Digital Commons Network^™

Compliance Of Canada’S Utility Doctrine With International Minimum Standards Of Patent Protection, Jerome H. Reichman

Faculty Scholarship

This article analyzes the Canadian court case of Eli Lilly v. Novopharm and the "utility" doctrine in Canada, and international standards of patent protection including TRIPS and NAFTA. The ‘‘promise of the patent’’ doctrine in Canada seeks to ensure that firms do not obtain a legal monopoly on the basis of speculative claims about increased utility — especially claims about therapeutic efficacy — that were unsubstantiated at the time of filing. Under this test, some of Eli Lilly’s patented pharmaceutical products have been invalidated retroactively.

Report And Recommendations Of The Balance Of Crop Research Working Group Of The National Agricultural Research, Extension, Education And Economics (Nareee) Advisory Board, Mark Mclellan, Leo Holt, Twilya L'Ecuyer, Robert Taylor, Julia Sabin, Milo Shult, Anne Marie Thro, Paul Heisey

Biology Faculty Publications and Presentations

In December of 2012, the President’s Council of Advisors on Science & Technology (PCAST) issued a report to the President on Agricultural Preparedness and the Agriculture Research Enterprise. The PCAST report recognizes the long-term history of public investment in agricultural research. The report also recognized significant private investment into agricultural research. Significantly, the report is adamant that the agricultural research enterprise is not prepared to meet the challenges of the 21st century. The report cited two reasons:

1. too little competitive research and
2. an imbalance of research priorities between private and public funding sources.

This report addresses the latter issue.

Members …

Declaration On Patent Protection: Regulatory Sovereignty Under Trips, Reto Hilty, Matthias Lamping, Dan L. Burk, Carlos M. Correa, Peter Drahos, N. S. Gopalakrishnan, Henning Große Ruse-Khan, Annette Kur, Geertrui Van Overwalle, Jerome Reichman, Hanns Ullrich

Faculty Scholarship

As a framework regulation for innovation markets, the patent system needs to be tailored to the innovation process, which it is supposed to serve, and to the competitive environment, within which it must operate. In order to ensure an efficient functionality of the patent system as an innovation policy tool, patent rights ought to be defined, justified and continually reconsidered by reference to their socio-economic benefits and costs.

Sovereign states should retain the discretion to adopt a patent system that best suits their technological capabilities as well as their social, cultural and economic needs and priorities, with the proviso that …

Developing Resources Within A Grassroots Nonprofit: The Journey From Volunteer To Financial Donor, Afton S. Devos

SPNHA Review

The United States of America has a rich tradition in philanthropy. Originating with industry titans in the late nineteenth century and embraced by everyday citizens of today, nonprofit organizations benefit from individuals who volunteer their time, make financial contributions, or both. As evidence points to a new generation of donors who value volunteer involvement prior to making a financial gift, nonprofit organizations must employ specific strategies and tactics to cultivate their volunteers into financial supporters. Literature findings demonstrate that individuals are motivated to volunteer and give financially due to organizational efficacy, values, personal benefit, and reputation. Additionally, empirical studies show …

A Fluid Two-Way Street: South African Hiv/Aids Ngos And Their Environment, Brittany Dernberger

SPNHA Review

Recognizing that Non-Governmental Organizations (NGOs) do not exist in isolation, this article seeks to analyze NGOs in South Africa who have the mission of addressing HIV/AIDS and how they impact, and are in turn affected, by the surrounding environment. Specific examples of this exchange are provided, along with an example of NGOs who are not best responding to the needs of the community. HIV/AIDS in South Africa is a prevailing public health issue. The rate of HIV/AIDS is very high, especially for women, and this is compounded by genderbased violence and stigma. As the HIV/AIDS crisis erupted in the 1990s, …

