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Expression Of The Alpha, Beta, And Gamma Subunits Of The Interleukin-2 Receptor By Human Vascular Smooth Muscle Cells, Sultan Mohammed Alhayyani

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Interleukin 2 (IL-2) is a member of the cytokine family and contributes to the proliferation, survival, and death of lymphocytes [1]. The interleukin-2 receptor (IL-2) is a tripartite receptor commonly expressed on the surfaces of many lymphoid cells and is composed of three non-covalently associated subunits, alpha (CD25), beta (CD122), and gamma (CD132) [2]. Our laboratory has previously described IL-2 receptor Beta expression by vasculature smooth muscle cells (VSMC) in mice and humans [3]. The current work expands our previous observations by assessing the expression of the alpha and gamma subunits of the IL-2R by VSMCs. Analysis of IL-2R expression …

Full Wave Electromagnetic Simulations Of Terahertz Wire Grid Polarizers And Infrared Plasmonic Wire Gratings, John Cetnar

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This dissertation is a study of the interaction of terahertz (THz) and long-wave infrared (LWIR) radiation with various periodic sub-wavelength metallic structures in free-space and on dielectric substrates. There are many new and useful applications for both THz and LWIR radiation. Unfortunately, heavy attenuation by the Earth's atmosphere and low output power from THz sources combine to make THz radiation weak and difficult to detect. LWIR is not as prone to atmospheric attenuation as THz radiation. Nevertheless, the detection of LWIR can be improved upon by strengthening the coupling between incoming radiation and LWIR detector systems.

Light passing through periodic …

Phylogenetics, Population Genetics, And Evolution Of The Mallard Complex, Philip Lavretsky

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Speciation is primarily regarded as an ancestral split that results in two distinct taxonomic units, and proceeds in stages along a continuum from initiation (i.e., population divergence) to completion (i.e., reproductively isolated species). Establishing how and why populations diverge, including the primary mechanisms influencing these events is a major objective for evolutionary scientists. Focusing on incipient forms, researchers attempt to disentangle the antagonistic nature of selection, genetic drift, and gene flow in the speciation process.

In chapter 1, I investigate the phylogenetic relationships of 14 closely related taxa within the mallard complex (Anas spp.) that underwent a radiation within the …

Rings Of Frobenius Operators, Mordechai Katzman, Karl Schwede, Anurag K. Singh, Wenliang Zhang

Department of Mathematics: Faculty Publications

Let R be a local ring of prime characteristic. We study the ring of Frobenius operators F(E), where E is the injective hull of the residue field of R. In particular, we examine the finite generation of F(E) over its degree zero component F⁰(E), and show that F(E) need not be finitely generated when R is a determinantal ring; nonetheless, we obtain concrete descriptions of F(E) in good generality that we use, for example, to prove the discreteness of F-jumping numbers for arbitrary ideals in determinantal rings.

Bootsie – Estimation Of Coefficient Of Variation Of Aflp Data By Bootstrap Analysis, Justin Payne, Erica Lindroth, K. M. Kneeland, Steven R. Skoda, Fatima Mustafa, Muhammad Irfan Ullah, John E. Foster

Department of Entomology: Faculty Publications

Bootsie is an English-native replacement for ASG Coelho's “DBOOT” utility for estimating coefficient of variation of a population of AFLP marker data using bootstrapping. Bootsie improves on DBOOT by supporting batch processing, time-to-completion estimation, builtin graphs, and a suite of export tools for creating data files for other population genetics software.

The Emerging Field Of Geogenomics: Constraining Geological Problems With Genetic Data, Paul A. Baker, Sherilyn C. Fritz, Christopher W. Dick, Andrew J. Eckert, Brian K. Horton, Stefano Manzoni, Camila C. Ribas, Carmala N. Garzione, David S. Battisti

Department of Earth and Atmospheric Sciences: Faculty Publications

The development of a genomics-derived discipline within geology is timely, as a result of major advances in acquiring and processing geologically relevant genetic data. This paper articulates the emerging field of “geogenomics,” which involves the use of large-scale genetic data to constrain geological hypotheses. The paper introduces geogenomics and discusses how hypotheses can be ad-dressed through collaboration between geologists and evolutionary biologists. As an example, geogenomic methods are applied to evaluate competing hypotheses regarding the timing of the Andean uplift, the closure of the Isthmus of Panama, the onset of trans-Amazon drainage, and Quaternary climate variation in the Neotropics.

