Digital Commons Network^™

Vagal Nerve Stimulation Therapy: What Is Being Stimulated?, Guy Kember, Jeffrey L. Ardell, John A. Armour, Mair Zamir

ETSU Faculty Works

Vagal nerve stimulation in cardiac therapy involves delivering electrical current to the vagal sympathetic complex in patients experiencing heart failure. The therapy has shown promise but the mechanisms by which any benefit accrues is not understood. In this paper we model the response to increased levels of stimulation of individual components of the vagal sympathetic complex as a differential activation of each component in the control of heart rate. The model provides insight beyond what is available in the animal experiment in as much as allowing the simultaneous assessment of neuronal activity throughout the cardiac neural axis. The results indicate …

Design, Assessment, And In Vivo Evaluation Of A Computational Model Illustrating The Role Of Cav1 In Cd4+ T-Lymphocytes, Brittany D. Conroy, Tyler A. Herek, Timonthy D. Shew, Matthew Latner, Joshua J. Larson, Laura Allen, Paul H. Davis, Tomáš Helikar, Christine E. Cutucache

Department of Biochemistry: Faculty Publications

Caveolin-1 (CAV1) is a vital scaffold protein heterogeneously expressed in both healthy and malignant tissue. We focus on the role of CAV1 when overexpressed in T-cell leukemia. Previously, we have shown that CAV1 is involved in cell-to-cell communication, cellular proliferation, and immune synapse formation; however, the molecular mechanisms have not been elucidated.We hypothesize that the role of CAV1 in immune synapse formation contributes to immune regulation during leukemic progression, thereby warranting studies of the role of CAV1 in CD4⁺ T-cells in relation to antigen-presenting cells. To address this need, we developed a computational model of a CD4⁺ immune …

Mating Dynamics Of The Calanoid Copepods Acartia Tonsa And Acartia Hudsonica, Zair P Lojkovic Burris

Doctoral Dissertations

Copepods are the most abundant metazoans in the ocean, link the microbial plankton to upper trophic levels, and affect ecosystem function through their role in biogeochemical cycles. This thesis focuses on an understudied area in copepods-- factors that determine mating success. First, I tested the hypothesis that female-biased adult sex ratios of Acartia tonsa may be explained by ratios already skewed at birth. Offspring of field-caught females were raised to adulthood and the corresponding adult sex ratios were used as proxies for birth ratios. Almost one-fifth of mothers produced significantly female-biased sex ratios, suggesting that secondary processes commonly used to …

Famine In Context: Possible Long-Term Effects Of Exposure To Starvation And Malnutrition In Early Life And Subsequent Implications For The Current Crisis In South Sudan, Jenna Mae Stoken

Honors Projects

Central focus

The central focus of this thesis is to examine the historical and sociopolitical roots of famine. In examining the root causes of famine, we can more carefully analyze its effects on the human condition. More specifically, in analyzing the pathologies associated with food deprivation and malnutrition at an early age, we can examine the possible long-term consequences of malnutrition on human health. In doing so, we can apply this understanding to the current crisis in South Sudan, to consider the implications that the current political situation presents for future generations of South Sudanese people.

Thesis rationale

This thesis …

The Impact Of Prenatal Stress On The Development Of Limbic System Structures, Alyssa Murray

Honors Theses

Stress in early life is well documented as detrimental for the brain’s developmental trajectory, while prenatal stress is minimally explored. In the prenatal period, the placenta prevents much of the mother’s cortisol from reaching the fetus, but the fetus is still exposed to some maternal cortisol, and exposure increases with increasing stress. One neural structure particularly susceptible to stress is the hippocampus. The goal of this review is to address the role prenatal stress may play in damaging the hippocampus, a structure integral to learning and memory functions. Correlations between prenatal stress and a reduction in volume and function of …

Spontaneous Asj-2j Mutant Mouse As A Model For Generalized Arterial Calcification Of Infancy: A Large Deletion/Insertion Mutation In The Enpp1 Gene., Qiaoli Li, C Herbert Pratt, Louise A Dionne, Heather Fairfield, Son Yong Karst, John P Sundberg, Jouni Uitto, Yin Tintut

