Digital Commons Network^™

New 4-Aminoquinoline Compounds To Reverse Drug Resistance In P. Falciparum Malaria, And A Survey Of Early European Antimalarial Treatments, Katherine May Liebman

Dissertations and Theses

Intermittent fevers caused by Plasmodium parasites have been known for millennia, and have caused untold human suffering. Today, millions of people are afflicted by malaria each year, and hundreds of thousands die. Historically, the most successful synthetic antimalarial drug was chloroquine, as it was safe, inexpensive, and highly efficacious. However, plasmodial resistance to chloroquine now greatly limits its utility. Previously in our laboratories it has been shown that attachment of a "reversal agent moiety" to the side chain of chloroquine can result in the restoration of activity against chloroquine-resistant strains of P. falciparum malaria. In the first part of the …

On The Indispensable Premises Of The Indispensability Argument, Andrea Sereni, Marco Panza

MPP Published Research

We identify four different minimal versions of the indispensability argument, falling under four different varieties: an epistemic argument for semantic realism, an epistemic argument for platonism and a non-epistemic version of both. We argue that most current formulations of the argument can be reconstructed by building upon the suggested minimal versions. Part of our discussion relies on a clarification of the notion of (in)dispensability as relational in character. We then present some substantive consequences of our inquiry for the philosophical significance of the indispensability argument, the most relevant of which being that both naturalism and confirmational holism can be dispensed …

Comparison On Different Discrete Fractional Fourier Transform (Dfrft) Approaches, Bal Santhanam

Electrical & Computer Engineering Technical Reports

No abstract provided.

Ferroelectric Polarization Dependent Interface Effects, Xiaohui Liu

Department of Physics and Astronomy: Dissertations, Theses, and Student Research

Utilization of the switchable spontaneous polarization of nanometer scale ferroelectric materials offers a promising avenue for future nanoelectronic devices. In this dissertation, we use density-functional calculations and phenomenological modeling to explore the effects of interface termination on thin-film heterostructures, the effects of electron doping in bulk ferroelectric materials on ferroelectric stability, and the effects of ferroelectric polarization switching on the electronic and transport properties of interfaces.

For SrRuO₃/BaTiO₃/SrRuO₃ epitaxial heterostructures grown on SrTiO₃, we find that the built-in dipole at the BaO/RuO₂ terminated interface leads to a strong preference for one polarization. …

A 3d Kinematic Study Of The Northern Ejecta 'Jet' Of The Crab Nebula, Christine S. Black, Robert A. Fesen

Dartmouth Scholarship

We present [O III] 4959,5007 emission line spectra (FWHM = 40 km/s) of the Crab Nebula's northern ejecta `jet'. These data, along with a recent [O III] image of the Crab, are used to build 3-dimensional models of the jet and adjacent remnant nebulosity to better understand the jet's properties and possible formation. We find that the jet's radial velocities range from -190 to +480 km/s with transverse velocities from 1600 to 2650 km/s from base to tip. The jet appears virtually hollow in [O III] emission with the exception of some material at the jet's base where the it …

A Study On The Relationships Of Professional Development, Teacher Working Conditions And Job Satisfaction While Controlling For Years Of Teaching Experience And Grade Level Taught, Daniel W. Silvia

Seton Hall University Dissertations and Theses (ETDs)

“Over the next ten years, 1.6 million teachers will retire, and 1.6 million new teachers will be needed to take their place. This poses both an enormous challenge and an extraordinary opportunity for our education system: “if we succeed in recruiting, preparing, and retaining great teaching talent, we can transform public education in this country and finally begin to deliver an excellent education for every child” (Duncan, 2011, pg. 1). Indeed, teacher preparation and professional development is an extremely important issue facing our educational system today. There is a great deal of research that supports the idea that the most …

Diffractive Optical Elements With A Large Angle Of Operation Recorded In Acrylamide Based Photopolymer On Flexible Substrates, Hoda Akbari, Izabela Naydenova, Lina Persechini, Sean Garner, Pat Cimo, Suzanne Martin

Articles

A holographic device characterised by a large angular range of operation is under development. The aim of this study is to increase the angular working range of the diffractive lens by stacking three layers of high efficiency optical elements on top of each other so that light is collected (and focussed) from a broader range of angles. The angular range of each individual lens element is important, and work has already been done in an acrylamide-based photosensitive polymer to broaden the angular range of individual elements using holographic recording at a low spatial frequency.This paper reports new results on the …