Daily Area Of Snow Melt Onset On Arctic Sea Ice From Passive Microwave Satellite Observations 1979–2012, Angela C. Bliss, Mark R. Anderson

Department of Earth and Atmospheric Sciences: Faculty Publications

Variability in snow melt onset (MO) on Arctic sea ice since 1979 is examined by determining the area of sea ice experiencing the onset of melting during the melt season on a daily basis. The daily MO area of the snow and ice surface is determined from passive microwave satellite-derived MO dates for the Arctic Ocean and sub-regions. Annual accumulations of MO area are determined by summing the time series of daily MO area through the melt season. Daily areas and annual accumulations of MO area highlight inter-annual and regional variability in the timing of MO area, which is sensitive …

Optimal Energy Scheduling For A Smart Entity, Amin Fakhrazari, Hamid Vakilzadian, F. Fred Choobineh

Department of Electrical and Computer Engineering: Faculty Publications

Real-time availability of electricity prices via a smart power grid has a potential bilateral benefit to electricity users and suppliers. The users can reduce their costs by consuming energy during low-price hours and balancing their energy usage during other hours. This in turn benefits energy utility companies by reducing their peak power demand. This article describes an optimal shrinking horizon model for electricity-consuming units based on user preferences. The proposed model optimizes the end user’s electricity cost while meeting preferred comfort levels. The user can set preferences in the model using a tristate flexibility parameter for each electric-power-consuming unit. The …

Simulation Supported Estimation Of End-To-End Transmission Parameters In Non-Viral Gene Delivery, Beata Wysocki, Timothy M. Martin, Tadeusz A. Wysocki, Angela K. Pannier

Department of Electrical and Computer Engineering: Faculty Publications

Communications, in general, involve delivery of information from a source to a sink. At nano-scale, an example of a man-made communications involving interfacing with biological systems at intra-cellular level is non-viral gene delivery. From a telecommunications engineering perspective, important end-to-end parameters of such a system are: the endto- end delay, system capacity, and packet loss rate. There are neither known methods to estimate those parameters theoretically nor they are ready available from standard measurements. The paper provides estimates for those parameters based on the simulation of non-viral gene delivery system based on the queuing theory. The simulator used has bee

Terahertz-Infrared Ellipsometer System, And Method Of Use, Craig H. Herzinger, Mathias M. Schubert, Tino Hofmann, Martin M. Liphardt, John A. Woollam

Department of Electrical and Computer Engineering: Faculty Publications

The present invention relates to ellipsometer and polarimeter systems, and more particularly is an ellipsometer or polarimeter or the like system which operates in a frequency range between 300 GHz or lower and extending to higher than at least 1 Tera-hertz (THz), and preferably through the Infra-red (IR) range up Sh and his th. 100 THz, including: a Source Such as a backward wave oscillator, a Smith-Purcell cell; a free electron laser, or an FTIR source and a solid state device; and a detector Such as a Golay cell; abolometer or a solid state detector: and preferably including a polarization …

Studies On Sensitivity Reduction In Solo And Mixture Treatments And Fungicide-Induced Mutagenesis In Monilinia Fructicola, Guido Schnabel, F. Chen, Sydney E. Everhart, W. C. Bridges, X. Liu

Department of Plant Pathology: Faculty Publications

Three fungicide-sensitive Monilinia fructicola isolates were exposed in weekly transfers of mycelia to a dose gradient of a DMI and a QoI fungicide (azoxystrobin) in solo or mixture treatments and fungicide sensitivity as well as genetic changes were assessed. Isolates showed a faster reduction in sensitivity (higher resistance factors) to azoxystrobin than to SYP-Z048; this process was slower in the mixture treatment. The decrease of fungicide sensitivity was not a heritable trait. Genomic mutagenesis at 8 of 15 microsatellite loci was evidenced in one of three isolates tested after exposure to azoxystrobin. These non-coding regions of the genome either showed …