Department of Dermatology and Cutaneous Biology Faculty Papers

Generalized arterial calcification of infancy (GACI), an autosomal recessive disorder caused by mutations in the ENPP1 gene, manifests with extensive mineralization of the cardiovascular system. The affected individuals in most cases die within the first year of life, and there is currently no effective treatment for this disorder. In this study, we characterized a spontaneous mutant mouse, asj-2J, as a model for GACI. These mice were identified as part of a phenotypic deviant search in a large-scale production colony of BALB/cJ mice at The Jackson Laboratory. They demonstrated a characteristic gait due to stiffening of the joints, with phenotypic similarity …

Changing Trends In The Content And Purpose Of Mexico's Intellectual Property Right Regime, Alan S. Gutterman

Georgia Journal of International & Comparative Law

No abstract provided.

Middle To Late Holocene Vegetation Shifts In The Nw Transylvanian Lowlands (Romania), Roxana Grindean, Ioan Tanţău, Sorina Fărcaş, Andrei Panait

Studia UBB Geologia

The Iaz peat bog, located in northwestern Transylvania at 300 m a.s.l., was cored to study the Middle to Late Holocene vegetation shifts in the area. The pollen record is supported by seven ¹⁴C datings. The base of the sequence starts in the Middle Holocene, when the outer woodlands were dominated by Corylus avellana together with other components of the Quercetum mixtum. The local establishment of Carpinus betulus occurred at 5700 cal. yr BP with maximum values at around 4900 cal. yr BP. At 4800 cal. yr BP, Fagus sylvatica became locally established and expanded, possibly as a …

Retired Education Professor Authors Book About Cherokee Myths And Legends, Winthrop University

Winthrop News 2014

• Written by Terry L. Norton ’81 and recently released by McFarland Publishers, the 232-page book contains some of the essential folklore of the Eastern Cherokees of western North Carolina.
• From 1981-2008, Norton worked as a professor of literacy education in Winthrop University’s Richard W. Riley College of Education. During his tenure at Winthrop, he taught courses for teachers and librarians in literacy acquisition and children’s and young adult literature.

A Comparative Map Of Seasonal Home Ranges Of Pumas By Sex, Jordan Ellington

Biology Presentations

The Ladder Ranch is a 156,439 acre property located in the southwestern portion of New Mexico. The ranch has a diverse set of biomes from pine forests to desert grasslands which supports a large array of biodiversity (bison to mountain lions to wolves). Ted Turner, the owner of the ranch, largely supports the conservation of its biodiversity, especially mountain lions (Turner Enterprises Inc., 2012). In order to properly conserve this species, the scientific community must first understand what impacts this species. M.M Grigione et al (2002) found that sex, body mass, deer relative abundance, and study site all influence home …

Spartan Daily, December 4, 2014, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily (School of Journalism and Mass Communications)

Volume 143, Issue 39

Kitchenham, Pfleeger, And Garvin's Five Perspectives Of Quality Applied To Theater Ticket Managing Software, Cortney Alyssa Wood

Honors Capstone Projects and Theses

No abstract provided.

Spartanburg Humane Society Data Analysis: Hotspots And Resource Management, Leigh Robertson

Earth and Environmental Sciences Presentations

A data set from the Spartanburg Humane Society was provided with the hope that the use of GIS could show patterns and hotspots of dog and cat pickup locations. With a better understanding of where the majority of the animals come from, the Humane Society can better distribute their man power and resources to help as many homeless animals as possible. According to Beck (1973) the main reasons for stray and abandoned animals is negligence causing pet releases or escapes, and also breeding. Therefore, finding and targeting areas where there are many strays (potentially as a result of a release, …

The Setonian, December 4, 2014, Seton Hall University

2014

No abstract provided.

