display normal morphology and the slow growth rate of mycoplasma can delay detection for extended periods of time, compromising experimental results. Positive identification of mycoplasma typically requires cells to be either fixed and stained for DNA or processed with PCR. We present a method to detect mycoplasma using live-cell optical microscopy typically used for routine observation of cell cultures. Images of untreated mycoplasma-infected epithelial cells alongside images of infected cells treated with Plasmocin, a commercially available antibiotic targeted to mycoplasma, are shown. We found …

Nestling Sex Ratios Do Not Support Long-Term Parity In Two Species With Different Life-History Strategies, Noah G. Perlut, Steven E. Travis, Catherine A. Dunbar, Allan M. Strong, Derek M. Wright

Environmental Studies Faculty Publications

To maximize fitness, breeding adults may respond to environmental processes by adjusting their progeny’s sex ratios. R. A. Fisher in 1930 hypothesized that frequency-dependent selection would result in equal investment in sons and daughters over the long term, yielding a balanced sex ratio if the costs of raising a son and daughter are equal. Diverse hypotheses have tried to explain population and brood-by-brood deviations from this mean as well as annual variation by focusing on adult sex ratios, resources, abiotic conditions, and female and male quality. We collected data in 2002-2010 to explore population-level variation in nestling sex ratios in …

The Servant Of Two Masters

Taylor Theatre Playbills

The playbill for Taylor University’s Spring 2014 performance of The Servant of Two Masters by Carlo Goldoni, translated by Jeffry Hatcher and Paolo Emilio Landi.

The Servant of Two Masters is a comedy by the Italian playwright Carlo Goldoni written in 1746. It follows the story of Beatrice and her comical servant, Truffaldino. Beatrice goes disguised as her dead brother to find her lover, Florindo, plotting to acquire money from her brother’s betrothed to help her run away with her lover. Meanwhile Truffaldino secretly takes on an additional service to Florindo, and must do his best to serve his two …

The Best Interest Is The Child: A Historical Philosophy For Modern Issues, Lahny R. Silva

Brigham Young University Journal of Public Law

A little over a century after the creation of the first juvenile court in America, the states and the federal government continue to try to find an effective and practical solution to juvenile delinquency. Beginning with the “Best Interest of the Child Standard” in 1899, juvenile justice policy has evolved into a mixed bag of philosophies. State statutes littered with “Best Interest” rhetoric, have interestingly resulted in state policies that are retributive in nature and disproportionately affect minority communities. The disconnect between theory and practice is the product of decades of socio-political influence on juvenile justice policy as well as …

Dreaming As Representation : Wild Grass And Realism's Responsibility = 夢的表意 :《野草》與現實主義的責任, Roy Chan

Journal of Modern Literature in Chinese 現代中文文學學報

No abstract provided.

Lysine Deacetylase (Kdac) Regulatory Pathways: An Alternative Approach To Selective Modulation, Michael W. Van Dyke

Faculty Articles

Protein lysine deacetylases (KDACs), including the classic Zn2+-dependent histone deacetylases (HDACs) and the nicotinamide adenine dinucleotide (NAD+)-requiring sirtuins, are enzymes that play critical roles in numerous biological processes, particularly the epigenetic regulation of global gene expression programs in response to internal and external cues. Dysregulation of KDACs is characteristic of several human diseases, including chronic metabolic, neurodegenerative, and cardiovascular diseases and many cancers. This has led to the development of KDAC modulators, two of which (HDAC inhibitors vorinostat and romidepsin) have been approved for the treatment of cutaneous T cell lymphoma. By their nature, existing KDAC modulators are relatively nonspecific, …

In Vitro Interaction Of Pseudomonas Aeruginosa With Human Middle Ear Epithelial Cells, Rahul Mittal, M'Hamed Grati, Robert Gerring, Patricia Blackwelder, Denise Yan, Jian-Dong Li, Xue Zhong Liu

Marine & Environmental Sciences Faculty Articles

Background: Otitis media (OM) is an inflammation of the middle ear which can be acute or chronic. Acute OM is caused by Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis whereas Pseudomonas aeruginosa is a leading cause of chronic suppurative otitis media (CSOM). CSOM is a chronic inflammatory disorder of the middle ear characterized by infection and discharge. The survivors often suffer from hearing loss and neurological sequelae. However, no information is available regarding the interaction of P. aeruginosa with human middle ear epithelial cells (HMEECs).