Variational Formulation Of Macro-Particle Plasma Simulation Algorithms, Bradley Allan Shadwick, Alexander B. Stamm, Evstati Georgiev Evstatiev

Department of Physics and Astronomy: Faculty Publications

A variation formulation of macro-particle kinetic plasma models is discussed. In the electrostatic case, the use of symplectic integrators is investigated and found to offer advantages over typical generic methods. For the electromagnetic case, gauge invariance and momentum conservation are considered in detail. It is shown that, while the symmetries responsible for these conservation laws are broken in the presence of a spatial grid, the conservation laws hold in an average sense. The requirements for exact invariance are explored and it is shown that one viable option is to represent the potentials with a truncated Fourier basis

Approximations To The Solution Of The Frank-Kamenetskii Equation In A Spherical Geometry, Moustafa A. Soliman

Chemical Engineering

In this paper, an approximate analytical solution for Frank-Kamenetskii equation modeling a thermal explosion in a sphere, is obtained. The approximate solution is obtained by perturbation methods in terms of small and large distance parameter. The approximate solution is compared with the numerical solution obtained from an initial value problem formulation to the original boundary value problem. The approximate solution obtained is valid for all values of the distance parameter. For the original boundary value problem and for a given Frank-Kamenetskii parameter, a nonlinear algebraic equation needs to be solved to be able to apply the approximate solution.

Surface-Enhanced Raman Spectral Biomarkers Correlate With Ankle Brachial Index And Characterize Leg Muscle Biochemical Composition Of Patients With Peripheral Arterial Disease, Kim Cluff, Abby M. Kelly, Panagiotis Koutakis, Xiang N. He, Xi Huang, Yongfeng Lu, Iraklis I. Pipinos, George P. Casale, Jeyamkondan Subbiah

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Peripheral arterial disease (PAD) is characterized by atherosclerotic blockages of the arteries supplying the lower extremities, which cause a progressive accumulation of ischemic injury to the skeletal muscles of the lower limbs. This injury includes altered metabolic processes, damaged organelles, and compromised bioenergetics in the affected muscles. The objective of this study was to explore the association of Raman spectral signatures of muscle biochemistry with the severity of atherosclerosis in the legs as determined by the Ankle Brachial Index (ABI) and clinical presentation. We collected muscle biopsies from the gastrocnemius (calf muscle) of five patients with clinically diagnosed claudication, five …

Stress Adaptation In A Pathogenic Fungus, Alistair J. P. Brown, Susan Budge, Despoina Kaloriti, Anna Tillmann, Mette D. Jacobsen, Zhikang Yin, Iuliana V. Ene, Iryna Bohovych, Doblin Sandai, Stavroula Kastora, Joanna Potrykus, Elizabeth R. Ballou, Delma S. Childers, Shahida Shahana, Michelle D. Leach

Department of Biochemistry: Faculty Publications

Candida albicans is a major fungal pathogen of humans. This yeast is carried by many individuals as a harmless commensal, but when immune defences are perturbed it causes mucosal infections (thrush). Additionally, when the immune system becomes severely compromised, C. albicans often causes life-threatening systemic infections. A battery of virulence factors and fitness attributes promote the pathogenicity of C. albicans. Fitness attributes include robust responses to local environmental stresses, the inactivation of which attenuates virulence. Stress signalling pathways in C. albicans include evolutionarily conserved modules. However, there has been rewiring of some stress regulatory circuitry such that the roles of …

Mechanisms Underlying The Exquisite Sensitivity Of Candida Albicans To Combinatorial Cationic And Oxidative Stress That Enhances The Potent Fungicidal Activity Of Phagocytes, Despoina Kaloriti, Mette Jacobsen, Zhikang Yin, Miranda Patterson, Anna Tillmann, Deborah A. Smith, Emily Cook, Tao You, Melissa J. Grimm, Iryna Bohovych, Celso Grebogi, Brahm H. Segal, Neil A.R. Gow, Ken Haynes, Janet Quinn, Alistair J.P. Brown

