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2014

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Divergence In A Master Variator Generates Distinct Phenotypes And Transcriptional Responses, J. E. G. Gallagher, W. Zheng, X. Rong, N. Miranda, Z. Lin, B. Dunn, H. Zhao, M. P. Snyder Jan 2014

Divergence In A Master Variator Generates Distinct Phenotypes And Transcriptional Responses, J. E. G. Gallagher, W. Zheng, X. Rong, N. Miranda, Z. Lin, B. Dunn, H. Zhao, M. P. Snyder

Faculty & Staff Scholarship

Genetic basis of phenotypic differences in individuals is an important area in biology and personalized medicine. Analysis of divergent Saccharomyces cerevisiae strains grown under different conditions revealed extensive variation in response to both drugs (e.g., 4-nitroquinoline 1-oxide [4NQO]) and different carbon sources. Differences in 4NQO resistance were due to amino acid variation in the transcription factor Yrr1. Yrr1YJM789 conferred 4NQO resistance but caused slower growth on glycerol, and vice versa with Yrr1S96, indicating that alleles of Yrr1 confer distinct phenotypes. The binding targets of Yrr1 alleles from diverse yeast strains varied considerably among different strains grown under the same conditions …

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The Phosphodiesterase-4 Inhibitor Rolipram Attenuates Heroin-Seeking Behavior Induced By Cues Or Heroin Priming In Rats, Miaojun Lai, Huaqiang Zhu, Anna Sun, Dingding Zhuang, Dan Fu, Weisheng Chen, Han-Ting Zhang, Wenhua Zhou Jan 2014

The Phosphodiesterase-4 Inhibitor Rolipram Attenuates Heroin-Seeking Behavior Induced By Cues Or Heroin Priming In Rats, Miaojun Lai, Huaqiang Zhu, Anna Sun, Dingding Zhuang, Dan Fu, Weisheng Chen, Han-Ting Zhang, Wenhua Zhou

Faculty & Staff Scholarship

Inhibition of phosphodiesterase-4 (PDE4), an enzyme that specifically hydrolyzes cyclic adenosine monophosphate (cAMP) increases intracellular cAMP/cAMP-response element binding protein (CREB) signaling. Activation of this signaling is considered as an important compensatory response that decreases motivational properties of drugs of abuse. However, it is not known whether PDE4 is involved in heroin seeking. Self-administration of heroin (50

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Comparing The Acute Effects Of Elastic Resistance Bands On Kinetics And Kinematics During The Bench Press Exercise, Blake Baxter Jan 2014

Comparing The Acute Effects Of Elastic Resistance Bands On Kinetics And Kinematics During The Bench Press Exercise, Blake Baxter

EWU Masters Thesis Collection

"Elastic resistance training is becoming very popular in the strength and conditioning realm and is used at the collegiate and professional levels for various sports. Elastic resistance training has been shown to increase the force, velocity, and power compared to traditional free weight movements. The purpose of this study was to determine if a specific loading condition could increase both kinetic and kinematic variables within a bench press. To test this, two loading conditions (15% and 25% of 1RM) were used and each resistance load was added to a base of 60% of 1RM free weights. Twelve recreationally trained male …

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An Exploration Of Mutation Effect Sizes In The Nematode Caenorhabditis Elegans, Melody Dossey Jan 2014

An Exploration Of Mutation Effect Sizes In The Nematode Caenorhabditis Elegans, Melody Dossey

EWU Masters Thesis Collection

Mutation rates vary within and among species, in part reflecting the variable input of the two main sources of mutation, DNA replication errors and DNA damage. In somatic tissues, oxidative damage resulting from free radical attacks on DNA is an important and well-characterized cause of mutation, contributing to many diseases and to the aging process. In contrast, it is not known whether oxidative damage can lead to heritable mutations in germline (sperm and egg) DNA. In a previous study, the germline mutation rate was estimated from a mutation accumulation study in two strains of rhabditid nematode (Caenorhabditis elegans), the N2 …

