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2014

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3-Amino-2-Piperidinequinoline A Novel Natural Product-Inspiried Synthetic Compound With Antimalarial Activity, Cristhian Valor Jan 2014

3-Amino-2-Piperidinequinoline A Novel Natural Product-Inspiried Synthetic Compound With Antimalarial Activity, Cristhian Valor

HIM 1990-2015

Malaria afflicts about 500 million people worldwide thus causing significant global economic toll. The drugs available to treat the disease are rapidly losing their efficacy because of widespread prevalence of drug resistant parasites. Thus there is an urgent need to discover novel malaria therapeutics. This research is focused on to study the properties of a novel naturallike synthetic scaffold and analyze its selectivity, and cellular mechanism of action in Plasmodium falciparum. We have identified a novel compound, 3-amino-2-piperidinequinoline (APQ), which we termed UCF401. APQ demonstrated IC[sub50] at submicromolar concentrations against Plasmodium falciparum using the SYBR Green-I fluorescence assay measuring cellular …

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The Role Of Intestinal Sweet Taste Receptors (Strs) In The Regulation Of Glucose Absorption: Effects Of Short Term High Sucrose Diet (Hsd), Tania Hussain Jan 2014

The Role Of Intestinal Sweet Taste Receptors (Strs) In The Regulation Of Glucose Absorption: Effects Of Short Term High Sucrose Diet (Hsd), Tania Hussain

HIM 1990-2015

Sweet taste receptors are primarily found in the oral cavity of the mammalian species. However, recent studies have shown that sweet taste receptors can be found in extraoral tissues such as the pancreas, intestines, and adipose tissue. Our lab has previously found that sweet taste receptors are down-regulated on the pancreas in the presence of high plasma glucose levels. In order to assess the possibility that sweet taste receptors respond to high levels of glucose by suppressing its expression, we wanted to see if they reacted similarly on the intestines. We found that intestinal sweet taste receptors are down regulated …

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University Of Central Florida Factbook 2013-2014, University Of Central Florida Jan 2014

University Of Central Florida Factbook 2013-2014, University Of Central Florida

Historical Fact Book and Enrollment

Historical fact book and enrollment data for the University of Central Florida.

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Reliability Of The Dynavision (Tm) D2 For Assessing Reaction Time Performance, Adam J. Wells, Jay R. Hoffman, Kyle S. Beyer, Adam R. Jajtner, Adam M. Gonzalez, Jeremy R. Townsend, Gerald T. Mangine, Edward H. Robinson Iv, William P. Mccormack, Maren S. Fragala, Jeffrey R. Stout Jan 2014

Reliability Of The Dynavision (Tm) D2 For Assessing Reaction Time Performance, Adam J. Wells, Jay R. Hoffman, Kyle S. Beyer, Adam R. Jajtner, Adam M. Gonzalez, Jeremy R. Townsend, Gerald T. Mangine, Edward H. Robinson Iv, William P. Mccormack, Maren S. Fragala, Jeffrey R. Stout

Faculty Bibliography 2010s

Recently, the Dynavision (TM) D2 Visuomotor Training Device (D2) has emerged as a tool in the assessment of reaction time (RT); however, information regarding the reliability of the D2 have been limited, and to date, reliability data have been limited to non-generalizable samples. Therefore, the purpose of this study was to establish intraclass correlation coefficients (ICC2,1) for the D2 that are generalizable across a population of recreationally active young adults. Forty-two recreationally active men and women (age: 23.41 +/- 4.84 years; height: 1.72 +/- 0.11 m; mass: 76.62 +/- 18.26 Kg) completed 6 trials for three RT tasks of increasing …

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Effects Of 28-Days Ingestion Of A Slow-Release Energy Supplement Versus Placebo On Hematological And Cardiovascular Measures Of Health, Adam J. Wells, Jay R. Hoffman, Adam M. Gonzalez, Kyle S. Beyer, Adam R. Jajtner, Jeremy R. Townsend, Leonardo P. Oliveira, David H. Fukuda, Maren S. Fragala, Jeffrey R. Stout Jan 2014