Correlates Of 25-Hydroxyvitamin D Among Chinese Breast Cancer Patients, Liang Shi, Sarah Nechuta, Yu-Tang Gao, Ying Zheng, Tsogzolmaa Dorjgochoo, Jie Wu, Qiuyin Cai, Wei Zheng, Wei Lu, Xiao Ou Shu

Peer Reviewed Articles

Background

Few studies have investigated vitamin D status in association with modifiable lifestyle factors and clinical characteristics among breast cancer patients, with no studies among Chinese women, who may be at higher risk of vitamin D deficiency. We aimed to evaluate circulating 25-hydroxyvitamin D (25(OH)D) levels in association with clinical and lifestyle factors among 1,940 Chinese breast cancer patients.

Methods

Participants included breast cancer cases aged 22–77 from a population-based case-control study conducted in Shanghai, China during 1996–1998 (n = 1,044) and 2002–2005 (n = 896). Circulating 25(OH)D levels were measured in plasma samples (95% collected ≤6 months post-diagnosis). Prevalence …

Sampled University Students' Perceived Risk Of Diabetes & Self-Reported Diabetes Risk Factors, Ajibike R. Shodunke

All Graduate Theses, Dissertations, and Other Capstone Projects

The purpose of this research was to measure university students' perceived risk of diabetes and self-reported diabetes risk factors. Informed consent forms and survey questionnaires were distributed to students in randomly sampled courses (n=357), with students aged 18 to 24. Out of the 357 surveys completed, 325 surveys were used for analysis of this study. Forty-eight percent of participants between ages 18 to 24 perceived themselves at minimal risk for developing type II diabetes. Sampled participants reported a mean of 2.25 (type II) diabetes risk factors out of 18 diabetes risk factors. Additionally, there were significant differences ( …

Moved To Move: Socially Contextualizing Women's Exercise Motivations, Dusti Rae Werner

All Graduate Theses, Dissertations, and Other Capstone Projects

Using qualitative data from 11 interviews with women who exercise regularly, this research explores women's motivations to exercise, how they make social comparisons and how they self-evaluate their bodies through the social context of gender, socio-economic status and race. Women with intrinsic motivations to exercise find more positive, long term outcomes than those with extrinsic motivations. Women compare themselves to similar others, such as their peers to form self-evaluations more readily than they do media images. Respondents also indicated the importance of relationships in beginning and maintaining exercise regimes.

The “Secret” Impact Of Population Statistics On The Metrics Of Diabetes, Lyndal H. Hunter, Sharon Brownie, Walter F. Robb

School of Nursing & Midwifery, East Africa

The accuracy of disease metrics is dependent on the quality of population-based data. Many diseases, including diabetes, are age and sex dependant. Accurate age- and sexspecific population survey data, population estimates and projections are required to assess the scale and trends in the burden of these diseases. No assessment of the quality of population data being used in the UAE diabetes metrics has been published. We provide insight into the availability and quality of published population data, which is currently being used to inform diabetes research and health services planning in the UAE. We show the absence of credible population-based …

Greater Polar Moment Of Inertia At The Tibia In Athletes Who Develop Stress Fractures, Lee A. Weidauer, Teresa Binkley, Matthew Vukovich, Bonny Specker

Health and Nutritional Sciences Faculty Publications

Background: Several previous investigations have determined potential risk factors for stress fractures in athletes and military personnel.
Purpose: To determine factors associated with the development of stress fractures in female athletes.
Study Design: Case-control study; Level of evidence, 3.
Methods: A total of 88 female athletes (cross-country, n ¼ 29; soccer, n ¼ 15; swimming, n ¼ 9; track and field, n ¼ 14; volleyball, n ¼ 12; and basketball, n ¼ 9) aged 18 to 24 years were recruited to participate in a longitudinal bone study and had their left distal tibia at the 4%, 20%, and 66% sites …

Feasibility, Compliance, And Efficacy Of A Randomized Controlled Trial Using Vibration In Pre-Pubertal Children, T.L. Binkley, E.C. Parupsky, B.A. Kleinasser, Lee A. Weidauer, Bonny Specker

