Digital Commons Network^™

Small-Molecule Probes Targeting The Viral Ppxy-Host Nedd4 Interface Block Egress Of A Broad Range Of Rna Viruses., Ziying Han, Jianhong Lu, Yuliang Liu, Benjamin Davis, Michael S Lee, Mark A Olson, Gordon Ruthel, Bruce D Freedman, Matthias J. Schnell, Jay E Wrobel, Allen B Reitz, Ronald N Harty

Department of Microbiology and Immunology Faculty Papers

Budding of filoviruses, arenaviruses, and rhabdoviruses is facilitated by subversion of host proteins, such as Nedd4 E3 ubiquitin ligase, by viral PPxY late (L) budding domains expressed within the matrix proteins of these RNA viruses. As L domains are important for budding and are highly conserved in a wide array of RNA viruses, they represent potential broad-spectrum targets for the development of antiviral drugs. To identify potential competitive blockers, we used the known Nedd4 WW domain-PPxY interaction interface as the basis of an in silico screen. Using PPxY-dependent budding of Marburg (MARV) VP40 virus-like particles (VLPs) as our model system, …

Systemic Hematogenous Maintenance Of Memory Inflation By Mcmv Infection., Corinne J Smith, Holly Turula, Christopher M. Snyder

Department of Microbiology and Immunology Faculty Papers

Several low-grade persistent viral infections induce and sustain very large numbers of virus-specific effector T cells. This was first described as a response to cytomegalovirus (CMV), a herpesvirus that establishes a life-long persistent/latent infection, and sustains the largest known effector T cell populations in healthy people. These T cells remain functional and traffic systemically, which has led to the recent exploration of CMV as a persistent vaccine vector. However, the maintenance of this remarkable response is not understood. Current models propose that reservoirs of viral antigen and/or latently infected cells in lymph nodes stimulate T cell proliferation and effector differentiation, …

Prosociality And The Military, Alexander J. Field

Economics

In this paper, I consider a body of observational evidence not commonly studied by social scientists, namely the behavior of men and women (mostly men) in the military. I focus here on two issues: first the behavioral foundations for creating an effective military unit and second, evidence that infantrymen have historically been reluctant to fire on the enemy and how this reluctance has been overcome in the last half century through changes in military training. The evidence in each of these areas reinforces the appeal of the idea of cognitive modularity, the view that thought and behavior are influenced by …

Preparing For Storms In Louisiana Student Manual, 2nd Edition, Pam Jenkins, Maggie Olivier, Race Hodges, Hazel Spaulding Parker, Monica Farris, Kim Mosby, Kyle Griffith, Jeff Rinehart, Kyle Tveten

CHART Publications

Louisiana is at risk from natural and man-made disasters. Flooding, tropical storms, and hurricanes happen. To stay safe, sometimes you and your family will need to leave home before a storm comes.

People in Louisiana need to be ready for emergencies. This guide will help you get prepared.

Preparing For Storms In Louisiana Take Home Guide, 2nd Edition (English), Pam Jenkins, Maggie Olivier, Race Hodges, Hazel Spaulding Parker, Monica Farris, Kim Mosby, Kyle Griffith, Jeff Rinehart, Kyle Tveten

CHART Publications

Louisiana is at risk from natural and man-made disasters. Flooding, tropical storms, and hurricanes happen. To stay safe, sometimes you and your family will need to leave home before a storm comes.

People in Louisiana need to be ready for emergencies. This is your take home guide. It helps you prepare for storms.

Preparing For Storms In Louisiana Take Home Guide, 2nd Edition (English/Spanish), Pam Jenkins, Maggie Olivier, Race Hodges, Hazel Spaulding Parker, Monica Farris, Kim Mosby, Kyle Griffith, Jeff Rinehart, Kyle Tveten, Alea Cot

CHART Publications

Louisiana is at risk from natural and man-made disasters. Flooding, tropical storms, and hurricanes happen. To stay safe, sometimes you and your family will need to leave home before a storm comes.

People in Louisiana need to be ready for emergencies. This take home guide will help you get prepared.