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The Relationship Between Simple Pleasures And Trait Gratitude, Megan Shupe Jan 2014

The Relationship Between Simple Pleasures And Trait Gratitude, Megan Shupe

EWU Masters Thesis Collection

Grateful disposition is associated with positive affect, happiness, high levels of overall well-being and an appreciation of simple pleasures. This study further examined the relationship between simple pleasures and trait gratitude. I hypothesized that people with higher trait gratitude scores would notice more simple pleasures in their lives and feel more gratitude for simple pleasures than less grateful people. I acquired data from 169 undergraduate students at Eastern Washington University. Results suggested that grateful people experienced the same number of simple pleasures as less grateful people but were more grateful for them. This suggests that although grateful people do not …

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Examining Sexual Satisfaction And Pretending Orgasm, Chelsea Twiss Jan 2014

Examining Sexual Satisfaction And Pretending Orgasm, Chelsea Twiss

EWU Masters Thesis Collection

An article in popular women’s magazine, Cosmopolitan, recently revealed a startling admission from its readers: 86% of respondents reported pretending orgasm during intercourse with a partner (Kylstra, 2011). Despite its apparent frequency, there is yet to be a study conducted investigating the relationship between pretending orgasm and overall sexual satisfaction (Ippolito, 2012). Sexual satisfaction is linked with important facets of life such as overall relationship satisfaction and general wellbeing. The present study examines the relationship between experiencing orgasm, pretending orgasm and overall sexual satisfaction. Participants were Eastern Washington University college students recruited via an online survey website (Qualtrics), and who …

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A Comprehensive Review Of Malaria With An Emphasis On Plasmodium Resistance, Lindsay O. Thomas Jan 2014

A Comprehensive Review Of Malaria With An Emphasis On Plasmodium Resistance, Lindsay O. Thomas

Honors Theses

Malaria is a disease that is caused by the Plasmodium genus. It is endemic in tropical areas. There are multiple drugs used for prophylaxis and treatment. However, the parasites have developed resistance towards most antimalarial pharmaceuticals. The pharmaceutical industry is generating new antimalarial pharmaceuticals, but the rate of new Plasmodium resistance is much faster.

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Disaster, Displacement, And Voluntourism: Helping Narratives Of College Student Volunteers In Post-Katrina New Orleans, Mary Elizabeth Smithson Jan 2014

Disaster, Displacement, And Voluntourism: Helping Narratives Of College Student Volunteers In Post-Katrina New Orleans, Mary Elizabeth Smithson

Honors Theses

This thesis is an ethnographic study of volunteer tourists' motivations for contributing to the ongoing recovery of the Lower Ninth Ward in New Orleans, LA. While it has been nearly a decade since Hurricane Katrina hit the Gulf Coast in 2005, there is still much work to be done. The urgency that once accompanied the chaotic environment of a post-disaster landscape does not exist anymore. In effect, the strategies for recuperating from the hurricane's impacts mirror this shift from an urgent disaster state to a stabilized recovery state. Instead of issuing direct relief to people, recovery efforts are presently focused …

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Role Of Speech-Language Pathologists In Aphasia Therapy And Rehabilitation As Reported By Practicing Speech-Language Pathologists, Meredith Wooley Jan 2014

Role Of Speech-Language Pathologists In Aphasia Therapy And Rehabilitation As Reported By Practicing Speech-Language Pathologists, Meredith Wooley

Honors Theses

This thesis examined the roles of speech-language pathologists (SLPs) within aphasia therapy and rehabilitation. Research compiled in the literature review explained the disorder of aphasia, and the roles of SLPs when working with people who have aphaisa, as outlined in the ASHA policy document Roles of Speech-Language Pathologists in The Identification, Diagnosis, and Treatment of Individuals with Cognitive-Communication Disorders: Position Statement (2005b). This study investigated ASHA-certified, masters-level SLPs' preparedness to work with aphasia patients, as well as their familiarity of their roles and resonsibilities in aphasia therapy and rehabilitation, and their awareness of the possible forms of treatment for aphasia. …

