Digital Commons Network^™

Beneficial Effects Of The Nutritional Supplements On The Development Of Diabetic Retinopathy, Renu A. Kowluru, Qing Zhong, Julia M. Santos, Mangayarkarasi Thandampallayam, Doug Putt, Dennis L. Gierhart

Wayne State University Associated BioMed Central Scholarship

Abstract

Purpose

Increased oxidative stress and inflammatory mediators are implicated in the development of diabetic retinopathy, and in rats, its development can be prevented by antioxidants. Carotenoids are some of the powerful antioxidants, and diabetes decreases lutein and zeaxanthin levels in the serum and retina. The aim of this study is to investigate the effect of carotenoid containing nutritional supplements (Nutr), which is in clinical trials for ‘Diabetes Vision Function’, on diabetic retinopathy.

Methods

Streptozotocin-induced diabetic rats (Wistar, male) were fed Purina 5001 supplemented with nutritional supplements containing zeaxanthin, lutein, lipoic acid, omega-3 fatty acids and other nutrients, or without …

Compare Effects Of Diets Made With Different Saturated Fatty Acids On Body Weight Regulation And Metabolism In Wister Rats, Dilruba Fatema

Wayne State University Theses

Animal fats are known to cause elevated blood total and low-density- lipoprotein (LDL) cholesterol levels in humans and animals. This study was designed to investigate the effects of both the quality (coconut oil and a modified beef tallow with reduced saturated fatty acid content) and quantity (low and high) of dietary fat in body weight regulation and alteration of blood cholesterol levels in an animal model. Forty two male Wister rats were randomly divided into 4 groups: Control Low Fat (CLF, n=10), Control High Fat (CHF, n=10), Modified Low Fat (MLF, n=11), and Modified High Fat (MLF, n=11). They were …

Comparative Phenolic Content And Antioxidant Activities Of Blueberry (Vaccinium Corymbosum) Afected By In Vitro Digestion, Sonia Gharbi

Wayne State University Theses

Abstract

COMPARATIVE PHENOLIC CONTENT AND ANTIOXIDANT ACTIVITIES OF BLUEBERRY (VACCINIUM CORYMBOSUM) AFECTED BY IN VITRO DIGESTION

By

SONIA GHARBI

May 2014

Adviser: Dr. Kevin Zhou

Major: Nutrition and Food Science

Degree: Master of Science

The biological properties of antioxidants depend on their release from the food matrix during the digestion process. Blueberry contains a wide range of phenolic compounds which are of great significance due to their antioxidant activity. In vitro digestion is a rapid and inexpensive method used to determine the availability of nutrients involved in the absorption studies with humans. Total phenolic content and antioxidant activity of Vaccinium …

Screening Of Natural Antimicrobial Agents And Antimicrobial-Resistant Bacteria Using A Soleris System, Mingyang Huang

Wayne State University Theses

ABSTRACT

SCREENING OF NATURAL ANTIMICROBIAL AGENTS AND ANTIMICROBIAL - RESISTANT BACTERIA USING A SOLERIS SYSTEM

by

MINGYANG HUANG

May 2014

Advisor: Dr. Yifan Zhang

Major: Food Science and Nutrition

Degree: Master of Science

Traditional broth micro-dilution method is a common assay of measuring Minimum Inhibitory Concentration (MIC) to determine the antimicrobial activity of an antimicrobial agent. However, this method is generally time-consuming and labor intensive. Alternatively, an automated optical method using the Soleris system was applied in this study. The system was compared to the traditional broth micro-dilution 96-well assay to test the antimicrobial activity of 11 essential oils and …

Antimicrobial Activity Of Essential Oil Emulsions And Possible Synergistic Effect On Food Borne Pathogens, Varun Tahlan

Wayne State University Theses

The objective of this study was to evaluate the antimicrobial activity of essential oil emulsions against food borne pathogenic bacteria and determine potential applications. The oils used for this study were cinnamon, oregano, clove, thyme, rosemary, sage, bergamot, nutmeg, lemon grass and bay. Oil in water emulsions were prepared using Tween 80 as an emulsifying agent, with a stock oil concentration in the emulsions of 20,000 ppm. Essential oil emulsions were individually screened against E. coli (ATCC 25922), E. coli (ATCC 700927), L. monocytogens (ATCC 19115), L. innocua (ATCC 33090) and S. Typhimurium (ATCC 19585) using the broth micro dilution …

