Digital Commons Network^™

Effectiveness Of Tailored Lifestyle Interventions, Using Web-Based And Print-Mail, For Reducing Blood Pressure Among Rural Women With Prehypertension: Main Results Of The Wellness For Women: Dashing Towards Health Clinical Trial, Patricia A. Hageman, Carol H. Pullen, Melody Hertzog, Linda S. Boeckner

Department of Nutrition and Health Sciences: Faculty Publications

Background: Lifestyle modification is recommended for management of prehypertension, yet finding effective interventions to reach rural women is a public health challenge. This community-based clinical trial compared the effectiveness of standard advice to two multi-component theory-based tailored interventions, using web-based or print-mailed delivery, in reducing blood pressure among rural women, ages 40–69, with prehypertension.

Methods: 289 women with prehypertension enrolled in the Wellness for Women: DASHing towards Health trial, a 12-month intervention with 12-month follow-up. Women were randomly assigned to groups using a 1:2:2 ratio, comparing standard advice (30-minute counseling session) to two interventions (two 2-hour counseling sessions, …

Dietary Cholesterol Promotes Adipocyte Hypertrophy And Adipose Tissue Inflammation In Visceral, But Not Subcutaneous, Fat In Monkeys, Soonkyu Chung, Helen Cuffe, Stephanie M. Marshall, Allison L. Mcdaniel, Jung-Heun Ha, Kylie Kavanagh, Cynthia Hong, Peter Tontonoz, Ryan E. Temel, John S. Parks

Department of Nutrition and Health Sciences: Faculty Publications

Objective—Excessive caloric intake is associated with obesity and adipose tissue dysfunction. However, the role of dietary cholesterol in this process is unknown. The aim of this study was to determine whether increasing dietary cholesterol intake alters adipose tissue cholesterol content, adipocyte size, and endocrine function in nonhuman primates.

Approach and Results—Age-matched, male African Green monkeys (n=5 per group) were assigned to one of three diets containing 0.002 (Lo), 0.2 (Med) or 0.4 (Hi) mg cholesterol/Kcal. After 10 weeks of diet feeding, animals were euthanized for adipose tissue, liver, and plasma collection. With increasing dietary cholesterol, free cholesterol (FC) content and …

Misunderstanding The Female Athlete Triad: Refuting The Ioc Consensus Statement On Relative Energy Deficiency In Sport (Red-S), Mary Jane De Souza, Nancy I. Williams, Aurelia Nattiv, Elizabeth Joy, Madhusmita Misra, Anne B. Loucks, Gordon Matheson, Marion P. Olmsted, Michelle Barrack, Rebecca J. Mallinson, Jenna C. Gibbs, Marci Goolsby, Jeanne F. Nichols, Barbara Drinkwater, Charlotte (Barney) Sanborn, Rosemary Agostini, Carol L. Otis, Mimi D. Johnson, Anne Zeni Hoch, Julia M. K. Alleyne, L. Tyler Wadsworth, Karsten Koehler, Jaci Vanheest, Paula Harvey, Amanda K. Weiss Kelly, Michael Fredericson, George A. Brooks, Emma O'Donnell, Lisa R. Callahan, Margot Putukian, Lauren Costello, Suzanne Hecht, Mitchell J. Rauh, Jacalyn Mccomb

Department of Nutrition and Health Sciences: Faculty Publications

We are concerned that readers of the IOC paper will be confused and misled by the poorly referenced statements and frank (and sometimes dangerous) errors in the paper. The IOC authors should publish a correction of these and other errors noted. Broadening research of low energy availability in other groups, such as the male athlete, athletes of diverse ethnicities and the disabled athlete may help to advance science and may one day warrant introduction of a specific term for whatever serious clinical sequelae of energy deficiency may be discovered in future research on men.