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Cardiovascular Protective Agents And Their Biochemical Role In Endothelial Cell Senescence, Nicholas Boullard Jan 2014

Cardiovascular Protective Agents And Their Biochemical Role In Endothelial Cell Senescence, Nicholas Boullard

Honors Theses

Cellular senescence is a slow, biological process of aging that involves the accumulation of various changes to the internal environment of a cell, most notably the buildup of acidic B-galactosidase. These changes, both structural and molecular in nature, disable metabolism of many cellular processes and eventually induce apoptosis. As cells divide, the ends of chromosomes, telomeres, slowly shorten. Once telomere shortening reaches critical levels, those chromosomes may no longer replicate properly, leading to cellular process complication and apoptosis. Telomerase is a reverse transcriptase that adds nucleotides to telomeres, elongating them and successfully delaying endothelial cell senescence. Endothelial cells serve an …

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Payday Lending In America: Profitability And Regulation In The Payday Lending Market, Orion Wilcox Jan 2014

Payday Lending In America: Profitability And Regulation In The Payday Lending Market, Orion Wilcox

Honors Theses

Payday lending is a highly contentious form of credit. Consumer advocates often argue for strict regulation or complete banning of the industry based on the idea that payday lending rates are usurious. Providers of payday loans argue that their product offers access to credit that would not be available otherwise. In order to reconcile this debate, I analyze financial data on the largest payday lender in the country Advance America. Furthermore, I examine the 2008 Arkansas payday lending law to analyze the impact of the ban on bounced check fees, overdraft charges, and Non-Sufficient Funds charges at state chartered Arkansas …

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How The Case United States V. Windsor Paved The Way For Same-Sex Marriage Legalization In The United States, Olivia C. Watkins Jan 2014

How The Case United States V. Windsor Paved The Way For Same-Sex Marriage Legalization In The United States, Olivia C. Watkins

Honors Theses

This thesis looks at how the United States Supreme Court came to decide upon the issue of same-sex marriage. Starting in the lower courts and moving to the Supreme Court in 2013 and how the decision handed down by the court changed the law of the land. As well as how this decision has allowed for future changes in the law. Furthermore, how the new land has led individual states to overturn laws restricting marriage equality and how the Fourteenth Amendment can be used as a vehicle to legalize same-sex marriage across the states using the Courts decisions in United …

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Chile Se Moviliza: Protest Movements And Inequality In Post-Dictatorship Chile, Shruti Jaishankar Jan 2014

Chile Se Moviliza: Protest Movements And Inequality In Post-Dictatorship Chile, Shruti Jaishankar

Honors Theses

On March 11, 1990, Augusto Pinochet, one of Latin America's most infamous dictators, left office after Chileans ordered him to step down in a nationwide plebiscite. Since Pinochet harshly punished any and all dissenters, protests re-emerged in Chile as a popular form of political action. In this thesis, I examine the relationship between economic and political inequality and the frequency of protests and peaceful demonstrations in the country. I examine the theory behind why people protest, and later examine the history of individual protest movements (such as the Chilean Education Movement). Lastly, I run a regression to evaluate the relationship …

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Evaluation Of Microbial Diversity Present In Herbal Supplements As Revealed By Pcr-Based 16s Sequence Analysis, Stephen Stone Jan 2014

Evaluation Of Microbial Diversity Present In Herbal Supplements As Revealed By Pcr-Based 16s Sequence Analysis, Stephen Stone

Honors Theses

Over the last few decades people have become more aware of their general wellness and have turned towards alternative measures to ensure good health. One of these alternative measures, the herbal supplement market, has risen significantly in recent years, even though there is no conclusive research that points to the effectiveness of herbal supplements. Also, because of sparse regulation from the FDA, there are many questions related to the efficacy, composition, processing methods, and, consequently, safety of these supplements. The aim of this study was to determine the microbial composition of herbal supplements in an attempt to identify potential targets …