Stochastic Adaptive Event-Triggered Control And Network Scheduling Protocol Co-Design For Distributed Networked Systems, Hao Xu, Avimanyu Sahoo, Sarangapani Jagannathan

Electrical and Computer Engineering Faculty Research & Creative Works

In a distributed 'networked control system' (NCS), multiple physical systems or agents are connected to their corresponding controllers through a shared packet-switched communication network. For such distributed NCS, periodic sampled controller design is unsuitable to handle packet-switched closed-loop control systems, and a novel stochastic optimal adaptive event-sampled controller scheme is proposed in the application layer for each physical system or agent expressed as an uncertain linear dynamic system. Lyapunov stability analysis will be utilized to derive the event trigger condition. In addition, a network scheduling protocol is also required for such NCS. Traditional network scheduling protocols are unsuitable for such …

Investigating Catalysis Through Quantum Mechanical Computations: An Analysis Of Phosphoryl Transfer Enzymes And Ccc-Nhc Pincer Complexes, Katherine Nicholls Leigh

Electronic Theses and Dissertations Archive

Chemical reactions are essential to the world we experience. Certain chemical reactions, though beneficial, occur at rates too slow to be practical. Catalysis, or the use of another species to increase the rate of a chemical reaction, is often utilized, allowing chemical reactions to become more beneficial. Catalysts increase reaction rates by lowering the amount of energy required to perform a reaction. Catalysis is abundant, as evidenced in nature in the form of enzymes, or in a myriad of non-biological processes such as chemical manufacturing and pharmaceutical materials. Phosphoryl transfer is a fundamental step in numerous processes central to life, …

Implementation Of Cross-Training For Multi-Shift Worker Allocation, Aditya Gandhi

Theses

In workforce allocation, gaps between workers available and workers needed at various operations result in production delays and a loss of profitability for the manufacturer. These gaps can be reduced by overtime assignments of workers from other shifts. However, for a multiple shift planning horizon, a mix of cross-training of workers over different tasks along with overtime assignments may be a good strategy. This work develops an industry-motivated cross-training framework that identifies workers and operations for normal, overtime, and training assignments. A mixed integer programming model that integrates all three assignment tasks is formulated and solved. The production scenario consists …

Radiaxial-Fibrous And Fascicular-Optic Mg-Calcitic Cave Cements: A Characterization Using Electron Backscattered Diffraction (Ebsd), Detlev K. Richter, Adrian Immenhauser, Rolf Dieter Neuser, Augusto Mangini

International Journal of Speleology

Electron backscattered diffraction (EBSD) applied to crystal fabric research in speleothems aids in our understanding of the origin of those fabrics. A significant advantage of this approach is the three dimensional data set of crystal c-axes. Here, we show a rare case of both convergent (radiaxial-fibrous) and divergent (fascicular-optic) orientations of the c-axes in pool calcites. The seemingly defective structure of the calcite lattice resulting in radiaxial-fibrous crystal orientations is probably caused by differential incorporation of Mg during crystal growth. The observation that radiaxial-fibrous and fascicular-optic fabrics co-exist in the same pool environment is remarkable and documents the complexity of …

An Innovative Partnership Between National And Regional Partnerships: Stars Meets Mcpie, Karen Bean, Kim K. Buch Dr., Teresa Dahlberg Dr., Tiffany Barnes Dr., Audrey Rorrer, Linda Cagley

PRISM: A Journal of Regional Engagement

The Students & Technology in Academia, Research, and Service (STARS) Computing Corps is a nationally-connected system of regional partnerships among higher education, K-12 schools, industry and the community, with a mission to broaden the participation of women, under-represented minorities and persons with disabilities in computing (BPC). With support from National Science Foundation funding, the University of North Carolina at Charlotte founded the STARS Alliance (now the STARS Computing Corps) which includes 44 universities, each with its own “constellation” of local and regional partnerships. McClintock Partners in Education (McPIE) is a partnership between a middle school, a church, and their surrounding …

Learning From Struggling Readers: The Impact Of A Community-Based Service Learning Project On Teacher Preparation, Jean Rattigan-Rohr, Ye He, Mary Beth Murphy

PRISM: A Journal of Regional Engagement

With the growing number of diverse struggling readers in K-12 settings in the United States, it is critical to provide opportunities for students to enhance reading skills beyond classroom settings, for families to be involved in reading education, and for teachers to be better prepared to work with both students and their families. In this study, we described a community-based service learning project, the Village Project, that highlights the collaboration among the university, schools, and local community partners. Through reciprocal learning process, not only did struggling readers and families benefited from the program, preservice teacher candidates involved in the project …