Research on the “Female Athlete Triad” …

Serum Coenzyme Q10, Α-Tocopherol, Γ-Tocopherol, And C-Reactive Protein Levels And Body Mass Index In Adolescent And Premenopausal Females, Weiwen Chai, Rachel Novotny, Gertraud Maskarinec, Loic Le Marchand, Adrian A. Franke, Robert V. Cooney

Department of Nutrition and Health Sciences: Faculty Publications

Objective

Lipid-soluble antioxidants are associated with a lower incidence for many chronic diseases of aging, possibly by preventing damage from chronic inflammation. In the current study, we compared serum levels of coenzyme Q₁₀ (CoQ₁₀), α-tocopherol, γ-tocopherol, and C-reactive protein (CRP) between adolescent girls and premenopausal women to assess changes from childhood to midlife.

Methods

Baseline serum CoQ₁₀, α-tocopherol, γ-tocopherol, and CRP levels were measured in 207 girls (13-19 years) and 183 premenopausal women (34-47 years) using standard methods and the two age groups were compared by t-test. The influence of age, body mass index (BMI) …

Egg Intake During Carbohydrate Restriction Alters Peripheral Blood Mononuclear Cell Inflammation And Cholesterol Homeostasis In Metabolic Syndrome, Catherine J. Andersen, Ji-Young Lee, Christopher N. Blesso, Timothy P. Carr, Maria Luz Fernandez

Department of Nutrition and Health Sciences: Faculty Publications

Egg yolk contains bioactive components that improve plasma inflammatory markers and HDL profiles in metabolic syndrome (MetS) under carbohydrate restriction. We further sought to determine whether egg yolk intake affects peripheral blood mononuclear cell (PBMC) inflammation and cholesterol homeostasis in MetS, as HDL and its associated lipid transporter ATP-binding cassette transporter A1 (ABCA1) reduce the inflammatory potential of leukocytes through modulation of cellular cholesterol content and distribution. Thirty-seven men and women classified with MetS consumed a moderate carbohydrate-restricted diet (25%–30% of energy) for 12 weeks, in addition to consuming either three whole eggs per day (EGG) or the equivalent amount …

Gene-Environment Interaction Of Body Mass Index And Apolipoprotein E Ε4 Allele On Cognitive Decline, Kumar B. Rajan, Kimberly A. Skarupski, Heather E. Rasmussen, Denis A. Evans

Department of Nutrition and Health Sciences: Faculty Publications

Genetic variation alone may not account for common chronic disease susceptibility. Rather, an interaction between genetic and environmental factors may clarify the underlying disease mechanism. Hence, we tested whether BMI modified the genetic association of the Apolipoprotein E (APOE) ε4 allele with cognitive decline. The data came from a longitudinal population-based sample of 4,055 participants interviewed at 3-year intervals from 1993 to 2012. Cognitive function was assessed using a standardized global cognitive score and BMI was assessed at baseline and classified as normal, overweight, and obese. There were 1,374 (34%) participants with the ε4 allele. In normal BMI participants, cognitive …

Safety And Immunogenicity Of Ontario Rabies Vaccine Bait (Onrab) In The First Us Field Trial In Raccoons (Procyon Lotor), Dennis Slate, Richard B. Chipman, Timothy P. Algeo, Samuel A. Mills, Kathleen M. Nelson, Christopher K. Croson, Edward J. Dubovi, Kurt C. Vercauteren, Randall W. Renshaw, Todd Atwood, Shylo Johnson, Charles E. Rupprecht

United States Department of Agriculture Wildlife Services: Staff Publications

In 2011, we conducted a field trial in rural West Virginia, USA to evaluate the safety and immunogenicity of a live, recombinant human adenovirus (AdRG1.3) rabies virus glycoprotein vaccine (Ontario Rabies Vaccine Bait; ONRAB) in wild raccoons (Procyon lotor) and striped skunks (Mephitis mephitis). We selected ONRAB for evaluation because of its effectiveness in raccoon rabies management in Ontario and Quebec, Canada, and significantly higher antibody prevalence rates in raccoons compared with a recombinant vaccinia-rabies glycoprotein (V-RG) vaccine, Raboral V-RGH, in US–Canada border studies. Raccoon rabies was enzootic and oral rabies vaccination (ORV) had never been …

