Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Physical Sciences and Mathematics (9800)
- Engineering (2729)
- Education (2723)
- Environmental Sciences (2159)
- Social and Behavioral Sciences (2034)
-
- Computer Sciences (1967)
- Life Sciences (1543)
- Physics (1475)
- Chemistry (1401)
- Earth Sciences (1044)
- Mathematics (995)
- Arts and Humanities (987)
- Medicine and Health Sciences (840)
- Electrical and Computer Engineering (785)
- Water Resource Management (769)
- Law (697)
- Higher Education (621)
- Statistics and Probability (547)
- Oceanography and Atmospheric Sciences and Meteorology (514)
- Science and Mathematics Education (508)
- Computer Engineering (488)
- Business (466)
- Astrophysics and Astronomy (434)
- Mechanical Engineering (411)
- Teacher Education and Professional Development (399)
- Civil and Environmental Engineering (373)
- Geology (360)
- Curriculum and Instruction (343)
- Educational Assessment, Evaluation, and Research (337)
- Public Affairs, Public Policy and Public Administration (313)
- Institution
-
- University of Nebraska - Lincoln (898)
- City University of New York (CUNY) (780)
- Purdue University (647)
- Brigham Young University (517)
- TÜBİTAK (445)
-
- Utah State University (433)
- Singapore Management University (423)
- Louisiana State University (417)
- Association of Arab Universities (401)
- Old Dominion University (401)
- University of Kentucky (396)
- University of South Florida (384)
- Missouri University of Science and Technology (381)
- Georgia Southern University (332)
- California Polytechnic State University, San Luis Obispo (323)
- Clemson University (291)
- Portland State University (285)
- University of Central Florida (283)
- University of New Mexico (231)
- University of Arkansas, Fayetteville (222)
- Wayne State University (212)
- Virginia Commonwealth University (196)
- University of Texas at El Paso (194)
- Nova Southeastern University (191)
- University of South Carolina (191)
- Wright State University (190)
- University of Texas Rio Grande Valley (189)
- University of Montana (186)
- Embry-Riddle Aeronautical University (180)
- Western Michigan University (179)
- Keyword
-
- 2014 International Conference on Hydroinformatics HIC (464)
- Education (254)
- Mathematics (196)
- Applied sciences (134)
- Climate change (102)
-
- Optimization (96)
- Georgia Southern University (84)
- Higher education (82)
- Modeling (81)
- Assessment (79)
- STEM (72)
- Technology (72)
- Sustainability (70)
- Energy (62)
- Simulation (62)
- Hydrodynamic Modelling (61)
- Engineering (60)
- Physics (59)
- Science (59)
- Research (53)
- Chemistry (52)
- Application of Data-driven Modelling in Water Sciences (51)
- Water quality (50)
- Pure sciences (49)
- Machine learning (48)
- Optimization of Water Resources Management and Control (48)
- Drought (47)
- Remote sensing (47)
- Security (46)
- Students (46)
- Publication
-
- Theses and Dissertations (812)
- International Conference on Hydroinformatics (464)
- Electronic Theses and Dissertations (432)
- Applied Mathematics & Information Sciences (367)
- Research Collection School Of Computing and Information Systems (346)
-
- Faculty Publications (321)
- Dissertations (276)
- Journal of Undergraduate Research (260)
- Open Access Theses (202)
- Theses (187)
- Open Access Dissertations (173)
- USF Tampa Graduate Theses and Dissertations (173)
- Dissertations, Theses, and Capstone Projects (138)
- Masters Theses (134)
- Doctoral Dissertations (133)
- Publications and Research (130)
- LSU Doctoral Dissertations (122)
- Turkish Journal of Electrical Engineering and Computer Sciences (121)
- Master's Theses (120)
- Graduate Theses and Dissertations (119)
- UNLV Theses, Dissertations, Professional Papers, and Capstones (114)
- LSU Master's Theses (112)
- Open Access Theses & Dissertations (110)
- Turkish Journal of Chemistry (106)
- Publications (101)
- Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions) (98)
- Honors Theses (96)
- Turkish Journal of Mathematics (96)
- All Graduate Theses and Dissertations, Spring 1920 to Summer 2023 (94)
- Articles (94)
- Publication Type
Articles 2971 - 3000 of 21926
Full-Text Articles in Entire DC Network
The Bg News October 06, 2014, Bowling Green State University
The Bg News October 06, 2014, Bowling Green State University
BG News (Student Newspaper)
The BGSU campus student newspaper. October 06, 2014. Volume 94-Issue 20.