Preparing For Storms In Louisiana English/Spanish Flashcards, Pam Jenkins, Maggie Olivier, Race Hodges, Hazel Spaulding Parker, Monica Farris, Kim Mosby, Kyle Griffith, Jeff Rinehart, Kyle Tveten, Alea Cot

CHART Publications

Louisiana is at risk from natural and man-made disasters. Flooding, tropical storms, and hurricanes happen. To stay safe, sometimes you and your family will need to leave home before a storm comes.

People in Louisiana need to be ready for emergencies. These flashcards will help you get prepared.

Why Retributivism Needs Consequentialism: The Rightful Place Of Revenge In The Criminal Justice System, Ken Levy

Journal Articles

Consider the reaction of Trayvon Martin’s family to the jury verdict. They were devastated that George Zimmerman, the defendant, was found not guilty of manslaughter or murder. Whatever the merits of this outcome, what does the Martin family’s emotional reaction mean? What does it say about criminal punishment – especially the reasons why we punish? Why did the Martin family want to see George Zimmerman go to jail? And why were – and are – they so upset that he didn’t? This Article will argue for three points. First, what fuels this kind of outrage is vengeance: the desire to …

Visual Propaganda And Extremism In The Online Environment, Cori E. Dauber, Carol K. Winkler

Books, Monographs & Collaborative Studies

Visual images have been a central component of propaganda for as long as propaganda has been produced. But recent developments in communication and information technologies have given terrorist and extremist groups options and abilities they never would have been able to come close to even 5 or 10 years ago. There are terrorist groups who, with very little initial investment, are making videos that are coming so close to the quality of BBC or CNN broadcasts that the difference is meaningless, and with access to the web they have instantaneous access to a global audience. Given the broad social science …

Gmos: Are They A Regulatory Or Food Safety Issue?, Richard E. Goodman

Department of Food Science and Technology: Faculty Publications

Most of the genetic diversity that has improved agricultural production throughout the history of farming was developed through natural mutations and selective breeding. However, since the early 1900s plant scientists have used chemical and radiation mutagenesis to increase genetic diversity (18). We know that the majority of mutations are harmful, and plant breeders work hard to select only those that are beneficial. This process has helped feed a growing human population, which is estimated to have been 300 million 2,000 years ago and is now more than 7 billion. However, methods used in the past to improve agricultural production are …

Experimental And Numerical Investigation Of The Mechanism Of Blast Wave Transmission Through A Surrogate Head, Yi Hua, Praveen Akula, Linxia Gu, Jeff Berg, Carl A. Nelson

Department of Mechanical and Materials Engineering: Faculty Publications

This work is to develop an experiment-validated numerical model to elucidate the wave transmission mechanisms through a surrogate head under blast loading. Repeated shock tube tests were conducted on a surrogate head, i.e., water-filled polycarbonate shell. Surface strain on the skull simulant and pressure inside the brain simulant were recorded at multiple locations. A numerical model was developed to capture the shock wave propagation within the shock tube and the fluid-structure interaction between the shock wave and the surrogate head. The obtained numerical results were compared with the experimental measurements. The experiment-validated numerical model was then used to further understand …

Finite Element Modeling Of Long-Term Phosphorus Leaching Through Macropores In The Ozark Ecoregion, Ryan P. Freiberger, Derek M. Heeren, Garey A. Fox, Chad J. Penn, Dean E. Eisenhauer

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Phosphorus (P) is a critical nutrient for plant growth in agriculture, but is also responsible for surface water enrichment that leads to toxic algal growth. While P loading to surface waters has traditionally been thought to occur from surface runoff, contributions from subsurface transport can also be significant. While P transport through many soil types is well-documented, the presence of highly conductive gravel outcrops and macropore networks can have a significant, yet poorly-documented effect on P movement to the aquifer. Floodplain soils in the Ozark ecoregion generally contain coarse chert gravel layers that exhibit macropore behavior. Previous research has evaluated …

Across-Year Social Stability Shapes Network Structure In Wintering Migrant Sparrows, Daizaburo Shizuka, Alexis S. Chaine, Jennifer Anderson, Oscar Johnson, Inger Marie Laursen, Bruce E. Lyon