Comparitive Study On Antioxidant Properties Of Dendrobium Officinale (Tiepishihu), Wenjun Zhu

Wayne State University Theses

For ages, Chinese herbs, such as Dendrobium Officinale (DO), have been used in Asian regions for treating various illnesses due to the high medicinal value. In this study, the DO plant Acetone and Ethanolic extracts possibly containing antioxidants were tested using different methodologies for comparison and determination of specific antioxidant capacity. The total phenolic content assay expressed as Gallic Acid Equivalent showed 9.43±;0.23 mg GAE /g of extract. Further analysis using DPPH· assay indicated that antioxidants presented in the sample were able to significantly scavenge 37% and 44% radicals at the concentrations of 25mg/ml and 50mg/mL respectively, after a period …

Bacteriophage Isolated From The Environment And E. Coli Of Meat Origin As A Reservoir Of Antibiotic Resistance, Manisha Polur

Wayne State University Theses

ABSTRACT

BACTERIOPHAGE ISOLATED FROM THE ENVIRONMENT AND E. COLI OF MEAT ORIGIN AS A RESERVOIR OF ANTIBIOTIC RESISTANCE

by

MANISHA POLUR

April 2014

Advisor: Dr. Yifan Zhang

Major: Nutrition and Food Science

Degree: Master of Science

This study was aimed to determine the extent of antibiotic resistance reservoir in bacteriophage. Bacteriophages were isolated and purified from waste water treatment plants, Detroit river, Belle Isle, Urban Garden soils and examined for the presence of beta-lactam antibiotic resistance genes. Thirty E. coli isolates from retail meat were analyzed for the presence of beta-lactam antibiotic resistance genes. 95% of E. coli them carried …

Desk Jockey: A Device To Increase Non-Exercise Activity Thermogenesis (Neat) In Adults, Jiangqi Tang

Wayne State University Theses

Increased sedentary behavior, just like reduced physical activity, has been shown to increase the risk of obesity and chronic diseases. This is mostly due to increased time spent sitting at the office desk. There is limited research studying how to decrease such risk in office workers (OW). This study was to investigate a portable device "Desk Jockey" (DJ) on increasing NEAT and reducing sedentary behavior in a simulated office environment. Participants whose daily work requiring long sitting hours were recruited (mean sitting hours/day: 8.6 ± 3 hr, mean age: 25 ± 7 yr, 54% male, 15% obese). Metabolic rates (METs), …

Effect Of Folate Deficiency On Mtor Signaling Network On The Liver Of Wild Type Mice, Essra Moussawi

Wayne State University Theses

Through various studies of dietary nutrients on the affects of the physiological and molecular pathways are a key study in understanding the interaction between dietary nutrients and the human genome that may severely impact the development of various cancers. A primary approach is observing the dietary nutrients, that we consume and how it plays a role in the cellular pathway of our bodies through experimental methods. Folate deficiency (FD) has shown, through studies, to play a role anti-cancer progression. Our goal was to observe the autophagy related proteins in the mTOR signaling pathway as it was suggested that mTOR may …

Effect Of Long Term Rapamycin Treatment On Mtor Signalling Network In Colon And Liver Of C57bl/6 Mice, John Sorge

Wayne State University Theses

Many studies have investigated the effects of rapamycin on aging and cancer. However, the effects of long-term rapamycin supplementation on a cancer model have not been performed. This is the first study that investigates the effects of long-term supplementation of rapamycin in a cancer model. ACF analysis of colon tissues in mice showed no significant difference between controls and those supplemented with rapamycin. Factors such as energy balance, cellular environment, PI3K/Akt/mTOR pathway, and more have been assessed in this study. The duration of rapamycin supplementation seems to play an important role in the protection against cancer. Ultimately, this study suggests …

Effect Of Folate Deficiency On Expression Of Proteins On The Mtor Signaling Pathway In The Brain Of C57/Bl6 Mice, Nikita Patel