Resistance And Lifetime Measurements Of Polymer Solar Cells Using Glycerol Doped Poly[3,4-Ethylenedioxythiophene]: Poly[Styrenesulfonate] Hole Injection Layers, Bhaskar Mantha, Emma Lewis, Richard P. Barber Jr.
Resistance And Lifetime Measurements Of Polymer Solar Cells Using Glycerol Doped Poly[3,4-Ethylenedioxythiophene]: Poly[Styrenesulfonate] Hole Injection Layers, Bhaskar Mantha, Emma Lewis, Richard P. Barber Jr.
Physics
We have performed resistivity measurements of poly[3,4-ethylenedioxythiophene]: poly[styrenesulfonate] (PEDOT:PSS) films with varying concentrations of glycerol. Resistivity is seen to decrease exponentially from roughly 3 Ω-cm for pure PEDOT:PSS to 3 × 10-2Ω-cm for 35 mg/cm3 glycerol in PEDOT:PSS. Beyond this concentration adding glycerol does not significantly change resistivity. Bulk heterojunction polymer solar cells using these variously doped PEDOT:PSS layers as electrodes were studied to characterize the effects on efficiency and lifetime. Although our data display significant scatter, lowering the resistance of the PEDOT:PSS layers results in lower device resistance and higher efficiency as expected. We also note that the lifetime …
The Collegian (2014-10-06), Cleiri Quezada
The Collegian (2014-10-06), Cleiri Quezada
UTB/TSC Archives - The Collegian [Newspaper]
Vol. 67, No. 7
Information Security Newsletter
Information Security Newsletter
Offices & Divisions: Division of Information Technology Services (Archived)
No abstract provided.
Effects Of Extreme Climate Events On Tea (Camellia Sinensis) Functional Quality Validate Indigenous Farmer Knowledge And Sensory Preferences In Tropical China, Selena Ahmed, John Richard Stepp, Colin M. Orians, Timothy S. Griffin, Corene Matyas, Albert Robbat, Sean Cash, Dayuan Xue, Chunlin Long, Uchenna Unachukwu, Sarabeth Buckley, Edward J. Kennelly
Effects Of Extreme Climate Events On Tea (Camellia Sinensis) Functional Quality Validate Indigenous Farmer Knowledge And Sensory Preferences In Tropical China, Selena Ahmed, John Richard Stepp, Colin M. Orians, Timothy S. Griffin, Corene Matyas, Albert Robbat, Sean Cash, Dayuan Xue, Chunlin Long, Uchenna Unachukwu, Sarabeth Buckley, Edward J. Kennelly
Publications and Research
Climate change is impacting agro-ecosystems, crops, and farmer livelihoods in communities worldwide. While it is well understood that more frequent and intense climate events in many areas are resulting in a decline in crop yields, the impact on crop quality is less acknowledged, yet it is critical for food systems that benefit both farmers and consumers through high-quality products. This study examines tea (Camellia sinensis; Theaceae), the world’s most widely consumed beverage after water, as a study system to measure effects of seasonal precipitation variability on crop functional quality and associated farmer knowledge, preferences, and livelihoods. Sampling was conducted in …
Efficient And Secure Code Dissemination In Sensor Clouds, Vimal Kumar, Sanjay Kumar Madria
Efficient And Secure Code Dissemination In Sensor Clouds, Vimal Kumar, Sanjay Kumar Madria
Computer Science Faculty Research & Creative Works
In this paper, we present an efficient and secure code dissemination technique aimed at sensor clouds. Previous code dissemination techniques were geared toward traditional wireless sensor networks. They did not take into account, the dynamic nature of a sensor cloud, where the applications running on the motes may not just be updated but changed completely in successive code disseminations. The technique presented in this paper is based upon the observation that a large amount of code is common between applications in wireless sensor networks. Our technique first discovers the code common across various wireless sensor applications. It then distributes this …
Dynamic Content And Route Management In Wireless Networks, Sanjay Kumar Madria, Anirban Mondal, Tridib Mukherjee
Dynamic Content And Route Management In Wireless Networks, Sanjay Kumar Madria, Anirban Mondal, Tridib Mukherjee
Computer Science Faculty Research & Creative Works
Significant advances in wireless and mobile technologies have been witnessed over the past decade. The ever-increasing prevalence and proliferation of mobile devices coupled with the popularity of social networking and increasingly technology-savvy residents have fueled the growth of mobile crowdsourcing and participatory sensing. This has catalyzed the growth of new-age applications, which necessitate dynamic management of information as well as content in wireless networks of different types such as Mobile Peer-to-Peer (MP2P), Vehicle-to-Vehicle (V2V) and Delay-Tolerant Networks (DTNs).