The Utah Statesman, December 4, 2014, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

Viral Hollywood: How Social Media & Other Emerging Technologies Have Molded The Modern Moviegoing Landscape, Benjamin P. Conniff

Mahurin Honors College Capstone Experience/Thesis Projects

There’s no denying that the rise of the internet has brought about change in the Hollywood landscape. Fans now use social media, like Facebook and Twitter, to share word-of-mouth about movies both good and bad. In a sense, anyone can use these new “spreadable media” to be a critic. I myself took it one step further and started my own film review blog. I was even published in the College Heights Herald student newspaper for over a year! In gauging my audience’s tastes in social media usage and in film, I have uncovered the fact that the hot-button marketing issues …

Curriculum Subcommittee Agenda, December 4, 2014, Utah State University

Educational Policies Committee

Department of Art and Design

• Prerequisite Change
• Prerequisite Change, Remove Repeatable for Credit
• Remove Repeatable for Credit
• Course Number Change, Course Description Change, Prerequisite Change

School of Applied Sciences, Technology and Education

• Prerequisite Change
• Change to Standard Letter Grade

Biological Engineering

• Course No. Change
• Prerequisite Change

Civil and Environmental Engineering

• Prerequisite Change

Electrical and Computer Engineering

• Prerequisite Change

Mechanical & Aerospace Engineering

• Prerequisite Change

History

• Inactivate Course
• Add Multiple List
• New Course
• Title Change
• Remove DHA

Language, Philosophy and Communication Studies

• New Course
• Prerequisite Change

Military Science

• Prerequisite Change

Political Science

• Course Description (there was not one)

Communicative Disorders and …

Curriculum Subcommittee Minutes, December 4, 2014, Utah State University

Educational Policies Committee

Department of Art and Design

• Prerequisite Change
• Remove Repeatable for Credit
• Prerequisite Change, Remove Repeatable for Credit
• Course Number Change, Course Description Change, Prerequisite Change

School of Applied Sciences, Technology and Education

• Prerequisite Change
• Change to Standard Letter Grade

Biological Engineering

• Course No. Change
• Prerequisite Change

Civil and Environmental Engineering

• Prerequisite Change

Electrical and Computer Engineering

• Prerequisite Change

Mechanical & Aerospace Engineering

• Prerequisite Change

History

• Inactivate Course
• Add Multiple List
• New Course
• Title Change
• Remove DHA

Language, Philosophy and Communication Studies

• New Course
• Prerequisite Change

Military Science

• Prerequisite Change

Political Science

• Course Description (there was not one)

Communicative Disorders and …

The Tiger Vol. 108 Issue 43 2014-12-04, Clemson University

Tiger Newspapers

No abstract provided.

Choral Ensembles Holiday Concert, "Hodie Christus Natus Est", Brenda Brent, Sherri N. Barrett, John Thomas Burson, Justin Rowen, David Anders, Michael Lockwood, Melinda Mason, Brittany Griffith, Terrell Flemings, Brian Reid, Cameron Austin, Joseph Donohue, Levi Lyman, Grace Mantelone, Annie Lovvorn, Corinne Veale, Patricia Poulter, Edward Eanes, Chanqueria Grimes, Karen Martin

Bailey School of Music Concert Programs

KSU School of Music presents Choral Ensembles Holiday Concert, "Hodie Christus natus est."

Nông Thôn Mới And Rural Development In The Mekong Delta: A Comparative Study Of Bàu Môn And Hòa Phụng C Hamlets, Alex Lintz

Independent Study Project (ISP) Collection

Vietnam’s Nông Thôn Mới or New Rural Development program is a relatively new target program introduced in 2010. As of yet there has been little research done on its effects on the economies in rural areas. This paper attempts to analyze the economic situation in the Bàu Môn and Hòa Phụng C hamlets with a particular emphasis placed on income and factors that affect income in terms of Vietnam’s Nông Thôn Mới or New Rural Development program. In order to assess the economic situation in the hamlets, a survey was administered to 25 participants in each hamlet and leaders from …

Comparing Disease Prevalence In Hard Corals At Four Different Reefs Near The Island Of Narganá In The Guna Yala Comarca Of Panamá, Connor Hinton

Independent Study Project (ISP) Collection

Coral reefs harbor much of the world’s known marine biodiversity. For a number of reasons, coral reefs are becoming increasingly threatened. Large portions of the world’s reefs have already been lost, and the number of degrading reefs is constantly on the rise. One cause for the destruction of coral reefs are coral diseases, ultimately causing coral mortality. With the death of corals, a key species is lost, endangering the entire reef ecosystem. Documenting the presence of such diseases could be useful in assessing current reef health and ameliorating the growing threat of coral diseases. In this project, 18 40m2 belt …