Influence Of Corn Residue Harvest Management On Grain, Stover, And Energy Yields, Keri B. Cantrell, Jeffrey M. Novak, James R. Frederick, Douglas Karlen, Donald W. Watts

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

Economic, environmental, and energy independence issues are contributing to rising fossil fuel prices, petroleum supply concerns, and a growing interest in biomass feedstocks as renewable energy sources. Potential feedstocks include perennial grasses, timber, and annual grain crops with our focus being on corn (Zea mays L.) stover. A plot-scale study evaluating stover removal was initiated in 2008 on a South Carolina Coastal Plain Coxville/Rains–Goldsboro– Lynchburg soil association site. In addition to grain and stover yields, carbon balance, greenhouse gas (GHG) emissions and soil quality impact reported elsewhere in this issue, variation in gross energy distribution within various plant fractions …

Fitting Outbreak Models To Data From Many Small Norovirus Outbreaks, Eamon B. O'Dea, Kim M. Pepin, Ben A. Lopman, Claus O. Wilke

United States Department of Agriculture Wildlife Services: Staff Publications

Infectious disease often occurs in small, independent outbreaks in populations with varying characteristics. Each outbreak by itself may provide too little information for accurate estimation of epidemic model parameters. Here we show that using standard stochastic epidemic models for each outbreak and allowing parameters to vary between outbreaks according to a linear predictor leads to a generalized linear model that accurately estimates parameters from many small and diverse outbreaks. By estimating initial growth rates in addition to transmission rates, we are able to characterize variation in numbers of initially susceptible individuals or contact patterns between outbreaks. With simulation, we find …

A Landscape-Based Approach For Delineating Hotspots Of Wildlife-Vehicle Collisions, Nathan P. Snow, David M. Williams, William F. Porter

United States Department of Agriculture Wildlife Services: Staff Publications

Imposing human perceptions about the scales of ecological processes can produce unreliable scientific inferences in wildlife research and possibly misinform mitigation strategies. An example of this disconnect occurs in studies of wildlife-vehicle collisions (WVCs). Subjective procedures are often used to delineate hotspots of WVCs, resulting in hotspots that are not spatially independent. We developed a new approach that identifies independent hotspots using attributes of the landscape to inform delineations instead of subjective measures. First, we generated a candidate set of grouping scenarios using unique combinations of kernel-density estimation parameterization (i.e., bandwidth and isopleth values). Next, we associated the groups of …

West Nile Virus Isolated From A Virginia Opossum (Didelphis Virginiana) In Northwestern Missouri, Usa, 2012, Angela Bosco-Lauth, Jessica R. Harmon, R. Ryan Jash, Sonja Weiss, Stanley Langevin, Harry M. Savage, Marvin S. Godsey Jr., Kristen Burkhalter, J. Jeffrey Root, Thomas Gidlewski, William L. Nicholson, Aaron C. Brault, Nicholas Komar

United States Department of Agriculture Wildlife Services: Staff Publications

We describe the isolation of West Nile virus (WNV; Flaviviridae, Flavivirus) from blood of a Virginia opossum (Didelphis virginiana) collected in northwestern Missouri, USA in August 2012. Sequencing determined that the virus was related to lineage 1a WNV02 strains. We discuss the role of wildlife in WNV disease epidemiology.

