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Reconsidering The Model Of Trim5Α Assembly: The Role Of The Linker2 (L2) Region In Trim5Α Assembly, Laura Johnsen

Master's Theses

The TRIM5α protein from rhesus macaques (TRIM5αrh) exhibits a remarkable ability to potently inhibit infection by Human Immunodeficiency Virus Type-1 (HIV-1). Extensive studies have shown that TRIM5α is capable of self-associating at many levels, eventually leading to the formation of a hexameric assembly that can superimpose on the hexameric lattice of the HIV-1 capsid. The mechanism underlying the self-association of TRIM5α and the molecular determinants of self-association remain to be completely understood. In this study, we show that the Linker 2 (L2) region of TRIM5rh is important for dimerization and higher order self-association, both of which are independent processes. Additionally, …

Characterizing The Mechanisms By Which Community Associated Methicillin-Resistant Staphylococcus Aureus Influences Keratinocyte Innate Immune Responses During Recurrent Infection, Ashley Lynn Larm

Master's Theses

Community associated–methicillin resistant Staphylococcus aureus (CA–MRSA) infection has become a major health concern. In human epidermal keratinocytes, S. aureus is mainly recognized through toll–like receptor 2 (TLR2) and its co–receptor, CD14. We hypothesize that CA–MRSA isolates cause recurrent infections by interrupting TLR2–mediated inflammation in keratinocytes. Recurrent CA–MRSA bacterial culture supernatant exposure to keratinocytes in vitro resulted in significant decreases in pro and anti–inflammatory cytokine and HMGB1 secretion from keratinocytes as assessed by ELISAs. Recurrent CA–MRSA live infection did not result in significant changes in cytokine or HMGB1 secretion, surface receptor expression, or NFκB activation post infection as assessed by ELISA …

History Of Freshwater Invasions In Illinois: Learning From The Past To Inform The Future, Abigail Jacobs

Master's Theses

Rates of introduction and spread of non-native species continue to increase worldwide, with freshwater ecosystems highly impacted. Many non-native species crossed between the Great Lakes and Mississippi watersheds by traveling through waterways in Illinois. I assembled a comprehensive database of occurrences of aquatic non-native species (n=99) in Illinois inland waters. The arrival of non-native species accelerated since 1873. The Great Lakes Basin was the main source of established species into Illinois. From 1990-2012 the dominant vector was unintentional release of established species non-native to North America. Sixty of the 99 introduced species established. Eighteen established species had high or very …

Denitrification In Urban Coastal Environments: A Functional Gene Study, Samantha Denise Lindemann

Master's Theses

Eutrophication is a major anthropogenic stressor on aquatic ecosystems worldwide. Jamaica Bay is located in the southeastern portion of New York City, NY (NYC). Like many other estuaries, Jamaica Bay is impacted by anthropogenic N inputs from various sources. Despite eutrophic conditions, improvements in water quality over the last few decades have prompted government agencies to promote oyster restoration to help reduce anthropogenic N in NYC waters. The effect of eastern oysters on sediment bacterial communities responsible for denitrification in Jamaica Bay was previously unknown. Those samples exposed to oysters were predicted to have high denitrification gene abundances, and thus …

Characterization Of The Female Urinary Microbiota And Their Association With The Female Bladder Uroepithelium, Evann Elizabeth Hilt

Master's Theses

The current clinical dogma assumes that urine is sterile in the absence of clinically relevant infection. However, recent evidence has demonstrated the existence of a female urinary microbiota in women with and without lower urinary tract symptoms. With the knowledge that the lower urinary tract possesses its own unique microbiota, I hypothesize that certain bacterial species of the female microbiota may be the cause or play a role in lower urinary tract syndromes such as overactive bladder syndrome (OAB). About 40-50% of OAB patients do not respond to conventional anti-muscarinic and beta-3 adrenergic agonist drug treatment. One possible explanation for …

Self-Objectification And Self-Surveillance In African American And Latina Girls: Links To Body Dissatisfaction And Self-Worth, Kimberly A. Burdette

Master's Theses

Drawing on a sample of low-income African American and Latina girls, the goal of the present investigation was to examine the relevance of self-objectification and self-surveillance to body dissatisfaction and self-worth. Body mass index (BMI), ethnicity, and perceived athletic competence were examined as moderators of these relations. Participants were 10- to 14-year-old African American and Latina girls recruited from a summer camp targeting low-income, urban girls. Surveys that include measures of self-objectification, self-surveillance, body dissatisfaction, self-worth, and perceived athletic competence were individually administered to participants by a research assistant. Height and weight were measured to calculate BMI. Ethnicity information was …