Health and Nutritional Sciences Faculty Publications

Objective: Interventions utilizing vibration may increase bone mass and size which may reduce forearm fractures in children. This randomized controlled pilot trial tested the feasibility, compliance and efficacy of forearm loading regimes in an after-school program in pre-pubertal children aged 6-10 years. Methods: A 12-week randomized controlled trial incorporated high (HMMS; N=10) and low (LMMS; N=10) magnitude mechanical stimulation vibration, floor exercises (N=9), and controls (N=10). Radial bone measures by DXA and pQCT were compared at the end of intervention (12-weeks) and 4-months post-intervention (4- months post). Results: Percent changes were significantly greater in floor vs. control for ultra-distal areal …

Committee On Foreign Investment In The United States And Judical Review, Christina E. Holzer

Journal of International Business and Law

No abstract provided.

Rationalizing Home And Community-Based Services Under Medicaid, Laura Hermer

Faculty Scholarship

This article examines efforts states are making to expand access to community-based services for elderly and disabled Medicaid beneficiaries and suggests several options that might improve such access nationally. Like much of Medicaid, Medicaid long term services and supports (LTSS) have developed through a complex process of accretion. Policymakers appear only rarely to have considered an overarching view of such services and the needs of those who require them. Rationalizing Medicaid LTSS will accordingly require not only additions but also substantial pruning, and may even warrant a reconsideration of who should have ultimate authority to develop and direct such services. …

Graduate And Undergraduate Catalog, 2014-2015, Eastern Washington University, Washington State Library. Electronic State Publications

Course Catalogs

Eastern Washington University's course catalog for the 2014-2015 academic year.

Eastern, Winter 2014, Eastern Washington University. Division Of University Relations.

Alumni Publications

This issue contains articles about: It's a Great "Time" to be an Eagle, EWU is moving onward and upward, and Funny Man, Comedian and EWU graduate Brad Upton brings laughter to audiences around the globe, and Building Success One City at a Time, Katy Allen's legacy of public service, and Lifelong Bonds, the brothers of Pi Kappa Alpha stay connected

Comprehension Of Science Text By African American Fifth And Sixth Grade Students: The Effects Of A Metalinguistic Approach, Karen Davis

Electronic Theses and Dissertations

Scientific literacy has been at the forefront of science education reform for the past 20 years, particularly for students from culturally and linguistically diverse (CLD) backgrounds (Lee et. al., 2005; Pearson, Moje & Greenleaf, 2010). The ability to extract meaning from text is an important skill. Yet many students struggle with effectively comprehending what they read, particularly in content areas of science, math and history. According to the National Assessment Educational Progress (NAEP, 2013) report, adolescents are not acquiring advanced literacy skills needed to succeed in the workplace and academic setting. Literacy experts have called for the use of disciplinary …

Meglumine Exerts Protective Effects Against Features Of Metabolic Syndrome And Type Ii Diabetes, Arturo Bravo Nuevo, Alice Marcy, Minzhou Huang, Frank Kappler, Jennifer Mulgrew, Lisa Laury-Kleintop, Melvin Reichman, Annette Tobia, George C Prendergast

PCOM Scholarly Works

Metabolic syndrome, diabetes and diabetes complications pose a growing medical challenge worldwide, accentuating the need of safe and effective strategies for their clinical management. Here we present preclinical evidence that the sorbitol derivative meglumine (N-methyl-D-glucamine) can safely protect against several features of metabolic syndrome and diabetes, as well as elicit enhancement in muscle stamina. Meglumine is a compound routinely used as an approved excipient to improve drug absorption that has not been ascribed any direct biological effects in vivo. Normal mice (SV129) administered 18 mM meglumine orally for six weeks did not display any gastrointestinal or other observable adverse effects, …

