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2014

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Surface Modification Of Adenovirus Type 5 Vectors Via Two-Step Metabolic Labeling For Pet Imaging, Jai Inder Pal Dec 2014

Surface Modification Of Adenovirus Type 5 Vectors Via Two-Step Metabolic Labeling For Pet Imaging, Jai Inder Pal

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Surface modification of viruses is of great interest for therapeutic gene delivery. Numerous viruses have been, and continue to be engineered in an attempt to optimize them for targeted in vivo gene therapy. Adenovirus has been shown by a myriad of publications to be the most efficient delivery vehicle in different cell types. But while it is the preferred delivery agent in many gene therapy studies, drawbacks such as off-targeting, immune response and toxicity still hinder it from being used in clinical studies. In an attempt to modify the surface of Adenovirus efficiently, our lab developed a simple two-step labeling …

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The Identification Of Guanosine-5'-Triphosphate Binding Protein 2 (Gtpbp2) As A Potential Drug Target For Diseases Involving Excessive Wnt Signaling, Jonathan Manit Wyrick Dec 2014

The Identification Of Guanosine-5'-Triphosphate Binding Protein 2 (Gtpbp2) As A Potential Drug Target For Diseases Involving Excessive Wnt Signaling, Jonathan Manit Wyrick

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Canonical Wnt signaling is involved in the regulation of many cellular behaviors dependent upon context, including the induction of cell proliferation, promotion of cell survival, repression of apoptosis, and regulation of cell differentiation. Perturbations in the Wnt signaling pathway have been shown to be present in a various amount of human diseases, such as cancers of the colon and breast, leading to aberrant cellular activity. As such, recent studies have focused on the inhibition of the Wnt signaling pathway in hopes of restoring normal cellular behaviors in diseases with excessive Wnt signaling activity. Our lab has discovered that the large …

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Analysis Of Principal Structural Orientation Of Trabecular Bone Using Quantitative Ultrasound, Liangjun Lin Dec 2014

Analysis Of Principal Structural Orientation Of Trabecular Bone Using Quantitative Ultrasound, Liangjun Lin

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Quantitative ultrasound (QUS) has been accepted widely as a non-invasive, economic, non-radioactive and portable modality for assessing bone heath status. This technology utilizes the basic physical mechanism of interaction between ultrasound wave and bone structure to provide mechanical and structural information of bone. Instead of only evaluating the quantity of bone like other traditional techniques such as duel energy X-ray absorptiometry (DXA), QUS is also capable of measuring the quality of bone such as anisotropy, microarchitecture and microfracture. This advantage of QUS is beneficial for treating the patient suffering from osteoporosis or other bone health deterioration, long term bed-rest patient …

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Low Intensity Vibrations Mitigate Cancer-Induced Bone Loss With Indications Of Reduced Tumor Progression, Gabriel M. Pagnotti Dec 2014

Low Intensity Vibrations Mitigate Cancer-Induced Bone Loss With Indications Of Reduced Tumor Progression, Gabriel M. Pagnotti

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Osteopenia is a comorbidity frequently observed in patients being treated for and recovering from cancer treatment, elevating their risk of fracture. These skeletal losses are compounded by chemotherapy and irradiation, damaging both bone and contents of the marrow, thereby undermining recovery efforts. Exercise is commonly prescribed as a non-pharmacological means of maintaining bone mass. However, in those with compromised bone strength, the loads imposed by rigorous exercises may facilitate a fracture it was intended to prevent. Low intensity vibrations (LIV), a mechanical signal demonstrated as anabolic to bone by biasing mesenchymal stem cells (MSCs) towards an osteogenic endpoint, may represent …

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Assembly, Structure And Properties Of Dna Programmable Nanoclusters, Cheng Chi Dec 2014

Assembly, Structure And Properties Of Dna Programmable Nanoclusters, Cheng Chi

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Finite size nanoclusters can be viewed as a nanoscale analogue of molecules. Just as molecules, synthesized from atoms, give access to new properties, clusters composed of nanoparticles modulate of their functional properties of nanoparticles. In contrast to synthetic chemistry which is a mature field, the creation of nanoscale clusters with well-defined architectures is a new and challenging area of research. My work explores how to assemble model systems of nanoclusters using DNA-programmable interparticle linkages. The simplest clusters of two particles, dimers, allow one to investigate fundamental effects in these systems. Such clusters serve as a versatile platform to understand DNA-mediated …

