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Primary Amoebic Meningoencephalitis Caused By Naegleria Fowleri: An Old Enemy Presenting New Challenges, Ruqaiyyah Siddiqui, Naveed Ahmed Khan

Department of Biological & Biomedical Sciences

First discovered in 1899, Naegleria fowleri is a protist pathogen, known to infect the central nervous system and produce primary amoebic meningoencephalitis. The most distressing aspect is that the fatality rate has remained more than 95%, despite our advances in antimicrobial chemotherapy and supportive care. Although rare worldwide, most cases have been reported in the United States, Australia, and Europe (France). A large number of cases in developing countries go unnoticed. In particular, religious, recreational, and cultural practices such as ritual ablution and/or purifications, Ayurveda, and the use of neti pots for nasal irrigation can contribute to this devastating infection. …

Educating The Whole Child: Evidence Of Health And Wellness Instruction In The Schools Serving Low-Income Students, Andria M. Shook Phd

Dissertations

Educators in the United States are expressing concern about student physical and mental well-being. Childhood obesity has more than doubled in the past three decades, and today, one in five children experiences symptoms of mental illness. Low-income children are especially subject to these conditions. The long-term consequences for the country as a whole are significant. Schools are particularly well placed to address these problems by supporting the well-being of the whole child. Efforts have begun in select schools and districts to incorporate health and wellness instruction into the school day. This study identifies existing health and wellness components that three …

Social Tipping Points And Earth Systems Dynamics, R.A. Bentley, E. Maddison, P. Ranner, J. Bissell, C. Caiado, P. Bhatanacharoen, Timothy Adrian Robert Clark, Botha M., Akinbami F., Hollow M., Michie R., Huntley B., Curtis S., Garnett P.

Research Collection Lee Kong Chian School Of Business

Recently, Early Warning Signals (EWS) have been developed to predict tipping points in Earth Systems. This discussion highlights the potential to apply EWS to human social and economic systems, which may also undergo similar critical transitions. Social tipping points are particularly difficult to predict, however, and the current formulation of EWS, based on a physical system analogy, may be insufficient. As an alternative set of EWS for social systems, we join with other authors encouraging a focus on heterogeneity, connectivity through social networks and individual thresholds to change.

August 2014 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

2014 Utah State University Student Orientation Guide, Utah State University

The Utah Statesman

A special supplemental magazine provided by The Utah Statesman to take a closer look at some of the services and departments available at Utah State University.

An Investigation Of The Soar Study Strategy For Learning From Multiple Online Resources, Tareq Daher

Department of Teaching, Learning, and Teacher Education: Theses and Other Student Research

This dissertation investigated the effects of the SOAR study strategy for learning from multiple online resources. SOAR includes the components of Selection, Organization, Association, and Regulation. In past research, the effects of SOAR training were investigated with one online resource and with students studying provided or partially provided materials following training. This dissertation examines the effects of SOAR when learning from multiple online resources and when students create their own study materials following training and thus addresses this research gap. One hundred thirty-four (134) college students were assigned randomly to the control or experimental groups. All students participated in online …

Vol. 37 No. 2 (2014): Pacific Studies Full Issue, The Jonathan Nāpela Center For Hawaiian And Pacific Islands Studies

Pacific Studies

Pacific Studies is published two times a year by The Jonathan Nāpela Center for Hawaiian and Pacific Studies, Brigham Young University Hawai‘i #1979, 55–220 Kulanui Street, Lāʻie, Hawai‘i 96762, but responsibility for opinions expressed in the articles rests with the authors alone. Subscription rate is US $26.00 yearly, payable to The Jonathan Nāpela Center for Hawaiian and Pacific Studies. The Jonathan Nāpela Center for Hawaiian and Pacific Studies (formerly The Pacific Institute) is an organization funded by Brigham Young University Hawai‘i. The Center assists the University in meeting its cultural and educational goals by undertaking a program of teaching, research, …

The Battle May Be Over, But What About The War? Examining The Esa In The Crusade Against Global Warming After In Re Polar Bear Endangered Species Act Listing And Section 4(D) Rule Litigation, Alanna Kearney

Villanova Environmental Law Journal (1991 - )

No abstract provided.