Curiosité Gastronomique Et Cuisine Exotique Dans L'Entre-Deux-Guerres Une Histoire De Goût Et De Dégoût, Lauren R. Janes

Faculty Publications

À partir de 1890, plusieurs revues de recettes de cuisine commencèrent à évoquer les habitudes culinaires des peuples colonisés. Les articles et recettes naviguèrent sans cesse entre deux pôles. Le plus puissant consistait à susciter une forme de dégoût chez le lecteur, fondant ainsi un sentiment d’altérité et de supériorité vis-à-vis de populations présentées comme primitives car mangeant du chien, des insectes ou des aliments avariés. Mais parallèlement, il existait un exotisme acceptable, non transgressif, lié à la consommation de fruits tropicaux ou de plats au curry, qui trouvèrent alors leur place dans la cuisine bourgeoise de l’entre-deux-guerres.

Children, Armed Conflict, And Genocide: Applying The Law Of Genocide To The Recruitment And Use Of Children In Armed Conflict, Jeffery R. Ray

Barry Law Review

This paper shows that the use of child soldiers in armed conflict has the potential to be considered as genocide. A brief background of genocide is presented prior to the analysis. Part I of the analysis will discuss three issues: first, the modern understanding of genocide and the substantive areas of law that govern it; second, the definition of “child” within the international arena as it relates to child soldiering; third, a discussion to determine if children can constitute a “group” in the context of the law of genocide.

Part II provides a discussion elaborating on Part I, then analyzes …

Unaccustomed Exercise Causes Rhabdomyolysis, Yuri Feito

Faculty Articles

Cross Fit TM is a relatively new strength and conditioning program defined as “constantly varied, functional movements, performed at a high intensity”. The goal of the program is to increase “work capacity across broad time and modal domains” [1]. Even though this training modality has been criticized by the main stream media for “high risk of injury” most of these claims have been anecdotal, as recent evidence suggest this training modality is not any more “dangerous” than other exercise programs [2]. One of the biggest criticisms of this training modality has been its association with Rhabdomyolysis, a condition that results …

Benthic And Pelagic Pathways Of Methylmercury Bioaccumulation In Estuarine Food Webs Of The Northeast United States, Celia Y. Chen, Mark E. Borsuk, Deenie M. Bugge, Terill Hollweg

Dartmouth Scholarship

Methylmercury (MeHg) is a contaminant of global concern that bioaccumulates and bioamagnifies in marine food webs. Lower trophic level fauna are important conduits of MeHg from sediment and water to estuarine and coastal fish harvested for human consumption. However, the sources and pathways of MeHg to these coastal fisheries are poorly known particularly the potential for transfer of MeHg from the sediment to biotic compartments. Across a broad gradient of human land impacts, we analyzed MeHg concentrations in food webs at ten estuarine sites in the Northeast US (from the Hackensack Meadowlands, NJ to the Gulf of Maine). MeHg concentrations …

European Youth In Urban Contexts: A Lost Generation?, Cristian Dumitrescu

Journal of Adventist Mission Studies

No abstract provided.

Right Upper-Quadrant Pain In A Patient With Drug Abuse, Secondary Syphilis And Occult Hepatitis B Virus, Cory M. Fielding, Paul Angulo

Internal Medicine Faculty Publications

OBJECTIVE: To describe the etiology of hepatitis and identify occult hepatitis B virus (HBV) infection.

