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2014

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A Revision Of The Genus Purenleon Stange (Neuroptera: Myrmeleontidae: Nemoleontini), Robert B. Miller, Lionel A. Stange Jan 2014

A Revision Of The Genus Purenleon Stange (Neuroptera: Myrmeleontidae: Nemoleontini), Robert B. Miller, Lionel A. Stange

Insecta Mundi

Twenty six species of the genus Purenleon Stange (Neuroptera: Myrmeleontidae: Nemoleontini) are recognized from the New World, of which ten are described as new species: P. oaxacae, P. fernandezi, P. tibialis, P. adamsi, P. andinus, P. apache, P. aztecus, P. cavei, P. farri and P. toltecus. Neotypes are designated for Psammoleon banksi Esben-Petersen 1933 and for Formicaleo inaequalis Navás 1913. The larvae of sixteen species have been reared and are described with data on their biologies. The genus is subdivided into three species groups based mostly on leg structure. The inscriptus group consists of five species, the tibialis …


Tracking Pod's Engagement With Diversity: A Content Analysis Of To Improve The Academy And Pod Network Conference Programs From 1977 To 2011, Stacy E. Grooters Jan 2014

Tracking Pod's Engagement With Diversity: A Content Analysis Of To Improve The Academy And Pod Network Conference Programs From 1977 To 2011, Stacy E. Grooters

To Improve the Academy: A Journal of Educational Development

This study examines the degree to which sessions from the annual Professional and Organizational Development (POD) Network Conference and articles from To Improve the Academy engage questions of diversity. The titles and abstracts of 3,946 conference sessions and 560 journal articles were coded for presence and type of diversity. A significant variation in inclusion of diversity over time was found for the conference sessions (p < 0.001) but not the journal articles. Overall, the findings suggest that the organization has been inconsistent in its scholarly engagement with diversity and should work to encourage more regular engagement with diversity by its members.


Preparing New Faculty For Leadership: Understanding And Addressing Needs, Anne Kelsch, Joan Hawthorne Jan 2014

Preparing New Faculty For Leadership: Understanding And Addressing Needs, Anne Kelsch, Joan Hawthorne

To Improve the Academy: A Journal of Educational Development

A perceived decline in effective faculty participation in campus leadership and governance is well documented, both in the literature and via anecdote. Characteristics common within the culture of higher education make nurturing campus “citizenship” among junior faculty challenging. This essay describes findings from an interview based study of junior faculty in which understanding of professional responsibilities beyond teaching and research was explored. The study documented the deep sense of unpreparedness with which new faculty approach key issues in higher education, including those associated with governance and leadership. Two possible strategies for redressing that unpreparedness, both showing preliminary but positive results, …


Developing Scholarly Teachers Through An Sotl Faculty Fellowship, Beth A. Fisher, Michelle D. Repice, Carolyn L. Dufault, Denise A. Leonard, Regina F. Frey Jan 2014

Developing Scholarly Teachers Through An Sotl Faculty Fellowship, Beth A. Fisher, Michelle D. Repice, Carolyn L. Dufault, Denise A. Leonard, Regina F. Frey

To Improve the Academy: A Journal of Educational Development

The increasing interest in incorporating evidenced based teaching in higher education has created a pronounced need for faculty to learn the theory and practice of the Scholarship of Teaching and Learning (SoTL). This article describes a program designed to prepare faculty to (a) draw on existing SoTL studies when designing and implementing evidenced based teaching methods, (b) design SoTL studies to test the effectiveness of those methods, and (c) integrate their new knowledge of SoTL into the practice of “scholarly teaching.” This program has proven to be a successful model for incorporating evidenced based teaching into undergraduate science, technology, engineering, …


Influence Of Corn Residue Harvest Management On Grain, Stover, And Energy Yields, Keri B. Cantrell, Jeffrey M. Novak, James R. Frederick, Douglas Karlen, Donald W. Watts Jan 2014

Influence Of Corn Residue Harvest Management On Grain, Stover, And Energy Yields, Keri B. Cantrell, Jeffrey M. Novak, James R. Frederick, Douglas Karlen, Donald W. Watts