Benchmarks 2014, August 8, The Rockefeller University

BenchMarks 2014

BenchMarks. Friday, August 8, 2014

The community newsletter of The Rockefeller University

BenchMarks is published monthly and is distributed on the campus of The Rockefeller University. It produced by the Office of Communications and Public Affairs

Effects Of Animal Assisted Therapy On Human Health, Gene Swanson

HIM 1990-2015

The purpose of this thesis is to conduct an integrative review of existing literature focusing on Animal Assisted Therapy (AAT), specifically canines, on human health. The reviewed articles were published between the years of 2000 to 2014, written in the English language, scholarly in nature, in peer-reviewed journals with access to full text electronic versions of the article, along with articles that provided current anecdotal information related to the effects of AAT. Search terms included the phrase, "animal assisted therapy" in the title. Results of the literature search yielded an enormous quantity of recent and innovative research on various aspects …

The Problem Of The Twenty-First Century In The Cherokee Nation Is The Problem Of The Color-Line : How The Cherokee Freedmen Have Articulated A Sense Of Cultural Identity And Citizenship Claims Over Time., Shannon Spears

Electronic Theses and Dissertations

This research investigates the Cherokee Freedmen, who are people of African-American descent and peoples of mixed African-American and Native American descent, who were once enslaved by Cherokees in the Cherokee Nation, and who have articulated their identity and tribal citizenship status as Cherokee Natives in the Cherokee Nation. Upon emancipation, the Cherokee Nation adopted the Cherokee Freedmen as equal citizens in the Cherokee Nation under article nine from the Treaty of 1866, but this changed after citizens were recorded on the Dawes Rolls based upon blood quantum. The theoretical framework of this research is Antonio Gramsci’s theoretical perspective of cultural …

Building A Metabolic Bridge Between Glycolysis And Sphingolipid Biosynthesis : Implications In Cancer., Morgan L. Stathem

Electronic Theses and Dissertations

Cancer therapeutics has seen an emergence and re-emergence of two metabolic fields in recent years, namely bioactive sphingolipids and glycolytic metabolism. Anaerobic glycolysis and its role in cancer has been recognized in cancer biology over 90 years. In recent decades, the role of sphingolipids in cancer cell metabolism has gained recognition, notably ceramide’s essential role in programmed cell death and the role of the glucosylceramide synthase (GCS) in chemotherapeutic resistance. Despite this knowledge, a direct link between these two fields has yet to be concretely drawn. Herein, we show that in a model of highly glycolytic cells, generation of the …

Inducible Tumor Difference Between Rapid And Slow Rat Nat2 Congenic Fischer 344 Rats Administered Methyl-Nitrosourea., Marcus W. Stepp

Electronic Theses and Dissertations

Human arylamine N-acetyltransferase 1 (NAT1) is a well-known phase II metabolic enzyme that has been associated with carcinogenesis. Its role in the biotransformation of aromatic and heterocyclic amine carcinogens has been investigated for many years, but more recent investigations focus on a possible endogenous role of human NAT1 in cancer initiation and progression. We conducted in vivo studies using homozygous Fischer 344 rats, congenic at the rat Nat2 locus for high (rapid) and low (slow) activity. Wistar Kyoto inbred rats were used to breed in the slow activity rat Nat2 locus into the Fischer 344 inbred rat, which contains the …

Effects Of Passive Immobilization On Locomotor Recovery After Spinal Cord Injury In Adult Rats., Kelsey Lee Stipp

Electronic Theses and Dissertations

Background: Spontaneous locomotor recovery in spinal rats has been attributed to animals moving freely in-cage. Environmental enrichment has been shown to increase in-cage movement and functional recovery subsequently. Anxiety has been shown to decrease overnight activity in rats. Methods: Rats were double-housed in medium cages (MC) or single-housed in tiny sized cages (TC). Slotted dividers allowed for partial isolation in TC. Overnight activity was monitored bi-weekly. The open field test and BBB’s were taken weekly. Gait analysis was performed at weeks six and eight. Results: MC showed higher overnight activity and improved gait overtime. No differences were found in BBB …

Penalized Regressions For Variable Selection Model, Single Index Model And An Analysis Of Mass Spectrometry Data., Yubing Wan

Electronic Theses and Dissertations

The focus of this dissertation is to develop statistical methods, under the framework of penalized regressions, to handle three different problems. The first research topic is to address missing data problem for variable selection models including elastic net (ENet) method and sparse partial least squares (SPLS). I proposed a multiple imputation (MI) based weighted ENet (MI-WENet) method based on the stacked MI data and a weighting scheme for each observation. Numerical simulations were implemented to examine the performance of the MIWENet method, and compare it with competing alternatives. I then applied the MI-WENet method to examine the predictors for the …

Entrepreneurial Decision-Making Under Risk : Prospect Theory And Dual-Process Theory., Dalong Ma