Department of Biochemistry: Faculty Publications

Immune cells exploit reactive oxygen species (ROS) and cationic fluxes to kill microbial pathogens, such as the fungus

Candida albicans. Yet, C. albicans is resistant to these stresses in vitro. Therefore, what accounts for the potent antifungal activity

of neutrophils? We show that simultaneous exposure to oxidative and cationic stresses is much more potent than the individual

stresses themselves and that this combinatorial stress kills C. albicans synergistically in vitro.We also show that the high

fungicidal activity of human neutrophils is dependent on the combinatorial effects of the oxidative burst and cationic fluxes, as

their pharmacological attenuation with …

Why American Higher Education Needs Parasitologists, John J. Janovy Jr.

John J. Janovy, Jr. Publications

Addresses four topics that characterize the discipline of parasitology and are largely missing from our national conversation in the United States about education, especially at the college and university level. Those topics are the production of transferable skills; our perceptions of the world, especially the natural world; access to reasonably difficult problems in natural settings; and intellectual epidemiology, or the movement of ideas, innovations, and cultural items through populations. These topics have been a part of the author's discussions with fellow parasitologists for at least half a century, beginning with his choice to pursue a graduate degree under the supervision …

Native Insect Herbivory Limits Population Growth Rate Of A Non-Native Thistle, James O. Eckberg, Brigitte Tenhumberg, Svata M. Louda

Brigitte Tenhumberg Papers

The influence of native fauna on non-native plant population growth, size, and distribution is not well documented. Previous studies have shown that native insects associated with tall thistle (Cirsium altissimum) also feed on the leaves, stems, and flower heads of the Eurasian congener Cirsium vulgare, thus limiting individual plant performance. In this study, we tested the effects of insect herbivores on the population growth rate of C. vulgare. We experimentally initiated invasions by adding seeds at four unoccupied grassland sites in eastern Nebraska, USA, and recorded plant establishment, survival, and reproduction. Cumulative foliage and floral herbivory …

The Unoccupied Electronic Structure Characterization Of Hydrothermally Grown Tho2 Single Crystals, T D. Kelly, J C. Petrosky, D Turner, J W. Mcclory, J M. Mann, J W. Kolis, Xin Zhang, Peter A. Dowben

Peter Dowben Publications

Single crystals of thorium dioxide ThO₂, grown by the hydrothermal growth technique, have been investigated by ultraviolet photoemission spectroscopy (UPS), inverse photoemission spectroscopy (IPES), and L₃, M₃, M₄, and M₅ X-ray absorption near edge spectroscopy (XANES). The experimental band gap for large single crystals has been determined to be 6 eV to 7 eV, from UPS and IPES, in line with expectations. The combined UPS and IPES, place the Fermi level near the conduction band minimum, making these crystals n-type, with extensive band tailing, suggesting an optical gap in the region …

In Memoriam: Robert Lloyd Rausch—A Life In Nature And Field Biology, 1921–2012, Eric P. Hoberg

Harold W. Manter Laboratory of Parasitology: Faculty Publications

During his distinguished career, Robert Rausch, a man of great integrity and principles, served in his lifetime as a singular ambassador for parasitology in a broad international arena. Robert was a friend to many, was honored to be considered an equal among the nomadic bands of Nunamiut traversing the Brooks Range 60 years ago, and will be long remembered for the strength of his science and his perceptive views of the natural world.

Van Der Waals Trilayers And Superlattices: Modification Of Electronic Structures Of Mos2 By Intercalation, Ning Lu, Hongyan Guo, Lu Wang, Xiaojun Wu, Xiao Cheng Zeng

Xiao Cheng Zeng Publications

We perform a comprehensive first-principles study of the electronic properties of van der Waals (vdW) trilayers via intercalating a twodimensional (2D) monolayer (ML = BN, MoSe₂, WS₂, orWSe₂) between a MoS₂ bilayer to form various MoS₂/ML/MoS₂ sandwich trilayers. We find that the BN monolayer is themost effective sheet to decouple the interlayer vdW coupling of the MoS₂ bilayer, and the resulting sandwich trilayer can recover the electronic structures of the MoS₂ monolayer, particularly the direct-gap character. Further study of the MoS₂/BN superlattices confirms the effectiveness of …