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

Economic, environmental, and energy independence issues are contributing to rising fossil fuel prices, petroleum supply concerns, and a growing interest in biomass feedstocks as renewable energy sources. Potential feedstocks include perennial grasses, timber, and annual grain crops with our focus being on corn (Zea mays L.) stover. A plot-scale study evaluating stover removal was initiated in 2008 on a South Carolina Coastal Plain Coxville/Rains–Goldsboro– Lynchburg soil association site. In addition to grain and stover yields, carbon balance, greenhouse gas (GHG) emissions and soil quality impact reported elsewhere in this issue, variation in gross energy distribution within various plant fractions …


Bio-Inspired Flow Sensing For Underwater Guidance And Navigation, Levi Devries Jan 2014

Bio-Inspired Flow Sensing For Underwater Guidance And Navigation, Levi Devries

Link Foundation Ocean Engineering and Instrumentation Fellowship Reports

Stream-dwelling fish and aquatic mammals have an innate ability to navigate often-tumultuous environments with impressive precision, a highly desirable trait for underwater vehicle applications. For example, trout use their lateral line to sense vortices shed by an upstream obstacle and slalom between the vortices to reduce energy expenditure compared to free-stream swimming [3]. Moreover, harbor seals can use their whiskers to follow the trail of flow disturbances created in the wake of an object that has passed minutes before [4]. Recent developments in materials science have produced sensors that can measure local flow velocity similar to seal whiskers, and integration …


A High-Need Azeri School: A Georgian Perspective, Nino Sharvashidze, Miles T. Bryant Jan 2014

A High-Need Azeri School: A Georgian Perspective, Nino Sharvashidze, Miles T. Bryant

Department of Educational Administration: Faculty Publications

This article contributes to the International Study of Leadership Development Network initiative to identify high-need schools around the globe by focusing on a small minority ethnic school in the country of Georgia. It will be clear in this article that the challenges the Karajala School administrator faces in this former Soviet bloc school stand as an example of the educational disadvantages common to rural minority ethnic schools in Georgia and to many small rural schools in former Soviet bloc nations. The Karajala School is populated with Azeri students and is located in an isolated agrarian village. In the Republic of …


Convection Enhanced Delivery And In Vivo Imaging Of Polymeric Nanoparticles For The Treatment Of Malignant Glioma, Giovanna M. Bernal, Michael J. Lariviere, Nassir Mansour, Peter Pytel, Kirk E. Cahill, David J. Voce, Shijun Kang, Rubin Spretz, Ulrich Welp, Sandra E. Noriega, Luis Nunez, Gustavo F. Larsen, Ralph R. Weichselbaum, Bakhtiar Yamini Jan 2014

Convection Enhanced Delivery And In Vivo Imaging Of Polymeric Nanoparticles For The Treatment Of Malignant Glioma, Giovanna M. Bernal, Michael J. Lariviere, Nassir Mansour, Peter Pytel, Kirk E. Cahill, David J. Voce, Shijun Kang, Rubin Spretz, Ulrich Welp, Sandra E. Noriega, Luis Nunez, Gustavo F. Larsen, Ralph R. Weichselbaum, Bakhtiar Yamini

Department of Chemical and Biomolecular Engineering: Faculty Publications

A major obstacle to the management of malignant glioma is the inability to effectively deliver therapeutic agent to the tumor. In this study, we describe a polymeric nanoparticle vector that not only delivers viable therapeutic, but can also be tracked in vivo using MRI. Nanoparticles, produced by a non-emulsion technique, were fabricated to carry iron oxide within the shell and the chemotherapeutic agent, temozolomide (TMZ), as the payload. Nanoparticle properties were characterized and subsequently their endocytosis-mediated uptake by glioma cells demonstrated. Convection enhanced delivery (CED) can disperse nanoparticles through the rodent brain and their distribution is accurately visualized by MRI. …


Hlm Behind The Curtain: Unveiling Decisions Behind The Use And Interpretation Of Hlm In Higher Education Research, Elizabeth Niehaus, Corbin M. Campbell, Karen Kurotsuchi Inkelas Jan 2014