Handiwork Of Our Creator, Carl P. Fictorie
Handiwork Of Our Creator, Carl P. Fictorie
Faculty Work Comprehensive List
"Chemistry certainly is a science that seeks to understand how creation works, working at the microscopic level of atoms, molecules, and ions; the basic building blocks of matter."
Posting about understanding the nature of creation from In All Things - an online hub committed to the claim that the life, death, and resurrection of Jesus Christ has implications for the entire world.
http://inallthings.org/handiwork-of-our-creator/
Climate Change And The Next Generation, Jugal Patel
E-Vet: Economic Reward/Penalty-Based System For Vehicular Traffic Management, Nilesh Padhariya, Ouri Wolfson, Anirban Mondal, Varun Gandhi, Sanjay Kumar Madria
E-Vet: Economic Reward/Penalty-Based System For Vehicular Traffic Management, Nilesh Padhariya, Ouri Wolfson, Anirban Mondal, Varun Gandhi, Sanjay Kumar Madria
Computer Science Faculty Research & Creative Works
We propose the E-VeT system for efficient vehicular traffic management in road networks using economy-based reward/penalty schemes. In E-VeT, base stations collaboratively facilitate dynamic vehicular route assignments for reducing the traffic congestion, average time of arrival and fuel consumption. The main contributions of this work are two-fold. First, it proposes an R2A (Revenue-based Route Allocation) scheme, which rewards vehicles for following system-assigned longer-time paths, and charges a fee for following system-assigned shorter-time paths. Furthermore, it penalizes vehicles for any deviations from the system-assigned paths. Second, it discusses a route allocation algorithm, which gives lesser-time paths as a preference to vehicles …
Supervised Material Classification In Oblique Aerial Imagery Using Gabor Filter Features, Michael L. Harris
Supervised Material Classification In Oblique Aerial Imagery Using Gabor Filter Features, Michael L. Harris
Theses
RIT's Digital Imaging and Remote Sensing Image Generation (DIRSIG) tool allows modeling of real world scenes to create synthetic imagery for sensor design and analysis, trade studies, algorithm validation, and training image analysts. To increase model construction speed, and the diversity and size of synthetic scenes which can be generated it is desirable to automatically segment real world imagery into different material types and import a material classmap into DIRSIG.
This work contributes a methodology based on standard texture recognition techniques to supervised classification of material types in oblique aerial imagery. Oblique imagery provides many challenges for texture recognition due …
Quantifying Economic Benefits For Rail Infrastructure Projects, Suzanna Long, Ruwen Qin, John Betak, Akhilesh Ojha, John J. Myers
Quantifying Economic Benefits For Rail Infrastructure Projects, Suzanna Long, Ruwen Qin, John Betak, Akhilesh Ojha, John J. Myers
Engineering Management and Systems Engineering Faculty Research & Creative Works
This project identifies metrics for measuring the benefit of rail infrastructure projects for key stakeholders. It is important that stakeholders with an interest in community economic development play an active role in the development of the rail network. Economic development activities in both rural and urban settings are essential if a nation is to realize growth and prosperity. Many communities have developed goals and visions to establish an economic development program, but they often fail to achieve their goals due to uncertainties during the project selection and planning process. Communities often select a project from a vast pool of ideas …
Health Literacy And Obesity Among Native Hawaiian And Pacific Islanders In The U.S., Jane Lassetter
Health Literacy And Obesity Among Native Hawaiian And Pacific Islanders In The U.S., Jane Lassetter
Faculty Publications
Objectives: Our purpose was to describe relationships between demographic characteristics, body mass index (BMI), and health literacy among Native Hawaiians and other Pacific Islanders (NHPIs).
Design and Sample: In this cross-sectional survey, we interviewed 364 NHPI adults.
Measures: We used Newest Vital Sign (NVS), a health literacy tool; measured heights and weights; and demographic questions.