CLINICAL PRESENTATION AND INTERVENTION: A 40-year-old man presented with severe abdominal pain and jaundice, a history of acute HBV infection that had cleared as well as the use of acetaminophen, methamphetamine, buprenorphine and marijuana. He admitted to having had unprotected sex with multiple partners of both genders. A thorough skin examination revealed papulosquamous lesions on his penis, scrotum, upper and lower extremities and feet. Transaminases and bilirubin were elevated. His rapid plasma reagin was reactive, and hepatitis serologies showed occult HBV. Liver biopsy showed severe …

Disability And Women's Health, Stephanie Stockburger, Hatim A. Omar

Pediatrics Faculty Publications

Children, adolescents, and women with disabilities experience the same sexual development, pubertal changes, concerns, and desire to reproduce as their typically developing counterparts. However, society has tended to stigmatize women with disabilities as "asexual" and ignore this aspect of their health care. These women are less likely to receive gynecological exams, contraception, and evaluation of sexual dysfunction. Unfortunately, having a disability places women at risk for sexual exploitation and abuse as well as sexually transmitted infections. Therefore, reproductive health care for these women is imperative. A number of barriers to receiving reproductive care exist. However, with proper education and knowledge …

Impact Of Gums On The Growth, Viability, And Enzyme Activity Of Lactobacillus Species, Bernice D. Karlton-Senaye

Dissertations

This study investigated the impact of ten selected gums (carrageenan, carrageenan-maltodextrin, guar, locust bean, pectin, pectin- dextrose, pectin-carrageenan, guar-locust bean-carrageenan, inulin, and xanthan) on the growth of eight Lactobacillus strains in laboratory media. The bacterial population for eight Lactobacillus strains was determined in modified basal media at different concentration (0%, 0.25% and 0.5% w/v) of gums stored up to 12 hours at 37 °C. Findings show significant differences (p < 0.05) between the treated and control sample. Guar was found to be the best gum to enhance growth of L. rhamnosus GG B101, L. rhamnosus GG B101, L. delbrueckii subsp. bulgaricus SD35, L. delbrueckii subsp. bulgaricus SD33, L. acidophilus SD 16, L. acidophilus EF7, L. reuteri DSM20016, L. reuteri CF2-2F during 12 hours of storage at 37 C in laboratory media. The population of L. rhamnosus GGB101 in the samples containing gums were significantly (p < 0.05) higher than the control without gums. Samples containing 0.5% gums showed slightly higher bacterial population than those with 0.25% of gum. A minimum of 12 hour of incubation period was shown to be adequate to reach a bacterial population of 6 log CFU/mL in the presence of gums. Addition of guar (0.5%) led to the highest (1.31 log CFU/mL) increase in population of the treated L. rhamnosus GGB101 over the control. There was no marked (p < 0.05) change in pH and titratable acidity. Four different gums (carrageenan, carrageenan-maltodextrin, pectin-carrageenan, guar-locust bean-carrageenan) were selected to determine the effect on the growth, viability and betagalactosidase activity of four selected Lactobacillus strains (L. rhamnosus GG B101, L. rhamnosus GG B101, L. reuteri DSM20016, L. reuteri CF2-2F). Effect of the four selected gums on thegrowth L. rhamnosus GG B101, L. rhamnosus GG B101, L. reuteri DSM20016 in milk were compared to those in modified basal media. Results showed that xanthan induced highest growth of L. rhamnosus GG B103, L. rhamnosus GG B101 in milk whereas carrageenanmaltodextrin led to highest growth of L. reuteri DSM 20016 in the media. Marked differences (p < 0.05) in viability were observed between milk samples containing gums and the control. The presence of carrageenan-maltodextrin led to the highest viable counts (8.76 ± 0.03 log CFU/mL) of L. rhamnosus GGB103 during storage. The average population of L. rhamnosus GGB101 and Lactobacillus rhamnosus GGB103 was 8 log CFU/mL, whereas that of Lactobacillus reuteri DSM20016 and Lactobacillus reuteri SD2112 decreased slightly ( 0.15-0.64 log CFU/mL) to 7 log CFU/mL during the storage period. Viable counts were retained at 7-8 log CFU with no significant difference in the control versus treated strains except in the presence of carrageenanmaltodex. Guar-locust bean-carrageenan led to significant (p < 0.05) highest levels of β-gal activity of L. rhamnosus GGB103 (1287 ± 4.24 Miller units/ mL) compared to the control (78 ± 2.83 Miller units/ mL). L. rhamnosus GG B101and L. rhamnosus GG B103 were the best strains to attain enhanced levels of β-galactosidase activity. This shows that the inclusion of carrageenan-maltodextrin and guar-locust bean-carrageenan in milk could improve growth, viability and achieve an enhanced level of β-galactosidase activity in L. rhamnosus GG B101 and L. rhamnosus GG B103. The information gleaned from this study could be used in the food industry to improve the quality of probiotic functional foods and thereby contribute to the alleviation of lactose malabsorption.