Hlm Behind The Curtain: Unveiling Decisions Behind The Use And Interpretation Of Hlm In Higher Education Research, Elizabeth Niehaus, Corbin M. Campbell, Karen Kurotsuchi Inkelas

Department of Educational Administration: Faculty Publications

Hierarchical linear modeling (HLM) has become increasingly popular in the higher education literature, but there is significant variability in the current approaches to the conducting and reporting of HLM. The field currently lacks a general consensus around important issues such as the number of levels of analysis that are important to include and how much variance should be accounted for at each level in order for the HLM analysis to have practical significance (Dedrick et al., Rev Educ Res 79:69–102, 2009). The purpose of this research is to explore the use of a 3-level HLM model, appropriate contextualizing of results …


Being And Belonging: A Critical Phenomenological Study Of Undergraduate Chinese International Students’ Sense Of Belonging In Residence Halls, Christina W. Yao Jan 2014

Being And Belonging: A Critical Phenomenological Study Of Undergraduate Chinese International Students’ Sense Of Belonging In Residence Halls, Christina W. Yao

Department of Educational Administration: Faculty Publications

Despite the large number of international students from China in U.S. higher education, little research exists on these students’ perceptions of the racial climate in residence halls. This research study illuminates the experiences affecting the sense of belonging of first-year Chinese international students and provides insights on how these students perceive the climate within their new collegiate ‘home’. I used a phenomenological orientation to understand participants’ lived experiences. A critical lens was used to analyze and examine the contextual influences on the participants’ experiences.

This study is centered on understanding how undergraduate Chinese international students’ experiences with domestic students affected …


Assessing The Metabolic Impact Of Nitrogen Availability Using A Compartmentalized Maize Leaf Genome-Scale Model, Margaret Simmons, Rajib Saha, Nardjis Amiour, Akhil Kumar, Lenaïg Guillard, Gilles Clément, Martine Miquel, Zhenni Li, Gregory Mouille, Peter J. Lea, Bertrand Hirel, Costas D. Maranas Jan 2014

Assessing The Metabolic Impact Of Nitrogen Availability Using A Compartmentalized Maize Leaf Genome-Scale Model, Margaret Simmons, Rajib Saha, Nardjis Amiour, Akhil Kumar, Lenaïg Guillard, Gilles Clément, Martine Miquel, Zhenni Li, Gregory Mouille, Peter J. Lea, Bertrand Hirel, Costas D. Maranas

Department of Chemical and Biomolecular Engineering: Faculty Publications

Maize (Zea mays) is an important C4 plant due to its widespread use as a cereal and energy crop. A second-generation genomescale metabolic model for the maize leaf was created to capture C4 carbon fixation and investigate nitrogen (N) assimilation by modeling the interactions between the bundle sheath and mesophyll cells. The model contains gene-protein-reaction relationships, elemental and charge balanced reactions, and incorporates experimental evidence pertaining to the biomass composition, compartmentalization, and flux constraints. Condition-specific biomass descriptions were introduced that

account for amino acids, fatty acids, soluble sugars, proteins, chlorophyll, lignocellulose, and nucleic acids as experimentally …


Structure And Function Of Preq1 Riboswitches, Catherine D. Eichhorn, Mijeong Kang, Juli Feigon Jan 2014

Structure And Function Of Preq1 Riboswitches, Catherine D. Eichhorn, Mijeong Kang, Juli Feigon

Department of Chemistry: Faculty Publications

PreQ1 riboswitches help regulate the biosynthesis and transport of PreQ1 (7-aminomethyl-7- deazaguanine), a precursor of the hypermodified guanine nucleotide queuosine (Q), in a number of Firmicutes, Proteobacteria, and Fusobacteria. Queuosine is almost universally found at the wobble position of the anticodon in asparaginyl, tyrosyl, histidyl and aspartyl tRNAs, where it contributes to translational fidelity. Two classes of PreQ1 riboswitches have been identified (PreQ1-I and PreQ1-II), and structures of examples from both classes have been determined. Both classes form H-type pseudoknots upon PreQ1 binding, each of which has distinct unusual features and modes …