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Structural And Computational Study On The Interaction Of Bacterial Cell Division Protein, Ftsz, With Its Inhibitors For New Antibacterial Drug Discovery, Edwin Ottoniel Lazo Dec 2014

Structural And Computational Study On The Interaction Of Bacterial Cell Division Protein, Ftsz, With Its Inhibitors For New Antibacterial Drug Discovery, Edwin Ottoniel Lazo

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Filamenting temperature-sensitive mutant Z (FtsZ) from Mycobacterium tuberculosis (Mtb) is an essential bacterial cell division protein that polymerizes into a structure called the " Z-ring" . Here it has been targeted for drug discovery. Compounds that exhibit anti-tuberculosis activity have been synthesized and used in crystallization conditions. Four crystal structures of MtbFtsZ have been determined, of which two are similar to the published dimer (PDB 1RQ7) which exhibits lateral interactions; they belong to P65 space group and crystals diffracted to about 2.6Å. The other two structures had two trimers in the asymmetric unit. The crystals diffracted to approximately 3.5Å and …

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Structural And Optical Characterization Of Semiconductors For Solar Water Splitting, Andrew Charles Malingowski Dec 2014

Structural And Optical Characterization Of Semiconductors For Solar Water Splitting, Andrew Charles Malingowski

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Finding a clean and renewable source of energy that can compete commercially with fossil fuels is one of the great challenges facing the world today. Photoactive semiconductors that can be used to split water into hydrogen and oxygen gas by absorbing visible light are one means of harvesting the sun's abundant energy and storing it as chemical fuel. Although several photoactive semiconductor systems have demonstrated water splitting, one is yet to be found that has a high enough H2 production efficiency to be a commercially viable source of renewable energy. Water splitting using a photoactive semiconductor is a complex process …

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Molecular Characterization Of Quahog Parasite Unknown (Qpx), A Thraustochytird Pathogen Of The Hard Clam, Mercenaria Mercenaria, Ewelina Rubin Dec 2014

Molecular Characterization Of Quahog Parasite Unknown (Qpx), A Thraustochytird Pathogen Of The Hard Clam, Mercenaria Mercenaria, Ewelina Rubin

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The hard clam or northern quahog, Mercenaria mercenaria, is one of the most valuable seafood products in the United States. Severe episodes of hard clam mortality have been consistently associated with infections caused by a thraustochytrid parasite called Quahog Parasite Unknown (QPX). Studies in the present dissertation examined the molecular bases of QPX virulence towards clams. Investigation of QPX transcriptome libraries generated a database of QPX putative virulence factors and other molecules potentially involved in interactions with the clam host. Multiple differential gene expression profiles were generated using oligoarray technology for QPX strains isolated from different geographic locations and for …

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Achieving Regulatory Compliance In Data Management, Sumeet Vijay Bajaj Dec 2014

Achieving Regulatory Compliance In Data Management, Sumeet Vijay Bajaj

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Regulations mandate consistent procedures for information access, processing, and storage. In the United States alone, over 10,000 data management regulations exist in the financial, life sciences, health care and government sectors. A recurrent theme in data management regulations is the need for regulatory compliant storage to ensure data confidentiality, data integrity, audit trails maintenance, data retention, and guaranteed deletion. This thesis describes the design and implementation of several regulatory compliant relational databases and file systems. The systems increase efficiency and lower costs of regulatory compliance through the use of novel cryptographic and system security constructs. The first system described in …

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Multilingual Named Entity Recognition, Vivek V. Kulkarni Dec 2014

Multilingual Named Entity Recognition, Vivek V. Kulkarni

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

With the massive amounts of unannotated text available from myriad sources, learning representations useful for natural language processing(NLP) tasks is an increasingly popular research area. Using deep learning techniques, we learn distributed representations for words (word embeddings) using Wikipedia as the source of text for 40 languages. These distributed representations represent each word as a point in feature space and capture useful semantic and syntactic properties of words amd have been shown to be useful in NLP Tasks like Part of Speech Tagging(POS) etc. We have built 2 classes of word embeddings namely Polyglot and Skipgram for these languages. We …