Perception Analytics Of An In-Depth Observational Analysis Of 6th Grade African American Male Students' Personal Agency, Devetta Holman Nash

Dissertations

Existing scholarship on self-concept and its relevance to personal agency in the classroom does not incorporate the lived experiences of African American middle school boys. Today, in the United States, only 10% of 8th grade African American boys can read proficiently (Holzman, 2011). This research study investigates the perceptions of seventeen middle school African American males' classroom experiences to determine factors that contribute to their classroom engagement and personal agency. The study also illustrates that there is a significant need for greater self-identity and self-concept within the learning environment, which allows African American male students to self–actualize their sense of …

Childhood Growth In An Oneota Community: Examining Long Bone Growth Differences In The The Juveniles At Norris Farms 36, Whitney Broughton

Electronic Theses and Dissertations

Oneota migration into the central Illinois River valley around ad 1300 resulted in a number of different interactions with Mississippian groups. Milner and colleagues (1991) identified significant numbers of perimortem injuries at the Norris farms 36 cemetery, along with biological markers for poor health, such as cribra orbitalia and porotic hyperostosis. They suggested that the threat of violence may have forced the Oneonta at Morton village to limit subsistence activities to circumscribed areas close to the settlement, thereby reducing the resource base and negatively impacting the health of the community. However, recent research (Bengtson et al. 2012; Bengtson and O'Gorman …

Is Marital Status A Determinant Of Self-Monitoring Of Blood Glucose?, Jasmine Evelyn Dixon Jones

Electronic Theses and Dissertations

Glycemic control is one of the most important aspects of diabetes management and is necessary for the prevention or delay of complications associated with diabetes mellitus (DM). Self-monitoring of blood glucose (SMBG) is a technique used achieve glycemic control by revealing day-to-day changes in blood glucose levels. Since marriage protective effects have been shown for mortality, especially for men, it is useful to determine whether a similar relationship is found between marriage and SMBG. The purpose of this study is to examine whether marital status is a determinant of SMBG, when controlling for other variables, and whether marital status determines …

Comparison Of Body Composition Measures In Older Adult Males, Cody Smith

Honors Projects

Body Mass Index (BMI) is a measure created to assess population wide staistics of obesity and stratify health risk. However, there are large differences in health risk when comparing BMI with measures of body composition. BMI is not a measure of body composition. Body composition measures are used to distinguish between fat mass, fat-free mass. This percent body fat is more significantly correlated with health risk.

This study analyzed various body composition methodologies including waist circumference at the umbilicus and at the narrowest point of the abdomen, sagittal abdominal diameter, bioelectrical impedance analysis, and air displacement plethysmography. The study’s purpose …

Extent Of Bgsu Student Food Insecurity And Community Resource Use, Kathryn Koller

Honors Projects

This research examines student food insecurity at Bowling Green State University (BGSU) and available resources in Bowling Green, Ohio. Seven classes from BGSU’s main campus were randomly chosen to complete a survey regarding participant background information, details concerning food attainment, food security level, and use of community resources to allow for food acquisition. These classes included undergraduate classes and ranged from 15 to 272 students per class. Less than one quarter of student participants had food insecurity (19%), and food insecurity was significantly associated with financial dependence (P=0.04). There was a significant relationship between not utilizing community food resources and …