Advances In Chemical And Structural Characterization Of Concretion With Implications For Modeling Marine Corrosion, Donald L. Johnson, Robert J. Deangelis, Dana J. Medlin, James D. Carr, David L. Conlin Jan 2014

Advances In Chemical And Structural Characterization Of Concretion With Implications For Modeling Marine Corrosion, Donald L. Johnson, Robert J. Deangelis, Dana J. Medlin, James D. Carr, David L. Conlin

Department of Chemistry: Faculty Publications

The Weinsnumber model and concretion equivalent corrosion rate methodology were developed as potential minimum-impact, cost-effective techniques to determine corrosion damage on submerged steel structures. To apply the full potential of these technologies, a detailed chemical and structural characterization of the concretion (hard biofouling) that transforms into iron bearing minerals is required. The fractions of existing compounds and the quantitative chemistries are difficult to determine from x-ray diffraction. Environmental scanning electron microscopy was used to present chemical compositions by means of energy-dispersive spectroscopy (EDS). EDS demonstrates the chemical data in mapping format or in point or selected area chemistries. Selectedarea EDS …


Analogues Of (-)-Picropodophyllin, Synthesis And Uses Thereof, David B. Berkowitz, Sylvain Broussy Jan 2014

Analogues Of (-)-Picropodophyllin, Synthesis And Uses Thereof, David B. Berkowitz, Sylvain Broussy

Department of Chemistry: Faculty Publications

Analogs of (-)-Picropodophyllin, synthesis thereof, and uses in pharmaceuticals as inhibitors of IGF1RK.


Iterative Assembly Of Two Separate Polyketide Chains By The Same Single-Module Bacterial Polyketide Synthase In The Biosynthesis Of Hsaf, Yaoyao Li, Haotong Chen, Yanjiao Ding, Yunxuan Xie, Haoxin Wang, Ronald Cerny, Yuemao Shen, Liangcheng Du Jan 2014

Iterative Assembly Of Two Separate Polyketide Chains By The Same Single-Module Bacterial Polyketide Synthase In The Biosynthesis Of Hsaf, Yaoyao Li, Haotong Chen, Yanjiao Ding, Yunxuan Xie, Haoxin Wang, Ronald Cerny, Yuemao Shen, Liangcheng Du

Ronald Cerny Publications

HSAF (1) was isolated from the biocontrol agent Lysobacter enzymogenes (Figure 1).[1-4]

This bacterial metabolite belongs to polycyclic tetramate macrolactams (PTM) that are

emerging as a new class of natural products with distinct structural features. [5, 6] HSAF

exhibits a potent antifungal activity and shows a novel mode of action.[1-4] The HSAF

biosynthetic gene cluster contains only a single-module hybrid polyketide synthasenonribosomal

peptide synthetase (PKS-NRPS), although the PTM scaffold is apparently

derived from two separate hexaketide chains and an ornithine residue.[1-4] This suggests that

the same PKS module would act not only iteratively, but also …


Identification Of Low Molecular Weight Compounds Inhibiting Growth Of Corynebacteria: Potential Lead Compounds For Antibiotics, Jaime L. Stark, Jennifer C. Copeland, Alexander Eletsky, Greg A. Somerville, Thomas Szyperski, Robert Powers Jan 2014

Identification Of Low Molecular Weight Compounds Inhibiting Growth Of Corynebacteria: Potential Lead Compounds For Antibiotics, Jaime L. Stark, Jennifer C. Copeland, Alexander Eletsky, Greg A. Somerville, Thomas Szyperski, Robert Powers

Robert Powers Publications

The genus Corynebacterium consists of nearly seventy species and is closely related to the genera Mycobacterium, Nocardia, and Rhodococcus. The characteristic traits of Corynebacteria include cells that are shaped like straight rods with clubbed ends, as well as an extra cell wall layer consisting of mycolic acids covalently bound to the peptidoglycan layer which adds an additional layer of protection against antibiotics. Corynebacteria are very well studied and outstandingly important for the large scale biotechnological production of amino acids and nucleotides. Moreover, Corynebacteria produce several pathogens that affect humans and livestock. Toxins produced by C. diphtheriae and C. …