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Greendm: A Versatile Tiering Hybrid Drive For The Trade-Off Evaluation Of Performance, Energy, And Endurance, Zhichao Li Dec 2014

Greendm: A Versatile Tiering Hybrid Drive For The Trade-Off Evaluation Of Performance, Energy, And Endurance, Zhichao Li

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

There are trade-offs among performance, energy, and device endurance for storage systems. These trade-offs become more complex in storage system comprising different storage technologies. Designs optimized for one dimension or workload often suffer in another. Therefore, it is important to study the trade-offs so as to be able to adapt the system to workloads. As different types of drives have different traits, tiering hybrid drives are studied more closely. However, previous tiering hybrids are often designed for high throughput, efficient energy consumption, or improving endurance--leaving empirical study on the trade-offs being unexplored. Past endurance studies also lack a concrete model …

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Gpu-Acceleration Of X-Ray Photon Scattering Simulation, Jaewoo Pi Dec 2014

Gpu-Acceleration Of X-Ray Photon Scattering Simulation, Jaewoo Pi

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Computed Tomography is widely used in numerous fields. To facilitate the development of an algorithm while avoiding additional radiation dose to the patient, the simulation of the CT imaging process is required. The scattering effect of X-ray photons impact on quality of output images. Thus, modeling the scattering is an important task to predict and eliminate the effects on energy. However, the simulation has been challenging task. Two approaches, deterministic and Monte Carlo method has been widely used, but both methods have to undergo trade-off between speed and sampling rate. In this research, the new algorithm which exploits Bi-directional ray …

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Adaptation And Mutation Dynamics In Populations Evolving Under Nutrient Limiting Conditions, Omar Mahmud Warsi Dec 2014

Adaptation And Mutation Dynamics In Populations Evolving Under Nutrient Limiting Conditions, Omar Mahmud Warsi

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

To study adaptation to nutrient limitation and to understand the generation of adaptive diversity in evolving populations, we evolved Escherichia coli populations in twelve chemostats under three nutrient limiting regimes: four under nitrogen limitation, four under magnesium limitation and four in environments where the concentrations for both these nutrients are low. We traced the fitness trajectory of these populations over a period of ~400 generations. We also sequenced populations at two different time points to identify targets of selection and to investigate the mutation dynamics in these different nutrient-limiting environments. Our results show that populations evolving under nutrient limiting conditions …

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On The Design Of High Performance Data Center Networks, Zhiyang Guo Dec 2014

On The Design Of High Performance Data Center Networks, Zhiyang Guo

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Massive modern data centers consisting of tens of thousands of servers have emerged to form the backbone of a variety of powerful distributed computing frameworks, in which efficient communication is often required among huge data sets stored in tens of thousands of servers across a data center. This renders the performance of the data center network (DCN) essential to the successful operation of a data center. This dissertation focuses on several important issues in the design space of high performance data center networks. First, we present a systematic study on optical packet switch, which is a key component in next …

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Investigation Of The Biochemical Mechanism For Cell-Substrate Mechanical Sensing, Vincent Anthony Ricotta Dec 2014

Investigation Of The Biochemical Mechanism For Cell-Substrate Mechanical Sensing, Vincent Anthony Ricotta

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Advancements in stem cell biology and materials science have enabled the development of new treatments for tissue repair. Dental pulp stem cells (DPSCs), which are highly proliferative and can be induced to differentiate along several mesenchymal cell lineages, offer the possibility for pulpal regeneration and treatment of injured dentition. Polybutadiene (PB) may be used as a substrate for these cells. This elastomer can be spun casted into films of different thicknesses with different moduli. DPSCs grown on PB films, which are relatively hard (less than 1500 Å thick), biomineralize depositing crystalline calcium phosphate without a requirement for the typical induction …

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Identification And Model Reduction Of Mimo Systems In Triangular Input Balanced Form, Xiao Yu Dec 2014

Identification And Model Reduction Of Mimo Systems In Triangular Input Balanced Form, Xiao Yu

