Entire DC Network | Open Access Articles | Digital Commons Network™

Anti-Apoe Antibody Given After Plaque Onset Decreases Aβ Accumulation And Improves Brain Function In A Mouse Model Of Aβ Amyloidosis, Fan Liao, Adam Q. Bauer, Hong Jiang, Thomas E. Mahan, Katheryn B. Lefton, Tony J. Zhang, Joshua T. Dearborn, Joseph P. Culver, David F. Wozniak, David M. Holtzman, Et Al

Open Access Publications

No abstract provided.

Go to article

Tumor-Induced Stat3 Activation In Monocytic Myeloid-Derived Suppressor Cells Enhances Stemness And Mesenchymal Properties In Human Pancreatic Cancer, Roheena Z. Panni, Dominic E. Sanford, Brian A. Belt, Jonathan B. Mitchem, Lori A. Worley, Brian D. Goetz, Pinku Mukherjee, Andrea Wang-Gillam, Daniel C. Link, David G. Denardo, S. Peter Goedegebuure, David C. Linehan

Open Access Publications

No abstract provided.

Go to article

Altered Microglial Response To Aβ Plaques In Appps1-21 Mice Heterozygous For Trem2, Jason D. Ulrich, Mary Beth Finn, Yaming Wang, Alice Shen, Thomas E. Mahan, Hong Jiang, Floy R. Stewart, Laura Piccio, Marco Colonna, David M. Holtman

Open Access Publications

No abstract provided.

Go to article

Astrocytes Modulate The Polarization Of Cd4+ T Cells To Th1 Cells, Eleonore Beurel, Laurie E. Harrington, William Buchser, Vance Lemmon, Richard S. Jope

Open Access Publications

No abstract provided.

Go to article

Genetic Modulation Of Soluble Aβ Rescues Cognitive And Synaptic Impairment In A Mouse Model Of Alzheimer's Disease, Stephanie W. Fowler, Angie C A Chiang, Ricky R. Savjani, Mathew A. Sherman, Dorothy R. Schuler, Sylvain E. Lesne, Joanna L. Jankowsky, John R. Cirrito

Open Access Publications

No abstract provided.

Go to article

Designing Vaccines To Neutralize Effective Toxin Delivery By Enterotoxigenic Escherichia Coli, James M. Fleckenstein, Alaullah Sheikh

Open Access Publications

No abstract provided.

Go to article

Phosphorylation Of Ribosomal Protein S6 Confers Parp Inhibitor Resistance In Brca1-Deficient Cancers, Chong-Kui Sun, Fan Zhang, Tao Xiang, Qianming Chen, Tej K. Pandita, Yuping Huang, Mickey C T Hu, Qin Yang

Open Access Publications

No abstract provided.

Go to article

Cns Amyloid-Β, Soluble App-Α And-Β Kinetics During Bace Inhibition, Justyna A. Dobrowolska, Bruce W. Patterson, Robert Chott, Vitality Ovod, Yuriy Pyatkivskyy, Kristin R. Wildsmith, Tom Kasten, Kevin E. Yarasheski, Randall J. Bateman, Et Al

Open Access Publications

No abstract provided.

Go to article

Inputs Drive Cell Phenotype Variability, James Park, Anthony Brureau, Kate Kernan, Alexandria Starks, Sonali Gulati, Babatunde Ogunnaike, James Schwaber, Rajanikanth Vadigepalli

Open Access Publications

No abstract provided.

Go to article

A Phase Ii Study Of Dacetuzumab (Sgn-40) In Patients With Relapsed Diffuse Large B-Cell Lymphoma (Dlbcl) And Correlative Analyses Of Patient-Specific Factors, Sven De Vos, Andres Forero-Torres, Stephen M. Ansell, Brad Kahl, Bruce D. Cheson, Nancy L. Bartlett, Richard R. Furman, Jane N. Winter, Henry Kaplan, John Timmerman, Nancy C. Whiting, Jonathan G. Drachman, Ranjana Advani

Open Access Publications

No abstract provided.