Effects Of 28-Days Ingestion Of A Slow-Release Energy Supplement Versus Placebo On Hematological And Cardiovascular Measures Of Health, Adam J. Wells, Jay R. Hoffman, Adam M. Gonzalez, Kyle S. Beyer, Adam R. Jajtner, Jeremy R. Townsend, Leonardo P. Oliveira, David H. Fukuda, Maren S. Fragala, Jeffrey R. Stout

Faculty Bibliography 2010s

Background: Recently, slow release tablets have been developed to prolong energy release throughout the day. The efficacy of the delivery of slow-release caffeine alone is fairly well documented; however, an assessment of safety and tolerability of prolonged use of slow-release energy supplements is lacking. Therefore the objective of this study was to investigate the effect of daily ingestion of a slow-release energy supplement for 28 days on blood chemistry and resting cardiovascular measures in healthy men and women. Methods: Forty healthy individuals (20 males, 20 females; age: 22.73 +/- 3.06 years; height: 171.68 +/- 10.45 cm; mass: 74.49 +/- 15.51 …

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The Effect Of Calorie Restriction On Insulin Signaling In Skeletal Muscle And Adipose Tissue Of Ames Dwarf Mice, Denise S. Wiesenborn, Vinal Menon, Xu Zhi, Andrew Do, Adam Gesing, Zhihui Wang, Andrzek Bartke, Deborah A. Altomare, Michal M. Masternak Jan 2014

The Effect Of Calorie Restriction On Insulin Signaling In Skeletal Muscle And Adipose Tissue Of Ames Dwarf Mice, Denise S. Wiesenborn, Vinal Menon, Xu Zhi, Andrew Do, Adam Gesing, Zhihui Wang, Andrzek Bartke, Deborah A. Altomare, Michal M. Masternak

Faculty Bibliography 2010s

Long-living Ames dwarf (df/df) mice are homozygous for a mutation of the Prop1(df) gene. As a result, mice are deficient in growth hormone (GH), prolactin (PRL) and thyrotropin (TSH). In spite of the hormonal deficiencies, df/df mice live significantly longer and healthier lives compared to their wild type siblings. We studied the effects of calorie restriction (CR) on the expression of insulin signaling genes in skeletal muscle and adipose tissue of normal and df/df mice. The analysis of genes expression showed that CR differentially affects the insulin signaling pathway in these insulin target organs. Moreover, results obtained in both normal …

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The Postoperative Morbidity Index: A Quantitative Weighing Of Postoperative Complications Applied To Urological Procedures, Jonathan Beilan, Ruth Strakosha, Diego Aguilar Palacios, Charles J. Rosser Jan 2014

The Postoperative Morbidity Index: A Quantitative Weighing Of Postoperative Complications Applied To Urological Procedures, Jonathan Beilan, Ruth Strakosha, Diego Aguilar Palacios, Charles J. Rosser

Faculty Bibliography 2010s

Background: The reporting of post-operative complications in the urological field is lacking of a uniform quantitative measure to assess severity, which is essential in the analysis of surgical outcomes. The purpose of this study was to evaluate the feasibility of estimating quantitative severity weighing of post-operative complications after common urologic procedures. Methods: Using a large healthcare system's quality database, complications were identified in eleven common urologic procedures (e.g., insertion or replacement of inflatable penile prosthesis, nephroureterectomy, partial nephrectomy, percutaneous nephrostomy tube placement, radical cystectomy, radical prostatectomy, renal/ureteral/bladder extracorporeal shockwave lithotripsy (ESWL), transurethral destruction of bladder lesion, transurethral prostatectomy, transurethral removal …

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Isotope Turnover Rates And Diet-Tissue Discrimination In Skin Of Ex Situ Bottlenose Dolphins (Tursiops Truncatus), Nicole E. Browning, Christopher Dold, Jack I-Fan, Graham A. J. Worthy Jan 2014

Isotope Turnover Rates And Diet-Tissue Discrimination In Skin Of Ex Situ Bottlenose Dolphins (Tursiops Truncatus), Nicole E. Browning, Christopher Dold, Jack I-Fan, Graham A. J. Worthy