Electronic Theses and Dissertations

This research addresses the question of why some people become entrepreneurs whereas others do not. The debate has been going on for decades in entrepreneurship. In this dissertation, I address this question by decomposing it into two related questions. The first question is whether entrepreneurs make different decisions compared to non-entrepreneurs when they are facing the same opportunities under risk. The second question is whether these differences in decision-making (if any) are due to the natural proclivity of entrepreneurs themselves. To identify the differences of entrepreneurial decision-making between entrepreneurs and non-entrepreneurs, this study investigates the nexus between entrepreneurs and opportunities …

Bdnf Maintains Adult Taste Innervation And Is Required For Taste Nerve Regeneration After Injury., Lingbin Meng

Electronic Theses and Dissertations

Brain derived neurotropic factor (BDNF) is required for the gustatory neuron survival,target innervation, and taste bud maintenance during development. However, whether BDNF has any function in the adult gustatory system in normal conditions or after nerve injury is unclear. To address these issues, I inducibly removed BDNF in all cells expressing BDNF in adult mice. In the experimental animals, Bdnf expression decreased to 5% of control mice in the lingual epithelium and geniculate ganglion (p< 0.01) at both two weeks and ten weeks after tamoxifen administration. I found no effect on taste bud morphology at four weeks following Bdnf gene deletion. However, ten weeks following Bdnf gene deletion, P2X3-positive and TUJ1-positive gustatory innervation to individual taste buds was reduced by nearly half (each with p < 0.01) and both taste bud volume and taste cell number decreased 30% (each with p< 0.01). These experiments demonstrate that BDNF is required for maintenance of normal levels of taste innervation and normal taste bud morphology in adulthood. In addition, taste cells expressing PLCß2 (phospholipase C ß2), a marker for taste cells that respond to sweet, bitter and umami, did not decrease after Bdnf gene deletion in the adult. Thus, the missing taste cells are of another type. This indicates that taste cell loss is not uniform across the various taste cell types, even if nearly all taste cell types receive the P2X3 and TUJ1 innervation. Since BDNF is required for initial innervation of the taste system and supports taste bud innervation and size in adulthood, it could also be required for nerve reinnervation after injury. To determine if Bdnf is still expressed following nerve section, the chorda tympani nerve (taste nerve) was sectioned and Bdnf level was detected with Real Time RT-PCR. Bdnf continued to be expressed at normal levels from two days to two months post-surgery in both geniculate ganglion and tongue epithelium. Therefore, BDNF could be involved with chorda tympani regeneration. To determine if this was the case, the Bdnf gene was deleted in adult inducible transgenic mice (under the control of a Ubiquitin promoter) two weeks before chorda tympani nerve section. Taste bud number was reduced by half in all genotypes at two weeks post-surgery (p < 0.01). For the remaining taste buds, gustatory innervation was nearly gone with only a little innervation from the trigeminal nerve remaining in the taste bud (p < 0.01). Taste bud volume (p < 0.01) and taste cell number (p< 0.01) were reduced by half for both control and experimental genotypes. Eight weeks post-surgery, taste bud number recovered in mice without Bdnf gene deletion, but did not recover in mice following Bdnf gene deletion (p < 0.01). Gustatory nerve innervation returned in 70% of the taste buds in control mice (p< 0.01). For those reinnervated taste buds, both taste bud volume and taste cell number increased to normal levels. However, in mice lacking the Bdnf gene, gustatory fibers only reinnervated 7.8% of the taste buds (p < 0.01); for most uninnervated taste buds, both taste bud volume and taste cell number remained small. These experiments demonstrate that BDNF is crucial for promoting regeneration of gustatory nerve fibers in adulthood. Following gustatory nerve section, considerable adult plasticity has been observed on the contralateral side including enlarged taste buds with more cells (Guagliardo and Hill, 2007). To determine if this anatomical change was associated with alter Bdnf expression. I examined Bdnf level in the geniculate ganglion and tongue epithelium on the contralateral side following chorda tympani nerve section. Results showed Bdnf expression increased two fold at two weeks post-surgery in geniculate ganglion on the contralateral side (p < 0.05), indicating BDNF may involve with the observed plastic changes. To determine if the increase in taste bud size was associated with increased innervation and/or regulated by BDNF, the Bdnf gene was then deleted in inducible knockout mice before nerve surgery, and taste bud size and amount of innervation were measured on the contralateral side. The results showed taste bud volume, taste cell number and a marker for nerve fibers all increased on the contralateral side in mice without Bdnf gene deletion at eight weeks post-surgery. This indicates that larger taste buds could be supported by increased TUJ1 positive fibers from trigeminal nerve. In addition, in mice lacking Bdnf, taste bud volume, taste cell number and innervation did not increase on the contralateral side after surgery, which indicates that Bdnf may contribute to larger taste buds on the contralateral side following nerve section by supporting increased innervation to the larger taste buds.