Go to article

In Vivo Evaluation Of A Reverse Thermosensitive Polymer For Ureteroscopy With Laser Lithotripsy: Porcine Model, Jonathan M. Mobley, Goutham Vemana, Marshall Strother, Robert Sherburne Figenshau, Joel M. Vetter, Jeffrey Larson, Brian M. Benway

Open Access Publications

No abstract provided.

Go to article

Tibet Orbivirus, A Novel Orbivirus Species Isolated From Anopheles Maculatus Mosquitoes In Tibet, China, Minghua Li, Yayun Zheng, Guoyan Zhao, Shihong Fu, David Wang, Zhiyu Wang, Guodong Liang

Open Access Publications

No abstract provided.

Go to article

A Gene-Based Analysis Of Variants In The Serum/Glucocorticoid Regulated Kinase (Sgk) Genes With Blood Pressure Responses To Sodium Intake: The Gensalt Study, Changwei Li, Xueli Yang, Jiang He, James E. Hixson, Dongfeng Gu, Dabeeru C. Rao, Lawrence C. Shimmin, Jianfeng Huang, Charles C. Gu, Jichun Chen, Jianxin Li, Tanika N. Kelly

Open Access Publications

No abstract provided.

Go to article

The Role Of Muscle Loading On Bone (Re)Modeling At The Developing Enthesis, Alexander M. Tatara, Justin H. Lipner, Rosalina Das, H. Mike Kim, Nikunj Patel, Eleni Ntouvali, Matthew J. Silva, Stavros Thomopoulos

Open Access Publications

No abstract provided.

Go to article

Sirt6 Is Required For Normal Retinal Function, Dafne M. Silberman, Kenneth Ross, Pablo H. Sande, Shunsuke Kubota, Sridhar Ramaswamy, Rajendra S. Apte, Raul Mostoslavsky

Open Access Publications

No abstract provided.

Go to article

Evaluating New Therapies In Gastrointestinal Stromal Tumor Using In Vivo Molecular Optical Imaging, Harvey Hensley, Karthik Devarajan, James R. Johnson, David Piwnica-Worms, Andrew K. Godwin, Margaret Von Mehren, Lori Rink

Open Access Publications

No abstract provided.

Go to article

Heterogeneous Immunological Landscapes And Medieval Plague : An Invitation To A New Dialogue Between Historians And Immunologists., Fabian Crespo, Matthew B. Lawrenz

Faculty and Staff Scholarship

Efforts to understand the differential mortality caused by plague must account for many factors, including human immune responses. In this essay we are particularly interested in those people who were exposed to the Yersinia pestis pathogen during the Black Death, but who had differing fates—survival or death—that could depend on which individuals (once infected) were able to mount an appropriate immune response as a result of biological, environmental, and social factors. The proposed model suggests that historians of the medieval world could make a significant contribution to the study of human health, and especially the role of human immunology in …

Go to article

Genetic Engineering, A Hope For Sustainable Biofuel Production : Review., Sudip Paudel, Michael Menze

Faculty and Staff Scholarship

The use of recently developed genetic engineering tools in combination with organisms that have the potential to produce precursors for the production of biodiesel, promises a sustainable and environment friendly energy source. Enhanced lipid production in wild type and/or genetically engineered organisms can offer sufficient raw material for industrial transesterification of plant-based triglycerides. Bio-diesel, produced with the help of genetically modified organisms, might be one of the best alternatives to fossil fuels and to mitigate various environmental hazards.

Go to article

Leukocyte Recruitment To The Peritoneum Of Cultured Summer Flounder (Paralichthys Dentatus) During Bacterial, Pilar Juliet Nelson

Open Access Master's Theses

Summer flounder (Paralichthys dentatus) constitutes a major fishery in the coastal northeastern United States. Spurred by population declines, cultivation of summer flounder began in 1996, but expansion of culture efforts has been constrained by disease outbreaks. Flounder Infectious Necrotizing Enteritis (FINE) causes significant mortality of juvenile flounder. The disease is characterized by ascites, intestinal prolapse, and severe inflammation of the mesentery and posterior intestinal serosa, often resulting in intestinal rupture. FINE is caused by Vibrio harveyi, a bacterial pathogen of cultured marine fish and invertebrates. To better understand the immune response to FINE, recruitment and fluctuation of …