Faculty Bibliography 2010s

Diet-tissue discrimination factors (Delta N-15 or Delta C-13) and turnover times are thought to be influenced by a wide range of variables including metabolic rate, age, dietary quality, tissue sampled and the taxon being investigated. In the present study, skin samples were collected from ex situ dolphins that had consumed diets of known isotopic composition for a minimum of 8 weeks. Adult dolphins consuming a diet of low fat (5-6%) and high delta N-15 value had significantly lower Delta N-15 values than animals consuming a diet with high fat (13.9%) and low delta N-15 value. Juvenile dolphins consuming a diet …

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Beta-Alanine Supplementation Improves Tactical Performance But Not Cognitive Function In Combat Soldiers, Jay R. Hoffman, Geva Landau, Jeffrey R. Stout, Matan Dabora, Daniel S. Moran, Nurit Sharvit, Mattan W. Hoffman, Yuval Ben Moshe, William P. Mccormack, Gil Hirschhorn, Ishay Ostfeld Jan 2014

Beta-Alanine Supplementation Improves Tactical Performance But Not Cognitive Function In Combat Soldiers, Jay R. Hoffman, Geva Landau, Jeffrey R. Stout, Matan Dabora, Daniel S. Moran, Nurit Sharvit, Mattan W. Hoffman, Yuval Ben Moshe, William P. Mccormack, Gil Hirschhorn, Ishay Ostfeld

Faculty Bibliography 2010s

Background: There are no known studies that have examined beta-alanine supplementation in military personnel. Considering the physiological and potential neurological effects that have been reported during sustained military operations, it appears that beta-alanine supplementation may have a potential benefit in maintaining physical and cognitive performance during high-intensity military activity under stressful conditions. The purpose of this study was to examine the effect of 28 days of beta-alanine ingestion in military personnel while fatigued on physical and cognitive performance. Methods: Twenty soldiers (20.1 +/- 0.9 years) from an elite combat unit were randomly assigned to either a beta-alanine ( BA) or …

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No Evidence Of Metabolic Depression In Western Alaskan Juvenile Steller Sea Lions (Eumetopias Jubatus), Lisa A. Hoopes, Lorrie D. Rea, Aaron Christ, Graham A. J. Worthy Jan 2014

No Evidence Of Metabolic Depression In Western Alaskan Juvenile Steller Sea Lions (Eumetopias Jubatus), Lisa A. Hoopes, Lorrie D. Rea, Aaron Christ, Graham A. J. Worthy

Faculty Bibliography 2010s

Steller sea lion (Eumetopias jubatus) populations have undergone precipitous declines through their western Alaskan range over the last four decades with the leading hypothesis to explain this decline centering around changing prey quality, quantity, or availability for this species (i.e., nutritional stress hypothesis). Under chronic conditions of reduced food intake sea lions would conserve energy by limiting energy expenditures through lowering of metabolic rate known as metabolic depression. To examine the potential for nutritional stress, resting metabolic rate (RMR) and body composition were measured in free-ranging juvenile Steller sea lions (N = 91) at three distinct geographical locations (Southeast Alaska, …

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Mediators Of Monocyte Migration In Response To Recovery Modalities Following Resistance Exercise, Adam R. Jajtner, Maren S. Fragala, Jeremy R. Townsend, Adam M. Gonzalez, Adam J. Wells, David H. Fukuda, Jeffrey R. Stout, Jay R. Hoffman Jan 2014

Mediators Of Monocyte Migration In Response To Recovery Modalities Following Resistance Exercise, Adam R. Jajtner, Maren S. Fragala, Jeremy R. Townsend, Adam M. Gonzalez, Adam J. Wells, David H. Fukuda, Jeffrey R. Stout, Jay R. Hoffman

Faculty Bibliography 2010s

Mediators of monocyte migration, complement receptor-3 (CR3), and chemokine ligand-4 (CCL4) were measured in response to recovery modalities following resistance exercise. Thirty resistance-trained men (23.1 +/- 2.9 y; 175.2 +/- 7.1 cm; 82.1 +/- 8.4 kg) were given neuromuscular electric stimulation (NMES), cold water immersion (CWI), or control (CON) treatments immediately following resistance exercise. Blood samples were obtained preexercise (PRE), immediately (IP), 30 minutes (30 P), 24 hours (24 H), and 48 hours (48 H) after exercise for measurement of circulating CCL4 and CR3 expression on CD14+ monocytes, by assay and flow cytometry. Circulating CCL4 showed no consistent changes. Inferential …

