Digital Commons Network^™

The Effects Of Cpg And Upa Dinucleotides On The Attenuation Of Poliovirus By Codon Pair Deoptimization, Malka Arabov

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Codon pair bias, the preferential pairing of certain codons over others, has been observed in all species analyzed ranging from bacteria to mammals. Previous research has shown that artificial coupling of underrepresented codon pairs (codon pair deoptimization) in viral genomes (such as poliovirus and influenza virus) reduces gene function and leads to virus death or attenuation. Although the reason for this phenomenon is unclear, increasing underrepresented codon pairs in an RNA viral coding region consequently increases the frequency of CpG and UpA dinucleotides. These dinucleotides are suppressed in a variety of species and may be responsible for attenuation by codon …

Using Seismic Observations And Modeling To Place Constraint On The Structure Beneath Japan And Central America, Hui Long

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Understanding Earth's internal structure by seismic observations, both temporally and spatially, is key in seismology. In this thesis, I constrained structural changes beneath the Japan subduction zone based on a newly developed theory, and detailed mid to lower mantle structure beneath Central America by waveform and travel time observations and modeling. A newly developed theory states that the differential wave field of two repeated sources in a temporally changed medium can be equivalently treated as wave fields propagating from virtual point sources or volumetric sources. The virtual point sources or volumetric sources are located at the place of temporal changes, …

Producciã³N Cultural E Ideologã­A. Formaciones Ideolã³Gicas, Gramã¡Ticas Polã­Ticas Y Movimientos De Lo Social En La Espaã±A Contemporã¡Nea (2000-2011) | Producción Cultural E Ideología. Formaciones Ideológicas, Gramáticas Políticas Y Movimientos De Lo Social En La España Contemporánea (2000-2011), Vicente Rubio-Pueyo

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This dissertation explores a series of transformations in the articulations between politics and cultural production in Spain between 2000 and 2011. The four chapters seek to document and theorize the nature and effects of these changes across three primary spheres of action. Thus the first chapter analyzes State policies and institutional arrangements in relation to cultural production during the last decades of the Spanish democratic regime. Chapters Two and Three consist of close readings of two relevant texts from recent Spanish literary production that offer divergent literary representations of the political. The analysis of Javier Cercas' Anatomia de un instante …

The Blues Continuum: New York Calls - Naples Responds, Alessandro Buffa

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

My dissertation traces a form of call and response between New York City and Naples in the 1970s and 1980s. It foregrounds the importance of the `blues' in the traffic of sound, images and oppositional ideas between these two cities located on the same geographical parallel. The blues here is understood as a musical style and feeling, as well as an affect of trauma, loss, memory and an intimate relationship that artists and activists established with their city spaces in the age of the so called " urban crisis." It proposes a " blutopia," based on utopian/dystopian tensions that promote …

Effects Of Ocean Acidification Combined With Hypoxia, Elevated Temperature, Or Restricted Food Supply On Early Life Stages Of The Forage Fish Menidia Beryllina, Menidia Menidia, And Cyprinodon Variegatus, Elizabeth Depasquale

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Estuarine organisms are experiencing many stressors related to climate change at an accelerated pace when compared to the open ocean. The co-occurrence of acidification and hypoxia has been observed during warmer months when many fish species spawn in temperate estuaries. Concurrently, estuarine systems can experience extreme temperatures during summer and dynamic levels of plankton. This study assessed the tolerance of early life stage estuarine fish to the co-occurrence of acidification with hypoxia, elevated temperatures, and varying levels of planktonic prey. Time to hatch, hatching rates, survival, and growth were quantified for larval Menidia beryllina, Menidia menidia, and Cyprinodon variegatus exposed …

High-Throughput Single-Cell Copy Number Profiling For Cancer Heterogeneity Analysis, Taimour Baslan

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Intra-tumoral genetic heterogeneity has long been recognized, yet remains poorly understood. This has primarily been due to the lack of sensitive technologies to measure it. Genome wide analysis at the level of single cells has recently emerged as a powerful tool to dissect cancer genome heterogeneity. However, to be truly transformative, single cell approaches must accommodate the analysis of large numbers of single cells. Here, using integrative informatics and molecular biology approaches this study presents a robust, low-cost, and high-throughput method to retrieve the genome-wide copy number landscape of hundreds of single cancer cells. Application of the method to human …