“We Are Jamaicans. We Are Brothers”: History, Brotherhood, And Independence In Kerry Young’S Pao, Tzarina T. Prater

Anthurium: A Caribbean Studies Journal

Kerry Young’s first Novel, Pao, is written in the “voice” of a Chinese Jamaican, a voice that exhibits little if no syntactical or grammatical difference from those with whom he works and lives in the underworld of Chinatown in Kingston, Jamaica. Pao, our central protagonist, arrives to Jamaica in 1938, a time of tremendous social upheaval. The novel charts Pao’s growing political consciousness through his romantic relationships with: the “improper” black prostitute and madam, Gloria Campbell, who is the site of romantic love, and the “proper” Fay Wong, daughter of a grocery store chain owner and link to respectability. …

December 10, 2014 Cal Poly Report, Public Affairs Office

Cal Poly Report

No abstract provided.

Spartan Daily, December 10, 2014, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily (School of Journalism and Mass Communications)

Volume 143, Issue 41

The Lumberjack, December 10, 2014, The Lumberjack Staff

2014

The student newspaper of Humboldt State University

Minutes Of The Faculty Senate Meeting, December 10, 2014, University Of Arkansas, Fayetteville. Faculty Senate

Faculty Senate Minutes

No abstract provided.

Jany, Roman, Gallegos-Ruiz, Long, Leh, Kohout Flc 14, Carmen Jany, Alexandru V. Roman, Thomas Long, Maria Gallegos-Ruiz, Amy Leh, Michal Kohout

Faculty Learning Communities

No abstract provided.

Cal Poly University Art Gallery To Feature Graphic Designer Aaron Draplin Jan. 9- Feb.6, Public Affairs Office

Press Releases

No abstract provided.

A Statistical Analysis Of The Role Of Critical-Thinking Games In College Students' Quantitative Reasoning, Melissa Radevicz

Honors Program Theses and Projects

Improving college students' quantitative reasoning is crucial to increase STEM-field retention rates. The National Survey of Student Engagement (NSSE), results indicate that "college students don't always get exposure to activities that develop [quantitative reasoning]" (Berrett & Sander, 2013). This study aimed to engage college students in quantitative reasoning through critical-thinking games. Phase 1, conducted in summer 2014 with a university research grant, involved a correlation analysis of the work of 133 college students enrolled in Elementary Statistics I, Chemical Principles II, Elements of Calculus, Pre-Calculus with Trigonometry, Multivariable Calculus, and Differential Equations. Participants held a variety of 39 different majors, …

Network Flexibility For Recourse Considerations In Bi-Criteria Facility Location, Jeremy North

Dissertations

What is the best set of facility location decisions for the establishment of a logistics network when it is uncertain how a company’s distribution strategy will evolve? What is the best configuration of a distribution network that will most likely have to be altered in the future? Today’s business environment is turbulent, and operating conditions for firms can take a turn for the worse at any moment. This fact can and often does influence companies to occasionally expand or contract their distribution networks. For most companies operating in this chaotic business environment, there is a continuous struggle between staying cost …

A Revisit Of The Equilibrium Assumption For Predicting Near-Wall Turbulence, Farid Karimpour, Subhas K. Venayagamoorthy

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

In this study, we revisit the consequence of assuming equilibrium between the rates of production (P) and dissipation (∈) of the turbulent kinetic energy (k) in the highly anisotropic and inhomogeneous near-wall region. Analytical and dimensional arguments are made to determine the relevant scales inherent in the turbulent viscosity (νt) formulation of the standard k-∈ model, which is one of the most widely used turbulence closure schemes. This turbulent viscosity formulation is developed by assuming equilibrium and use of the turbulent kinetic energy (k) to infer the relevant velocity scale. We show that such turbulent viscosity formulations are not suitable …

Composite Index As A Way Of Measuring Economic Distress In Nebraska, Cornelius S. Okumu

Community and Regional Planning Program: Theses

The Nebraska state department of economic development, just like any other state’s department of economic development in the United States receives funding for economic development programs. These programs are mostly geared toward revitalizing economic situations of villages, cities or counties that are under economic distress. The purpose of this paper is to assess how the Nebraska Department of Economic Development (NEDED) currently measure distress in Nebraska Counties, and develop composite distress indexes that might improve the measure, interpretation and use of Economic distress index to help in their allocation of Economic development resources to Nebraska counties.