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Valuation And Financial Statement Analysis For Activision-Blizzard, Inc., Stephen Wittmann Jan 2014

Valuation And Financial Statement Analysis For Activision-Blizzard, Inc., Stephen Wittmann

Honors Theses

Activision-Blizzard (ATVI), a market-leading publisher and developer in the videogame industry, represents a fascinating case study of a player in a relatively new industry as it struggles to find a permanent place among entrenched entertainment staples such as music, television, and movies. The company in its present form is the product of a 2008 merger between Activision Inc. and Vivendi Games, thus creating a massive publisher with rights to several of the industry's most popular franchises, including World of Warcraft, StarCraft, and Call of Duty. This industry domination has not gone unnoticed, and as of March 2013, ATVI's share price …

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Mary Elizabeth Braddon's Aurora Floyd Revisited: An Experiment In Neovictorianism, Vivian Walker Lang Jan 2014

Mary Elizabeth Braddon's Aurora Floyd Revisited: An Experiment In Neovictorianism, Vivian Walker Lang

Honors Theses

My thesis is a combination of analysis and creativity. It is an exploration in the literary genre Neovictorianism, and specifically it explores a two-year period in the life of Aurora Floyd. Aurora Floyd is the protagonist of Mary Elizabeth Braddon's novel, Aurora Floyd. While many of the major themes, characters, and literary elements stem from Braddon's work, the following pages are my original work and have accumulated over the past year and a half of my time as an honors student.

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Performance Enhancing Drugs In America's Pastime, William A. Hodges Jan 2014

Performance Enhancing Drugs In America's Pastime, William A. Hodges

Honors Theses

Over the last couple of decades, steroids use has been a part of baseball. The goal of steroid users is to gain a physical advantage over other players in the league by taking these drugs. The drugs have a variety of different effects to benefit baseball players. Along with the benefits, steroids have many health risks. The history of steroids in baseball, although relatively recent, is still vast and is still being written. The MLB has worked hard to determine the proper action to deal with steroids. The first part of the thesis is to look into what steroids are …

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Validation Of A Recurrent Nitroglycerin Migraine Model In The Rat, Ainslee Johnson Jan 2014

Validation Of A Recurrent Nitroglycerin Migraine Model In The Rat, Ainslee Johnson

Honors Theses

The present research sought to determine if repeated nitroglycerin (NTG) administrations elicited responses on clinically relevant behavioral endpoints of migraine in rats. Rats were given five saline, three NTG or five NTG administrations over a two-week period. After their fifth injection rats were evaluated using the rat grimace scale, modified light/dark box, thermal tail flick tests, elevated plus maze and forced swim test. Repeated NTG administration affected weight gain, movement in the modified light/dark box and photophobia. The thermal tail flick tests, elevated plus maze and forced swim test did not reveal treatment effects. Based on these findings, we conclude …

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Dieting For Diabetes: A Mobile 'App'roach, Alaina Brooks Darby Jan 2014

Dieting For Diabetes: A Mobile 'App'roach, Alaina Brooks Darby

Honors Theses

Diabetes mellitus, being a prevalent disease in modern society, is moderately influenced by one's nutrition. Due to this, mobile programs created especially for tracking food intake can be an important aid for diabetics. The objective of this project was to analyze eight of the most prominent of these applications — MyNetDiary, GoMeals, MyFitnessPal, Fooducate, Lose It!, The Carrot, Diabetes In Check, and Daily Carb — to determine the subsets of diabetics that would benefit most from the utilization of each. Data was obtained through testing of each app and through the information provided by users on iTunes and Google Play …

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Simulated Diabetes Testing Experiment Using Artificially Manipulated Livestock Blood, Hollie E. Ables Jan 2014

Simulated Diabetes Testing Experiment Using Artificially Manipulated Livestock Blood, Hollie E. Ables