A Novel Diffusion Tensor Imaging-Based Computer-Aided Diagnostic System For Early Diagnosis Of Autism., Mahmoud Mostapha

Electronic Theses and Dissertations

Autism spectrum disorders (ASDs) denote a significant growing public health concern. Currently, one in 68 children has been diagnosed with ASDs in the United States, and most children are diagnosed after the age of four, despite the fact that ASDs can be identified as early as age two. The ultimate goal of this thesis is to develop a computer-aided diagnosis (CAD) system for the accurate and early diagnosis of ASDs using diffusion tensor imaging (DTI). This CAD system consists of three main steps. First, the brain tissues are segmented based on three image descriptors: a visual appearance model that has …

The Second Generation Of The Cccm System For In-Vitro Cardiac Tissue Engineering., Mai-Dung Thi Nguyen

Electronic Theses and Dissertations

Cardiovascular disease is the leading cause of death worldwide. When a myocardial infarction occurs, scar tissue compensates the damaged myocardial tissue. This scar tissue increases the stiffness of the heart tissue, reduces the heart’s function, and finally leads to the heart failure (HF) disease. To have the tissue engraftment, in-vitro cardiac tissue should have the same properties as the native mature cardiac tissue. However, current in-vitro cell culture technologies fail to accurately recreate the in-vivo like mechanically physiological environment for in-vitro cardiac tissue culture, and therefore, fail to regenerate the in-vivo like mature cardiac tissue. Hence, a microfluidic cardiac cell …

Composing College And Career : Mobility, Complexity And Agency At The Nexus Of High School, College And Work., Brice Nordquist

Electronic Theses and Dissertations

This dissertation offers and theorizes findings of a two-year mobile ethnography investigating the complexity of students’ movements within and among secondary and tertiary educational institutions and the labor market. The project illustrates the lateral and recursive natures of students’ educational and occupational trajectories and thereby reveals the mutually constitutive relations among scenes of writing across space and time. While the study follows eleven students moving from different tracks of high school English through their first years at research universities, colleges and full-time jobs, this text focuses specifically on the mobilities of three students: Nadif, Katherine and James. I draw upon …

Mirna-21 Has Anti-Inflammatory Effects In The Macrophage Response To Peritonitis., Rebecca Elise Barnett

Electronic Theses and Dissertations

This project investigated the role of miRNA-21 in the macrophage response to peritonitis; with the goal of understanding whether the associated mechanism has potential benefits in the clinical treatment of peritonitis. A novel therapeutic intervention in the treatment of peritonitis could modulate the host immune response to decrease an exaggerated pro-inflammatory innate response and then prevent or ameliorate the development of sepsis and organ failure. We found the following: 1. MiRNA-21 expression increases in peritoneal macrophages after lipopolysaccharide (LPS) stimulation. 2. Over expression of miRNA-21 decreases TNF-a secretion from macrophages after LPS stimulation. Suppression of miRNA-21 expression results in increased …

Evaluation Of The Safety And Pharmacokinetic Profile Of The Broad Spectrum Antiviral Lectin Griffithsin., Christopher Lynn Barton

Electronic Theses and Dissertations

Carbohydrate binding agents that target viral envelope glycans are being studied for their potential use as microbicides and antiviral therapeutics. Griffithsin is a lectin originally identified in a red alga Griffithisia sp. Multiple studies have shown that GRFT inhibits HIV-1, Coronaviruses, Hepatitis C, influenza and Ebola virus replication in vitro. This antiviral activity suggests potential uses in chemoprophylaxis and disease treatment. However, safety of GRFT administration has not been extensively studied. In vivo testing--chronic subcutaneous treatment as well as single dose subcutaneous, oral, and intravenous administrations of Griffithsin in Sprague Dawley Rats (Rattus Norvegicus)--was used to assess Griffithsin’s pharmacokinetic properties …

An Analysis Of The Potential Effects Of Urbanization On The Water Quality Of The Middle Fork Of Beargrass Creek, Louisville, Kentucky., Olivia Brooks

Electronic Theses and Dissertations

This thesis examined whether water quality diminished as a result of increasing pollution downstream along the Middle Fork of Beargrass Creek, Louisville, Kentucky in response to urbanization. Samples of key water quality indicators/pollutants were collected for 12 weeks (November - January) along the Middle Fork of Beargrass Creek at three different stream gauges. A spatial and statistical analysis was performed to verify any significant correlations between the water quality indicators and pollutants, and whether basin wide landcover/sewer outlet numbers led to an increase in these indicators downstream. Following ANOVA and Kruskal-Wallis statistical testing it was established that turbidity significantly increased …