Posttraumatic Stress, Family Functioning, And Adjustment In Urban African American Youth Exposed To Violence: A Moderated Mediation Model, Kyle Deane

Master's Theses

Exposure to community violence is a pressing public health issue that disproportionately impacts poor, urban, and ethnic minority youth. It has been associated with a multitude of negative externalizing and internalizing symptoms, most frequently with posttraumatic stress. This study investigates the role that posttraumatic stress has in mediating the relation between exposure to community violence and other adjustment difficulties. Moreover, because not all adolescents experience these difficulties in the face of significant violence exposure, the study examines the moderating role of family cohesion and support in buffering the effect of violence and posttraumatic stress on later adjustment. A sample of …

Rethinking Teacher Quality: Narrow Versus Broad Conceptions Of Capability, Anthony Costa

Master's Theses

This paper examines the prevailing notion of teacher quality today. While there is wide agreement that teachers are the primary factor in schools determining student achievement, there is disagreement about which attributes constitute a high-quality teacher. Different approaches to improving teaching spring from different conceptualizations of capability. Since teacher quality consists of particular abilities that allow teachers to excel in their work, we need to understand how the abilities of high quality teachers are acquired, maintained and expanded, or, conversely, how these abilities are unrealized, arrested and diminished. The Strategic Management of Human Capital (SMHC) project represents the dominant approach …

Sexual Behavior Problems In Child Welfare: Predictors Of Reliable Change, Anne Kathleen Fuller

Master's Theses

This study examined predictors of changes in children's sexual behaviors across two time points within a sample of youth in the child welfare system. Hypothesized predictors of increases or decreases in children's sexual behaviors included child attributes, positive parenting, exposure to sexuality and violence, maltreatment history and child welfare placement history, and treatment variables. Participants included 145 children with reported sexual behavior problems and their primary caregivers and mental healthcare providers. Children's sexual behaviors were classified as improved, worsened, or unchanged. Optimal Data Analysis (ODA) and multivariate classification tree analysis (CTA) via ODA were used to identify predictors of children's …

A Study Of Functional Recovery And Axonal Plasticity Following Tbi And Anti-Nogo-A Immunotherapy, Jennifer Crystal Biesiadecki

Master's Theses

Traumatic brain injury (TBI) is a leading cause of morbidity and mortality globally and often results in long term disability. Unfortunately, the success of rehabilitation techniques as therapy for TBI is limited, which may be due to the growth restrictive environment of the adult central nervous system (CNS). This environment is thought to result from glial scars, lack of neurotrophic factors, and the presence of an array of growth-inhibitory molecules. One such growth-inhibitory molecule is the protein Nogo-A. Our laboratory has shown that neutralization of Nogo-A with anti-Nogo-A immunotherapy after ischemic stroke results in improvement in functional recovery in the …

Examining The Moderating Role Of Specific Coping Strategies On The Relationship Between Body Image And Eating Disorders In College-Age Women, Alexandra Calvert Kirsch

Master's Theses

A sample of college age women assessed at three time points (Time 1: Baseline, assessed before college, Time 2: End of first semester, Time 3: End of first year of college) completed measures of disordered eating, coping, and body image. Results indicated that neither adaptive (problem-focused coping or social support seeking) nor maladaptive coping styles (active emotional coping or avoidant coping) as measured at Time 1 or Time 2 moderated the significant predictive relationship between body dissatisfaction at Time 1 and disordered eating attitudes at Time 3, when adjusting for disordered eating attitudes and BMI at Time 1. However, significant …

Afghan University Women Graduates Are Not Well-Represented In The Job Market In Afghanistan, Mohammad Kazem Shakib

Master's Theses

Higher education has been one of the prominent sectors in Afghanistan for the past decade. There has been a steady increase in the representation of women within the higher education system in the country. However, the growth of an educated workforce within the job market and the growth of the national economy have not been equal. A high number of university women graduates are jobless, employed in non-relevant professions, or working in part-time jobs like teaching in primary and secondary school.

This paper explores the contribution and representation of university women graduates in the economy of Afghanistan. Through a liberal …

Domestic Violence And The Legal System: A Case Study Of 10 Mexican Women And The Process Of Seeking Legal Recourse, Martha Cecilia Espinosa

Master's Theses

This study explores the experiences of ten Mexican women currently receiving services with Safe Pathways, a non-profit organization dedicated to providing resources to survivors of domestic violence. In this study, I attend to how these women experience and negotiate gender, intimate relationships, and the legal system, and I explore the strategies that they develop to overcome gendered constraints associated with being undocumented and battered. I find that women's experiences with the legal system are shaped by a variety of factors outside of its auspices, including gendered norms and class constraints. Existing literature on Latinas and battered women in the legal …