Results: According to participants’ NVS scores, 45.3% had at least a possibility of low health literacy. Lower NVS scores were associated with increased BMI (r = -0.12, p = 0.027) and increased age (r = -0.26, p < 0.001). Higher NVS scores were associated …
Mega, Digital Storage Lockers, And The Dmca: Will Innovation Be Stifled By Fears Of Piracy?, Ali V. Mirsaidi
Mega, Digital Storage Lockers, And The Dmca: Will Innovation Be Stifled By Fears Of Piracy?, Ali V. Mirsaidi
Duke Law & Technology Review
Kim Dotcom, founder of Megaupload Limited, has been in many news headlines over the past year. Megaupload—one of Dotcom’s many peer-to-peer sharing sites—was the center of controversy, as it allowed users to upload and share all sorts of files, including copyrighted material. After an organized effort by the Department of Justice and several foreign governments, Dotcom was arrested for (secondary) copyright infringement and his site was ultimately shut down. Dotcom has recently launched a new service, MEGA, which he claims will evade copyright laws entirely. Like other well-known cloud-sharing services such as Dropbox and Google Drive, MEGA allows users to …
Triangular Treaties: The Nature And Limits Of Investment Treaty Rights, Anthea Roberts Prof
Triangular Treaties: The Nature And Limits Of Investment Treaty Rights, Anthea Roberts Prof
Harvard International Law Journal
Investment treaties are triangular treaties. Investment treaties are entered into by two states but they are unusual because they provide enforceable protections to investors as third party beneficiaries. State A (the host state) agrees to provide certain protections to investors coming from State B (the home state). If the investor considers that these protections have been violated, investment treaties also grant the investor permission to bring an arbitral claim directly against the host state.
Investment treaties clearly protect investors against certain unilateral actions by host states, such as expropriation without compensation. But do they also protect investors against unilateral actions …
Board Of Trustees Meeting Minutes 2014-10-03, Bowling Green State University
Board Of Trustees Meeting Minutes 2014-10-03, Bowling Green State University
Board of Trustees Meeting Minutes
The official meeting minutes of Bowling Green State University's Board of Trustees.
Characteristics Of Gravitational And Electromagnetic Radiation, Maria Babiuc-Hamilton
Characteristics Of Gravitational And Electromagnetic Radiation, Maria Babiuc-Hamilton
Physics Faculty Research
Gravitational waves from the early universe are detectable, but detection is difficult. The strain is extremely small of magnitude 10-3 the width of a proton. There are detection and computational challenges.
Kawamura V. Kawamura Respondent's Brief Dckt. 42112
Kawamura V. Kawamura Respondent's Brief Dckt. 42112
Idaho Supreme Court Records & Briefs, All
No abstract provided.
Observation Of D0 Meson Nuclear Modifications In Au+Au Collisions At √SNn=200 Gev, J. Kevin Adkins, Renee Fatemi, Suvarna Ramachandran, G. Webb, L. Adamczyk, G. Agakishiev, M. M. Aggarwal, Z. Ahammed, I. Alekseev, J. Alford, C. D. Anson, A. Aparin, D. Arkhipkin, E. C. Aschenauer
Observation Of D0 Meson Nuclear Modifications In Au+Au Collisions At √SNn=200 Gev, J. Kevin Adkins, Renee Fatemi, Suvarna Ramachandran, G. Webb, L. Adamczyk, G. Agakishiev, M. M. Aggarwal, Z. Ahammed, I. Alekseev, J. Alford, C. D. Anson, A. Aparin, D. Arkhipkin, E. C. Aschenauer
Physics and Astronomy Faculty Publications
We report the first measurement of charmed-hadron (D0) production via the hadronic decay channel (D0→K−+π+) in Au+Au collisions at √SNN=200 GeV with the STAR experiment. The charm production cross section per nucleon-nucleon collision at midrapidity scales with the number of binary collisions, Nbin, from p+p to central Au+Au collisions. The D0 meson yields in central Au+Au collisions are strongly suppressed compared to those in p+p scaled by Nbin, for transverse momenta pT>3 GeV/c …
2014-October-03-Godbole Leads Center Of Excellence In Mathematics And Science Education, University Marketing And Communications, East Tennessee State University
2014-October-03-Godbole Leads Center Of Excellence In Mathematics And Science Education, University Marketing And Communications, East Tennessee State University
ETSU News
No abstract provided.