Honors Theses

Due to the prevalence of diabetes and lack of simple endocrine experiments, a laboratory protocol was developed in order to increase student knowledge of the disease and the diabetic testing process. In this paper, we present the protocol for manipulating the glucose concentration of commercially available bovine blood. The bovine blood was manipulated using Ringer's solution to which glucose was added, and six samples were prepared (pre-prandial and postprandial, normal; pre-prandial and postprandial, pre-diabetic; pre-prandial and postprandial, diabetic). This laboratory exercise provides a physical, hands-on student activity that highlights pancreatic endocrinology and the results of pancreatic malfunction. The laboratory exercise …

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The Changing Climate And Adaptation Strategies For The Mississippi Delta, John Jenks Jan 2014

The Changing Climate And Adaptation Strategies For The Mississippi Delta, John Jenks

Honors Theses

No abstract provided.

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Bolivian Public Health Care: Interculturation For Indigenous Rights, Kendra Leigh Wright Jan 2014

Bolivian Public Health Care: Interculturation For Indigenous Rights, Kendra Leigh Wright

Honors Theses

This thesis is concerned with Bolivian public health care, specifically how interculturation plays a part in bringing indigenous rights and representation. By examining indigenous traditional healing and Western medicine, this thesis attempts to answer the question of: is the role of pluralizing medical practices a mechanism that successfully gives more power toward the representation and inclusion of indigenous rights in Bolivia? If so, how exactly has interculturation taken place? This thesis hypothesizes that through projects of cultural sensitivity and the respecting of Aymara and Quechua languages, rituals, and traditions, indigenous representation is enhanced in the Bolivian public health care field, …

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Analysis Of Body Type Preferences Among Young Adults, Khyati Maheshkumar Ganatra Jan 2014

Analysis Of Body Type Preferences Among Young Adults, Khyati Maheshkumar Ganatra

Honors Theses

Based on a study conducted by Devendra Singh in 1993, it is believed that males prefer females with a lower waist-to-hip ratio of 0.7, as compared to higher ones. This may be due to the evolutionary advantage of these females being more fertile and able to reproduce. However, social media has been suggesting that thinner females are more attractive. One way society measures thinness is by a characteristic known as the 'thigh-gap' that many females strive to obtain. This study was conducted to discover whether or not a difference exists between males and females regarding their preference of the thigh-gap …

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Prepulse Inhibition Of The Acoustic Startle Reflex: Comparing Low And High Trait Anxious Individuals, Krista Sturm Jan 2014

Prepulse Inhibition Of The Acoustic Startle Reflex: Comparing Low And High Trait Anxious Individuals, Krista Sturm

Honors Theses

This investigation examined whether prepulse inhibition of the acoustic startle reflex was impaired among individuals with high trait anxiety compared to controls. PPI has traditionally been theorized to be a psychophysiological index of information processing and sensorimotor gating, and is now being used to help identify various psychological disorders. Although results of existing research on reduced PPI across the anxiety spectrum are equivocal, previous findings indicate that highly anxious (HA) participants exhibit significantly reduced PPI at lead intervals of 60 ms relative to low anxious (LA) controls. This study paired a 70 dB (A) white noise prepulse stimulus with a …

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The Effect Of Auditory Distractions On Working Memory In People Diagnosed With Attention Deficit Hyperactivity Disorder, Kristen Laprade Johnson Jan 2014

The Effect Of Auditory Distractions On Working Memory In People Diagnosed With Attention Deficit Hyperactivity Disorder, Kristen Laprade Johnson

Honors Theses

This study compared the effect of an auditory distractor on working memory in participants with and without ADHD. Undergraduate students (N-65) were asked to complete a memory task for 25 words in which a pulsating beep sounded from the computer during the middle 5 words. The results indicated that students with ADHD performed significantly worse in the presence of a distraction than those without ADHD. However, the present study also examined the effect of ADHD medication, taken the same day, on working memory. The results indicated that participants with ADHD who had taken medication performed better than those who did …

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Bacteria Con Leche: Bacterial Populations And Antibiotic Resistance Within Conventional, Usda Organic, And Local Milk, Kristen M. Wilson Jan 2014