Ashfall Tephra In The Ogallala Group Of The Great Plains: Characteristics And Significance, Michael E. Perkins, Robert F. Diffendal Jr., Michael R. Voorhies, Barbara P. Nash, Bruce E. Bailey

Robert F. Diffendal, Jr., Publications

The Miocene Ogallala Group blankets the Great Plains east of the Rocky Mountains. This sheet of largely fluvial deposits, lying downwind of major silicic volcanic fields to the west, was ideally located to receive and preserve tephra from these fields. This investigation brings modern methods of tephrochronlogy to bear on the age and identity of Ogallala tephra. Results indicate that ~40 separate tephra layers, ranging in age from ~16.5–5.0 Ma, in the Ogallala. Most tephra came from Yellowstone hotspot sources. The relative frequency of hotspot tephra in the Ogallala matches that in more proximal regions to the west with peak …

Phosphatase-Inert Glucosamine 6‑Phosphate Mimics Serve As Actuators Of The Glms Riboswitch, Xiang Fei, Thomas Holmes, Julianna Diddle, Lauren Hintz, Dan Delaney, Alex Stock, Danielle Renner, Molly Mcdevitt, David B. Berkowitz, Juliane K. Soukup

David Berkowitz Publications

The glmS riboswitch is unique among generegulating riboswitches and catalytic RNAs. This is because its own metabolite, glucosamine-6-phosphate (GlcN6P), binds to the riboswitch and catalytically participates in the RNA selfcleavage reaction, thereby providing a novel negative feedback mechanism. Given that a number of pathogens harbor the glmS riboswitch, artificial actuators of this potential RNA target are of great interest. Structural/kinetic studies point to the 2- amino and 6-phosphate ester functionalities in GlcN6P as being crucial for this actuation. As a first step toward developing artificial actuators, we have synthesized a series of nine GlcN6P analogs bearing phosphatase-inert surrogates in place …

Metallurgical And Corrosion Assessment Of Submerged Tanker S.S. Montebello, Dana Medlin, James D. Carr, Donald L. Johnson, David L. Conlin

Department of Chemistry: Faculty Publications

The Union Oil Tanker S.S. Montebello was torpedoed and sunk six miles (9.7 km) off the coast of Cambria, California by a Japanese submarine on December 23, 1941, two weeks after the attack on Pearl Harbor. With close proximity to the National Monterey Bay Marine Sanctuary, concern about possible crude oil contamination led to the most recent expedition to the site in October 2011. Assessment of the shell plate found that the average corrosion rate was very low and the structure will remain stable for many decades.

Inference Of Strata Separation And Gas Emission Paths In Longwall Overburden Using Continuous Wavelet Transform Of Well Logs And Geostatistical Simulation, C. Ozgen Karacan, Ricardo A. Olea

United States Geological Survey: Staff Publications

Prediction of potential methane emission pathways from various sources into active mine workings or sealed gobs from longwall overburden is important for controlling methane and for improving mining safety. The aim of this paper is to infer strata separation intervals and thus gas emission pathways from standard well log data. The proposed technique was applied to well logs acquired through the Mary Lee/Blue Creek coal seam of the Upper Pottsville Formation in the BlackWarrior Basin, Alabama, using well logs froma series of boreholes aligned along a nearly linear profile. For this purpose, continuous wavelet transform (CWT) of digitized gamma well …

A Bayesian Network Model For Assessing Natural Estrogen Fate And Transport In A Swine Waste Lagoon, Boknam Lee, Seth W. Kullman, Erin Yost, Michael T. Meyer, Lynn Worley-Davis, C. Michael Williams, Kenneth H. Reckhow