The Role Of Tolc In Francisella Tularensis Virulence, Christopher Richard Doyle

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Francisella tularensis is a Gram-negative, facultative intracellular pathogen and the causative agent of tularemia. F. tularensis is a Tier 1 agent of bioterrorism that is highly lethal via the pulmonary route of infection. F. tularensis invades host cells, escapes the phagosome, and replicates in the cytosol prior to being released upon host cell death. The molecular mechanisms behind the virulence of F. tularensis are largely unknown. Among the described virulence factors of F. tularensis is a functional type I secretion system (T1SS). The T1SS is important for the secretion of virulence factors from the bacterial cytoplasm to the extracellular environment. …

Identification Of Sporulation-Defective Genes And A Rab-Cascade Model For The Formation Of The Forespore Membrane In Schizosaccharomyces Pombe, Esma Ucisik-Akkaya

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

In the fission yeast, Schizosaccharomyces pombe, environmental stress conditions such as nitrogen starvation induce mating of two haploid cells. The newly formed diploid cells immediately undergo meiosis and form spores, which are equivalent to gametes in higher organisms. The packaging of the haploid nuclei, which are formed after two rounds of meiosis, is achieved by the de novo formation of double membranes called forespore membranes, which form adjacent to the meiotic spindle pole bodies (SPBs). This work focuses on the initiation of the forespore membrane at the SPB and the genes that are required for the proper formation of the …

Contextual Influences On Political Cognition, April Johnson

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This dissertation argues that electoral supply, as measured by the effective number of parties across U.S. Congressional districts, shapes the way in which individuals conceptualize and think about politics at a fundamental, cognitive level. Via socialization processes and repeated exposure over time, individuals nested within dissimilar supply environments learn to interact with political stimuli in ways which systematically differ. In contexts with traditionally less electoral supply, or a fewer number of viable parties, individuals become accustom to characterizing partisan dynamics in dichotomous, black and white terms. Alternatively, in contexts with more electoral supply individuals learn to view partisan dynamics as …

Conflict And Cooperation As Social Responses To Ecological Change, Nicholas A. Seltzer

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This dissertation examines ways the environment conditions individual incentives to participate in collective action. I hypothesize that as resources become scarce, individuals are more willing to participate in individually-costly collective action, including intragroup cooperation and intergroup hostility. The first and second of three studies establish a unit-of-selection based, game-theoretic foundation for intergroup conflict. The final study explores macro-level implications for the relationship between climate change and violence in Africa. For human beings and other highly social creatures, cooperation is the key adaptation with which we respond to environmental challenges. Faced with resource scarcity, group living becomes increasingly vital for individual …

Understanding Online Fashion Networks, Kota Yamaguchi

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Emergence of online social networks has transformed how people interact with digital media. Any user is a consumer and a publisher of media content, such as texts, images, or videos, in the online community. In such an environment, it is crucial to develop technology to help people by organizing and utilizing plethora of media content to meet the community demands. To this goal, this dissertation studies and tries to establish computational approaches to understand networked content, using large-scale data from a real-world online fashion network, Chictopia. This study focuses on two major challenges of fashion networks: understanding of visual content, …

University Of Dayton Magazine, Winter 2014-15, University Of Dayton Magazine

University of Dayton Alumni Publications

This issue includes information about work UD students are doing in Africa, stories long told on campus, and the death penalty.

Cdc Grant To Create Network For Young Breast Cancer Survivors In Southern States, Tyler Greer

Browse All News

No abstract provided.

Volume 34, Number 4, December 2014 Olac Newsletter, Marcy Strong, Heather Pretty, Christina Hennessey, Jan Mayo, T.J. Kao, Jay Weitz, Lisa Romano

OLAC Newsletters

Digitized December 2014 issue of the OLAC Newsletter.

October To December 2014

All Summaries

No abstract provided.

Tracking The Movement Of Pseudomonas Syringae Strains- On The Adaxial Leaf Surface Of Arabidopsis Thaliana, Vincent Nguyen

2014 Fall Honors Capstone Projects - Archive

Detection of population density is a form of communication for certain phytobacteria that usually involves the association of small diffusible chemical signals, particularly N-acyl homoserine lactones. It is pondered whether or not this molecule and the phytotoxin, coronatine, play a significant role in the directional motility of the wild type (Pst DC3000) and mutant strains (Pst DC3118, Pst DB29, and Pst psy/IR-) of Pseudomonas syringae pv. tomato on the adaxial surface of Arabidopsis thaliana leaves. A leaf assay and in vivo experimentation by spotting a set of leaves for each bacteria and making an imprint on an agar plate following …

