Digital Commons Network^™

Toward A Jurisprudence Of Drug Regulation, Matthew Herder

Articles, Book Chapters, & Popular Press

Efforts to foster transparency in biopharmaceutical regulation are well underway: drug manufacturers are, for example, legally required to register clinical trials and share research results in the United States and Europe. Recently, the policy conversation has shifted toward the disclosure of clinical trial data, not just trial designs and basic results. Here, I argue that clinical trial registration and disclosure of clinical trial data are necessary but insufficient. There is also a need to ensure that regulatory decisions that flow from clinical trials — whether positive (i.e. product approvals) or negative (i.e. abandoned products, product refusals, and withdrawals) — are …

Prediction Of Structure Borne Noise Radiation And Propagation From Offshore Impact Pile Driving, Huikwan Kim

Open Access Dissertations

This study investigates prediction of structure borne noise radiation and propagation from offshore impact pile driving in shallow water environment. Noise generated by offshore impact pile driving radiates into and propagates through the air, water, and sediment medium. Predicting noise levels around the pile structure at sea is required to estimate the effects of the noise and vibration on marine life. This study used one of the commercial FE (Finite Element) code Abaqus 6.11 to calculate harmonic and transient response of the offshore wind turbine support structure and associated acoustic pressure amplitudes due to hydraulic hammer impact on top. First …

The Cycle Intersection Matrix And Applications To Planar Graphs And Data Analysis For Postsecondary Mathematics Education, Caitlin R. Phifer

Open Access Dissertations

Given a finite connected planar graph G with s finite faces, we define the cycle-intersection matrix, C(G) = (c_ij) to be a symmetric matrix of size s x s where c_ii is the length of the cycle which bounds finite face i, and c_ij is the negative of the number of common edges in the cycles bounding faces i and j for i ≠ j. We will show that detC(G) equals the number of spanning trees in G. As an application, we compute the number of spanning trees of grid graphs …

Implicitly Restarted Krylov Subspace Methods For Large-Scale Least-Squares Problems, Daniel J. Richmond

Open Access Dissertations

The LSQR algorithm is a popular Krylov subspace method for obtaining solutions to large-scale least-squares problems. For some matrices, however, LSQR may require a prohibitively large number of iterations to determine an approximate solution within a desired accuracy. This is often the case when the solution vector has large components in the direction of the singular vectors associated with the smallest singular values of the matrix. This dissertation describes how the Krylov subspaces generated from LSQR can be conveniently updated to contain good approximations to the singular vectors corresponding to the smallest singular values of the matrix. The updates can …

An Investigation Of The Relationship Between School Leadership, Teacher Job Satisfaction, And Student Achievement, Beth-Ann Tek

Open Access Dissertations

This correlational cross-sectional study identifies and tests research-based constructs of school leadership and teacher job satisfaction on the 2012 Tell MASS survey using exploratory factor analyses, confirmatory factor analyses, and reliability analyses. Hierarchical linear modeling is used to examine the relationship between the survey’s school leadership and teacher job satisfaction scales. Multiple regression analyses are used to investigate the hypothesis that school leadership and student achievement on standardized tests in English Language Arts and Mathematics are also related, though this relationship is mediated by teacher job satisfaction.

Analyses revealed four major findings. First, EFA, CFA, and reliability analyses determined that …

Validation Of A Social Skills Construct Using Multitrait Multimethod And Generalizability Approaches, Monica Mabe

Open Access Dissertations

Social skills are important components of social‐emotional functioning that allow children to be successful in school, both socially and academically. A single, agreed‐upon definition of social skills has not been identified in the literature, however, which has led to variations in the measurement and assessment of social skills. Issues of measurement may be linked to the ineffectiveness of school‐based social‐skills interventions. Commonly used conceptualizations and operationalizations of social skills are presented, as well as a review of issues surrounding social‐skills interventions. The use of a multitrait‐multimethod approach is presented for the use of establishing a unified set of social skills …

A Case Study Of Student And Teacher Relationships And The Effect On Student Learning, Patricia Brady Gablinske

Open Access Dissertations

This research study explored the affective domain of teacher-student relationships using a single case study design. This single case study produced a synthesis of information that guides a classroom teacher in the development and maintenance of her relationships with her students. The resulting analysis and interpretation provided a description of major themes that developed regarding strong teacher student relationships, as well as, specific components to the interactions considered essential for the student’s learning environment.