Photocatalytic Hydrogen Production From A Noble Metal Free System Based On A Water Soluble Porphyrin Derivative And A Cobaloxime Catalyst, Theodore Lazarides, Milan Delor, Igor V. Sazanovich, Theresa M. Mccormick, Irene Georgakaki, Georgios Charalambidis, Julia A. Weinstein, Athanassios G. Coutsolelos Jan 2014

Photocatalytic Hydrogen Production From A Noble Metal Free System Based On A Water Soluble Porphyrin Derivative And A Cobaloxime Catalyst, Theodore Lazarides, Milan Delor, Igor V. Sazanovich, Theresa M. Mccormick, Irene Georgakaki, Georgios Charalambidis, Julia A. Weinstein, Athanassios G. Coutsolelos

Chemistry Faculty Publications and Presentations

A combination of noble-metal free components, a water soluble porphyrin photosensitizer zincmeso-tetrakis(1-methylpyridinium-4-yl)porphyrin chloride [ZnTMPyP4+]Cl4 (1) with cobaloxime complex [CoIII(dmgH)2(py)Cl] (2) as a catalyst, creates an efficient system for photochemical hydrogen production acting under visible light with 280 TONs. This is the first example of a water soluble porphyrin acting as a photosensitizer for cobaloxime catalysed H2 production.


Gratitude In Relationship Marketing: Theoretical Development And Directions For Future Research, Randle D. Raggio, Anna M. Walz, Mousumi Bose Godbole, Judith Anne Garretson Folse Jan 2014

Gratitude In Relationship Marketing: Theoretical Development And Directions For Future Research, Randle D. Raggio, Anna M. Walz, Mousumi Bose Godbole, Judith Anne Garretson Folse

Marketing Faculty Publications

Purpose – For centuries, gratitude has represented an integral component of social relationships, yet it remains relatively overlooked by marketing scholars in the study of commercial relationships. The purpose of this paper is to demonstrate how gratitude helps to build, maintain and transform commercial relationships and to suggest noteworthy areas of investigation for those researchers seeking to help companies understand the role of gratitude in relationship marketing.

Design/methodology/approach – Gratitude's role in relational exchange is explored by a review of relevant literature and two qualitative studies. Questions developed from the literature and exploratory interviews are then investigated in a main …


How Consumers’ Use Of Brand Vs. Attribute Information, Randle D. Raggio, Robert P. Leone, William C. Black Jan 2014

How Consumers’ Use Of Brand Vs. Attribute Information, Randle D. Raggio, Robert P. Leone, William C. Black

Marketing Faculty Publications

Prior research has identified that brands have a differential impact on consumer evaluations across various brand benefits. But no work has considered whether these effects are stable over time, or evolve in a consistent way. We address this question by decomposing consumer evaluations of brand benefits into overall brand and detailed attribute-specific sources in order to understand whether brand effects remain stable or evolve over time. With two unique datasets, the first containing cross-sectional data from Kodak across four different consumer goods categories, and another longitudinal dataset from the U.S. and Canada in the surface-cleaning category, covering seven brands over …


Beyond Title Vii: Rethinking Race, Ex-Offender Status, And Employment Discrimination In The Information Age, Kimani Paul-Emile Jan 2014

Beyond Title Vii: Rethinking Race, Ex-Offender Status, And Employment Discrimination In The Information Age, Kimani Paul-Emile

Faculty Scholarship

More than sixty-five million people in the United States—more than one in four adults—have had some involvement with the criminal justice system that will appear on a criminal history report. A rapidly expanding, for-profit industry has developed to collect these records and compile them into electronic databases, offering employers an inexpensive and readily accessible means of screening prospective employees. Nine out of ten employers now inquire into the criminal history of job candidates, systematically denying individuals with a criminal record any opportunity to gain work experience or build their job qualifications. This is so despite the fact that many individuals …


Don't Give Up On Taxes, Linda Sugin Jan 2014

Don't Give Up On Taxes, Linda Sugin

Faculty Scholarship

Professor Sugin discusses professor Edward D. Kleinbard's latest book, We are Better Than This (2015, Oxford) about the fiscal system and the broader implications of progressive taxation as a policy goal.


