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2014

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“I Would Like To Live A Better Life:” How Young Mothers Experience Entrepreneurship Education In East Africa, Elisabeth E. Lefebvre, Amy Pekol, Brooke L. Krause Jan 2014

“I Would Like To Live A Better Life:” How Young Mothers Experience Entrepreneurship Education In East Africa, Elisabeth E. Lefebvre, Amy Pekol, Brooke L. Krause

Education Faculty Publications

This paper examines the capabilities, values, and constraints of young mothers participating in a youth entrepreneurship program in Tanzania and Uganda. Entrepreneurship education is an increasingly popular development strategy for vulnerable and out-of-school youth. The ultimate value of these programs rests in the ability of these youth to convert the knowledge and skills they acquire into valued livelihood opportunities. It is therefore important to understand the characteristics, experiences, and needs of the participants, as well as the socio-economic conditions that shape their abilities to apply their newly acquired knowledge and skills. Findings from this study suggest young mothers enter the …

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Regulatory Control Of Palatogenesis And Odontogenesis By Specificity Protein 7, John Christopher Clarke Jan 2014

Regulatory Control Of Palatogenesis And Odontogenesis By Specificity Protein 7, John Christopher Clarke

All ETDs from UAB

Runx2 and its downstream target Specificity Protein 7 (Sp7) are essential for skeletogenesis. In humans, mutations in Sp7 gene are associated with osteogenesis imperfecta. Unlike Runx2, the role of Sp7 in palatogenesis, tooth development or differentiation of ameloblasts and odontoblasts remains unknown. The main goal of this research was to identify the functional requirement of Sp7 transcription factor during tooth development and palatogenesis. Molecular, biochemical, and histological approaches were employed to answer this question. We established Sp7-null mice that are completely void of mineralized tissue, exhibit craniofacial dysmorphogenesis and die shortly after birth. Surprisingly, Sp7 homozygous mutants exhibited normal tooth …

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Actions Of Grape Seed Extract In Rodent Brain And Differences In Metabolism Of Its Polyphenols In A Rodent Model Of Menopause, John Kenneth Cutts Jan 2014

Actions Of Grape Seed Extract In Rodent Brain And Differences In Metabolism Of Its Polyphenols In A Rodent Model Of Menopause, John Kenneth Cutts

All ETDs from UAB

Grape seed extract (GSE), a dietary supplement, has potential in the treatment and prevention of human chronic age-related diseases including cancers, cardiovascular diseases, and neurodegenerative diseases. GSE and adult hippocampal neurogenesis, independently, have enhanced learning and memory in rodents. We hypothesized that GSE enhances learning and memory, at least partially, by enhancing hippocampal neurogenesis. However, adult mice given GSE did not exhibit increased number of progenitor cells or new neurons, established markers of neurogenesis, in the dentate gyrus (DG). Also, 26-day-old pups whose mother was given GSE only while nursing had fewer new neurons in the DG compared to control …

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Nutrition And Health Related Outcomes In Patients On Hemodialysis, Shawona Cannon Daniel Jan 2014

Nutrition And Health Related Outcomes In Patients On Hemodialysis, Shawona Cannon Daniel

All ETDs from UAB

Millions of Americans are affected by kidney disease and a large proportion of these individuals require hemodialysis to sustain life. This is a life changing event. The nutritional lifestyle changes associated with hemodialysis may be a key factor to health related outcomes such as depression and health-related quality of life (HRQOL). This study examined the relationship between selected demographic characteristics, nutritional status, measured by serum albumin, normalized protein catabolic rate (nPCR), body mass index (BMI), percent body fat, and self-report dietary protein intake, and HRQOL and depression in patients undergoing chronic hemodialysis. This study also examines the magnitude of correlation …

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Evaluation Of Environmental Factors And Dengue Fever In Sri Lanka Using Geospatial Tools, Meghan Tipre Jan 2014

Evaluation Of Environmental Factors And Dengue Fever In Sri Lanka Using Geospatial Tools, Meghan Tipre