Go to article

Slow Swimming, Fast Strikes: Effects Of Feeding Behavior On Scaling Of Anaerobic Metabolism In Epipelagic Squid, Lloyd A. Trueblood, Brad A. Seibel

Biological Sciences Faculty Publications

Many pelagic fishes engage prey at high speeds supported by high metabolic rates and anaerobic metabolic capacity. Epipelagic squids are reported to have among the highest metabolic rates in the oceans as a result of demanding foraging strategies and the use of jet propulsion, which is inherently inefficient. This study examined enzymatic proxies of anaerobic metabolism in two species of pelagic squid, Dosidicus gigas and Doryteuthis pealeii (Lesueur 1821), over a size range of six orders of magnitude. We hypothesized that activity of the anaerobically poised enzymes would be high and increase with size as in ecologically similar fishes. In …

Go to article

Partial Pathogen Protection By Tick-Bite Sensitization And Epitope Recognition In Peptide-Immunized Hla Dr3 Transgenic Mice, Wendy M. C. Shattuck, Megan C. Dyer, Joe Desrosiers, Loren D. Fast, Frances E. Terry, William D. Martin, Leonard Moise, Anne S. De Groot, Thomas N. Mather

Institute for Immunology and Informatics Faculty Publications

Ticks are notorious vectors of disease for humans, and many species of ticks transmit multiple pathogens, sometimes in the same tick bite. Accordingly, a broad-spectrum vaccine that targets vector ticks and pathogen transmission at the tick/host interface, rather than multiple vaccines against every possible tickborne pathogen, could become an important tool for resolving an emerging public health crisis. The concept for such a tick protective vaccine comes from observations of an acquired tick resistance (ATR) that can develop in non-natural hosts of ticks following sensitization to tick salivary components. Mice are commonly used as models to study immune responses to …

Go to article

Peptide-Pulsed Dendritic Cells Induce The Hepatitis C Viral Epitope-Specific Responses Of Naïve Human T Cells, Sasmita Mishra, Phyllis T. Losikoff, Alyssa A. Self, Frances Terry, Matthew T. Ardito, Ryan Tassone, William D. Martin, Anne S. De Groot, Stephen H. Gregory

Institute for Immunology and Informatics Faculty Publications

Hepatitis C virus (HCV) is a major cause of liver disease. Spontaneous resolution of infection is associated with broad, MHC class I- (CD8⁺) and class II-restricted (CD4⁺) T cell responses to multiple viral epitopes. Only 20% of patients clear infection spontaneously, however, most develop chronic disease. The response to chemotherapy varies; therapeutic vaccination offers an additional treatment strategy. To date, therapeutic vaccines have demonstrated only limited success in clinical trials. Vector-mediated vaccination with multi-epitope-expressing DNA constructs provides an improved approach. Highly-conserved, HLA-A2-restricted HCV epitopes and HLA-DRB1-restricted immunogenic consensus sequences (ICS, each composed of multiple overlapping and …

Go to article

Tregitope: Immunomodulation Powerhouse, Leslie Cousens, Nader Najafian, William D. Martin, Anne S. De Groot

Institute for Immunology and Informatics Faculty Publications

IVIG is frequently used in the ‘pre-conditioning’ regimens for higher risk transplants; its effects are attributed in part to induction of Tregs. We have identified regulatory T cell (Treg) epitopes, now known as Tregitopes, in IgG, the main component of intravenous immunoglobulin therapy (IVIg). Tregitopes provide one explanation for the expansion and activation of Treg cells following IVIg treatment. Tregitopes are peptides that exhibit high affinity binding to multiple human HLA Class II DR; they are conserved across IgG isotypes and mammalian species. In vitro and in vivo, for human PBMC and in animal models, Tregitopes activate Tregs. Studies to …

Go to article

Human Leptospirosis In The Federated States Of Micronesia: A Hospital-Based Febrile Illness Survey, Susannah Colt, Boris I. Pavlin, Jacob L. Kool, Eliaser Johnson, Judith P. Mccool, Alistair J. Woodward