School of Biological Sciences: Faculty Publications

Migratory birds often form flocks on their wintering grounds, but important details of social structure such as the patterns of association between individuals are virtually unknown. We analysed networks of co-membership in short-term flocks for wintering golden-crowned sparrows (Zonotrichia atricapilla) across three years and discovered social complexity unsuspected for migratory songbirds. The population was consistently clustered into distinct social communities within a relatively small area (~ 7 ha). Birds returned to the same community across years, with mortality and recruitment leading to some degree of turnover in membership. These spatiotemporal patterns were explained by the combination of space …

Explaining Research Utilization Among 4-H Faculty, Staff, And Volunteers: The Role Of Self-Efficacy, Learning Goal Orientation, Training, And Previous Experience, Julianne Tillman, Lynette H. Bikos

Journal of Youth Development

An investigation of factors that facilitate the utilization of research evidence among faculty, staff, and volunteers in the 4-H Youth Development Program is presented in this paper. Participants (N = 368; 86 4-H faculty, 153 staff, and 129 volunteers) represented 35 states; structural equation modeling was utilized in the analyses. Results of the path analysis explained 56% of variance in research utilization and 28% in research utilization self-efficacy. Among the factors impacting research utilization, self-efficacy played the most important role. In turn, self-efficacy for research utilization was positively influenced by participants’ learning goal orientation, frequency of 4-H training during the …

Transcriptome Of The Female Synganglion Of The Black-Legged Tick Ixodes Scapularis (Acari: Ixodidae) With Comparison Between Illumina And 454 Systems, Noble Egekwu, Daniel E. Sonenshine, Brooke W. Bissinger, R. Michael Roe

Biological Sciences Faculty Publications

Illumina and 454 pyrosequencing were used to characterize genes from the synganglion of female Ixodes scapularis. GO term searching success for biological processes was similar for samples sequenced by both methods. However, for molecular processes, it was more successful for the Illumina samples than for 454 samples. Functional assignments of transcripts predicting neuropeptides, neuropeptide receptors, neurotransmitter receptors and other genes of interest was done, supported by strong e-values (<-6), and high consensus sequence alignments. Transcripts predicting 15 putative neuropeptide prepropeptides ((allatostatin, allatotropin, bursicon α, corticotropin releasing factor (CRF), CRF-binding protein, eclosion hormone, FMRFamide, glycoprotein A, insulin-like peptide, ion transport peptide, myoinhibitory peptide, inotocin ( = neurophysin-oxytocin), Neuropeptide F, sulfakinin and SIFamide)) and transcripts predicting receptors for 14 neuropeptides (allatostatin, calcitonin, cardioacceleratory peptide, corazonin, CRF, eclosion hormone, gonadotropin-releasing hormone/AKH-like, insulin-like peptide, neuropeptide F, proctolin, pyrokinin, SIFamide, sulfakinin and tachykinin) are reported. Similar to Dermacentor variabilis, we found transcripts matching pro-protein convertase, essential for converting neuropeptide hormones to their mature form. Additionally, transcripts predicting 6 neurotransmitter/neuromodulator receptors (acetylcholine, GABA, dopamine, glutamate, octopamine and …

The Saco River Plume: A Discussion Of The Near-Field Dynamics, Barbara A. Fortier

All Theses And Dissertations

This study focused on the freshwater discharge plume from the Saco River in southwestern Maine to determine the mechanisms responsible for the largest impacts on the near-field dynamics in this region. We examined the forcing factors that tended to increase the plume's spatial extent upshelf of the river mouth. Salinity, temperature, and density data were collected during cruises from May through November 2010 and by two surface moorings deployed upshelf of the Saco River mouth. We found a distinct variation in the latitude of the upshelf boundary of the plume during and after periods of high discharge. Furthermore, we found …

Got Lost Behind The Scenes: Underexposed Television Producers In Magazines, Jordan King

Pell Scholars and Senior Theses

Award-winning television shows are popularly depicted through digital media and magazine coverage. However, the strenuous efforts of TV producers are hidden behind the publicity of celebrities and plotlines of the show. Using Eugene Shaw's agenda-setting theory and Robert Entman's framing theory as a basis, the author created a case study analyzing how the producers of Lost and Game of Thrones are portrayed in magazines. The research shows that reporters tend to perpetuate the anonymity of these producers, which in effect, leads an audience to deem them as unimportant.