Volume Loss From Lower Peyto Glacier, Alberta, Canada, Between 1966 And 2010, Laura M. Kehrl, Robert L. Hawley, Erich C. Osterberg, Dominic A. Winski, Dominic A. Winski, Alexander P. Lee
Volume Loss From Lower Peyto Glacier, Alberta, Canada, Between 1966 And 2010, Laura M. Kehrl, Robert L. Hawley, Erich C. Osterberg, Dominic A. Winski, Dominic A. Winski, Alexander P. Lee
Dartmouth Scholarship
Mass loss from mountain glaciers contributes to sea-level rise and reduces freshwater availability in glacier-fed river basins, with negative effects on hydropower generation, agriculture and the health of aquatic ecosystems. In this study, we determine the volume of lower Peyto Glacier, Alberta, Canada, from ground-penetrating radar surveys in 2008–10, and compare our volume estimate with previous estimates from 1966 and 1984. The long-term record of mass-balance estimates on Peyto Glacier highlights Peyto’s importance as an ‘index’ glacier for the region. We calculate a mean volume of (3.39 0.30) 10m for the glacier snout for the period 2008–10. Glacier volume decreased …
Comminution Of Solids Due To Kinetic Energy Of High-Rate Shearing: Impact, Shock, And Shale Fracturing, Zdenek P Bazant, Yewang Su, Marco Salviato, Ferhun Caner
Comminution Of Solids Due To Kinetic Energy Of High-Rate Shearing: Impact, Shock, And Shale Fracturing, Zdenek P Bazant, Yewang Su, Marco Salviato, Ferhun Caner
Society of Engineering Science 51st Annual Technical Meeting Archive
Keynote: Fragmentation, crushing, and pulverization of solids, briefly called comminution, has long been a problem of interest for mining, tunneling, explosions, meteorite impact, missile impact and penetration, groundshock, defence against terrorist attack, and various kinds of industrial processes. Particularly intriguing is the idea that shock waves generated in the borehole by electrohydraulic pulsed arc could comminute gas shale so as to achieve a sufficient increase of permeability, which might allow reducing the discharge of contaminated water needed for hydraulic fracturing. Although many semi-empirical models for impact analysis abound in the literature, and whereas the fragmentation in the so-called “Mescall” zones …
Multiphase Elastic Homogenization, And The Mechanics Of Tendon-To-Bone Attachment, Guy Genin, F. Salimeh Saadat, Stavros Thomopoulos, Victor Birman
Multiphase Elastic Homogenization, And The Mechanics Of Tendon-To-Bone Attachment, Guy Genin, F. Salimeh Saadat, Stavros Thomopoulos, Victor Birman
Society of Engineering Science 51st Annual Technical Meeting Archive
Estimates of the effective stiffness of a composite containing multiple types of inclusions are needed for the design and study of functionally graded systems in engineering and biologic materials. One important stiffening mechanism in biologic systems is the accumulation of a high volume fraction of mineral inclusions within and upon collagen fibers. Modeling of this mechanism is critical for understanding how stresses are transmitted from tendon to bone and for designing improvements to surgical procedures for reattaching tendon to bone. The latter is a critical need because failure rates following surgical reattachment are as high as 94% in some populations. …
On Assessing Accuracy Of Numerical Solutions Of Porous Media Models, Mohammad Shabouei
On Assessing Accuracy Of Numerical Solutions Of Porous Media Models, Mohammad Shabouei
Society of Engineering Science 51st Annual Technical Meeting Archive
Error estimation techniques [1, 2] are widely used as the solution verification in the numerical simulations. One can employ either a posteriori error estimation based on known quantities in the solution or a priori error estimation by controlling the error parameters in unknown quantities. This study proposes a posteriori criteria for finite element approximation of the problems in flow through porous media. We introduce a technique to verify the numerical solution of Darcy and Darcy–Brinkman models and their modifications. We show that for given boundary conditions of all kinematically admissible vector fields, the Darcy and the Darcy–Brinkman velocities have minimum …
Stability Of Active Muscle Tissue, Luis Dorfmann, Chris Paetsch
Stability Of Active Muscle Tissue, Luis Dorfmann, Chris Paetsch
Society of Engineering Science 51st Annual Technical Meeting Archive
In this discussion, the notion of material stability is examined in the context of active muscle tissue modeling, where the nonlinear constitutive law is dependent on both the physiologically-driven muscle contraction and the finite mechanical deformation. First, the governing equations and constitutive laws for a general active-elastic material are linearized about a homogeneous underlying configuration. In order to obtain mathematical restrictions analogous to those found in elastic materials, stability conditions are derived based on the propagation of homogeneous plane waves with real wave speeds, and the generalized acoustic tensor is obtained. Focusing on 2D motions, and considering a simplified, decoupled …
Transforming Small Localized Loading Into Large Rotational Motion In Soft Anisotropically-Structured Materials, Stephan Rudykh, Mary Boyce
Transforming Small Localized Loading Into Large Rotational Motion In Soft Anisotropically-Structured Materials, Stephan Rudykh, Mary Boyce