Bacteria Con Leche: Bacterial Populations And Antibiotic Resistance Within Conventional, Usda Organic, And Local Milk, Kristen M. Wilson

Honors Theses

Concerns over food production and processing, along with increasing outbreaks of foodborne illnesses and antibiotic resistant infections have led many consumers to seek alternative food sources in the organic and local food markets. This study compared conventional, USDA certified organic, and local farmer's market milk types to determine whether there is any noticeable benefit to purchasing organic or locally harvested milk in terms of their bacterial populations and level of antibiotic resistance. Samples from various milk types were plated on Tryptic Soy Agar and Milk Agar plates to enumerate bacteria, and the cultivated bacteria tested for resistance to the antibiotics …

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The Effects Of Prenatal Education And Hospital Intervention On Breastfeeding Initiation, Lauren Camp Jan 2014

The Effects Of Prenatal Education And Hospital Intervention On Breastfeeding Initiation, Lauren Camp

Honors Theses

Breastfeeding is considered an important health practice for mothers and babies. However, Mississippi has the lowest breastfeeding rate of any state in the nation. Because of the numerous potential benefits of breastfeeding, the overall health of Mississippians could benefit from improved breastfeeding outcomes. Using 2010 data retrieved by the Pregnancy Risk Assessment Monitoring System (PRAMS) survey, which is administered through the Mississippi State Department of Health (MDH) in partnership with the Centers for Disease Control and Prevention (CDC), this study explores the factors that influence the breastfeeding decisions of mothers in Mississippi. In the PRAMS survey, women were asked whether …

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The Effects Of Population Disbursement, Percentage Of Medicare Beneficiaries, And Per Capita Income On Medicare Fee Schedule Prices, Ann Marie Mercier Jan 2014

The Effects Of Population Disbursement, Percentage Of Medicare Beneficiaries, And Per Capita Income On Medicare Fee Schedule Prices, Ann Marie Mercier

Honors Theses

The thesis is an overview of the existing pay disparity in the fee-for-service billing amounts for professional medical services provided by physicians to Medicare patients in the United States. Will improvements in the per capita income, percentage of Medicare participants, or change in the population disbursement result in higher Medicare fee-for-service billing amounts for healthcare providers? Mississippi has one of the fewest primary care physicians per capita rates than any other state. One reason may be the Medicare fee-for-service prices paid to physicians. This paper will show Mississippi Medicare fee-for-service fee schedule prices for a sample of HCPCS codes compared …

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University Of Mississippi Prepharmacy And Early Entry Students' Professional Commitment And Perceptions Of The Professional Role Of Pharmacists, Blake A. Williams Jan 2014

University Of Mississippi Prepharmacy And Early Entry Students' Professional Commitment And Perceptions Of The Professional Role Of Pharmacists, Blake A. Williams

Honors Theses

Introduction: The profession of pharmacy is now largely focused on patient-centered care, rather than the drug-centered focus of the past. Schools of pharmacy have a vested interest in recruiting student pharmacists who are patient-focused. The purpose of this study is to assess University of Mississippi prepharmacy and Early Entry students' perceptions of the professional role of pharmacists, and to determine if these perceptions are related to student characteristics. Methods: This cross-sectional, descriptive study utilized an online, self-administered survey, administered to prepharmacy and Early Entry students enrolled at the University of Mississippi. The survey included constructs of the theory of planned …

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Perceptions Of Health Information On General And Medical Social Media Sites, Brea Hope Rich Jan 2014

Perceptions Of Health Information On General And Medical Social Media Sites, Brea Hope Rich

Honors Theses

The goal of this thesis is to identify and discuss the public's perception on health information found on general and medical social media sites. To discover this information, a survey was sent to employees of South Tippah School District. It was found that people are more likely to use general social media sites compared to medical social media sites. People are more likely to share medical information than receive information on either type of site. Most people doubt or are uncertain of the credibility of health information on social media sites. The benefit found most in reading or sharing medical …

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