Advisor: Rodrigo Cantarero

Overview Of The Sdss-Iv Manga Survey: Mapping Nearby Galaxies At Apache Point Observatory, Kevin Bundy, Matthew A. Bershady, David R. Law, Renbin Yan, Niv Drory, Nicholas Macdonald, David A. Wake, Brian Cherinka, José R. Sánchez-Gallego, Anne-Marie Weijmans, Daniel Thomas, Christy Tremonti, Karen Masters, Lodovico Coccato, Aleksandar M. Diamond-Stanic, Alfonso Aragón-Salamanca, Vladimir Avila-Reese, Carles Badenes, Jésus Falcón-Barroso, Francesco Belfiore, Dmitry Bizyaev, Guillermo A. Blanc, Joss Bland-Hawthorn, Michael R. Blanton, Joel R. Brownstein, Nell Byler, Michele Cappellari, Charlie Conroy, Aaron A. Dutton, Eric Emsellem, Kai Zhang

Physics and Astronomy Faculty Publications

We present an overview of a new integral field spectroscopic survey called MaNGA (Mapping Nearby Galaxies at Apache Point Observatory), one of three core programs in the fourth-generation Sloan Digital Sky Survey (SDSS-IV) that began on 2014 July 1. MaNGA will investigate the internal kinematic structure and composition of gas and stars in an unprecedented sample of 10,000 nearby galaxies. We summarize essential characteristics of the instrument and survey design in the context of MaNGA's key science goals and present prototype observations to demonstrate MaNGA's scientific potential. MaNGA employs dithered observations with 17 fiber-bundle integral field units that vary in …

Professional Development And The Growth Of Professional Learning Communities In Education, Chelsie Hinrichs

Counselor Education Capstones

Professional development will most certainly always be a part of education. Even though professional development standards and practices may change over the course of time, its importance and implications for students will not. It is part of the educator’s job to continually their teaching techniques and practices. One must stay up-to-date on the most current methods in education in order to assure student success. With that being said, professional development has evolved into more than just attending workshops and meetings. It has evolved into professional learning communities (PLC’s), which enable educator’s to reach out to their students in new way, …

Aerosols, Hurricanes, And Their Interactions : A Case Study Of Hurricane Sandy, Andrew Fontenot, Hesham El-Askary, W. Lau

Student Scholar Symposium Abstracts and Posters

While the effects of aerosols on precipitation have been studied, their effects on more extreme precipitation events like Tropical Cyclones have only been questioned relatively recently. Because of the rarity of the intersection of significant quantities of aerosols and forming/formed tropical cyclones, as well as the possible destruction caused, most experiments about their effects take place in computer models that may not fully simulate the effects of the aerosols. Limitations in satellite sensing make it difficult to track processes and material distributions in hurricanes from afar as well. Hurricane Sandy, a devastating hurricane that formed in October of 2012, may …

Volume 52, Number 17: December 10, 2014, University Of North Dakota

University Letter Archive

No abstract provided.

Distribution, Growth, And Impact Of The Coral-Excavating Sponge, Cliona Delitrix, On The Stony Coral Communities Offshore Southeast Florida, Ari Halperin

HCNSO Student Theses and Dissertations

Bioerosion is a major process that affects the carbonate balance on coral reefs, and excavating sponges from the genus Cliona are some of the most important bioeroders on Caribbean reefs. The orange boring sponge, Cliona delitrix, is an abundant excavating sponge offshore southeast Florida that frequently colonizes dead portions of live stony corals, killing live coral tissue as it grows. With the recent decline in coral cover attributed to combined environmental and anthropogenic stressors, the increasing abundance of excavating sponges poses yet another threat to the persistence of Caribbean coral reefs.

In the first part of this study, I …

Computing Singular Values Of Large Matrices With An Inverse-Free Preconditioned Krylov Subspace Method, Qiao Liang, Qiang Ye

Mathematics Faculty Publications

We present an efficient algorithm for computing a few extreme singular values of a large sparse m×n matrix C. Our algorithm is based on reformulating the singular value problem as an eigenvalue problem for C^TC. To address the clustering of the singular values, we develop an inverse-free preconditioned Krylov subspace method to accelerate convergence. We consider preconditioning that is based on robust incomplete factorizations, and we discuss various implementation issues. Extensive numerical tests are presented to demonstrate efficiency and robustness of the new algorithm.