Chicago Housing: Understanding How Local Organizations Mobilize To Preserve Public And Affordable Housing, Cameron Williams

Master's Theses

Under the Plan for Transformation section 8 voucher use and mixed-income developments have increased in Chicago. Several developments have been demolished and replaced with mixed-income developments that are argued to provide better conditions and opportunities for public housing residents, but empirically have mixed results. Lathrop Homes is a public housing development that has withstood the mass demolitions and efforts to make it mixed-income because of resident and organizer challenges to the Chicago Housing Authority. Resident and organizer input for this study reveals their strong stance against the mixed-income development Lathrop Homes could become. The interests behind opposition might diverge, but …

Embedded Librarianship In Academic Health Sciences Programs: Cases From The Frontline, Elizabeth Retzel Bucciarelli

Faculty Scholarship - University Library

No abstract provided.

Conference Program [2014], Gurc

Georgia Undergraduate Research Conference (Archived)

N/A

Research Of The Sustainability Of U.S. Public Debt And The Influence For Chinese Economy And Finance, Zikun Xu

Senior Honors Theses and Projects

In the summer of 2010, the U.S. debt ceiling dispute attracted the attention of the world, and financial markets were shocked when Standard & Poor's finally cut the United States AAA rating. But with the increase of the debt ceiling as well as the European sovereign debt crisis intensified, the U.S. national debt problem was temporarily covered up. It must be noted, however, that the U.S. national debt has ballooned to the highest level since World War II, the ratio of national debt to GDP has reached to nearly 100%, coupled with the long-term U.S. fiscal deficit and the continuing …

Speaking Of Science: Introducing Notice And Comment Into The Legislative Process, Gregory Dolin

All Faculty Scholarship

Congress enacts, on a nearly continuous basis, a variety of laws that affect scientific research and progress. Some of these laws have an unquestionably positive effect. For instance, Congress's creation of the National Institutes of Health, the National Academy of Sciences, and NASA; its various appropriations to fund ground-breaking research; and a multitude of other laws have incalculably advanced human knowledge, and it is to Congress's great credit that these laws have been and are continuing to be enacted. However, not all laws that affect the progress of sciences are an unalloyed good. Quite the opposite, often the laws aim …

Crime? No, It Wasn't Really Crime': Using Oral History And Memoirs To Teach Crime History, Rosalind Watkiss-Singleton

SOLON Law, Crime and History (previously SOLON Crimes and Misdemeanours: Deviance and the Law in Historical Perspective)

This article suggests that oral interviews, autobiographies and memoirs provide a new perspective on the teaching of crime history. Oral testimony can augment the traditional sources which are generally used for this purpose, giving fresh insights into popular attitudes to criminal activities and behaviour. Through the use of interviews, either student-generated or culled from existing oral history archives, the words and opinions of the perpetrators, victims and the general public will allow students and lecturers to supplement existing evidence in a way which will enhance both their critical understanding of behavioural patterns and developments within society. Student motivation may be …

Putting Undergraduates On Trial: Using The Old Bailey Online As A Teaching And Assessment Tool, David Gray

SOLON Law, Crime and History (previously SOLON Crimes and Misdemeanours: Deviance and the Law in Historical Perspective)

No abstract provided.

Researching The Arcane: The Duchy Of Cornwall And How A Country Lawyer Was Radicalised, John Kirkhope

SOLON Law, Crime and History (previously SOLON Crimes and Misdemeanours: Deviance and the Law in Historical Perspective)

No abstract provided.

Smedley D. Butler And The Militarisation Of The Philadelphia Police, 1924-1925, Ellen Leichtman

SOLON Law, Crime and History (previously SOLON Crimes and Misdemeanours: Deviance and the Law in Historical Perspective)

The importance of the military as a police model in the U.S. had been eliminated, for the most part, from criminal justice and police studies until the 1980s-1990s, even as the professional model was studied extensively. The military, however, had been a strong presence since at least the turn of the last century. As reformers from that time began to fight against machine rule in city after city, they often adopted the military paradigm as their police model, and sought those with military backgrounds to head police departments. The new mayor of Philadelphia chose a Marine Brigadier General, Smedley D. …

Our Free Society Is Worthy Of Better': Caryl Chessman, Capital Punishment, And Cold War Culture, David Ruth

SOLON Law, Crime and History (previously SOLON Crimes and Misdemeanours: Deviance and the Law in Historical Perspective)

Convict author Caryl Chessman was the focus of international attention from 1954 until his 1960 execution at San Quentin. Americans used Chessman to articulate understandings about themselves, their society, and their place in the world. Many used the case to comment on new understandings of behaviour and its modifiability, the apparent post-war rise in juvenile delinquency, and the prospects for individual autonomy in an increasingly conformist society. Cold War concerns profoundly shaped the discourse about Chessman. For some activists, global save-Chessman sentiment pointed to the possibility of transcending bitter international divisions. Execution opponents believed commutation would highlight the progressive social …