The outcome of this study is an account of experiences and procedures that guide the development and maintenance of relationships between a teacher and her students. …

Using Activated Carbon To Enhance The Vocs And Heavy Metals Removal Of A Porous Asphalt Pavement System, Hui Chen

Open Access Dissertations

Two different porous asphalt pavement systems (PAPS) were designed to enhance the removal of VOCs (dichloromethane and toluene) and heavy metals (cadmium, copper and lead) from roadway runoff. These two PAPS utilized granular activated carbon (GAC) additions to the conventional PAPS. One PAPS, the CPP system (carbon in porous pavement), had GAC added directly to the top porous asphalt mix, and the other PAPS, the CCA system (carbon in coarse aggregates), had GAC added to the sub-base filter course below the porous asphalt layer. The removal of selected VOCs and heavy metals through the CPP and the CCA systems was …

Determination Of Residue Levels Of Alpha-Chloralose In Duck Tissues, David A. Goldade, Randal S. Stahl, John. J. Johnston

Human–Wildlife Interactions

Alpha-chloralose (AC) is used to capture nuisance waterfowl so that they can be relocated. Concerns for food safety limit its use prior to or during the waterfowl hunting season. To determine its half-life in tissue, we administered AC to adult male (n = 7) and female (n = 5) mallard ducks (Anas platyrhynchos) via oral gavage. A gel capsule containing 100 μCi of radioactive AC (14C-AC) and sufficient nonlabeled AC to produce a dose of approximately 30 mg/kg was given to each duck.The ducks were euthanized at 2, 6, 10, and 18 hours postdosing …

Summary Of Large-Scale C-Shaped Reinforced Concrete Wall Tests, Anahid A. Behrouzi, Andrew Mock, Laura Lowes, Dawn Lehman, Daniel Kuchma

Architectural Engineering

Flexural concrete walls (i.e., walls the yield in flexural prior to failure) are used commonly as the lateral load resisting system for mid‐ and high‐rise buildings on the West Coast. They are relatively stiff under service‐level loading, can take on various configurations to accommodate architectural constraints, and are generally assumed to exhibit ductile response under severe earthquake loading. Despite heavy reliance on concrete walls, relatively little research has been done to investigate the earthquake performance of walls with modern design details. Few data exist characterizing the performance of modern walls under variable levels of earthquake loading or the impact of …

Micro (Wind) Generation: 'Urban Resource Potential & Impact On Distribution Network Power Quality', Keith Sunderland

Doctoral

Of the forms of renewable energy available, wind energy is at the forefront of the European (and Irish) green initiative with wind farms supplying a significant proportion of electrical energy demand. This type of distributed generation (DG) represents a ‘paradigm shift’ towards increased decentralisation of energy supply. However, because of the distance of most DG from urban areas where demand is greatest, there is a loss of efficiency. The solution, placing wind energy systems in urban areas, faces significant challenges. The complexities associated with the urban terrain include planning, surface heterogeneity that reduces the available wind resource and technology obstacles …

Keys To Understanding And Addressing Consumer Perceptions And Concerns About Processed Foods, Y. Meneses, K. J. Cannon, R. A. Flores

Department of Agricultural Leadership, Education, and Communication: Faculty Publications

Some processed food products have been targeted lately as “evils” that are preventing us from maintaining healthy lives. From the perspective of the food industry community, it seems as if this is one of those issues that should fade away with time, since the benefits of food processing are very obvious to us. We have never been so wrong! The challenges in front of us are big, and we need to do a better job of communicating with consumers about the benefits food processing offers, including increasing the availability of high-quality foods year round. We also need to promote the …

Teaching Introductory Life Science Courses In Colleges Of Agriculture: Faculty Experiences, Mark Balschweid, Neil A. Knobloch, Bryan J. Hains

Department of Agricultural Leadership, Education, and Communication: Faculty Publications