Autopsy Reports And The Confrontation Clause: A Presumption Of Admissibility, Daniel J. Capra, Joseph Tartakovsky Jan 2014

Autopsy Reports And The Confrontation Clause: A Presumption Of Admissibility, Daniel J. Capra, Joseph Tartakovsky

Faculty Scholarship

Courts nationwide are divided over whether autopsy reports are “testimonial” under the Sixth Amendment’s Confrontation Clause. Resolving that split will affect medical examiners as dramatically as Miranda did police. This article applies the latest Supreme Court jurisprudence to the work of modern medical examiners in a comprehensive inquiry. It argues that autopsy reports should be presumed non-testimonial—a presumption overcome only by a showing that law enforcement involvement materially influenced the examiner’s autopsy report.


The Sec Adds A New Weapon: How Does The New Admission Requirement Change The Landscape?, Paul Radvany Jan 2014

The Sec Adds A New Weapon: How Does The New Admission Requirement Change The Landscape?, Paul Radvany

Faculty Scholarship

Over the past several years, the Securities and Exchange Commission (the “SEC”) has settled the vast majority of the cases it has brought. Some people have suggested, however, that settlements by public agencies such as the SEC should be scrutinized more closely. For instance, in a series of recent opinions, Judge Jed S. Rakoff of the Southern District of New York has “question[ed] the wisdom” of the SEC’s well-established practice of permitting defendants to enter into consent judgments while neither admitting nor denying the allegations. During the past two years, the SEC has implemented new policies that have altered its …


Annual Report: 2014, Centracare Health Jan 2014

Annual Report: 2014, Centracare Health

Annual Report

  • Farewell letter from Terry Pladson
  • Various changes to organizations operations
  • Story of how the St. Cloud Hospital saved the life of a patient
  • Financial information regarding CentraCare Health Foundation
  • List of Donors


Citations To Foreign Courts -- Illegitimate And Superfluous, Or Unavoidable? Evidence From Europe, Martin Gelter, Mathias M. Siems Jan 2014

Citations To Foreign Courts -- Illegitimate And Superfluous, Or Unavoidable? Evidence From Europe, Martin Gelter, Mathias M. Siems

Faculty Scholarship

The theoretical arguments in favour and against citations to foreign courts have reached a high degree of sophistication. Yet, this debate is often based on merely anecdotal assumptions about the actual use of cross-citations. This article aims to fill this gap. It provides quantitative evidence from ten European supreme courts in order to assess the desirability of such cross-citations. In addition, it examines individual cases qualitatively, developing a taxonomy of cross-citations based on the degree to which courts engage with foreign law. Overall, this article high-lights the often superficial nature of cross-citations in the some courts; yet, it also concludes …


Housing Development Erodes Avian Community Structure In U.S. Protected Areas, Eric M. Wood, Anna M. Pidgeon, Volker C. Radeloff, David Helmers, Patrick D. Culbert, Nicholas S. Keuler, Curtis H. Flather Jan 2014

Housing Development Erodes Avian Community Structure In U.S. Protected Areas, Eric M. Wood, Anna M. Pidgeon, Volker C. Radeloff, David Helmers, Patrick D. Culbert, Nicholas S. Keuler, Curtis H. Flather

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

Protected areas are a cornerstone for biodiversity conservation, but they also provide amenities that attract housing development on inholdings and adjacent private lands. We explored how this development affects biodiversity within and near protected areas among six ecological regions throughout the United States. We quantified the effect of housing density within, at the boundary, and outside protected areas, and natural land cover within protected areas, on the proportional abundance and proportional richness of three avian guilds within protected areas. We developed three guilds from the North American Breeding Bird Survey, which included Species of Greatest Conservation Need, land cover affiliates …


A New Metric For Quantifying Burn Severity: The Relativized Burn Ratio, Sean A. Parks, Gregory K. Dillon, Carol Miller Jan 2014

A New Metric For Quantifying Burn Severity: The Relativized Burn Ratio, Sean A. Parks, Gregory K. Dillon, Carol Miller