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Consider a discrete-time linear time invariant (LTI) d-dimensional innova- tions model, z(t+1) = Az(t)+Bx(t), (1) y(t) = Cz(t)+x(t), (2) where y (t) is a sequence of d-dimensional measurement vectors and z (t) is a state vector of dimension n. The triangular input balanced (TIB) representation of the LTI system was introduced by A.Mullhaupt and K.Riedel [1] in 1995. In the Single-Input Single-Output (SISO) case, the TIB pair is uniquely determined by the poles of the system. However, the poles alone are not enough to fully characterize the Multi-Input Multi-Output (MIMO) TIB pair. We parametrize MIMO transfer functions in terms of …

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Squamous Cell Carcinoma Antigen 1 (Scca1) Promotes Mammary Tumorigenesis By Inducing The Unfolded Protein Response (Upr) And Il-6 Signaling, Namratha Sheshadri Dec 2014

Squamous Cell Carcinoma Antigen 1 (Scca1) Promotes Mammary Tumorigenesis By Inducing The Unfolded Protein Response (Upr) And Il-6 Signaling, Namratha Sheshadri

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

SCCA1 is a member of the serine/cysteine protease inhibitor (serpin) family whose intracellular targets include lysosomal cathepsins L, S and K. Its expression correlates with resistance to cell death resulting from lysosomal membrane permeabilization and cathepsin release in response to radiation and chemotherapy. Elevated SCCA1 expression has been reported in a wide array of cancers including squamous cell carcinomas of the lung, head and neck, skin, cervix, as well as hepatocellular carcinoma. Our laboratory recently found that increased expression of SCCA1 also correlates with high-grade, poorly differentiated breast carcinoma and poor prognosis. However, despite SCCA1's clear relevance in human cancer, …

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Graphene Nanoribbons Elicit Cell Specific Uptake And Drug Delivery Via Activation Of Epidermal Growth Factor Receptors, Sayan Mullick Chowdhury Dec 2014

Graphene Nanoribbons Elicit Cell Specific Uptake And Drug Delivery Via Activation Of Epidermal Growth Factor Receptors, Sayan Mullick Chowdhury

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Ligands such as peptides, antibodies or other epitopes bind and activate specific cell receptors, and can be employed for targeted cellular delivery of pharmaceuticals such as drugs, genes and imaging agents. In this dissertation, I investigate the in vitro and hematological compatibility of oxidized graphene nanoribbons, non-covalently functionalized with PEG-DSPE (1, 2-distearoyl-sn-glycero-3-phosphoethanolamine-N[amino(polyethyleneglycol)]) (O-GNR-PEG-DSPE) and evaluate its potential as a drug delivery agent. Although, O-GNR-PEG-DSPE was found to interact with RBC membrane and induce structural changes in them, they did not affect other hematological parameters. In vitro studies showed that these particles activate epidermal growth factor receptors (EGFRs) and elicit cell …

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Hollywood On The Tiber And Italian Cinema: Practices Of Transatlantic Stardom 1949-1965, Maria Elena D'Amelio Dec 2014

Hollywood On The Tiber And Italian Cinema: Practices Of Transatlantic Stardom 1949-1965, Maria Elena D'Amelio

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

My dissertation aims to contribute to the emergent scholarly conversation on transnational stardom by examining the transatlantic career of the three male stars Amedeo Nazzari, Vittorio Gassman, and Steve Reeves, as case studies to define specific transnational practices of film production, aesthetics, and reception between Italy and the United States. | 205 pages

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Piratical Designations: Power And Possibility In Representations Of Piracy, Michael D. High Dec 2014

Piratical Designations: Power And Possibility In Representations Of Piracy, Michael D. High

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This dissertation analyzes how designations and representations of piracy define, police, and challenge legitimate production and circulation. From antiquity through the present, the labeling of others as pirates has excluded the less powerful from the authorized distribution of tangible and intangible property. Such discursive exclusion not only defines piracy but also creates it, distinguishing it from other, sanctioned forms of appropriation. This exclusion generates political, legal, and cultural subjectivity, thereby allowing so-called pirates to affect the very discourses and processes from which they are excluded. The first chapter traces the term piracy from its linguistic origin in Ancient Greece to …

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Representations Of Gender In Young Adult (Ya) Literature, 1960-2010, Maria I. Cipriani Dec 2014

Representations Of Gender In Young Adult (Ya) Literature, 1960-2010, Maria I. Cipriani