"My Watch Begins" : Identification And Procedural Rhetoric On Second Screens And Social Networks., K. Shannon Howard

Electronic Theses and Dissertations

Digital rhetoric creates opportunities for examining rhetoric as it evolves daily. This evolution may be described in terms of network circulation and immediate opportunities for publishing and creating. This project analyzes mobile applications and live feeds used during television broadcasts, where rhetoric is closely tied to the work of identifying with another point of view. Producers and designers of dual-screen applications prompt us to answer how we would act if we assumed the role of protagonist and saw the world through her or his eyes. These questions support the idea that identification is not just a relative of empathy or …

Bone Strength And Architecture : Pharmacological Targeting Of Camkk2 As A Method For Enhancing Bone Quality., Zachary James Pritchard

Electronic Theses and Dissertations

Mice lacking or pharmacologically inhibited for calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) have enhanced bone mass and microarchitecture. This enhanced bone mass and architecture is due to changes in osteoblast and osteoclast numbers as well as activity. Whether the enhanced bone mass translated to increased bone quality and strength was further explored by developing a method to directly test the trabecular strength of the distal femur. Micro computed tomography (CT)-based measurement of the length of the epiphysis of the distal femur, aided in its removal, allowing the exposure of the trabecular bone volume used to determine the microarchitecture parameters. Following …

The Powerful Literacy Posse And The Common Core State Standards : A Collection Of Scholarly Papers., Katherine J. Grindon

Electronic Theses and Dissertations

This dissertation is a collection of scholarly papers on the implementation of the English/Language Arts Common Core State Standards (CCSS) and the integration of the standards with critical literacy. The dissertation is divided into five sections, including three papers intended for publication. The first section is the introduction to the dissertation. It explains the context of critical literacy and the CCSS and outlines the study to be conducted. The introduction also explains the three paper format of the collection. The second section explores the integration of critical literacy and the CCSS in one classroom. Through The Advocacy Project, students find …

Michigan's Clay Bluffs: The Description And Comparison Of An Erosion-Dependent Natural Community, Nathaniel G. Fuller

Masters Theses

The clay bluffs of Michigan are a natural community found along the shores of the Great Lakes. Groundwater is found to be critical to sustaining the alkaline wetlands on the face of the bluff as well as the source of most erosion events. The clay bluffs are unusual in their vegetation, disturbance regime and geographical context. This thesis focuses primarily on describing seeping clay bluffs and exploring the comparison to other natural communities. The purpose of this is twofold, to better understand the ways in which natural communities are described as distinct from one another, and to assess the distinctness …

Integrating Art Education And Literacy Education: A Curriculum For The Secondary Level, Erin Moody-Zoet

Masters Theses

The purpose of this paper is to examine, through the design of a new curriculum, how the integration of reading and writing literacy into a visual arts curriculum can strengthen literacy skills as well as foster creative thinking at the middle school level. There is a growing demand for the integration of literacy in all core, and non-core curricula. By developing a curriculum that integrates literacy strategies in a visual arts program, as well as touches on the disconnect that I see between individuals and their own creative outlets, a curriculum is established that fosters and engages students in creative …

A Gross National Happiness Infused Curriculum: The Promise Of A More Meaningful Education In Bhutan, Sonam Zangmo

Masters Theses

Schooling in our modern society is aimed primarily to secure a career so that individuals will find their places in the political and economic systems. However, many believe that education should be reconceived so that student skills and attributes are understood more fully in relation to their impact on the local as well as the global community. The Gross National Happiness infused curriculum aspires to facilitate the holistic education that would address some of the humanistic values we need in this era. In this paper I study the concepts of Gross National Happiness and how the Gross National Happiness infused …

Effects Of Pubertal Status And Number Of Estrous Cycles Prior To Breeding In Beef Heifers, Average Daily Gain On Reproductive Performance And Comparison Of Two Fixed Time Ai Estrus Synchronization Protocols, Rebecca A. Vraspir

Department of Animal Science: Dissertations, Theses, and Student Research

Reproductive success is the most important factor in beef cattle production and is affected by timing of pubertal onset in heifers, and reproductive biotechnologies utilized. Three studies were conducted to evaluate the effects of pubertal status, ADG, and 2 fixed time AI protocols on reproductive success in beef heifers.

In the first study, heifers that were pubertal prior to breeding had a greater AI and overall pregnancy rate; produced more calves born within the first 21 d of the calving season; and weaned older, heavier calves than non-pubertal heifers. Additionally, heifers that had ≥2 estrous cycles, prior to the first …