The Impact Sex Trafficking Education Has On Reported Cases, Ivette Cervantes

2014 Fall Honors Capstone Projects - Archive

The purpose of this research study was to determine whether educating the public on the issue of sex trafficking has an impact on cases being reported. Several non-profit organizations located across Texas were interviewed. The organizations' mission is to provide services to sex trafficking victims and raise public awareness. Interviews were conducted with organizations located in Dallas, Fort Worth, Austin, and Houston. A major finding is that failure to properly identify victims is a core issue. Public awareness has increased. The public is aware that sex trafficking is a current issue, but their awareness does not impact cases being reported. …

First Amendment Sexual Privacy: Adult Sexting And Federal Age-Verification Legislation, Jennifer M. Kinsley

New Mexico Law Review

The modern sexting phenomenon amongst adults raises important questions at the intersection of relational privacy, free expression, and federal criminal law. A little-known but long-standing federal statutory scheme—18 USC 2257, 2257A, and the accompanying Attorney General regulations (“Section 2257”)—threatens to criminalize the private exchange of sexual communication between consenting adults. While there has been relatively frequent litigation involving Section 2257 initiated by the commercial adult entertainment industry, courts and scholars alike have been all but silent as to Section 2257’s impact on private, not-for-profit sexual speech. So too has the literature on the legality of sexting focused almost exclusively on …

When The Mountain Goes To Mohammad: The Internet And Judicial Decision-Making, Layne S. Keele

New Mexico Law Review

Part I of this Article explores that ambivalence by examining conflicting judicial canons and court opinions addressing the issue. Part II examines the benefits and drawbacks of judicial Internet research with respect to adjudicative facts. In particular, it elaborates on arguments offered by defenders of this kind of research, most notably Judge Richard A. Posner. Part II also highlights the dangers by showing that adjudicative fact research detracts from the reliability of our justice system and undermines due process of law. Part III addresses judges’ online research of legislative facts. It discusses the use of legislative facts by courts generally, …

Step Outside The Door: An Ethnography Of Homeschooling In North Texas, Hannah Keller

2014 Fall Honors Capstone Projects - Archive

Homeschooling is now recognized as a rapidly growing and, for some, a preferred method of imparting grade-level education to American students. It is important to note that homeschooling impacts and shapes family and community, thus providing a unique perspective on anthropological considerations of modernity, education, and subculture. Despite this, few studies have explained the growth in this form of pedagogy. This paper attempts to fill this gap through an ethnographic study of homeschoolers in North Texas. In particular, this study focuses on the reasons behind homeschooling and the cultural perceptions of homeschoolers in North Texas. Research for this project is …

The Effect Of Warning Labels On Media Advertisements And The Influence On Women's Body Satisfaction, Kaysha Herd

2014 Fall Honors Capstone Projects - Archive

Research shows one probable source of body dissatisfaction is the thin ideal prevalent in media images (Hargreaves & Tiggemann, 2004). This bombardment of thin images can lead individuals to internalize the thin ideal, possibly leading to body dissatisfaction, poorer life satisfaction, and/or irregular eating behaviors. The focal hypothesis investigated if women's internalization of the thin ideal affects their body satisfaction, even when warning labels were present on advertisements. Secondly, it examined if body satisfaction varies among different ethnicities. Participants were 150 female undergraduates randomly assigned to one of four conditions: (1) control, (2) thin ideal, (3) thin ideal with subtle …

The Linguistic Mechanisms Of Knock-Knock Jokes, Jared Weide

2014 Fall Honors Capstone Projects - Archive

Humor analysts have not yet accounted for the longstanding popularity of knock-knock jokes, a common and recognizable joke format. A better understanding of the linguistic mechanisms behind these jokes can provide opportunities in fields such as education, technology, and, of course, entertainment. In order to analyze the processes involved, a corpus of jokes was compiled from seven online sources, with a total of 132 different knock-knock jokes collected. A taxonomy of the mechanisms that drive these jokes was created by identifying the linguistic features that generate humor in each. The study found that the pun or alternate meaning at the …

Installments, University Of Texas At Arlington Library

Installments

A marketing periodical installed on the back of bathroom stall doors.

Library Connection, V2n1, Fall 2014, University Of Northern Iowa. Rod Library.