Microeconomic Analysis Of Socio-Economic Determinants Of Primary School Dropouts In Tanzania: The Case Of Rombo District, Monica Sebastian Kauky

Journal of Humanities and Social Sciences

Based on Professor Maghimbi’s ideas about the expansion of education in the country, this study analyses socio-economic determinants of primary school dropouts in Tanzania. The article employs both qualitative and quantitative design using primary data (cross-section), and the population of interest were children who had dropped out of school, and their parents/heads of the households. A simple logistic regression model was employed for analysis. The study uses the data gathered through semi structured interviews, in-depth interviews, questionnaires and direct observation of phenomena. The results found that the gender of the head of the household, the highest education attained by other …

African Philosophy: A Link Between Traditional And Modern Praise Poetry, Method Samwel

Journal of Humanities and Social Sciences

This article argues that traditional and modern praise poetry do relate. This relationship stems from the fact that the two are similar in several aspects ranging from content to form. Only one similarity among them—similarity in philosophy—is discussed here. The article, therefore, presents how different kinds of African poetry of different generations can never diverge totally from African philosophy. That is to say, both traditional and modern praise poetry carry similar beliefs: how Africans view things is similar in the two kinds of poetry. Traditional praise poetry used here is Bahaya praise poetry, ebyebugo, and the praises seen in Basukuma …

Similar’ Language Contact But ‘Different’ Language Change: Historical Lessons From Loanwords In Tanzanian Bantu Communities, Amani Lusekelo

Journal of Humanities and Social Sciences

This paper contributes to the on-going discussion about integration of foreign cultures into African communities, one of the areas documented by Sam Maghimbi. It articulates the results of human contacts through examination of loanwords for similar semantic notions across Bantu languages of Tanzania. The rationale for this study emanates from a lacuna in previous works that focused on phonological and morphological changes, and undervalued the power of internal semantic modifications that accommodate new concepts. The paper analyses loanwords of individual words that surround three contact areas: western (formal) education, Christian religion, and (modern) healthcare. The paper shows that contact situations …

December 4, 2014, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

2014-12-04 Minutes & Appendices, Longwood University

Board of Visitors Meeting Minutes 1964-

No abstract provided.

Hawks' Herald -- December 4, 2014, Roger Williams University

Hawk's Herald

No abstract provided.

A Quantitative Analysis Of The Value-Enhancing Effects Of Nicotine, Bupropion, And Varenicline In Male And Female Rats, Scott Barrett

Department of Psychology: Dissertations, Theses, and Student Research

Smoking and tobacco dependence are serious health concerns in the United States and globally. Reward via the pharmacological effects of nicotine are believed to be the principal motivating factor that drive tobacco dependence. Research reveals differences in sensitivity between males and females to the motivational effects of nicotine in tobacco use. Enhancement of reinforcement value of non-nicotine rewards contributes to overall nicotine reward. Similar value-enhancing effects have been observed by the two most commonly prescribed smoking cessation aids, bupropion and varenicline. The present dissertation investigated the value-enhancing effects of nicotine, bupropion and varenicline in both male and female rats using …

Analysis Of Drug Interactions With Lipoproteins By High Performance Affinity Chromatography, Matthew R. Sobansky

Department of Chemistry: Dissertations, Theses, and Student Research

High density lipoprotein (HDL), low density lipoprotein (LDL), and very low density lipoprotein (VLDL) are lipoproteins previously shown to bind many basic and neutral hydrophobic drugs in serum. These interactions impact the distribution, delivery, metabolism, and excretion of drugs and are important in determining drug activity, pharmacokinetics, and toxicity in the human body. Information about drug-lipoprotein interactions and the strength of these interactions can be useful in determining the distribution of drugs following administration.

The research presented in this dissertation uses high performance affinity chromatography (HPAC) and packed columns to study binding of the drug propranolol to immobilized lipoproteins such …