Insignificant numbers of college students declaring STEM majors creates concern for the future of the U.S. economy within the global marketplace. This study highlights the educational development and teaching strategies employed by STEM faculty in teaching first-year students in contextualized life science courses, such as animal, plant, and food sciences. Teaching strategies employed by faculty were reported as largely influenced by the “way they were taught.” Faculty members shared they used ‘lecture’ and ‘laboratory’ interchangeably as both educational environment and instructional practice. This study provides evidence for engaging university teaching faculty in a systematic process of professional development in teaching …

Towards Proactive And Flexible Agent-Based Generation Of Policy Packages For Active Transportation, Araz Taeihagh, Rene Bañares-Alcántara

Research Collection School of Social Sciences

One of the approaches gaining ground in policy design is the implementation of combinations of policy measures as policy packages with the aim of increasing efficiency and effectiveness of the designed policies. In this paper, we describe the recent advancements in the developments of a virtual environment for the exploration and analysis of policy packages. The virtual environment uses an agent-based modelling approach for the generation of different configurations of policy measures in the policy packages. The benefit of using the approach is the proactive and flexible generation of policy packages as the agents can react to the changes that …

Heat Misconceptions Among 11th Grade Students, Amnah Mohamed Abdullah Al Kaabi

Theses

This study explores the misconception of the female students at 11^thgrade about the heat concepts (e.g., latency, conduction, equilibrium, boiling point, etc.) the study targets to i – classifying the misconception nature, and ii- distinguishing the heat misconception from point of the lack of knowledge and lucky guess. A sample of 230 female students at 11^th grade randomly selected from five secondary schools in the Emirates of Fujairah; northern UAE. The heat misconception test (HMT), a three –tier diagnostic instrument comprising of ten question is used as data collection tool. The study raises the three research questions. …

กิจกรรมสิ่งแวดล้อม

Thai Environment

No abstract provided.

Bright Microwave Pulses From Psr B0531+21 Observed With A Prototype Transient Survey Receiver, J. A. O'Dea, F. A. Jenet, Tsan Huei Cheng, Chau M. Buu, Martin Beroiz, Sami W. Asmar, J. W. Armstrong

Physics & Astronomy Faculty Publications

Recent discoveries of transient radio events have renewed interest in time-variable astrophysical phenomena. Many radio transient events are rare, requiring long observing times for reliable statistical study. The National Aeronautics and Space Administration/Jet Propulsion Laboratory's Deep Space Network (DSN) tracks spacecraft nearly continuously with 13 large-aperture, low system temperature radio antennas. During normal spacecraft operations, the DSN processes only a small fraction of the pre-detection bandwidth available from these antennas; any information in the remaining bandwidth, e.g., from an astronomical source in the same antenna beam as the spacecraft, is currently ignored. As a firmware modification to the standard DSN …

Parallel Phase Modulation Scheme For Interferometric Gravitational-Wave Detectors, M. T. Hartman, V. Quetschke, D. B. Tanner, D. H. Reitze, G. Mueller

Physics & Astronomy Faculty Publications

Advanced LIGO (aLIGO) requires multiple frequency sidebands to disentangle all of the main interferometer's length signals. This paper presents the results of a risk reduction experiment to produce two sets of frequency sidebands in parallel, avoiding mixed 'sidebands on sidebands'. Two phase modulation frequencies are applied to separate Electro-Optic Modulators (EOMs), with one EOM in each of the two arms of a Mach-Zehnder interferometer. In this system the Mach-Zehnder's arm lengths are stabilized to reduce relative intensity noise in the recombined carrier beam by feeding a corrective control signal back to the Rubidium Titanyl Phosphate (RTP) EOM crystals to drive …

Quantitative Mass Spectrometric Investigations Of Protein Biomarkers: Serum Thymidine Kinase 1 And Human Osteopontin, Morse Faria

Theses and Dissertations

Mass spectrometry is being increasingly used in biomarker research mainly due to its ability to achieve high selectivity coupled with high sensitivity. This dissertation focuses on quantitative mass spectrometric investigations of two protein biomarkers i.e. serum thymidine kinase 1 (TK1) and human osteopontin (OPN).