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Determination Of Critical Rest Interval Using Repeated Sprint Ability Testing, Michael La Monica Jan 2014

Determination Of Critical Rest Interval Using Repeated Sprint Ability Testing, Michael La Monica

Electronic Theses and Dissertations

The critical power (CP) concept has been used to determine the appropriate rest interval during intermittent exercise through the investigation of critical rest interval (CRI). Repeated sprint ability (RSA) testing has been developed to define the athlete’s ability to recover and maintain maximal effort during successive bouts. The CP model has been used to understand the physiological responses involved with intermittent exercise delineating between severe and heavy exercise intensity domains. The primary purpose of this study was to determine the CRI from the work-time relationship given by RSA testing using varying work to rest ratios. The secondary purpose was to …

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Bioarchaeological Assessment Of Diet And Changes In Femoral And Humeral Stable Isotopic Values Among Subadults At Medieval Alytus, Lithuania., Katherine Page Jan 2014

Bioarchaeological Assessment Of Diet And Changes In Femoral And Humeral Stable Isotopic Values Among Subadults At Medieval Alytus, Lithuania., Katherine Page

Electronic Theses and Dissertations

Establishing a chronology of variation in isotopic values can reveal frailty associated with biological and social age, as well as highlight individuals who vary from typical patterns. Although general dietary characteristics and infant feeding practices were previously unknown for subadults excavated from the cemetery at Alytus, Lithuania (14th-18th centuries), previous research concludes that Alytus' subadults experienced high rates of physiological, metabolic, non-specific stress, in addition to specific diseases like tuberculosis. To investigate nuanced relationships between diet and mortality, nitrogen and carbon stable isotopes from the femoral and humeral midshaft diaphyses of 70 subadults (32 weeks gestation to16 years) were analyzed. …

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Effects Of Weaning Age On Body Composition And Growth Of Ex Situ California Sea Lion (Zalophus Californianus) Pups, Brandon Davis Jan 2014

Effects Of Weaning Age On Body Composition And Growth Of Ex Situ California Sea Lion (Zalophus Californianus) Pups, Brandon Davis

Electronic Theses and Dissertations

Pinnipeds exhibit a wide range of lactation strategies that vary from just a few days to nearly three years in duration. Phocids have a relatively short, intense nursing period culminating with weaning after just a few days or weeks, while dependent otariids generally take several months of consuming a combined milk and solid food diet before being completely independent. The transition to nutritional independence can be particularly challenging for newly weaned pups, which must adjust to behavioral, physiological and nutritional changes as a milk diet is replaced with solid food. An interruption in energy resources during this formative stage could …

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Investigating Personal Fitness Trainers' Qualifications, Michael Akerson Jan 2014

Investigating Personal Fitness Trainers' Qualifications, Michael Akerson

Electronic Theses and Dissertations

A threefold approach was utilized to analyze the problem of defining personal fitness trainers’ qualifications. First, the problem was explored nationally, internationally and locally. Within the local context, the history of the exercise science program, stakeholders and culture at the University of Central Florida and in the central Florida marketplace was examined. Next, a systematic literature review examined possible causes within the knowledge context, learning/motivational context and organizational/cultural context. Then, an original research study investigated the qualifications for Central Florida, Personal Fitness Trainers (PFTs) by examining the relationship(s) and/or differences between variables such as education, certification, years of experience and …

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A Comparative Analysis Of Top Performing Countries In Eighth Grade Mathematics As Measured By 2011 Trends In International Mathematics And Science Study, Courtney Wilson Jan 2014

A Comparative Analysis Of Top Performing Countries In Eighth Grade Mathematics As Measured By 2011 Trends In International Mathematics And Science Study, Courtney Wilson