United States Geological Survey: Staff Publications

Commercial swine waste lagoons are regarded as a major reservoir of natural estrogens, which have the potential to produce adverse physiological effects on exposed aquatic organisms and wildlife. However, there remains limited understanding of the complex mechanisms of physical, chemical, and biological processes that govern the fate and transport of natural estrogens within an anaerobic swine lagoon. To improve lagoon management and ultimately help control the offsite transport of these compounds from swine operations, a probabilistic Bayesian network model was developed to assess natural estrogen fate and budget and then compared against data collected from a commercial swine field site. …

Biogeochemical Aspects Of Uranium Mineralization, Mining, Milling, And Remediation, Kate M. Campbell, Tanya J. Gallegos, Edward R. Landa

United States Geological Survey: Staff Publications

Natural uranium (U) occurs as a mixture of three radioactive isotopes: 238U, 235U, and 234U. Only 235U is fissionable and makes up about 0.7% of natural U, while 238U is overwhelmingly the most abundant at greater than 99% of the total mass of U. Prior to the 1940s, U was predominantly used as a coloring agent, and U-bearing ores were mined mainly for their radium (Ra) and/or vanadium (V) content; the bulk of the U was discarded with the tailings (Finch et al., 1972). Once nuclear fission was discovered, the economic importance of U increased greatly. The mining and milling …

Comparing Cropland Net Primary Production Estimates Frominventory, A Satellite-Based Model, And A Process-Based Model In Themidwest Of The United States, Zengpeng Li, Shuguang Liu, Zhengxi Tan, Normann B. Bliss, Claudia J. Young, Tristram O. West, Stephen M. Ogle

United States Geological Survey: Staff Publications

Accurately quantifying the spatial and temporal variability of net primary production (NPP) for crop-lands is essential to understand regional cropland carbon dynamics. We compared three NPP estimates for croplands in the Midwestern United States: inventory-based estimates using crop yield data from the U.S. Department of Agriculture (USDA) National Agricultural Statistics Service (NASS); estimates from the satellite-based Moderate Resolution Imaging Spectroradiometer (MODIS) NPP product; and estimates from the General Ensemble biogeochemical Modeling System (GEMS) process-based model. The three methods estimated mean NPP in the range of 469–687 g C m−2yr−1and total NPP in the range of318–490 Tg C yr−1for croplands in …

Radiocarbon Dating Loess Deposits In The Mississippi Valley Using Terrestrial Gastropod Shells (Polygyridae, Helicinidae, And Discidae), Jeffrey S. Pigati, John Mcgeehin, Daniel R. Muhs, David A. Grimley, Jeffrey C. Nekola

United States Geological Survey: Staff Publications

Small terrestrial gastropod shells (mainly Succineidae) have been used successfully to date late Quaternary loess deposits in Alaska and the Great Plains. However, Succineidae shells are less common in loess deposits in the Mississippi Valley compared to those of the Polygyridae, Helicinidae, and Discidae families. In this study, we conducted several tests to determine whether shells of these gastropods could provide reliable ages for loess deposits in the Mississippi Valley. Our results show that most of the taxa that we investigated incorporate small amounts (1–5%) of old carbon from limestone in their shells, meaning that they should yield ages that …

Immediate Return To Ambulation And Improved Functional Capacity For Rehabilition In Complex Regional Pain Syndrome Following Early Implantation Of A Spinal Cord Stimulation System, Brandon Jesse Goff, Jeremy Wingseng Naber, John Patrick Mccallin, Edward Michael Lopez, Kevin Brant Guthmiller, Karl Alan Lautenschlager, Tristan Toll Lai, Dean Harry Hommer, Gonzalez Raul Marin

PCOM Scholarly Works

Complex regional pain syndrome (CRPS) is a neuropathic pain condition that is characterized by vasomotor, sensory, sudomotor, and motor symptoms. Spinal cord stimulation (SCS) has been successfully utilized for the treatment of pain refractory to conventional therapies. We present a case of a previously highly functioning 54-year-old female who developed a rarely reported case of idiopathic CRPS of the right ankle which spontaneously occurred four months after an uncomplicated anterior cervical disc fusion. This condition resulted in severe pain and functional impairment that was unresponsive to pharmacological management. The patient's rehabilitation was severely stymied by her excruciating pain. However, with …