An Agent-Based Movement Model To Assess The Impact Of Landscape Fragmentation On Disease Transmission, Jeff A. Tracey, Sarah N. Bevins, Sue Vandewoude, Kevin R. Crooks

United States Department of Agriculture Wildlife Services: Staff Publications

Landscape changes can result in habitat fragmentation and reduced landscape connectivity, limiting the ability of animals to move across space and altering infectious disease dynamics in wildlife. In this study, we develop and implement an agent-based model to assess the impacts of animal movement behavior and landscape structure on disease dynamics. We model a susceptible/infective disease state system applicable to the transmission of feline immunodeficiency virus in bobcats in the urbanized landscape of coastal southern California. Our agent-based model incorporates animal movement behavior, pathogen prevalence, transmission probability, and habitat fragmentation to evaluate how these variables influence disease spread in urbanizing …

From Passive Receptacles To Active Contenders: Ovulation And Intrasexual Competition In Human Females, Andres E. Munoz 14

Honor Scholar Theses

Recent evidence has suggested that ovulation in humans might be accompanied by subtle cues. Furthermore, several studies have suggested that women engage in intrasexual competition, or competition with members of the same sex, with the aim of obtaining high quality mates. This competition involves the use of complex strategies including self-promotion and rival derogation. The link between ovulation and intrasexual competition remains largely underexplored, although a few studies have suggested that intrasexual competition might become intensified during ovulation. This paper explores the relationship between ovulatory cue detection and intrasexual competition and outlines two research proposals for future analysis of this …

Assessing The Viability Of Converting Indiana's Energy Framework To Renewable Sources By 2050, Lincoln Barlow 14

Honor Scholar Theses

Conflicting views exist with regard to the feasibility of transitioning the world from a dependence on fossil fuel energy production to a completely renewable, emission-free energy climate. Findings show that the potential for Indiana to match its current energy production solely utilizing renewable energy capabilities existing on the Indiana landscape is available using a calculated combination of available resources from available analytical data. The annual required energy production, phased in gradually through the year 2050 and excluding the transportation sector, would consist of ~61% onshore wind energy (443,900 GWh), ~1% offshore wind energy (8,129 GWh), ~1% hydroelectric power (6,833 GWh), …

Unpacking The Suitcase: The Real Last Chapter Of Alice Paul And Peg Edwards’S Activism, And Why These Stories Matter, Clark Edwards 14

Honor Scholar Theses

I was fortunate enough to find a thesis topic within my own family. My paternal grandmother was guardian ad litem for Alice Paul in the later 1970s. Paul was instrumental in securing the passage of the 19th amendment, which gave women the right to vote, and author of the Equal Rights Amendment among other contributions for women’s rights. Fortunately my grandmother saved court records, letters, her notes, and more for her period of activism with Paul and as part of the Ridgefield Connecticut National Women’s Political Caucus. I knew nothing of my grandmother’s work until last year. My thesis seeks …

Social Childbirth And Communities Of Women In Early America, Jocelyn Jessop 14

Honor Scholar Theses

None

Heritable Health: An Exploration Of Parental Epigenetics And Their Impact On Individual And Public Health, Brittany F. Hayes 14

Honor Scholar Theses

None

Evolutionary Eating: A Critical Evaluation Of The Paleo Diet, Ben Roess 14

Honor Scholar Theses

None

Phenotype Of Transgenic Mice Carrying A Very Low Copy Number Of The Mutant Human G93a Superoxide Dismutase-1 Gene Associated With Amyotrophic Lateral Sclerosis, Jeffrey S. Deitch, Guillermo M. Alexander, Andrew Bensinger, Steven Yang, Juliann T. Jiang, Terry D. Heiman-Patterson

PCOM Scholarly Works

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of the motor neuron. While most cases of ALS are sporadic, 10% are familial (FALS) with 20% of FALS caused by a mutation in the gene that codes for the enzyme Cu/Zn superoxide dismutase (SOD1). There is variability in sporadic ALS as well as FALS where even within the same family some siblings with the same mutation do not manifest disease. A transgenic (Tg) mouse model of FALS containing 25 copies of the mutant human SOD1 gene demonstrates motor neuron pathology and progressive weakness similar to ALS patients, leading to death …

Emergency Airway Preparedness At Ambulatory Surgery Centers With Solo Anesthesia Providers: An Educational Intervention, Michael Shaylan Lord

Yale School of Nursing Digital Theses

Objectives: The unanticipated difficult airway is a life-threatening circumstance that requires skilled and immediate intervention by trained staff in order to avoid the complications of cardiac arrest, anoxic brain injury, and death. Ambulatory surgery centers with solo anesthesia providers are unique environments where interdisciplinary team members may be relied upon to support emergency airway management, thereby reducing the gap created by absent expert backup anesthesia personnel. An educational intervention was developed to increase emergency airway preparedness, as indicated by change in knowledge and self-efficacy.