All ETDs from UAB

The incidence of dengue fever has increased exponentially in Sri Lanka, from 24.4 cases per 100,000 in 2003 to 165.3 per 100,000 population in 2013. Despite concerted effort by the Sri Lankan government, dengue control remains a challenge in the country, indicating a need for novel approach for dengue prevention and control. The aim of this research was to identify environmental risk factors that may be associated with dengue incidence rate at the Gram Niladhari Divisions level (smallest administrative unit) in Colombo city, Sri Lanka, using geospatial tools such as remote sensing and geographic information system. These factors included climate …

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Analysis Of Debris From Implant Prostheses, Mehran Varedi Jan 2014

Analysis Of Debris From Implant Prostheses, Mehran Varedi

All ETDs from UAB

Objectives: The specific aim of this study was to analyze any entrapped debris in implant abutment screw threads from post processed constructs from dental laboratories. Materials and Methods: Forty implant screws were used to collect debris where screws were removed from the implant prosthesis as received from dental laboratories. In all samples, laboratory procedures including fabrication of the custom abutment, definitive prosthesis and finishing/polishing were completed prior to sampling. Twenty-nine screws were from titanium and eleven screws were from zirconia abutments. Scanning Electron Microscope (SEM) analyses of collected particulate products from abutment screws were done for all specimens. Results: The …

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Targeting Tau-Mediated Nmdar Hypofunction Reverses Deficits In A Mouse Model Of Frontotemporal Dementia, Brian Andrew Warmus Jan 2014

Targeting Tau-Mediated Nmdar Hypofunction Reverses Deficits In A Mouse Model Of Frontotemporal Dementia, Brian Andrew Warmus

All ETDs from UAB

Frontotemporal dementia (FTD) is a rapidly progressive and lethal disease, with no disease-modifying treatments. It is known that tau mutations cause FTD, but the underlying neurobiology is undefined. We sought to identify how tau affects the neurobiology in order to find potential treatment targets. Here, we address this question using a new mouse model expressing human tau with an FTD-associated mutation. We studied behavior, physiology, biochemistry, and neuropathology in several cohorts of mice at different ages. These mutant tau mice had abnormal repetitive behavior characteristic of FTD and synaptic deficits selectively in regions associated with FTD (ventral striatum and insula). …

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Syndecan Knockdown In The Insulin Producing Cells Of Drosophila Melanogaster Affects Energy Metabolism And Life Span, Jonathan Lund Warren Jan 2014

Syndecan Knockdown In The Insulin Producing Cells Of Drosophila Melanogaster Affects Energy Metabolism And Life Span, Jonathan Lund Warren

All ETDs from UAB

Drosophila melanogaster is a powerful model organism for studying human metabolic disease due to the conservation of various signaling processes and pathways. The insulin producing cells (IPCs) in the brain of adult flies sense circulating nutrients and respond by producing three insulin-like peptides (dILP2, dILP3, and dILP5). Several studies have shown that dILPs play a major role in Drosophila reproduction, metabolism, growth, and longevity. Previous data showed that flies homozygous for a hypomorphic mutation in the Drosophila syndecan (dSdc) gene had defects in energy metabolism and lower expression of brain dilp2-3 and dilp5 genes. Syndecan is a transmembrane proteoglycan that …

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Print Vs. Pulpit: Representations Of Religion In The Harlem Renaissance, Sondra Bickham Washington Jan 2014

Print Vs. Pulpit: Representations Of Religion In The Harlem Renaissance, Sondra Bickham Washington

All ETDs from UAB

At the turn of the twentieth century, African American race leaders believed that literature and other creative works could strengthen the fight against the social, economic, and political oppression facing members of their race across the country. However, when younger writers began explicitly focusing their narratives and poems on the more taboo and less religious elements of African American life such as heavy drinking, sensual dancing at jazz and blues clubs, and unmarried sexual relationships, black religious leaders often expressed opposition to their creative work. This sometimes harsh disapproval only served to create a larger gap between the religious and …

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Understanding The Described Experiences Of Court Judges, Court Appointed Special Advocates (Casa) Volunteers, Department Of Human Resources Caseworkers, And Foster Parents, Mitsy Collier Wilbourne Jan 2014

Understanding The Described Experiences Of Court Judges, Court Appointed Special Advocates (Casa) Volunteers, Department Of Human Resources Caseworkers, And Foster Parents, Mitsy Collier Wilbourne