Purpose And Design In Organisms And Artifacts: The Search For A Unified Philosophical Theory Of Function, Mark L. Bourgeois

Dissertations

This work examines the concept of function in both biological organisms and designed artifacts. Function is routinely attributed within both kinds of systems, yet it is unclear whether it can mean the same thing within each, and indeed whether function attribution within natural systems is legitimate at all. Function is typically understood to have teleological content; yet in true teleological causation, the end is somehow the cause of its own means. In artifacts the consciously envisioned design of an artifact is taken to be the cause of its parts and their roles. Yet in naturalistic science there is no prior …

Understanding The Impact Of Adolescent Attachment On Academic Success, Cristina Cortesi

Dissertations

In recent years, studies are citing an increase in adolescent mental health diagnoses and symptomotology related to AD/HD, Bipolar Disorder, Depression, Anxiety, and Conduct Disorders. While the associated behaviors may be the result of several variables, recent neurobiological studies combined with Attachment Theory have pointed to a possible link to attachment issues. Because of the developmental stage of adolescents, these behaviors have been observed in both home and school environments. Schools, in general in the United States, have been experiencing significant struggles in terms of lack of adequate educational success which prompted the implementation of legislation commonly known as No …

Science Youth Action Research: Promoting Critical Science Literacy Through Relevance And Agency, Elizabeth Coleman

Dissertations

This three-article dissertation presents complementary perspectives on Science Youth Action Research (Sci-YAR), a K-12 curriculum designed to emphasize relevance and agency to promote youth's science learning. In Sci-YAR, youth conduct action research projects to better understand science-related issues in their lives, schools, or communities, while they simultaneously document, analyze, and reflect upon their own practices as researchers. The first article defines Sci-YAR and argues for its potential to enhance youth's participation as citizens in a democratic society. The second article details findings from a case study of youth engaged in Sci-YAR, describing how the curriculum enabled and constrained youth's identity …

Just Water: A Feminist Catholic Response To The Commodification Of Water, Rachel Noelle Hart Winter

Dissertations

Any Catholic ecological ethic today that does not focus sustained attention to our worldwide water crisis is inadequate, for it fails to engage one of today's core social justice violations and neglects to offer any moral guidance for one of the human family's most pressing challenges. A responsible Catholic approach to water justice that addresses the problems stemming from a commodified view of water must be informed by ecofeminist concerns and by the Catholic social justice tradition of moral reasoning. As populations grow and water sources run dry, access to water has become a pressing ethical issue. Today, nearly one …

Host Entry Factors For Human Coronaviruses, Taylor Heald-Sargent

Dissertations

Coronaviruses infect a diverse range of animals from birds to pigs and cats to humans. Coronaviruses employ RNA-based replicative processes and as such are genetically adaptable to acquire novel host ranges. A coronavirus from one species can jump to another by shifting its entry requirements. As we learned from the Severe Acute Respiratory Syndrome (SARS) pandemic, this shift in species can have detrimental consequences. Thus, it is imperative that we understand the virus-host interaction during the entry process.

This dissertation focuses on host entry factors that influence human coronavirus entry. Recently, a new class of proteases, the type II transmembrane …

Teacher Impact On Supporting The Parent-Teacher Partnership During The Middle School Years, Karen R. Love

Dissertations

The purpose of this study was to investigate the perceptions and experiences of middle school teachers in supporting parents as they move from traditional forms of parental involvement and towards engagement to support their children as they move into the middle school years of education. The design of this study was qualitative using in-depth interviews of middle school teachers. Bronfenbrenner's bioecological system theory of human development was the theoretical framework for this study to examine the factors influencing the child's development during the middle school years. Participants demonstrated that their perceptions and experiences did impact how they viewed parental involvement …

Eq, Not Just Iq: The Relationship Between Emotional Intelligence And The Success Of High School Principals Who Have Been Awarded The Illinois Principals Association's High School Principal Of The Year Award, Rowena Mak

Dissertations

As educational reforms become more complex, the role of the principal as a change agent also becomes more challenging and dynamic. To confront the leadership demands of schools, principals require focus, passion, wisdom, courage, and integrity.

An underlying assumption of these traits is the principal's emotional fortitude. Emotional intelligence is as complicated as it is organic, in that its foundation rests on an individual's awareness of himself/herself and how these emotions drive his/her ability to relate with others. With this comes the question, what makes a successful principal? The purpose of this research was to explore the relationship between a …