Electronic Theses and Dissertations

The focus of this research was to shed light on factors contributing to global international rankings in mathematics released by the 2011 administration of the Trends in International Mathematics and Science Study. This study focused on factors contributing to the global ranking of international scores in mathematics. Although students in the United States performed below students in the other sample countries (Singapore, Japan, and the Republic of Korea), American students scored within one standard deviation of the top performer, the Republic of Korea. The study also revealed that although other countries had their brightest and most advantaged students participate in …

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The Anti-Toxin Properties Of Grape Seed Phenolic Compounds, Patrick Cherubin Jan 2014

The Anti-Toxin Properties Of Grape Seed Phenolic Compounds, Patrick Cherubin

Electronic Theses and Dissertations

Corynebacterium diphtheriae, Pseudomonas aeruginosa, Ricinus communis, Shigella dysentariae, and Vibrio cholerae produce AB toxins which share the same basic structural characteristics: a catalytic A subunit attached to a cell-binding B subunit. All AB toxins have cytosolic targets despite an initial extracellular location. AB toxins use different methods to reach the cytosol and have different effects on the target cell. Broad-spectrum inhibitors against these toxins are therefore hard to develop because they use different surface receptors, entry mechanisms, enzyme activities, and cytosolic targets. We have found that grape seed extract provides resistance to five different AB toxins: diphtheria toxin (DT), P. …

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Defining And Building Excellence: A Model For Professional Development At Arete Charter School, Shloe Kerness Jan 2014

Defining And Building Excellence: A Model For Professional Development At Arete Charter School, Shloe Kerness

Electronic Theses and Dissertations

In the U.S., there is increased awareness that what teachers know and are able to do play a significant role in the achievement of their students (Sanders & Rivers, 1996). Consequently, there is an unprecedented interest in improving instruction, a job that is normally assumed by the schools and school districts where teachers are employed. However, long-established professional development options provided by school districts usually fail to have any significant positive impact on teachers' instructional practices and often have the unintended consequence of making teachers feel more like workers on an assembly line than professionals doing emotionally complicated work (Borko …

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Endocrine And Contralateral Muscle Responses To Short-Term Unilateral Resistance Training, Carleigh Boone Jan 2014

Endocrine And Contralateral Muscle Responses To Short-Term Unilateral Resistance Training, Carleigh Boone

Electronic Theses and Dissertations

PURPOSE: The purpose of this study was to examine the effects of short-term lower body unilateral resistance training on hormonal, muscle morphological, and performance measures in young men. METHODS: Seventeen healthy, untrained young men (Age: 22.8 ± 3.7 y; BMI: 26.5 ± 4.9 kg/m2) were randomly assigned to one of two groups (UT: 22.9 ± 4.6 y, 25.3 ± 4.2 kg/m2; CON: 24.0 ± 4.6 y, 27.7 ± 5.1 kg/m2). Resistance training consisted of 4 weeks of unilateral lower body and bilateral upper body exercises on 3 days per week. Each training session entailed unilateral countermovement jumps (3 × 8), …

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The Effect Of Moderate Altitude On High Intensity Running Performance During A Game With Collegiate Female Soccer Players, Jonathan Bohner Jan 2014

The Effect Of Moderate Altitude On High Intensity Running Performance During A Game With Collegiate Female Soccer Players, Jonathan Bohner

Electronic Theses and Dissertations

Competition often requires teams that reside at sea level to compete against opponents whose residence is at a moderate altitude. This may pose a potential competitive disadvantage considering that moderate altitude may cause decrements in VO2max, distance covered, and time to exhaustion in endurance athletes. The purpose of this study was to examine the effect of altitude on game performance measures. Six NCAA Division I female soccer players (20.33 ± 1.21 y; 168 ± 6.45 cm; 62.5 ± 6.03 kg) were retrospectively examined. Comparisons were made between two competitions that were played at sea level (SL) within two weeks of …

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Development Of Genomic Resources And Identification Of Marker-Trait Associations In Strawberry, Lise L. Mahoney Jan 2014

Development Of Genomic Resources And Identification Of Marker-Trait Associations In Strawberry, Lise L. Mahoney