All ETDs from UAB

UNDERSTANDING THE DESCRIBED EXPERIENCES OF COURT JUDGES, COURT APPOINTED SPECIAL ADVOCATES (CASA) VOLUNTEERS, DEPARTMENT OF HUMAN RESOURCES'CASEWORKERS, AND FOSTER PARENTS MITSY COLLIER WILBOURNE EARLY CHILDHOOD EDUCATION ABSTRACT The purpose of this study was to identify the described experiences of court judges, Court Appointed Special Advocates (CASA) volunteers, Department of Human Resources' caseworkers, and foster parents in the southeastern United States to enhance the early childhood educational needs and development of children in out-of-home care. The study was designed with cases so various perspectives were examined. Children who were neglected and abused, specifically those who must be removed from their parent's …

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Modulation Of Neocortical Gabaergic Interneurons By Voltage-Gated Ion Channels, Sidney B. Williams Jan 2014

Modulation Of Neocortical Gabaergic Interneurons By Voltage-Gated Ion Channels, Sidney B. Williams

All ETDs from UAB

GABAergic interneurons provide the main source of inhibition in the neocortex and are important in regulating neocortical network activity. In the presence of the K+ channel blocker 4-AP and the glutamate receptor blockers, CNQX and D-APV, large amplitude evoked and spontaneous depolarizing responses are observed in the neocortex. These large propagating responses are blocked by GABAA receptor antagonists indicating that these events are due to synchronized activity of GABAergic interneurons. Cortical GABAergic networks are comprised of several types of interneurons, each with its own protein expression pattern, receptor profile, firing properties, synaptic targets and role in network activity. Voltage-gated ion …

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Skeletal Muscle Stem Cell Function Following Burn Injury, Katie Leigh Wilson Jan 2014

Skeletal Muscle Stem Cell Function Following Burn Injury, Katie Leigh Wilson

All ETDs from UAB

The pathophysiological response to burn injuries involves severe inflammation and a hypermetabolic state, both contributing to prolonged muscle atrophy. However, the relationship between inflammation and hypermetabolism following burn injury is poorly defined. Catabolism results from energy storage depletion, in part due to futile substrate cycling, and preferentially involving amino acids. This rapid turnover of amino acids leads to massive, full body muscle wasting. The extent and duration of muscle loss is directly related to the total body surface area burned (TBSA). Severely burned patients may experience metabolic derangements and impaired muscle synthesis for up to two years. In order to …

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Using Computers And The Internet: The Experiences Of Older, Vicki P. Winstead Jan 2014

Using Computers And The Internet: The Experiences Of Older, Vicki P. Winstead

All ETDs from UAB

reproduction such as egg survival, hatchling survival, and sex ratios. The initial two

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Predictors Of Smoking Cessation Among Dental Patients Participating In A Web-Assisted Tobacco Intervention: A National Dental Practice-Based Research Network Study, Midge N. Ray Jan 2014

Predictors Of Smoking Cessation Among Dental Patients Participating In A Web-Assisted Tobacco Intervention: A National Dental Practice-Based Research Network Study, Midge N. Ray

All ETDs from UAB

MIDGE N. RAY HEALTH PROMOTION AND EDUCATION ABSTRACT Nicotine addiction is a chronic and relapsing disease that has serious health consequences. Tobacco continues to be the leading preventable cause of morbidity and mortality in the United States. In 2010, approximately 58.3 million Americans were identified as cigarette smokers. This study was part of the Hygienists' Internet Tobacco Cessation Study (Hi Quit), a randomized controlled trial that employed a web-assisted tobacco intervention (WATI) called Decide2Quit to assist smokers in quitting. Smokers (N=258) were enrolled in the study by dental practices (N=100) that referred patients who smoke to the website. The control …

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Finding Bands In Optical Coherence Tomography Images Using Curve And Function Fitting, Douglas Howard Ross Jan 2014

Finding Bands In Optical Coherence Tomography Images Using Curve And Function Fitting, Douglas Howard Ross

All ETDs from UAB

Optical Coherence Tomography (OCT) is a noninvasive method to create a volume of data that is a measurement of the reflectance properties of tissue. The retina of the human eye has a layered structure that presents as bands in the OCT images. Evaluation of OCT images can be used to diagnose abnormal structure due to disease or damage. The principal task in evaluating the OCT images is segmentation. While the images can be evaluated by trained personnel, the quantity of OCT image data is increasing rapidly, therefore, the creation of methods for automatic segmentation is vital. Prior work in segmenting …