Methodology and Findings: In the present investigation, we demonstrate that P. …

Common Sunflower Seedling Emergence Across The U.S. Midwest, Sharon A. Clay, Adam Davis, Anita Dille, John Lindquist, Analiza H. M. Ramirez, Christy Sprague, Graig Reicks, Frank Forcella

Agronomy, Horticulture and Plant Science Faculty Publications

Predictions of weed emergence can be used by practitioners to schedule POST weed management operations. Common sunflower seed from Kansas was used at six Midwestern U.S. sites to examine the variability that 16 climates had on common sunflower emergence. Nonlinear mixed effects models, using a flexible sigmoidal Weibull function that included thermal time, hydrothermal time, and a modified hydrothermal time (with accumulation starting from January 1 of each year), were developed to describe the emergence data. An iterative method was used to select an optimal base temperature (Tb) and base and ceiling soil matric potentials (ψb and ψc) that resulted …

Faculty Achievements, March 2014, Otterbein University

Faculty Achievement Reports

No abstract provided.

Cluster M Mycobacteriophages Bongo, Pegleg, And Rey With Unusually Large Repertoires Of Trna Isotypes, Welkin H. Pope, Kirk R. Anders, Madison Baird, Charles A. Bowman, Michelle M. Boyle, Gregory W. Broussard, Tiffany Chow, Kari L. Clase, Shannon Cooper, Kathleen A. Cornely, Randall J. Dejong, Veronique A. Delesalle, Lisa Deng, David Dunbar, Nicholas P. Edgington, Christina M. Ferreira, Kathleen Weston Hafer, Grant A. Hartzog, J. Robert Hatherill, Lee E. Hughes, Khristina Ipapo, Greg P. Krukonis, Christopher G. Meier, Denise L. Monti, Matthew R. Olm, Shallee T. Page, Craig L. Peebles, Claire A. Rinehart, Michael R. Rubin, Daniel A. Russell, Erin R. Sanders, Morgan Schoer, Christopher D. Shaffer, James Wherley, Edwin Vazquez, Han Yuan, Daiyuan Zhang, Steven G. Cresawn, Deborah Jacobs-Sera, Roger W. Hendrix, Graham F. Hatfull

Chemistry & Biochemistry Faculty Publications

Genomic analysis of a large set of phages infecting the common host Mycobacterium smegmatis mc2155 shows that they span considerable genetic diversity. There are more than 20 distinct types that lack nucleotide similarity with each other, and there is considerable diversity within most of the groups. Three newly isolated temperate mycobacteriophages, Bongo, PegLeg, and Rey, constitute a new group (cluster M), with the closely related phages Bongo and PegLeg forming subcluster M1 and the more distantly related Rey forming subcluster M2. The cluster M mycobacteriophages have siphoviral morphologies with unusually long tails, are homoimmune, and have larger than average genomes …

Roadmap For Graduating Students With Expertise In The Analysis And Development Of Secure Cyber-Systems, Ann Q. Gates, Salamah Salamah, Luc Longpre

Departmental Technical Reports (CS)

Modern society is intensely and irreversibly dependent on software systems of extraordinary size and complexity. This includes software systems in domain areas such as defense, energy, communication, transportation, and manufacturing. Due to the rapid expansion and reliance on the global Internet for day-to-day functions of individuals, organizations, governments, and industry around the world, cyber-security has emerged as an essential component of computing curricula. To address regional and national needs, the Computer Science Department has defined a roadmap for educating and preparing students who have expertise in the analysis and development of secure cyber-systems. Toward that vision, the department has set …

Photoassisted Access To New Polyheterocycles, Teresa M. Cowger

Electronic Theses and Dissertations

Photoassisted diversity-oriented synthesis holds great promise in its ability to provide rapid access to complex and diverse molecular scaffolds. As it stands, while photochemical techniques have this potential, their implementation in the field of synthetic organic chemistry is very limited. The main goal of this project was to utilize photochemically assisted techniques in the synthesis of a variety of novel polyheterocycles.

