Digital Commons Network^™

The End Of An Era: The Cancer Stem Cell Hypothesis And Its Therapeutic Implications, Emily Paton

Independent Study Project (ISP) Collection

Cancer, a leading cause of death in many developed countries, has become a global health burden. Much of the drain on healthcare systems has resulted from the high cost and ineffectiveness of conventional cancer treatments, which often lead to cancer relapse or metastasis. The failures of chemotherapy, radiation, and surgery have been elucidated by the cancer stem cell (CSC) hypothesis, which postulates that a small percentage of tumor cells drive tumorigenesis. These cells can sustain cancer through their capacity to self-renew and differentiate into specialized tumor cell types, similar to how healthy stem cells maintain healthy tissues. Conventional cancer treatments …

Hiv Drug Resistance Among Infants And Children In South Africa: How Efficient Is Genotypic Testing?, Ellen Hendrix

Independent Study Project (ISP) Collection

Background: South Africa has the largest prevalence of HIV infection. This epidemic impacts adults as well as the pediatric population. The presence of drug-resistant mutations to antiretroviral therapies among infants and children is on the rise. Few studies have been conducted on this topic. Objective: The study aims to determine whether drug resistance testing in the form of genotypic testing is cost-effective when deciding whether to switch to a new HIV antiretroviral therapy following drug failure. Method: An interactive research approach is taken by collecting primary data from experts in this field. Secondary sources including guidelines from the World Health …

The Significance Of Comunidade Sabiaguaba Within The Developing City Of Fortaleza, Ce, Katherine Davis

Independent Study Project (ISP) Collection

The city of Fortaleza, Ceará has experienced rapid population growth and development over the last century, especially concentrated in the last fifty years. Today, this growth results in the creation of a beautiful tourist destination that many wish to visit, but also a dangerous and unequal city in which many have to live. Many state planners view this growth in infrastructure and tourism as the solution for the economic hardships of Fortaleza. However, many residents are unsatisfied with this development plan, and feel that there is a disconnect between the needs of the people and the plans of the state. …

Violence Against Women And Machismo A Research Study Of How Machismo Justifies Cases Of Violence Against Women And The Psychological Process That Influence Women To Remain In Abusive Relationships In The City Of Fortaleza, Rosa Cabrera

Independent Study Project (ISP) Collection

This research is a study on the phenomenon of violence against women that the city of Fortaleza is currently experiencing. Violence against women is an issue that is affecting women worldwide, however in the context of Fortaleza it has become extremely prominent. This study looks whether or not the socialization process of men and women influence rates of violence against women, if institutions are giving life to this violence, and how violence is manifesting in the lives of women in Fortaleza through the eyes of three professionals at Centro de Referencia, one professional at the Delegacia de Defesa da Mulher …

Eradicating Slavery In Maranhão: Impunity And Capitalism, Zachary Patton

Independent Study Project (ISP) Collection

The purposes of this research are to raise awareness of the occurrence of slavery in the 21st century, explain how and why slavery still exists in the northeast of Brazil, more specifically in Maranhão, and to explain what state and federal agencies and NGOs are attempting to do to eradicate slavery. Despite the emancipation of slavery in 1888, this insidious practice continues in regions with a history of slavery and a lack of anti-slavery legislation implementation. Through examining the challenges of enforcing legislation in the criminal justice system, the author constructs a current characterization of slavery in Maranhão. In the …

La Psiquiatría Comunitaria En La Corporación Bresky / Community Psychiatry In The Bresky Corporation, Connery O’Brien

Independent Study Project (ISP) Collection

The purpose of this paper is to provide insight on the community model of rehabilitation for individuals with mental health disorders in Chile with a specific focus on schizophrenia. Stigmas surrounding mental health are still very prevalent in this society. These stigmas make it difficult for patients to integrate themselves into society, and in turn, add stress to the patients’ families, who must support and care for them. The community model of mental health rehabilitation is important to consider in the efforts to re-integrate these patients into society. La Corporación Bresky, a rehabilitation center in Peñablanca, will be used as …

We Are Not The Future, We Are The Present: Cantera, Young People, And Community Development, Emily Rapport

Independent Study Project (ISP) Collection

CANTERA, a community organization in Ciudad Sandino with a popular education methodology, has a mission that emphasizes both personal development of its participants and social change in its community as outcomes of its work. The author of this paper looks at the connection between personal and community development in the youth programs at CANTERA, which include a variety of sociocultural and advocacy groups. The author spent three and a half weeks conducting participant observation of CANTERA's youth programs and interviewing its young people and staff members. The author presents her findings in three distinct sections. First, two case studies of …

Blood Sacrifice: The Connection Between Roman Death Rituals And Christian Martyrdom, Angela Dawne Kennedy