Methods: A 75-minute pretest/posttest educational intervention focused on emergency airway preparedness at ambulatory surgery centers with …

Practice Authority For Advanced Practice Registered Nurses: Troubling Trends In Regulatory Variability, Susanne Johnson Phillips

Yale School of Nursing Digital Theses

In response to the national call to increase the healthcare provider workforce, states are enacting more laws to give APRNs full practice authority. However, the approach is incremental and often politically motivated, leading to wide variation in state laws. A significant area of regulatory variability relates to the point at which APRNs have full practice authority. Some states never allow it for one or more APRN roles; some states have a transition to practice, where, following licensure there is a period of oversight or supervision; some states allow full practice authority upon licensure. Full practice authority for APRNs upon licensure …

Immediate Return To Ambulation And Improved Functional Capacity For Rehabilition In Complex Regional Pain Syndrome Following Early Implantation Of A Spinal Cord Stimulation System, Brandon Jesse Goff, Jeremy Wingseng Naber, John Patrick Mccallin, Edward Michael Lopez, Kevin Brant Guthmiller, Karl Alan Lautenschlager, Tristan Toll Lai, Dean Harry Hommer, Gonzalez Raul Marin

PCOM Scholarly Works

Complex regional pain syndrome (CRPS) is a neuropathic pain condition that is characterized by vasomotor, sensory, sudomotor, and motor symptoms. Spinal cord stimulation (SCS) has been successfully utilized for the treatment of pain refractory to conventional therapies. We present a case of a previously highly functioning 54-year-old female who developed a rarely reported case of idiopathic CRPS of the right ankle which spontaneously occurred four months after an uncomplicated anterior cervical disc fusion. This condition resulted in severe pain and functional impairment that was unresponsive to pharmacological management. The patient's rehabilitation was severely stymied by her excruciating pain. However, with …

Who Writes? Gender And Judgment Assignment On The Supreme Court Of Canada, Peter Mccormick

Osgoode Hall Law Journal

This article poses the question: Now that women are receiving an increasing share of the seats on the Supreme Court of Canada (the Court), can we conclude with confidence that they have been admitted to full participation, with a mix of judgments—including the more significant decisions—that is fully comparable to their male colleagues? The author looks at the assignment of reasons for judgment on the Court over the last three chief justiceships, with specific reference to the relative rate of assignments to male and female judges. He finds that the male/female gap is more robust than ever, although he also …

Does Driver Safety Education Have An Impact On Texting While Driving?, Kelli Noble, Duane Young

Graduate Research Projects

In today’s society, Americans are more connected than ever. Gone are the days of pulling to the side of the road in order to find a pay phone to call for help, check in with family or find an address of a business in the yellow pages. All these tasks can now be accomplished while driving down the road. Most Americans have become accustomed to driving with distractions; changing the radio station, eating a snack or carrying on an in car conversation with passengers. Many profess that these distractions can be accomplished while maintaining an awareness of traffic conditions and …

The Role Of Translational Neuroscience In The Evidence-Based Practice Of Clinical Psychology, Anthony Beers

University Honors Theses

Is the Information Age progressing to the Knowledge Overload Age? The presence of big data, complex systems, and vast knowledge networks can overwhelm a clinician’s capacity to sift through abundant research findings and theoretical models. Demand for economically-driven evidence-based practice and the ethics of incorporating continuing education place enormous demands on clinicians that are difficult to achieve effectively, efficiently, and ethically. Translational science is a research discipline focused specifically on the production of valid and reliable uses developed from scientific research findings. In the discussions on translational science, one controversial issue has been the role translational neuroscience plays in clinical …