Initially, we explored the how the strain installed in these polycycles could be harnessed to trigger cationic rearrangements in the framework of the system. This was achieved via the high yield and rapid assembly of a highly strained system …

Foreign Investment In African Resources: The Ecological Aspect To Imperialism And Unequal Exchange, Mariko Frame

Electronic Theses and Dissertations

This dissertation examines the issue of foreign investment in African resources from the theoretical perspective of ecological imperialism and ecologically unequal exchange theory (EUE). Pulling from Marxist ecology, critical political ecology, and an environmental reading of Polanyi, this dissertation seeks to theoretically deepen and clarify the concept of `ecological imperialism.' It posits that the wave of neoliberal policies that swept through the developing world in the 1980s can be interpreted as a historically distinct moment of ecological imperialism, a `counter-countermovement' to the era of economic nationalism that sought to bring developing world resources under state control. Focusing on Africa and …

Mandatory Labeling Laws: What Do Recent State Enactments Portend For The Future Of Gmos?, Ross H. Pifer

Dickinson Law Review (1908-2003)

A debate on the propriety of establishing mandatory GMO labeling at the state level is well underway. Based on the results of recent ballot initiatives and state legislation, it is apparent that the concept of mandatory labeling enjoys significant support. Vermont has led the way with its enactment of a "no-strings attached" GMO labeling law, but federal courts and Congress will ultimately determine how the labeling issue will proceed. Regardless of how court challenges or preemptive federal legislation develop on the labeling issue, consumers still must decide whether they support the existing genetically modified food system. It is reasonable to …

Pollen Drift: Reframing The Biotechnology Liability Debate, A. Bryan Endres, Lisa Schlessinger

Dickinson Law Review (1908-2003)

The advent of genetic engineering and its application to agriculture has transformed the rural landscape at a microscopic level. A cursory glance of current production fails to reveal the underlying legal tensions at work in post-modem agriculture. The seemingly natural and necessary event of drifting, sexually viable pollen, however, implicates legal rights and responsibilities at the farm level with a ripple effect felt throughout the international commodity food and feed supply chain. Despite the ubiquitous nature of agricultural biotechnology, disputes arising from simple pollen drift lack a clear legal doctrine to define the multitude of subjects implicated, including tort liability, …

2,9-Bis(5-Sulfanylidene-4,5-Di­Hydro-1,3,4-Oxa­Diazol-2-Yl)-1,10-Phenanthroline Dimethyl Sulfoxide Disolvate, Mohammad A. Rahman, Mohammad R. Karim, Md Arifuzzaman, Tasneem Siddiquee, Lee M. Daniels

Chemistry Faculty Research

In the title compound, C₁₆H₈N₆O₂S₂·2C₂H₆OS, the phenanthroline mol­ecule resides on a twofold axis, and the asymmetric unit also contains a slightly disordered [occupancy ratio for S atom of 0.95 (3):0.047 (3)] mol­ecule of dimethyl sulfoxide. The O atoms of the solvent mol­ecule accept hydrogen bonds from the N-H groups of the five-membered 2,3-di­hydro-1,3,4-oxa­diazole-2-thione ring. This ring is nearly coplanar with the phenanthroline ring, with a dihedral angle between their least-squares planes of 8.86 (6)°. In the crystal, the mol­ecules are linked by C-HO inter­actions.

Nafissatou Dia Diouf’S Critical Look At A “Senegal In The Midst Of Transformation”, Molly Krueger Enz

School of American and Global Studies Faculty Publications with a Focus on Modern Languages and Global Studies

Nafissatou Dia Diouf is a Senegalese author who has garnered recognition both in her home country and internationally since she began publishing in the 1990s. Her work, including fiction, poetry, children’s literature, and philosophical essays, portrays diverse topics as they relate to her country such as education, marriage, polygamy, maternity/paternity, the influence of the West, the roles of business and government, and the power of the media. Diouf provides her reader with a comprehensive yet critical view of Senegal and shows how her homeland is affected by and reacts to the changes it currently faces. In a recent interview, Diouf …

A 54 Year-Old Man With Progressive Vision And Hearing Loss, A. A. Gru, G. Kolar, N. D. Wagner-Johnston, R. Schmidt, N. R. Yaseen

Biological Sciences Faculty Research & Creative Works

No abstract provided.

Prism #78, March 2014, Office Of The Provost

Prism: Western Michigan University's Newsletter for Academic Affairs

No abstract provided.