Wayne State University Theses

ABSTRACT

EFFECT OF FOLATE DEFICIENCY ON EXPRESSION OF PROTEINS ON THE mTOR SIGNALING PATHWAY IN THE BRAIN OF C57/BL6 MICE

by

NIKITA PATEL

December 2014

Advisor: Dr. Ahmad Heydari

Major: Nutrition and Food Science

Degree: Master of Science

Nutrient-gene interactions can significantly impact several cellular processes in the human body by altering important molecular pathways. Nutrition can affect brain structure, function and development throughout the life cycle; it can have a profound effect on cognition ad mental health leading to neurodegenerative diseases. It is important to elucidate the mechanisms by which diet can effect signaling pathways in the brain. The …

Assessing The Influence Of Religious Involvement On Health Behaviors Among Gender And Racial/Ethnic Groups, Charlotte Roshelle Winston

Wayne State University Dissertations

The purpose of this study was to assess the relationship between measures of public and private religiosity and various measures of health behavior. Previous studies have shown that religious involvement is associated with health outcomes (Koenig & Vaillant, 2009; Chatters, 2000; Meisenhelder, 2003). However, many studies use religious attendance as the single measure of religiosity This research used multiple indicators of religiosity that reflected both public and private dimensions in order to predict various health behaviors, including preventive health behaviors, abstention from alcohol and smoking, and physical activity. In addition to taking a multi-dimensional approach to assessing the religion-health relationship …

Peri-Exercise Co-Ingestion Of Branched-Chain Amino Acids And Carbohydrate In Men Does Not Preferentially Augment Resistance Exercise-Induced Increases In Pi3k/Akt-Mtor Pathway Markers Indicative Of Muscle Protein Synthesis, Maria Pontes Ferreira, Rui Li, Matthew Cooke, Richard B. Kreider, Darryn S. Willoughby

Nutrition and Food Science Faculty Research Publications

The effects of a single bout of resistance exercise (RE) in conjunction with peri-exercise branched chain amino acid (BCAA) and carbohydrate (CHO) ingestion on skeletal muscle signaling markers indicative of muscle protein synthesis (MPS) were determined. It was hypothesized that CHO + BCAA would elicit a more profound effect on these signaling markers compared to CHO. Twenty-seven males were randomly assigned to CHO, CHO + BCAA, or placebo (PLC) groups. Four sets of leg presses and leg extensions were performed at 80% 1RM. Supplements were ingested 30 min and immediately prior to and after RE. Venous blood and muscle biopsy …

The Effect Of Education On Elder Abuse, Kathleen M. Evanina

Electronic Theses and Dissertations

This study was designed examine the effect of education on prevention of abuse in a long term care center. Participants in this study included direct care worker staff at a nursing home and nursing home residents.

The New Endangered Species: Community-Anchoring Public Schools, Karen Ferrick-Roman

Electronic Theses and Dissertations

Often, school closures are seen as a "natural order" of events in communities with extreme economic struggles. My work challenges this premise.

In Pennsylvania, communities where schools selected for closure are often composed of rural, largely white or urban, largely minority, populations living at the margins amid the persistent yet growing economic divide. Within this milieu, communities and people at the margins are swept up in general educational trends, such as the risk of charter schools, siphoning students and funding from traditional, community-anchoring public schools and perpetuating systematic power and economic inequities, driven by political and philanthropic initiatives. The economic …

An Ethical Justification For Post-Trial Access To Anti-Retroviral Drugs For Participants And Host Populations In Developing Countries: A Global Justice Perspective, Evaristus Chiedu Obi

Electronic Theses and Dissertations

The pandemic nature of HIV/AIDS in developing countries engenders global health emergency which establishes the urgent need to address the issue of affordable access to anti-retroviral drugs in developing countries. The dissertation discusses an ethical justification for post-trial access to anti-retroviral drugs for participants and host populations in developing countries within the context of global justice, stressing the combination of national and global responsibilities in realizing this objective. Drawing on the strengths of Rawls's statist and Pogge's cosmopolitan theories and on the International Human Rights Law, the dissertation proposes a paradigm of Global Health Justice involving a sliding scale of …

A Retrospective Data Analysis In Veterans With Inflammatory Bowel Disease: Using Wagner's Chronic Care Model To Explore Medication Adherence, Lori K. Rizzo

Electronic Theses and Dissertations

Background

Medication adherence in inflammatory bowel disease (IBD) ranges between 7-72% . Increased healthcare utilization has been associated with non-adherence in IBD. Wagner's Chronic Care Model (CCM) posits that care coordination between primary and gastroenterology (GI) specialty care could improve adherence and healthcare utilization.