Library Connection

Contents:

-- Developing UNI ScholarSpace
-- Anyone, Anywhere, Anytime UNI ScholarWorks
-- West Entrance and Book Bistro Cafe
-- RodCon 2015
-- New Curator of the UNI Museums

Prankster Questionaire., Matthew Landan 1972-

Electronic Theses and Dissertations

The creative thesis that I have written is a memoir. It is not complete in its detail or ambition but instead focuses on themes and topics of self-transformation, reinvention and the unintentional consequences of several nervous breakdowns and experiments with psychedelic substances. This thesis is just a beginning for a longer more drawn out memoir that will explore the themes above but also discuss family, one’s sense of self worth in the world and how patterns between fathers and sons repeat themselves. I hope to eventually publish this work in a commercial setting.

Transient Heat Transfer Between A Magnetocaloric Packed Particle Bed And Stagnant Interstitial Fluid., Michael G. Schroeder 1988-

Electronic Theses and Dissertations

In the field of magnetocaloric heat pumps, many system models have been made. What most of these models lack is heat transfer occurring while there is no fluid motion. It is the objective of this paper to analytically determine and experimentally verify heat transfer with no bulk fluid motion. The addition of a pure dwell period to the typical magnetocaloric cycle was shown to have a positive performance impact in specific conditions. These conditions correspond to regenerators that are heat transfer rate limited in operation. The heat transfer mechanism for this particular case was shown to be pure conduction via …

Enzyme Kinetics : 6-Phosphofructo-2-Kinase/2,6-Bisphosphatase., Jennifer Clark

Electronic Theses and Dissertations

Altered energy metabolism is an established hallmark of cancer cells. Fructose-2,6-bisphosphate is an allosteric activator of glycolysis and its concentration in a cell is dictated by the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFKFB1-4) family of bifunctional enzymes. The PFKFB family of enzymes are characterized by their different kinase: bisphosphatase activities and were originally determined to be tissue-specific. More recent data however suggest that multiple isoforms are co-expressed in both normal and neoplastic tissues. PFKFB4 is highly expressed in human cancer, strongly induced by hypoxia, and required for the survival of cancer cells. However, it remains unclear whether the kinase or phosphatase activity of human …

Graduate Students Who Are Part-Time Workers : How Does Occupational Stress And Gender Role Affect Job Satisfaction?, Megan Church-Nally

Electronic Theses and Dissertations

Job satisfaction and occupational stress have consistently been examined in professionals for decades due to its link to turnover and reduced productivity. Similar concepts have been investigated in undergraduate students, but there is paucity of research of attrition in graduate students. This gap persists despite estimates that 50% of graduate students fail to graduate (Cassuto, 2013). Such attrition is not due to deficiency in academic skills, as Carroll, Ng, and Birch (2009) reported that personal reasons were cited more than academic concerns for attrition. The purpose of this dissertation was to address this job satisfaction and occupational stress gap with …

Modulation Of Host Polyubiquitination By The Ankb F-Box Protein Of Legionella Pneumophila., William M. Bruckert

Electronic Theses and Dissertations

Legionella pneumophila is a facultative intracellular pathogen that infects a wide array of protozoan hosts and human alveolar macrophages. L. pneumophila is dependent on a functional Dot/Icm type IVB secretion system that translocates bacterial effector proteins into the host cell cytosol. L. pneumophila genomes encode more than 250 effector proteins, many of which inhibit host cellular processes to form a favorable niche termed the Legionella-containing vacuole (LCV). The eukaryotic-like Dot/Icm translocated effector AnkB contains two eukaryotic-like ankyrin protein-protein interacting domains, one eukaryotic-like F- box domain and an eukaryotic C-terminal CaaX motif. Immediately following attachment of extracellular bacteria, AnkB is translocated …

Development Of A Thin-Film Porous-Microelectrode Array (P-Mea) For Electrical Stimulation Of Engineered Cardiac Tissue., Hiren Vrajlal Trada 1977-

Electronic Theses and Dissertations

Electrical stimulation has been increasingly used by research groups to enhance and increase maturation of cells in an engineered cardiac tissue (ECT). Current methods are based on using off-the-shelf wires or electrodes to deliver a stimulus voltage to the in-vitro tissue in culture medium. A major issue with this approach is the generation of byproducts in the medium due to the voltage levels required, which are typically in the range of 5V-10V. No solution currently exists that can accomplish electrical stimulation of cells in an ECT at a low voltage level. Therefore, in this study a novel, porous, thinfilm, microelectrode …