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

Satellite-inferred burn severity data have become increasingly popular over the last decade for management and research purposes. These data typically quantify spectral change between pre-and post-fire satellite images (usually Landsat). There is an active debate regarding which of the two main equations, the delta normalized burn ratio (dNBR) and its relativized form (RdNBR), is most suitable for quantifying burn severity; each has its critics. In this study, we propose and evaluate a new Landsat-based burn severity metric, the relativized burn ratio (RBR), that provides an alternative to dNBR and RdNBR. For 18 fires in the western US, we compared the …


Characterization Of A Dual-Tropic Human Immunodeficiency Virus (Hiv-1) Strain Derived From The Prototypical X4 Isolate Hxbc2, Shi-Hua Xiang, Beatriz Pacheco, Dane Bowder, Wen Yuan, Joseph Sodroski Jan 2014

Characterization Of A Dual-Tropic Human Immunodeficiency Virus (Hiv-1) Strain Derived From The Prototypical X4 Isolate Hxbc2, Shi-Hua Xiang, Beatriz Pacheco, Dane Bowder, Wen Yuan, Joseph Sodroski

Nebraska Center for Virology: Faculty Publications

Human immunodeficiency virus type 1 (HIV-1) coreceptor usage and tropism can be modulated by the V3 loop sequence of the gp120 exterior envelope glycoprotein. For coreceptors, R5 viruses use CCR5, X4 viruses use CXCR4, and dual-tropic (R5X4) viruses use either CCR5 or CXCR4. To understand the requirements for dual tropism, we derived and analyzed a dual-tropic variant of an X4 virus. Changes in the V3 base, which allow gp120 to interact with the tyrosine-sulfated CCR5 N-terminus, and deletion of residues 310/311 in the V3 tip were necessary for efficient CCR5 binding and utilization. Thus, both sets of V3 changes allowed …


Risk Factors For Early Childhood Infection Of Human Herpesvirus-8 In Zambian Children: The Role Of Early Childhood Feeding Practices, Kay L. Crabtree, Janet M. Wojcicki, Veenu Minhas, David R. Smith, Chipepo Kankasa, Charles D. Mitchell, Charles Wood Jan 2014

Risk Factors For Early Childhood Infection Of Human Herpesvirus-8 In Zambian Children: The Role Of Early Childhood Feeding Practices, Kay L. Crabtree, Janet M. Wojcicki, Veenu Minhas, David R. Smith, Chipepo Kankasa, Charles D. Mitchell, Charles Wood

Nebraska Center for Virology: Faculty Publications

Background—Human herpesvirus-8 (HHV-8) infection in early childhood is common throughout sub-Saharan Africa with prevalence increasing throughout childhood. Specific routes of transmission have not been clearly delineated, though HHV-8 is present in high concentrations in saliva.

Methods—To understand the horizontal transmission of HHV-8 within households to children we enrolled for cross-sectional analysis, 251 households including 254 children, age two and under, in Lusaka, Zambia. For all children, plasma was screened for HHV-8 and HIV-1 and health and behavioral questionnaires were completed. Multi-level logistic regression analysis was conducted to assess independent factors for HHV-8 infection in children.

Results—Risk factors for HHV-8 infection …


Review Of Epidemiology And Transmission Of Kaposi’S Sarcoma-Associated Herpesvirus, Veenu Minhas, Charles Wood Jan 2014

Review Of Epidemiology And Transmission Of Kaposi’S Sarcoma-Associated Herpesvirus, Veenu Minhas, Charles Wood

Nebraska Center for Virology: Faculty Publications

This review summarizes the current knowledge pertaining to Kaposi sarcoma-associated herpesvirus (KSHV) epidemiology and transmission. Since the identification of KSHV twenty years ago, it is now known to be associated with Kaposi’s sarcoma (KS), primary effusion lymphoma, and multicentric Castleman’s disease. Many studies have been conducted to understand its epidemiology and pathogenesis and their results clearly show that the worldwide distribution of KSHV is uneven. Some geographical areas, such as sub-Saharan Africa, the Mediterranean region and the Xinjiang region of China, are endemic areas, but Western Europe and United States have a low prevalence in the general population. This makes …