Strad Pseudokinases Regulate Axogenesis And Lkb1 Stability, Biliana O. Veleva-Rotse, James L. Smart, Annette F. Baas, Benjamin Edmonds, Zi-Ming Zhao, Allyson Brown, Lillian R. Klug, Kelly Hansen, Gabrielle Rielly, Alexandria P. Gardner, Krishnaveni Subbiah, Eric A. Gaucher, Hans Clevers, Anthony P. Barnes

Faculty Publications - Department of Biological & Molecular Science

No abstract provided.

44th Annual Wku Student Research Conference, Scott Lyons, Chair, Student Research Council

Student Research Conference Select Presentations

Abstracts available as a separate download on bottom of page.

Catalog Addendum Spring 2014, Kingsborough Community College

Course Catalogs

No abstract provided.

Faculty Attitudes Towards Integrating Technology And Innovation, Colleen Marzilli, Julie Delello, Shelly Marmion, Rochell Mcwhorter

Nursing Faculty Publications and Presentations

Technological innovation is an important aspect of teaching and learning in the 21st century. This article examines faculty attitudes toward technology use in the classroom at one regional public university in the United States. Building on a faculty-led initiative to develop a Community of Practice for improving education, this study used a mixed-method approach of a faculty-developed, electronic survey to assess this topic. Findings from 72 faculty members revealed an overall positive stance toward technology in the classroom and the average faculty member utilized about six technology tools in their courses. The opportunities, barriers and future uses for technologies in …

Role Of Erk1, 2, And 5 In Dopamine Neuron Survival During Aging, Mayur S. Parmar, Juliann D. Jaumotte, Stephanie L. Wyrostek, Michael J. Zigmond, Jane E. Cavanaugh

HPD Articles

Extracellular signal-regulated kinases (ERKs) 1, 2, and 5 have been shown to play distinct roles in proliferation, differentiation, and neuronal viability. In this study, we examined ERK1, 2, and 5 expression and activation in the substantia nigra (SN), striatum (STR), and ventral tegmental area (VTA) during aging. An age-related decrease in phosphorylated ERK5 was observed in the SN and STR, whereas an increase in total ERK1 was observed in all 3 regions. In primary cultures of the SN and VTA, inhibition of ERK5 but not ERK1 and 2 decreased dopamine neuronal viability significantly. These data suggest that ERK5 is essential …

The Implications Of Global Warming Upon United States Dairy Herds: Effects On The Economics Of Dairying And Stability Of Herds With Low Genetic Diversity, Lauren Lusby

Dairy Science

Global warming (GW) is of real concern for the current U.S. agricultural industry. The agricultural industry has had a hand in emitting into the atmosphere. Severe heat spells seen nationwide and volatile climate shifts have pushed states such as California to implement governmental support to high impact areas due to dwindling water sources. Motivated dairy industry members have created plans to reduce dairy GHE contribution. Some research has suggested a benefit in GHG emissions from fewer cow-higher production approaches to dairy farmers. Most U.S. dairy cattle are specialized due to high inbreeding values created by selecting for few production traits …

Molecular Pap Biomarkers For Cervical Cancer Risk Assessment In Thinprep® Clinical Specimens, Jennifer Taylor

Graduate School of Biomedical Sciences Theses and Dissertations

Approximately 500,000 patients are diagnosed with cervical cancer worldwide each year, thus making it the second most common cause of cancer-related deaths in women. Persistent high-risk human papillomavirus (HR-HPV) infections induce cervical dysplasia by increasing the expression of two viral oncogenes, E6 and E7. Utilization of the Papanicolaous smear test (Pap test) has contributed to a decrease in morbidity and mortality of cervical cancer; however, subjective analysis of cell morphology with a limited amount of cells has led to a substantial rate of false positive and false negative diagnoses. A more objective and sensitive diagnostic tool for the detection of …

Communicating The Science Of Igcp 591 To The Public, Lewandowski J. Katherine

Faculty Research and Creative Activity

Selling the broader impacts of science to funding agencies has become a necessity in a time when competition for grant money is high. While involving students in research is still important for maintaining a pipeline of trained scientists, the bar has been raised and it is increasingly incumbent on us to communicate to the public what is so important about our work. To be competitive in the search for funds, there must be a plan for the science funded to be disseminated to the public. The education and outreach plan for IGCP 591 attempts to appeal to this broader audience …