Product Of The Past: The Struggle Between The Lakota Sioux Nation And The United States Government, Brittany Lombardo

Pell Scholars and Senior Theses

Many may be familiar with the national landmark that is Mount Rushmore, located in South Dakota. The heroes represent the leaders of the United States, the founding fathers. However, it shadows a rich history that is what came before the United States' invasion. The Lakota Sioux roamed freely throughout the Midwest, that is until the the US began to expand westward. The rich history of the Lakota lingers throughout their lives today, but is suppressed under a thick lair of oppression and mistreatment by the United States Government.

1.0 Mission, History, General Organization And Governance Of Saint Mary’S College, Saint Mary's College Of California

Faculty Handbook

No abstract provided.

Complete Handbook, Saint Mary's College Of California

Faculty Handbook

No abstract provided.

Part Ii: Graduate And Professional Honor Code, Saint Mary's College Of California

Graduate and Professional Student Handbook (2009-2018)

No abstract provided.

Complete Handbook, Saint Mary's College Of California

Graduate and Professional Student Handbook (2009-2018)

No abstract provided.

Part Iv. Community And Student Policies, Saint Mary's College Of California

Graduate and Professional Student Handbook (2009-2018)

No abstract provided.

3.0 Academic Policies And Services, Saint Mary's College Of California

Faculty Handbook

No abstract provided.

From Self-Sacrifice To Self-Preservation: The Changing Roles Of Southern Women During America's Civil War, Jennifer E. Edine

Pell Scholars and Senior Theses

The Civil War is an event in American history that will continue to be discussed and analyzed for years to come. The conflict affected the entire population of the country, regardless of social class or race. One of the most important changes in southern society was the change in the roles and ideologies of southern women as a result of the war. Before the war, the South was a patriarchal society with prominent gender roles and ideologies on how the perfect Southerner should behave. Ideally, the Cavalier Man, filled with honor and chivalry, was meant to be in complete control. …

2014/2015 University Of The Pacific [Stockton] Graduate Catalog, University Of The Pacific

Catalogue, Bulletin, Catalog

No abstract provided.

4.0 Administrative Policies, Services And Facilities, Saint Mary's College Of California

Faculty Handbook

No abstract provided.

Analysis Of Data Center Network Convergence Technologies, Robert-Lee Daniel Leblanc

Theses and Dissertations

The networks in traditional data centers have remained unchanged for decades and have grown large, complex and costly. Many data centers have a general purpose Ethernet network and one or more additional specialized networks for storage or high performance low latency applications. Network convergence promises to lower the cost and complexity of the data center network by virtualizing the different networks onto a single wire. There is little evidence, aside from vendors' claims, that validate network convergence actually achieves these goals. This work defines a framework for creating a series of unbiased tests to validate converged technologies and compare them …

Cognitive Function Following Bubble-Contrast Transcranial Doppler For Evaluation Of Right-To-Left Shunt, Erin Elizabeth Krauskopf

Theses and Dissertations

Background: Stroke is a leading cause of significant physical, cognitive, and psychiatric morbidity. One risk factor for stroke is paradoxical embolization through a patent foramen ovale (PFO). In cardiac clinical practice, power M-mode Transcranial Doppler (TCD) evaluation is the gold standard for diagnosis of PFO, or right-to-left cardiac shunt (RLS). Brain micro-embolization due to diagnostic bubble contrast echocardiography may cause neurological symptoms in patients with PFO. However, the neurocognitive effects of TCD have not been studied. Objective: The purpose of this study was to evaluate cognitive outcomes in patients who undergo routine diagnostic bubble contrast TCD. The aims of the …

Caves As Anti-Places: Robert Penn Warren’S The Cave And Cormac Mccarthy’S Child Of God, Ralph Crane, Lisa Fletcher

Reconstruction: Studies in Contemporary Culture

In Robert Penn Warren's poem "Speleology," a young boy turns off his flashlight deep in a cave and knows "darkness and depth and no Time." This poem's powerful imagery of the spatial otherness of caves is the starting point for this article, which argues that analyzing the literary representation of natural subterranean voids requires a careful re-theorisation of the dynamic relations of space and place. The difficult question of how meaning comes to be attached to a particular space, thus transforming it into place, is central to Robert Penn Warren's The Cave and Cormac McCarthy’s Child of God, both …