Honors Theses

Scholars from a variety of disciplines have done some incredible work on the subject of martyrdom, but the story is far from complete, particularly in terms of how and why it was so similar to the Roman concept of public deaths. The primary sources include the surviving Christian martyrologies, Greco-Roman philosophical treatises, and Roman, Christian, and Jewish histories. Martyrdom itself was a tool of assimilation that somehow bridged the communities of the empire together. There is a huge body of information in a variety of genres that contribute to this project. But there exists a hole in the combined scholarship …

Social Networking Site Use Among Caregivers Of Children With Autism Spectrum Disorders, Murad Moqbel, Lauren Little

Information Systems Faculty Publications

Caregivers of children with autism spectrum disorder (ASD) experience higher levels of stress relative to those of children with other developmental disabilities and typical development. To date, little research has empirically examined the relationship between social supports, social networking site (SNS) use, and stress among caregivers of children with ASD. Using the resiliency model of family stress, adjustment, and adaptation as a theoretical framework, we explore the links between perceived social supports, SNS use, and stress among caregivers of children with ASD. We do this by conducting a crosssectional research design and using a structural equation modeling statistical approach. Practical …

Teacher And Administrator Perceptions Of The Implementation Of The Teacher Incentive Fund (Tif) Grant In Mississippi Pilot Schools, Albert William Carter

Dissertations

The purpose of this research study was to assess administrators and teachers’ perceptions of the key components of the Mississippi Teacher Incentive Fund (TIF) grant in Mississippi pilot schools. The study examines the difference in perceptions between administrators and teachers. The study also investigated if there was a relationship with the TIF grant and student achievement by comparing the percent of students who scored a minimum of proficient on the MCT2 in TIF schools before and after the grant. Achievement was also examined by comparing percent of proficiency of TIF schools with comparable, non-TIF Mississippi schools.

The participants in the …

Comparing Mississippi's Public University Graduation Rates For Community College Completers And Non-Completers, Andrew Clark Dale

Dissertations

This study is based on the notion that in Mississippi, a large number of Mississippi community college academic students transfer to 4-year universities in-state, as is the case in Alabama (Sacksteder LaClair, 2010). Mississippi community colleges have had a hard time tracking students who leave the institution without graduating. This study sought to document the most accurate numbers in community college completers and discover how many of Mississippi’s community college students are successful at the university level. Data were collected on former community college students at five of the state’s eight public four-year universities. The study revealed that 82% of …

Tuning Responsiveness Of Polypeptide Based Block Copolymers For Drug Delivery, Ashley J. Johnson

Dissertations

The goal of this dissertation was to tune the pH response and self-assembled morphologies of amphiphilic polypeptide block copolymers for use as drug delivery vehicles. Poly(L-lysine) and poly(L-glutamtic acid) are responsive, ionizable polypeptides that undergo secondary structure transitions, from α-helix to random coil, whereby the change in conformation of the peptide chain results in changes to the global morphology of a self-assembled system. The main focus of this work was to understand how changes in the polymer composition and the local environment can lead to control over the behavior of the overall system. First, the responsive behavior of poly(L-lysine) block …

Elementary Teachers' Sense Of Self Efficacy And Professional Development Experiences Of Teaching Informational Text, Mary Desiree Lee

Dissertations

According to the International Reading Association, becoming a successful citizen in one’s career and personal life requires the use of literacy skills (International Reading Association, 1999). However, students in the United States have scored low on the literacy portions of the National Assessment of Educational Progress and the ACT prompting the National Governor’s Association to author a set of standards with a goal of providing students a balance between narrative and informational text (National Governors Association Center for Best Practices, Council of Chief State School Officers, 2010). Scores were below the national average in the southeastern region of the United …

The Self-Directedness, Metacognitive Awareness, Self-Efficacy Beliefs, And Grammatical Competence Of College Students Studying Spanish, Juan Guillermo Loaiza

Dissertations

Differential performance is a frequent issue in formal education in general and in second language education in particular. Three variables that may have an effect on college language learners’ performance were identified in the literature on adult education and second language acquisition, namely, self-directed learning, metacognitive awareness, and self-efficacy beliefs. The relationship among those three predictors as well as their relationship with academic performance (in the form of college learners’ grammatical competence in Spanish) was explored using a multiple regression analysis. The statistical analysis showed that none of those three variables predicted learners’ grammatical competence in Spanish. However, participants’ answers …

Blue Mountain: A Chamber Opera For Winds And Voices By Justin Dello Joio: A Unique Contribution For Wind Band Literature, Armando Saldarini