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This dissertation focuses the lens of queer studies and trauma studies on YA literature published in the United States between 1960 and 2010 to demonstrate that authors embed cultural messages in YA texts. Those messages for YA readers intend to model behavior considered appropriate and teach about normative sex and gender roles. Individuals between the ages of 10 and 20 comprise YA readership, and the means of teaching these readers cultural norms include imagery and cautionary tales. The content of the literature inculcates views of acceptable behaviors with respect to sexuality and gender roles and generally conflates sex and gender. …

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El Code Switching En Las Redes Sociales: La Expansión De Lengua, Cultura E Identidad. | El Code Switching En Las Redes Sociales: La Expansiã³N De Lengua, Cultura E Identidad., Daniel Stephan Cueva Dec 2014

El Code Switching En Las Redes Sociales: La Expansión De Lengua, Cultura E Identidad. | El Code Switching En Las Redes Sociales: La Expansiã³N De Lengua, Cultura E Identidad., Daniel Stephan Cueva

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This study investigates why and how bilinguals speakers tend to code switch on social media such as; Facebook, Twitter, and Instagram. Bilingual speakers who were born in the US, who adapted English as their second language or who have learned Spanish as their second language in school, usually tend to combine the two languages, English and Spanish, in order to get across their point of view to others. For this reason, this investigation was created to analyze how code- switching can influence people when it's exposed on media. There were three social medias with the total of 37 participants who …

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Millennium Accidents, Breaking Narratives In Pedro Almodã³Var And Alejandro Gonzã¡Lez Iã±Ã¡Rritu | Millennium Accidents, Breaking Narratives In Pedro Almodóvar And Alejandro González Iñárritu, Anna S Shilova Dec 2014

Millennium Accidents, Breaking Narratives In Pedro Almodã³Var And Alejandro Gonzã¡Lez Iã±Ã¡Rritu | Millennium Accidents, Breaking Narratives In Pedro Almodóvar And Alejandro González Iñárritu, Anna S Shilova

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Millennium Accidents is an attempt to show the relation between the shattered, fragmented and decentralizing nature of contemporary, globalized reality and the texts it produces. In my research I aim to reveal the changes in the building and development of a story as a narrative and cognitive phenomenon. Economic globalization and the high-tech revolution have led to a modification of our mental, emotional and social functioning, converting the whole world into a huge network. Consequently, narrative-- be it verbal or iconic--shows the same metamorphosis as it generates multiple plots, neglects temporal and spatial conventions, and moves beyond national identities. Six …

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Consuming Modernity: Photography In Pre-Colonial Korea, 1876-1910, Heejeong Sohn Dec 2014

Consuming Modernity: Photography In Pre-Colonial Korea, 1876-1910, Heejeong Sohn

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Postcolonial studies have successfully unveiled the cultural, social, and political networks of imperial and colonial representations embedded in visual documents of the non-Western world. Within this context, the early photography of Korea has been presented as a cultural force imposed on Koreans in relation to colonialism and Orientalism. This dissertation rethinks the representational politics of early photography during the pre-colonial period of 1876 to 1910 by problematizing the master narratives and suggesting alternative ways to interpret this historical material. Through analyzing the historical contexts of photographic materials and practices, this dissertation argues that photography, as a device of cultural expression, …

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Effects Of Ocean Acidification Combined With Hypoxia, Elevated Temperature, Or Restricted Food Supply On Early Life Stages Of The Forage Fish Menidia Beryllina, Menidia Menidia, And Cyprinodon Variegatus, Elizabeth Depasquale Dec 2014

Effects Of Ocean Acidification Combined With Hypoxia, Elevated Temperature, Or Restricted Food Supply On Early Life Stages Of The Forage Fish Menidia Beryllina, Menidia Menidia, And Cyprinodon Variegatus, Elizabeth Depasquale

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Estuarine organisms are experiencing many stressors related to climate change at an accelerated pace when compared to the open ocean. The co-occurrence of acidification and hypoxia has been observed during warmer months when many fish species spawn in temperate estuaries. Concurrently, estuarine systems can experience extreme temperatures during summer and dynamic levels of plankton. This study assessed the tolerance of early life stage estuarine fish to the co-occurrence of acidification with hypoxia, elevated temperatures, and varying levels of planktonic prey. Time to hatch, hatching rates, survival, and growth were quantified for larval Menidia beryllina, Menidia menidia, and Cyprinodon variegatus exposed …