Methods

Guided by the CCM, a retrospective analysis was conducted in veterans with IBD to: describe medication adherence rates; describe healthcare utilization measured by ER visits and inpatient admissions; and describe care coordination measured by primary care and GI specialty care use. A secondary study aim was to explore the relationships between those key outcome variables …

Tackling Urban Poverty In The Secondary Learning Environment, Nina Marie Sacco

Electronic Theses and Dissertations

The problem of practice examined in this dissertation in practice is that many urban schools that serve low socioeconomic communities fail to engage and, therefore, empower students to succeed. The purpose of this dissertation is to identify how urban poverty presents in secondary learning environments (i.e. high schools), to report findings on how urban poverty presents in one urban high school, and to report on an emerging model for engaging stakeholders across the boundaries of school, academy, and community to improve student success for those who attend such schools. Urban students of low socioeconomic status who attend secondary schools with …

The Search For Novel Antibiotic Compounds Through Molecular Modeling And Structure-Function Analysis Of Cspe In E. Coli K12, Andre Duane Samuel

Electronic Theses and Dissertations

Escherichia coli K12 has the capacity to express nine Csp (Cold shock-related protein) gene products (CspA-I). These proteins share between 29 and 83 percent identity in their amino acid sequences and only one, CspA, has a solved crystal structure. One of the Csps shown to be involved in chromosome condensation is a 6.3 kDa protein called CspE and deletion studies of its homologues in Bacillus subtilis show that at least one of the Csp proteins is required for cell viability. All of the Csp proteins studied to date bind to single stranded nucleic acids. Knowing that at least one of …

Being Better At Doing Good: Organizational Engagement And Foreign Management Practices In Dpr (North) Korea, Rajarshi Sen

Electronic Theses and Dissertations

Foreign organizations work in DPR Korea under multiple external and internal pressures, and these organizations try to respond to their working environment in their own ways. However, it is important that these foreign organizations are able to work effectively, in order for engagement with DPRK to be meaningful. In this research, utilizing the case study method, I explore the questions: How can foreign organizations effectively work in DPR Korea? What can they do to more easily achieve their outputs and outcomes? What are the dynamics of the mutual embeddedness process as foreign organizations become immersed in the context of DPRK? …

Factors Influencing Nurses' Intentions To Provide Weight Management Education To Hospitalized Obese Adults, Milissa Volino

Electronic Theses and Dissertations

Obesity is a sensitive, global health problem that impacts individuals of all ages and places individuals at risk for various chronic health problems. Nurses caring for hospitalized obese clients are in a prime position to provide them with timely information on weight management. This study utilized an exploratory sequential mixed method design to examine medical-surgical nurses' intentions to provide weight management education to hospitalized obese adults and the factors that influence nurses' intentions.

In phase 1, a focus group interview guide and nurse demographic form (NDF) were developed. Focus groups were conducted and analysis resulted in the creation of 15 …

Moving To A New Paradigm: A Reflection On Ethics, Sara Bajor '15

Richard T. Schellhase Essay Prize in Ethics

No abstract provided.

The Effect Of Multiple Single Nucleotide Polymorphisms In The Folic Acid Pathway Genes On Homocysteine Metabolism, Shuang Liang, Yuanpeng Zhou, Huijun Wang, Yanyan Qian, Duan Ma, Weidong Tian, Vishwani Persaud-Sharma, Chen Yu, Yunyun Ren, Shufeng Zhou, Xiaotian Li

Pharmacy Faculty Publications

Objective. To investigate the joint effects of the single nucleotide polymorphisms (SNPs) of genes in the folic acid pathway on homocysteine (Hcy) metabolism. Methods. Four hundred women with normal pregnancies were enrolled in this study. SNPs were identified by MassARRAY. Serum folic acid and Hcy concentration were measured. Analysis of variance (ANOVA) and support vector machine (SVM) regressions were used to analyze the joint effects of SNPs on the Hcy level. Results. SNPs of MTHFR (rs1801133 and rs3733965) were significantly associated with maternal serum Hcy level. In the different genotypes of MTHFR (rs1801133), SNPs of RFC1 (rs1051266), …

Is A Parent-Focused Intervention More Effective Than A Child-Focused Approach In Treating Childhood Obesity?, Jessica E. Jankowski

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not a parent-focused intervention is more effective than a child-focused approach in treating childhood obesity.