Society of Engineering Science 51st Annual Technical Meeting Archive
Actuation of rotational motion in machines and robotics is generally achieved through highly engineered mechanical or electromechanical devices. As the field of soft robotics develops, there is an emerging and expanding need for novel actuation mechanisms. Here, we show the ability to transform small localized loading into large rotational motion via the design of soft anisotropically structured composite materials. The transformation mechanism governing the rotational actuation capitalizes on the underlying coupling of shear and normal modes of stress and strain in anisotropic materials together with the ability of the soft material to locally undergo large deformation [1, 2]. The transformation …
An Eulerian Framework For Modeling And Simulating The Nonlinear Dynamics Of Soft Hyperelastic Materials, Robert Lowe
An Eulerian Framework For Modeling And Simulating The Nonlinear Dynamics Of Soft Hyperelastic Materials, Robert Lowe
Society of Engineering Science 51st Annual Technical Meeting Archive
In this discussion, we present a novel framework for modeling and simulating the nonlinear elastodynamics of soft hyperelastic materials such as rubbers, elastomers, and biological tissues. The proposed framework differs fundamentally from the standard paradigm in computational mechanics in concept, structure, and methodology. A key feature of our approach is the use of a fixed mesh in tandem with a novel shock-capturing scheme from computational fluid dynamics designed specifically for first-order hyperbolic systems. Our use of a fixed mesh demands an Eulerian formulation of the mathematical model. The mathematical model we employ bridges the Eulerian conservation laws of mass, linear …
Application Of Finite Element Modeling And Viscoelasticity Theory In Characterization And Prediction Of Dielectric Relaxation Process In Polymer Nanodielectrics, He Zhao, Yang Li, Xiaolin Li, L. Catherine Brinson, Yanhui Huang, Timothy M. Krentz, Ke Wu, Curt Breneman, Linda Schadler
Application Of Finite Element Modeling And Viscoelasticity Theory In Characterization And Prediction Of Dielectric Relaxation Process In Polymer Nanodielectrics, He Zhao, Yang Li, Xiaolin Li, L. Catherine Brinson, Yanhui Huang, Timothy M. Krentz, Ke Wu, Curt Breneman, Linda Schadler
Society of Engineering Science 51st Annual Technical Meeting Archive
Nanodielectrics, typically defined as polymer composites with nanosized ceramic fillers, have demonstrated significant improvements in electrical endurance, breakdown strength and dielectric constant relative to their constituent materials, which leads to enhanced energy storage capabilities. The key role played by the large interfacial area surrounding nanofillers proves to be essential to the enhancement, yet quantitative models to predict the altered dielectric properties in the interfacial area are rarely seen. In this presentation, we apply a finite element modeling approach, originally developed for viscoelasticity analysis, to predict the frequency and temperature dependence of dielectric permittivity spectra in polymer nanodielectrics containing functionalized silica …
Predicting The Degradation Rate As A Function Of Drug Load In Solid-State Drug Products, Steven Baertschi, Allison Dill, David Sperry, Timothy Kramer
Predicting The Degradation Rate As A Function Of Drug Load In Solid-State Drug Products, Steven Baertschi, Allison Dill, David Sperry, Timothy Kramer
Society of Engineering Science 51st Annual Technical Meeting Archive
A model for predicting the rate of degradation as a function of drug load was recently developed (J. Pharm. Sci., 101(11), 2012, 4170‑4177). In this case study, we explore both the mathematical model as well as the conceptual construct from which the model was developed. We applied the model to a formulated product of varying drug loads. Our results not only confirm the validity of the mathematical model, but also call into question the proposed conceptual construct. We will discuss the generality of the model and how the use of this model can speed development of lower dose drug formulations …
Modeling Structure Property Relationships Using Finite Elements And High Energy X-Rays, Matthew Miller
Modeling Structure Property Relationships Using Finite Elements And High Energy X-Rays, Matthew Miller
Society of Engineering Science 51st Annual Technical Meeting Archive
Mechanical design with structural materials has been well-served by traditional methods for linking microstructure to mechanical properties using image-based data and mechanical testing. Modern “micrographs” might include three-dimensional microstructural models with spatially resolved orientation and/or chemical composition. Regardless of the level of detail, however, image-based data contain no information regarding the mechanical response of the aggregate. Often the connections between the microstructure and resulting mechanical properties are derived by intuition and inference. This highly empirical process is one of the reasons that materials design and selection are such time and resource-intensive process. The creation of mathematical models of the microstructure …