First part of this research was focused on developing a liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) method for measuring the activity of TK1 in serum by monitoring the conversion of a TK1 specific exogenous substrate, 3’-deoxy-3’-fluorothymidine (FLT), to its mono-phosphorylated form 3’-deoxy-3’-fluorothymidine monophosphate (FLT-MP). A method to quantify FLT-MP on LC-MS/MS was developed and …

Dynamic Bayesian Approaches To The Statistical Calibration Problem, Derick Lorenzo Rivers

Theses and Dissertations

The problem of statistical calibration of a measuring instrument can be framed both in a statistical context as well as in an engineering context. In the first, the problem is dealt with by distinguishing between the "classical" approach and the "inverse" regression approach. Both of these models are static models and are used to estimate "exact" measurements from measurements that are affected by error. In the engineering context, the variables of interest are considered to be taken at the time at which you observe the measurement. The Bayesian time series analysis method of Dynamic Linear Models (DLM) can be used …

Latent Variable Models Given Incompletely Observed Surrogate Outcomes And Covariates, Chunfeng Ren

Theses and Dissertations

Latent variable models (LVMs) are commonly used in the scenario where the outcome of the main interest is an unobservable measure, associated with multiple observed surrogate outcomes, and affected by potential risk factors. This thesis develops an approach of efficient handling missing surrogate outcomes and covariates in two- and three-level latent variable models. However, corresponding statistical methodologies and computational software are lacking efficiently analyzing the LVMs given surrogate outcomes and covariates subject to missingness in the LVMs. We analyze the two-level LVMs for longitudinal data from the National Growth of Health Study where surrogate outcomes and covariates are subject to …

New Synthetic Strategies For Improved Gas Separation By Nanoporous Organic Polymers, Suha Altarawneh

Theses and Dissertations

Abstract NEW SYNTHETIC STRATEGIES FOR IMPROVED GAS SEPARATION BY NANOPOROUS ORGANIC POLYMERS Suha S. Altarawneh, Ph.D. The emission of carbon dioxide (CO2) from fossil fuel combustion is a major cause of climate change. Therefore, the efficient separation of CO2 from mixtures of gases such as flue gas and impure sources of CH4 (e.g. natural gas and landfill gas) is an essential step in meeting the ever increasing demands on natural gas and creating a cleaner environment. Carbon capture and storage technology (CCS) is one of the methods employed for gas separation using chemisorption and/or physisorption processes. Several materials such as …

Pools / Dreams / Parental Gaze, Tal Gafny

Theses and Dissertations

This thesis is a testimony of thoughts and ideas that have been circulating in my studio for the past few years, in their current form. It is also an experiment in writing an autobiographical piece of prose. It was written parallel to, and after, making the film Double Take with Perrin Turner. The film is an exploration of a number of relationships, related and sometimes haunted by one another. I wish for this text to operate not only as an after-the-fact recollection of thoughts, but also in relation to what will follow it – similarly to the way a trailer …

Predicting And Classifying Packet Transmission Efficiency In Bio-Inspired Wireless Sensor Networks, Ahmad Alkazzaz

Theses and Dissertations

Biological networks (specifically genetic regulatory networks) are known to be robust to various external perturbations. Bio-inspired wireless sensor networks (WSN) are known to be smart communication structures and have a have high packet transmission efficiency. In earlier work neural network models that correlate the average packet receival rates to the five topological features of the bio-inspired WSN were investigated. These features include the degree index, sink coverage, network density, hub node density, and motif index. In this thesis, an appropriate classification algorithm that works with these five features is investigated. The random forest algorithm is the best classification algorithm compared …