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Copper Homeostasis In Mycobacteria, Jennifer L. Rowland Jan 2014

Copper Homeostasis In Mycobacteria, Jennifer L. Rowland

All ETDs from UAB

Mycobacterium tuberculosis, the causative agent on tuberculosis in humans, is a globally important pathogen. In 2013, nearly 1.2 million people died from tuberculosis. Drug treatments and effective vaccines are lacking for this pathogen. A better understanding of the basic physiology of M. tuberculosis is required to improve disease outcomes. Upon inhalation into the lungs, M. tuberculosis is taken up by macrophages, in a process called phagocytosis, which normally destroys invading bacteria. As the phagosome inside the macrophage matures, bactericidal mechanisms are activated including: lowering pH, and introducing reactive oxygen and nitrogen species and hydrolytic enzymes to degrade bacterial cell walls. …

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Molecular Profiling In Cervical Carcinogenesis And Progression, Kathryn Elizabeth Royse Jan 2014

Molecular Profiling In Cervical Carcinogenesis And Progression, Kathryn Elizabeth Royse

All ETDs from UAB

Coexisting lesions can reduce genomic heterogeneity in precancer progression analysis by reducing variation and bias that can mask gene effects. Our goal was to use novel methodologies to depict the neoplastic stage effect (Normal v. LSIL v. HSIL) in cervical precancer. We analyzed the neoplastic stage effect via in silico and in vivo methodologies. For in silico analyses, we calculated differential expression (DE) estimates from a systematic review of DNA methylation and gene expression literature. Significant genes (FC≤2.0 or p-value≥0.05) were grouped by histology for pathway analysis. For in vivo analyses, we performed RNA-seq on microdissected FFPE coexisting cervical tissue …

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Genetic And Epigenetic Changes Regulated By Bioactive Molecules In Cancer Therapeutics, Sabita Saldanha Jan 2014

Genetic And Epigenetic Changes Regulated By Bioactive Molecules In Cancer Therapeutics, Sabita Saldanha

All ETDs from UAB

Cancer biogenesis stems from genetic and epigenetic changes that regulate various signaling pathways responsible for growth, division, and proliferation. Genetic changes occur through mutations that contribute to loss of function, overexpression or repression of proteins involved in metabolic pathways. The changes place individuals at risk to diseases, including cancer. However, epigenetics is a mechanism of gene control that occurs through changes in chromatin structure without alterations to the DNA sequence and is mostly reversible. Epigenetic alterations have been implicated in colorectal cancers (CRCs), transforming normal colonic epithelial cells. Aberrant DNA methylation and chromatin modifications have been shown to contribute to …

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Rhodopsin As A Model For Gpcr Trafficking And Its Role In Outer Segment Formation, Joshua D. Sammons Jan 2014

Rhodopsin As A Model For Gpcr Trafficking And Its Role In Outer Segment Formation, Joshua D. Sammons

All ETDs from UAB

Rhodopsin is a prototypical G-protein coupled receptor whose biological function has been well worked out, yet little is known about the mechanism by which it is so efficiently transported to the rod outer segment (ROS) after synthesis. If rhodopsin is not efficiently transported to the ROS, rod cells will apoptose leading to cone cell apoptosis as well which results in the blinding disease retinitis pigmentosa. Work has begun to elucidate proteins responsible for transporting rhodopsin to the ROS using Xenopus laevis as a model since the photoreceptors of this amphibian are large and transgenic animals are relatively easy to prepare. …

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Clinical Evaluation Of Non-Carious Cervical Lesions- A Five Year Prospective Evaluation, Kanchan Sawlani Jan 2014

Clinical Evaluation Of Non-Carious Cervical Lesions- A Five Year Prospective Evaluation, Kanchan Sawlani

All ETDs from UAB

Non-carious cervical lesions (NCCLs) have a non-bacterial origin and produce a loss of tooth structure at the cemento-enamel junction. A review of the literature reveals that these lesions may have a multifactorial etiology (chemical, abrasion, abfraction). The role of heavy biting forces in the pathogenesis of NCCLs is yet to be firmly established. Treatment and preventive measures for NCCLs can be improved if the etiology can be clearly identified and treated.Objective: This prospective clinical trial measured the volume loss (increase in size) of NCCLs and the occlusal biting forces applied to these teeth; diet and tooth brushing analysis, followed by …