STUDY DESIGN: This review consists of three randomized controlled trials published in the English language between the years 2004 and 2010.

DATA SOURCES: Data sources were articles published in peer reviewed journals comparing parent-focused intervention as a treatment of childhood obesity compared to a child-focused approach found using Cochrane and PubMed databases.

OUTCOMES MEASURED: The outcomes measured were the child’s obesity status and quality of life. These outcomes …

2014 Annual Reports And Resolutions, American Dental Association

ADA Transactions

This item is part of the Annual Reports and Resolutions subtitle of the ADA Transactions, a serial publication of the annual activities of the ADA House of Delegates (HOD)/Board of Trustees (BOT) made up of three separate subtitles: Annual Reports and Resolutions, Supplements, and Transactions. Generally, the ADA Transactions are published in multiple volumes throughout the year. Older versions include reports from all departments as subsections, while more recent versions include only those of councils, commissions, and committees.

Targeted Social Transparency As Global Corporate Strategy, Stephen Kim Park

Northwestern Journal of International Law & Business

Recent years have seen the emergence of mandatory disclosure regimes under U.S. federal securities law with the express purpose of advancing geographically defined, issue-specific social policy objectives, which I collectively refer to as “targeted social transparency” (TST) regimes. This Article addresses the appeal and shortcomings of mandatory disclosure as a means of regulating global corporate conduct—focusing on the unique challenges posed by TST. Two contemporary examples of TST are analyzed: (i) the “conflict minerals” provisions in the Dodd-Frank Act, which require the disclosure of minerals whose mining is associated with human rights violations in the Democratic Republic of Congo; and …

Human Disturbance Of Snowy Plovers (Charadrius Nivosus) In Northwest Florida During The Breeding Season, Jonathan B. Cohen, Maureen M. Durkin, Margo Zdravkovic

Florida Field Naturalist

No abstract provided.

Eating Healthy On A Budget: A Grocery Cart Display, Kara R. Wilcoxon

Undergraduate Honors Theses

Many barriers to healthy eating have been reported including having to give up favorite food dishes, consuming lesser desired food items, and perceiving that fresh, unprocessed food is too expensive. For a week, customers were able to view a display of two grocery carts: one filled with healthy foods and the other filled with unhealthy foods. Each cart had the cost and nutritive values of the contents posted. For 6 hours on 3 different days, the researcher interviewed interested shoppers (n=33). While the majority of the shoppers indicated they were very concerned about their families eating healthy (mean score 4.2/5), …

Fast Food Results In Similar Post-Exercise Glycogen Recovery And Exercise Performance Compared To Sport Supplements, Michael Joseph Cramer

Graduate Student Theses, Dissertations, & Professional Papers

A variety of dietary choices are marketed to enhance glycogen recovery after physical activity. Past research provides recommendations regarding the timing, dose, and nutrient compositions to facilitate glycogen resynthesis. This study examined the effects of isocaloric sport supplements (SS) vs fast-food (FF) on glycogen resynthesis and exercise performance. Eleven male completed two experimental trials in a randomized, counterbalanced order. Each trial included a 90-minute glycogen depletion ride followed by a 4-hour recovery period. Absolute amounts of macronutrients (1.54±0.27 g.kg-1 carbohydrate, 0.24±0.04 g.kg-1 fat, and 0.18±0.03 g.kg-1 protein) as either SS or FF were provided at 0 and 2 hours. Muscle …

The Extent Of The Use Of Data-Driven Instruction Techniques In Middle School Instruction, Scheherazade Dedman

Theses and Dissertations

This study investigated whether data-driven instruction affects or informs strategies that middle school teachers use in their planning, teaching strategies, and assessments, and explored whether teachers use these data in order to make changes in their classroom and instruction. In addition, this study examined the types of data middle school teachers use in order to inform their instruction, whether the number of years taught had an effect on how they used data-driven instruction, and whether they found it effective. To this effect, teachers at a middle school in Southern California were asked to complete an online survey. This study provided …