Folate Conjugated Dendrimers For Targeted Anticancer Therapy, Shannon Andrews

Theses and Dissertations

Anticancer therapeutics are often limited to suboptimal doses due to their lack of selectivity for tumor cells and resultant damage to healthy tissue. These limitations motivated researchers to develop tumor-specific delivery systems for improved therapeutic efficacy and reduced unintended cytotoxicity. Polyamidoamine dendrimers offer an ideal platform for designing targeted therapeutics with tunable characteristics that optimize pharmacokinetic behavior and targeting specificity. Ligand conjugation to dendrimer provides the biochemical interaction necessary to activate tumor-specific receptors for receptor-mediated endocytosis and effective internalization of polyplexes. Tumor-specific receptors overexpressed in carcinomas, like folate receptor-alpha (FOLRα), are targeted by ligand-conjugated dendrimer to allow enhanced internalization of …

Predicting The Academic Functioning Of College Students With Attention-Deficit/Hyperactivity Disorder: The Importance Of Executive Functions And Parent Report, Melissa Dvorsky

Theses and Dissertations

This study examined the impact of several dimensions of executive functioning (EF), as well as Attention-Deficit/Hyperactivity Disorder (ADHD) symptoms, in relation to college students’ academic and overall functional impairment. Participants were 62 college students comprehensively diagnosed with ADHD and their parents/guardians who completed measures of symptoms of ADHD, EF, school maladjustment and functional impairment. The primary goal of the study was to evaluate whether parent- and self-ratings of EFs completed at the beginning of the school year longitudinally predict end of the school year academic and overall functioning above and beyond symptoms of ADHD. Mediation analyses controlling for covariates, including …

Management's Aggressiveness And Fair Value Accounting: An Examination Of Realized And Unrealized Gains And Losses On Asc 820 Level 3 Assets, Robson Glasscock

Theses and Dissertations

Prior research has shown that even the most subjective fair value estimates are value-relevant (Song et al. 2010, Kolev 2009, Goh et al. 2009) and that managers appear to use Level 3 valuations opportunistically (Valencia 2011, Fiechter and Meyer 2009). However, the association between “traditional” measures of aggressiveness in financial reporting and biased estimates of fair value has not been previously studied. I test whether aggressiveness, as measured by discretionary accruals, real activities manipulation, and meeting-or-beating analysts’ consensus estimates, is positively associated with realized and unrealized gains and losses on Level instruments. Overall, I find limited support that aggressive firms …

The Role Of Toll-Like Receptor 9 In Periodontitis, Paul Kim

Theses and Dissertations

Periodontitis is a biofilm-initiated inflammatory disease, resulting in soft tissue damage and alveolar bone loss. A nucleic acid sensor, toll-like receptor 9 (TLR9), has been recently implicated in periodontal inflammation. This study utilized an in vivo periodontitis model using TLR9 knockout (TLR9-/-) mice to assess the role of TLR9 in periodontitis. Significant bone loss was observed in wild type, but not in TLR9-/- mice. Further experiments using ex vivo assays revealed significantly higher IL-6 production in splenocytes of wild type mice compared to knockout cells in response to Porphyromonas gingivalis (a keystone pathogen for periodontitis) challenge. In conclusion, TLR9 contributes …

Computational Study Of Protein-Protein Interactions In Misfolded States, Oscar Bastidas

Theses and Dissertations

Protein-protein interactions (PPI’s) play important roles in biological systems. In particular, intra-protein interactions help create and maintain correctly folded protein states and mutations that result in misfolded states may be associated with significant changes in PPI behavior. Six unrelated protein systems with known structure files, each consisting of a wild-type and mutant strain, were studied using the computational algorithm OpenContact©. OpenContact© is a simple tool that can be used to rapidly identify or map interactions “hot-spots” in a protein and was, consequently, used in this study as a starting point to examine the potential or possible role of PPI’s on …

Early Prediction Of Fracture In Bodies Bounded By Random Rough Surfaces, Hector Medina

Theses and Dissertations

Under certain loading conditions, surfaces topography coupled with materials degree of brittleness can significantly compromise the mechanical performance of structures. The foregoing remains valid even if roughness is intentionally introduced for engineering reasons. In either case, stress can concentrate. The case of the stress concentration in surfaces having randomly distributed pits is a problem that, although being very practical, yet it remains unsolved. The complexity of a random configuration renders difficult the problem of analytically finding relationships between surface parameters and markers indicative of mechanical failure. Another difficulty is the reproducibility of replicates of specimens possessing random rough surfaces, for …