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American Masculinity And Home In Antebellum Literature, Derek Scott Mcgrath Dec 2014

American Masculinity And Home In Antebellum Literature, Derek Scott Mcgrath

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The conventional argument in literary and gender studies of nineteenth-century United States culture has been that the home was women's claimed sphere of influence, whereas men were excluded from the home because of their economic, cultural, and societal commitments to the public sphere. Even as Catharine Beecher, Lydia Maria Child, Sarah Josepha Hale, and other adherents to a conservative domestic ideology closely associated the private sphere with women, these same writers identified specific roles and spaces that they expected men to occupy in the home. Hardly only a woman's domain, the home was a powerful force in motivating constructions of …

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Internal Resistive Heating Of An Almax-Boehler Diamond Anvil Cell, Adairé Tuandé Heady Dec 2014

Internal Resistive Heating Of An Almax-Boehler Diamond Anvil Cell, Adairé Tuandé Heady

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

A new internal resistively heated diamond anvil cell (DAC) for the investigation of Earth materials at simultaneous high pressure and temperature will be developed on base of the Almax-Boehler type DAC. Combining resistively heated strip heater with the large opening angle design of the Almax-Boehler DAC will be beneficial for in situ diffraction and spectroscopy experiments of the structure-property relationships in Earth materials at pressure and temperature conditions of the Earth's interior. This new design will address some of the technical shortcomings of the laser-heated DACs method, such as inhomogeneous temperature distribution and imprecise measurement of the temperature. Previous studies …

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(Re)Vindicando A La Madre: Matriherencias, Orfandad Y Memoria Colectiva En La Narrativa Contemporã¡Nea Espaã±Ola Escrita Por Mujeres | (Re)Vindicando A La Madre: Matriherencias, Orfandad Y Memoria Colectiva En La Narrativa Contemporánea Española Escrita Por Mujeres, Maria Nieves Alonso Almagro Dec 2014

(Re)Vindicando A La Madre: Matriherencias, Orfandad Y Memoria Colectiva En La Narrativa Contemporã¡Nea Espaã±Ola Escrita Por Mujeres | (Re)Vindicando A La Madre: Matriherencias, Orfandad Y Memoria Colectiva En La Narrativa Contemporánea Española Escrita Por Mujeres, Maria Nieves Alonso Almagro

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This study adds to the current discussion on the literary treatment of the mother-daughter bond as used by Spanish contemporary women writers (1945-2013). It examines a representative corpus of novels to show how Spanish cultural, social and historical idiosyncrasy has produced differing modes of representation of the mother-daughter bond. This bond responds to a historically specific, autochthonous literary tradition as presented by the narrative of women writers of different generations: the postwar, the transition to democracy, and new novelists of the transition to the XXI century. Two main topics shape the treatment of the mother/daughter bond in these works: orphanage …

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Using Seismic Observations And Modeling To Place Constraint On The Structure Beneath Japan And Central America, Hui Long Dec 2014

Using Seismic Observations And Modeling To Place Constraint On The Structure Beneath Japan And Central America, Hui Long

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Understanding Earth's internal structure by seismic observations, both temporally and spatially, is key in seismology. In this thesis, I constrained structural changes beneath the Japan subduction zone based on a newly developed theory, and detailed mid to lower mantle structure beneath Central America by waveform and travel time observations and modeling. A newly developed theory states that the differential wave field of two repeated sources in a temporally changed medium can be equivalently treated as wave fields propagating from virtual point sources or volumetric sources. The virtual point sources or volumetric sources are located at the place of temporal changes, …

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Genetic Contributions To Susceptibility And Resistance To Learned Helplessness, Craig Scott Garafola Dec 2014

Genetic Contributions To Susceptibility And Resistance To Learned Helplessness, Craig Scott Garafola

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Depression is a disease with a complex etiology that is only beginning to be studied from a genetic perspective. A selectively bred line of rats, susceptible to the learned helplessness model of depression, presents an opportunity to search for genes affecting either the depressive symptoms or the predisposition towards developing the disease. A microarray revealed a small set of genes with altered expression in the hippocampus of the congenitally helpless rats. We selected one of these genes, a member of the γ -protocadherin family, for further study to determine the basis for the change in expression. Helpless animals demonstrated an …

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