Doctoral Dissertations

Crosses were performed and progeny populations were developed in diploid and octoploid strawberry (Fragaria) species for the purposes of genetic analysis and breeding. A high throughput genotyping platform - the Affymetrix IStraw90® Axiom® strawberry SNP array - was evaluated and employed for these purposes. Phenotyping was conducted with respect to several traits of interest, including flower color, flower and fruit pigment compositions, and verticillium wilt resistance, for the ultimate purpose of identifying marker-trait associations useful in breeding. In the ancestral diploid species Fragaria iinumae, an F2 mapping population was developed from a cross between two accessions previously collected in Hokkaido, …

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Ahhs 325.01: Introduction To Gerontology, Gayle A. Hudgins Jan 2014

Ahhs 325.01: Introduction To Gerontology, Gayle A. Hudgins

University of Montana Course Syllabi

No abstract provided.

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Psyx 391.01: Special Topics - Health Psychology, Craig P. Mcfarland Jan 2014

Psyx 391.01: Special Topics - Health Psychology, Craig P. Mcfarland

University of Montana Course Syllabi

No abstract provided.

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Coa 405.01: Advanced Concepts In Coaching, Steven Gaskill Jan 2014

Coa 405.01: Advanced Concepts In Coaching, Steven Gaskill

University of Montana Course Syllabi

No abstract provided.

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Hee 233.03: Health Issues Of Children And Adolescents, Annie Sondag Jan 2014

Hee 233.03: Health Issues Of Children And Adolescents, Annie Sondag

University of Montana Course Syllabi

No abstract provided.

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Hee 233.02: Health Issues Of Children And Adolescents, Carly M. Holman Jan 2014

Hee 233.02: Health Issues Of Children And Adolescents, Carly M. Holman

University of Montana Course Syllabi

No abstract provided.

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Kin 320.00: Physiology Of Exercise, Charles L. Dumke Jan 2014

Kin 320.00: Physiology Of Exercise, Charles L. Dumke

University of Montana Course Syllabi

No abstract provided.

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Nutr 221n.02m: Basic Human Nutrition, Blakely D. Brown Jan 2014

Nutr 221n.02m: Basic Human Nutrition, Blakely D. Brown

University of Montana Course Syllabi

No abstract provided.

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Assessment Of The Capacity Of Ugandan Health Facilities, Personnel, And Resources To Prevent And Control Noncommunicable Diseases, Hilary Eileen Rogers Jan 2014

Assessment Of The Capacity Of Ugandan Health Facilities, Personnel, And Resources To Prevent And Control Noncommunicable Diseases, Hilary Eileen Rogers

Public Health Theses

Due to the rapid rise of noncommunicable diseases (NCDs), the Uganda Ministry of Health (MoH) has prioritized NCD prevention, early diagnosis, and management. In partnership with the World Diabetic Foundation, MoH has embarked on a countrywide program to build capacity of the health facilities to address NCDs. A needs assessment was developed and conducted in 13 regional referral hospitals, 27 general hospitals, and 14 health center IVs in Uganda to: (1) assess the capacity of health units to detect and manage noncommunicable diseases; (2) describe provider knowledge, attitudes, resources, and practices, and (3) identify areas of improvement and areas in …

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Association Between Life Event Stressors And Risk Of Low Birth Weight Among African American And White Mothers ------A Multilevel Analysis Of The Los Angeles Mommy And Baby (Lamb) Surveys, Yuan Zhao Jan 2014

Association Between Life Event Stressors And Risk Of Low Birth Weight Among African American And White Mothers ------A Multilevel Analysis Of The Los Angeles Mommy And Baby (Lamb) Surveys, Yuan Zhao

Public Health Theses

We examined the association between life events stressors during pregnancy and low birth weight (LBW) among African Americans and Whites, while systematically controlling for potential confounders including individual characteristics and city-level variations and clustering. Data from 4970 women with singleton births from the 2007 and 2010 Los Angeles Mommy and Baby Surveys were analyzed. Multilevel logistic regression was used to assess the association between emotional, financial, spousal and traumatic stressors and LBW among African Americans and Whites. Potential confounders included were: city-level Economic Hardship Index, maternal demographics, pre-pregnancy conditions, insurance, behavioral risk factors and social support. African Americans were significantly …

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