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The Effects Of Estrogen On Learning And Memory, Carol Yvette Harden Jan 2014

The Effects Of Estrogen On Learning And Memory, Carol Yvette Harden

All ETDs from UAB

Learning is the process in which new information is acquired and requires cellular modifications that occur in the hippocampus. These cellular changes can be seen through behavioral modifications which indicate memorization of the previously learned material. Increases in phosphorylation of the extracellular regulated protein kinase (ERK), a subfamily of MAPKs alters synaptic efficacy making it a correlate for learning and memory. Additionally, surges in plasma 17ß estradiol (E2) levels can increase synaptic plasticity, suggesting an importance for the role of E2 in cognition. Both human and animals studies have shown that elevated levels of estrogen correlated to an enhancement in …

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An Analysis Of Tax-Revenue Diversifcation Of State Governments (2000-2011), Muhammad Ali Hanif Jan 2014

An Analysis Of Tax-Revenue Diversifcation Of State Governments (2000-2011), Muhammad Ali Hanif

All ETDs from UAB

States are facing tremendous challenges in the Twenty-First Century. Changing federal-state relationships, demographic changes, and economic changes are creating fiscal stress for states. Within all these challenges, one of most important one is frequent economic fluctuations that are creating fiscal instability for American States. Theorists have argued that states needs to overcome revenue instability for continuation of state programs, which can be done by increasing revenue diversification. Thus, by using data from the US Census Bureau between years 2000 to 2011, this paper attempts to determine whether states are increasing revenue diversification over time. The findings suggest that states have …

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Gene Expression Signatures In Tree Shrew Retina, Rpe, And Choroid During Experimental Myopia And Recovery, Li He Jan 2014

Gene Expression Signatures In Tree Shrew Retina, Rpe, And Choroid During Experimental Myopia And Recovery, Li He

All ETDs from UAB

During the development of induced myopia and recovery, the emmetropization mechanism is stimulated to modulate ocular growth. Emmetropization signals originate in the retina, are transmitted and transformed by retinal pigment epithelium (RPE) and choroid, and reach sclera to induce tissue remodeling. Induced myopia occurs in response to myopiagenic stimuli - minus lens, form deprivation, and darkness - (three GO conditions) which increase ocular elongation; recovery from lens-induced myopia (STOP) occurs when minus-lens wear is discontinued after complete compensation, slowing ocular elongation. This dissertation examined gene expression signatures in the retina, RPE, and choroid under GO and STOP conditions to examine …

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Protein O-Glcnac Modification In Diabetic Vascular Calcification, Jack Heath Jan 2014

Protein O-Glcnac Modification In Diabetic Vascular Calcification, Jack Heath

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Vascular calcification is prevalent in patients of diabetes mellitus, which represents an independent risk factor that positively correlated with morbidity and mortality in these patients. Vascular calcification is now recognized as a cell-regulated process of osteogenic differentiation of vascular smooth muscle cells (VSMC) in response to stress, such as hyperglycemia and oxidative stress. Both hyperglycemia and oxidative stress have been shown to induce protein modification by O-linked ß-N-acetylglucosamine modification (O-GlcNAcylation), which is also elevated in diabetes. The present studies aimed to determine the effects of protein O-GlcNAcylation on vascular calcification in diabetes, and uncover the underlying molecular mechanisms. With the …

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Social Capital And Economic Opportunity: Implications For Increasing Social Mobility, Kalena Thomhave Jan 2014

Social Capital And Economic Opportunity: Implications For Increasing Social Mobility, Kalena Thomhave

Honors Capstones

No abstract provided.