Dissertations

Blue Mountain is an opera in one act scored for four voices, and thirty-three instruments, commissioned by Det Norske Blaseensemble. Under the direction of Kenneth Jean, the premiere took place on October 8, 2007, at Kanonhalen in Oslo, Norway, as part of the Edvard Grieg Centennial celebrations and the 2007 Ultima contemporary Music Festival. The opera takes place in Troldhaugen, Norway, during the last days of Edvard Grieg’s life. Suffering from emphysema, Grieg was being treated by his doctor with morphine that created great anxiety, fear, and mental torment. A visit from his friend, Percy Grainger, gave Grieg great …

Self-Regulated Strategy Development (Srsd) For Writing: A Tier 2 Intervention For Fifth Grade, Christina A. Flanders Psyd

All Student Scholarship

The purpose of this study was to examine whether Self-Regulated Strategy Development (SRSD) for writing could be used as a Tier 2 intervention to improve the writing of fifth grade students identified as performing below the 50th percentile on AIMSweb curriculum-based measures of correct writing sequences (WE-CBM CWS). Results of RMANOVA indicated that students in the SRSD Group made significant improvements in their WE-CBM mean score compared to the Control Group from pre- to post-test. Additional analyses using a modified WE-CBM that added one minute for students to organize their writing thoughts (EWE-CBM) did not show significant improvements to mean …

Thermal And Mechanical Response Of Particulate Composite Plates Under Inertial Excitation, Jacob K. Miller, Daniel C. Wood, Jeffrey F. Rhoads

Purdue Energetics Research Center Articles

The thermal and mechanical, near-resonant responses of particulate composite plates formed from hydroxyl-terminated polybutadiene (HTPB) binder and varying volume ratios of ammonium chloride (NH4Cl) particles (50, 65, 75%) are investigated. Each test specimen is clamped and forced with three levels of band-limited, white noise inertial excitation (10–1000 Hz at 1.00, 1.86 and 2.44 g RMS). The mechanical response of each plate is recorded via scanning laser Doppler vibrometry. The plates are then excited at a single resonant frequency and the thermal response is recorded via infrared thermography. Comparisons are made between the mechanical operational deflection shapes of each plate and …

2014 Owl Usability Report, Michael Salvo, Andrea Alvarez, Kira M. Cazenave, Carly A. Harmon, Tanner Heffner, Mary Mccall, Kristin Mcfarland, Kaitlyn Neis, Jessica Schwingendorf, Broc Smith, Andrew H. Yim

Purdue Writing Lab/Purdue OWL Research Reports

Consisting of six sections, this report was completed by groups composed of students registered for ENGL515: Advanced Professional Writing. Studying the concepts of User-centered Design, Usability, and User Experience Design (UxD), the students offer this report and accompanying redesign materials for the use of Purdue’s Online Writing Lab (OWL). It is presented to Tammy S. Conard-Salvo, Associate Director of the OWL, in support of user research conducted throughout fall 2014 and into spring 2015. This report is aimed at improving the user’s experience of the OWL and as such offers methods of learning more about the site’s audience and both …

Enhancement Of The Low Frequency Performance Of Thin, Film-Faced Layers Of Foam By Surface Segmentation, J Stuart Bolton, Benoit Nennig, Nicolas Dauchez

Publications of the Ray W. Herrick Laboratories

While the control of high frequency noise by the use of porous treatments is relatively straightforward, it is correspondingly difficult to control low frequency noise owing to the general requirement that a porous layer should be a significant fraction of a wavelength in depth. Thus, it is of interest to develop low frequency sound absorbing treatments that are relatively compact by the use of surface treatments. Here, we illustrate an approach, in which a surface film is cut, to allow the incident sound to communicate directly with the air within the foam behind the film facing.

The present work was …

Collection Management Matters: Frienemies: Vendor Tech Support, Glenda Alvin

Against the Grain

No abstract provided.

Don's Conference Notes: Charleston Seminar: Introduction To Data Curation, Donald T. Hawkins

Against the Grain

No abstract provided.

Table Of Contents

Against the Grain

No abstract provided.

And They Were There: Reports Of Meetings, Sever Bordeianu

Against the Grain

No abstract provided.

You Complete Me: On Building A Vertically Integrated Digital Humanities Program At The University Of Georgia, Lisa Bayer

Against the Grain

No abstract provided.

Little Red Herrings: The Coming Bubble Bust, Mark Y. Herring

Against the Grain

No abstract provided.

Academic Publishing Is Not In Crisis: It's Just Changing, John Hussey

Against the Grain

No abstract provided.

Publishing, Libraries, Publishers And Librarians, Maria Bonn

Against the Grain

No abstract provided.

Library And University Press Publishing: Then And Now, Bob Nardini

Against the Grain

No abstract provided.

Booklover: Synchronicity, Donna Jacobs

Against the Grain

No abstract provided.

If Rumors Were Horses, Katina Strauch

Against the Grain

No abstract provided.