Disposable Platform Provides Visual And Color-Based Point-Of-Care Anemia Self-Testing, Erika A. Tyburski, Scott E. Gillespie, William A. Stoy, Robert G. Mannino, Alexander J. Weiss, Alexa F. Siu, Rayford H. Bulloch, Karthik Thota, Anyela Cardenas, Wilena Session, Hanna J. Khoury, Siobhán O'Connor, Silvia T. Bunting, Jeanne Boudreaux, Craig R. Forest, Manila Gaddh, Traci Leong, L. Andrew Lyon, Wilbur A. Lam

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Anemia, or low blood hemoglobin (Hgb) levels, afflicts 2 billion people worldwide. Currently, Hgb levels are typically measured from blood samples using hematology analyzers, which are housed in hospitals, clinics, or commercial laboratories and require skilled technicians to operate. A reliable, inexpensive point-of-care (POC) Hgb test would enable cost-effective anemia screening and chronically anemic patients to self-monitor their disease. We present a rapid, standalone, and disposable POC anemia test that, via a single drop of blood, outputs color-based visual results that correlate with Hgb levels.

METHODS. We tested blood from 238 pediatric and adult patients with anemia of varying …

Palestinian Women Of The Intifada: The Women’S Committees, 1987-1988, Melinda Cohoon

University Honors Theses

This study situates the Palestinian women’s committees within the initial year of Intifada, 1987-1988, to show that women’s committees were politically active yet were an inherent creation due to class issues. It became evident that these unofficial women’s popular organizations were a development of the 1970s. Furthermore, this study argues that the women’s committees were affected by issues of class, politics and gender; after all, their creation was due to the charitable societies exclusivity to upper and upper-middle class women, while gendered differences in tactics of women and women’s committees during the Intifada in comparison to the Shabbiba (youth movement) …

Gender Complex Curriculum For The Portland Public School District: Proposal, Kathryn Hayes

University Honors Theses

GLSEN states that 43.9% of students felt unsafe in school to express their preferred gender in the year 2011. This lack of safety can be attributed to a variety of factors including peer harassment, harassment by teachers or staff, lack of support or resources, unintentionally offensive language in the classroom, and lack of gender variety in historical figures and role models. The first part of this project is an original gender-complex curriculum aimed at creating a safer space inside the classroom for elementary aged students who may identify or express as gender variant by encouraging these, and other supportive behaviors …

The Media’S Presentation Of The Second Chance Act: Funding For Reentry Following Prison, A Content Analysis, Ailene Joyce Farkac

University Honors Theses

The US prison system has multiplied by four since 1980; each year about 730,000 people enter state and federal prisons and 700,000 people exit. As a result of this expansion, there is a massive increase of formerly incarcerated people reentering local communities every year. Budget cuts in prison programs and in local government’s social services are causing these individuals to be less educated and less prepared for reintegration; communities are also ill prepared to absorb them. The Second Chance Act was signed into law by President Bush on April 9, 2008. It authorized a pool of about $393m (renewed in …

The Changing Landscape Of Peer Aggression: A Literature Review On Cyberbullying And Interventions, Katie Davis, Justin Reich, Carrie James

Journal of Youth Development

While traditional forms of bullying have been steadily decreasing over the course of the last two decades, cyberbullying has emerged as a major concern among parents, teachers, and other professionals working with young people. Because cyberbullying is a relatively new phenomenon, its research base is not as well developed as research on traditional bullying. In this literature review, the authors synthesize current knowledge on cyberbullying’s prevalence among youth; its relationship to offline bullying; which youth are most likely to be perpetrators and victims; the negative effects of cyberbullying on victims; and the landscape of intervention efforts currently employed in the …