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Chloramination And Corrosion: Case Studies, Utility Experience, And Statistical Comparisons With Chlorination, Jason Heberling Jan 2014

Chloramination And Corrosion: Case Studies, Utility Experience, And Statistical Comparisons With Chlorination, Jason Heberling

All ETDs from UAB

The United States Environmental Protection Agency (EPA) began implementing the Stage 2 Disinfectant By-products (DBP) Rule (Stage 2) in 2012. The purpose of this regulation is to protect water utility customers from potentially harmful DBP's, most importantly, total trihalomethanes (TTHM) and haloacetic acids (HAA). DBP's have been directly linked to health problems, especially bladder cancer. Regulated DBP's are formed by the chemical reaction of chlorine and naturally occurring organic matter. Chloramines do not produce TTHM's and HAA's and water utilities have used chloramines in place of chlorine in an attempt to meet Stage 2 rules. However, a possible problem of …

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Examining Predictors Of The Longitudinal Trajectories Of Diabetes Distress And Depressive Symptoms In A Sample Of Older Adults With Diabetes, Larita Jones Jan 2014

Examining Predictors Of The Longitudinal Trajectories Of Diabetes Distress And Depressive Symptoms In A Sample Of Older Adults With Diabetes, Larita Jones

All ETDs from UAB

Objectives: The authors investigated the relationships between race, cognitive function, life-space mobility, comorbidity, and depressive symptoms over time; as well as the relationships between race, cognitive function, life-space mobility, comorbidity, and diabetes distress over time. Methods: The sample included 224 community-dwelling older adults (age 65<) previously diagnosed with diabetes. The current study utilized data from telephone interviews at three different time points (baseline, 1 year follow up, and 2 year follow up). Results: A number of significant correlations were found. Potentially most importantly, results from the final model indicated that those participants who were lowest in self-efficacy were the most at-risk for experiencing diabetes distress and/or depressive symptoms. Conclusion: Findings suggest that interventions aimed at reducing diabetes distress and/or depressive symptoms within this population should focus on social support and disease specific self-management education as two cost-effective and easily manipulated avenues to achieving this goal.

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Southern African American Women's Perception Of Cononary Artery Disease After A Myocardial Infarction: A Phenomenological Inquiry, Loretta Jones Jan 2014

Southern African American Women's Perception Of Cononary Artery Disease After A Myocardial Infarction: A Phenomenological Inquiry, Loretta Jones

All ETDs from UAB

The American Heart Association (AHA) reported that cardiovascular diseases kill nearly 50,000 African-American (AA) women annually. Of AA women ages 20 and older, 49% have heart diseases. Only 52% of AA women are aware of the signs and symptoms of a heart attack and only 36% of AA women know that heart disease is their greatest health risk. The purpose of this phenomenological study was to explore the lived experience of African American women, 50 years and older, who had experienced a myocardial infarction within the past five years. The primary research questions addressed the women's knowledge of risk factors, …

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Characterization Of Glycosylation-Associated Protein, Gap2, Required For The Biogenesis Of Streptococcus Parasanguinis Fimbriae-Associated Protein, Fap1, Haley Echlin Jan 2014

Characterization Of Glycosylation-Associated Protein, Gap2, Required For The Biogenesis Of Streptococcus Parasanguinis Fimbriae-Associated Protein, Fap1, Haley Echlin

All ETDs from UAB

Streptococcal species possess a multitude of adhesins that facilitate adherence to a wide range of substrates; this is the first step necessary for the development of disease. Streptococcus parasanguinis is a primary colonizer of the oral cavity and adheres to the tooth surface using long fimbriae, which are composed of Fap1, a serine-rich repeat glycoprotein (SRRP). SRRPs are conserved in many Gram-positive bacteria and play a role in bacterial adhesion, fimbrial formation, biofilm formation, and bacterial pathogenesis. Although SRRPs play such an important role, the exact mechanism of their biogenesis remains a mystery. For Fap1, an eleven gene cluster is …

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The Expression And Function Of Icam-2 In Neuroblastoma, Joseph Feduska Jan 2014

The Expression And Function Of Icam-2 In Neuroblastoma, Joseph Feduska

All ETDs from UAB

Neuroblastoma (NB) is the most common extracranial solid tumor in childhood, accounting for 15% of all childhood cancer deaths. At the time of initial diagnosis, the majority of patients present with NB that has already metastasized. While initial remission is often achieved following treatment, roughly 50% of these patients will relapse and die from the development of intractable metastatic progression. Intercellular adhesion molecule-2 (ICAM-2) is a transmembrane glycoprotein, normally expressed only in endothelial cells and subsets of leukocytes. ICAM-2 expression in cancer cells had not been previously investigated, until our lab recently reported the novel finding of endogenous ICAM-2 expression …

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