Cell and Molecular Biology Faculty Publications

Background: Human leptospirosis is an emerging infectious disease of global significance, and is endemic to several countries in the Pacific. Zoonotic transmission dynamics combined with diagnostic challenges lead to difficulties in prevention and identification of cases. The Federated States of Micronesia (FSM) lacks surveillance data for human leptospirosis. This hospital-based serologic survey sought to estimate the burden of leptospirosis, collect information relating to associated factors, and assess the leptospirosis point-of-care rapid diagnostic test (RDT) commonly used in FSM. Methods: A four-month hospital-based survey was conducted in Pohnpei State, FSM in 2011. Patients with undifferentiated fevers presenting to hospital …

Go to article

Transcriptional Regulation Of Neurogenic Atrophy-Induced Gene Expression By Muscle Ring Finger-1 And Myogenic Regulatory Factors, Theodore Olson

UNF Graduate Theses and Dissertations

Skeletal muscle wasting is a consequence of numerous physiological conditions, including denervation, corticosteroid treatment, immobilization, and aging. The E3 ubiquitin ligases, MuRF1 and MAFbx, are induced under nearly all atrophy conditions and are believed to play a key role in protein degradation in atrophying muscle. However, the preliminary data described in this study provides new evidence that MuRF1 may also act as a transcriptional modulator of atrophy-induced gene activity, including the regulation of MAFbx and MuRF1 expression. To characterize the transcriptional regulation of MuRF1 and MAFbx, reporter gene constructs containing fragments of the proximal promoter regions of these genes were …

Go to article

Food For Thought And Thought For Food: Applying Care Ethics To The American Eater, Catherine Manners Bucolo

UNF Graduate Theses and Dissertations

This piece provides an application of care ethics to the typical American diet. In the first chapter, the problems surrounding the Standard American Diet are discussed at both the individual, familial, global, animal, and environmental levels. The second chapter provides an overview of the theoretical components of care ethics, and lays a framework for analysis. The third and final chapter demonstrates how in applying many of the core principles of care, great strides can be made in remedying the numerous problems that are a direct result of typical consumption habits in the United States.

Go to article

Effects Of Osteoarthritis And Chronic Pain Management For Companion Animals, Rebecca A. Cason

Research Papers

No abstract provided.

Go to article

Promoting A Shared Vision: Identifying Intersections Between Food And Fiber Systems Literacy Benchmarks And Illinois State Board Of Education Standards, Daniel P. Ingold Mr.

Research Papers

Understanding of agricultural systems has been an accepted and necessary aspect of a child’s education for centuries. Conventional agricultural education has proven effective in creating well-trained agricultural professionals and scholars, but has had the unintentional effect of limiting access to agricultural concepts to the non-agricultural student. This effect has potentially negative cultural consequences considering the importance agricultural issues. In response, agricultural educators have carried out an initiative to promote agricultural literacy in the classroom through an integration of agricultural concepts into core curriculum. A Guide to Food and Fiber Systems Literacy Benchmarks (Leising, 1998) is an example of programs that …

Go to article

Modification And Optimization Of A Gaussian Noise Generation System For The Study Of Noise-Induced Hearing Loss, Kelly Wepsiec

Research Papers

No abstract provided.

Go to article

The Effects Of Sampling Design On Abundance And Distribution Of Bottlenose Dolphins In The St. Johns River, Florida, Samantha Ryanne Nekolny

UNF Graduate Theses and Dissertations

The National Oceanic and Atmospheric Administration (NOAA) is tasked with upholding the regulations prescribed in the Marine Mammal Protection Act of 1972. One of the ways this is accomplished is by producing regular stock assessment reports. For these reports, knowledge about a species abundance and distribution is a vital component, allowing informed management decisions to be made that may potentially reduce the natural and anthropogenic impacts on the organisms. In 2010, an Unusual Mortality Event (UME) occurred in the lower St. Johns River, resulting in an unusually large number of bottlenose dolphin strandings. As the data regarding this population was …

Go to article

Full-Text Articles in Entire DC Network

Open Access Publications

Open Access Publications

Altered Microglial Response To Aβ Plaques In Appps1-21 Mice Heterozygous For Trem2, Jason D. Ulrich, Mary Beth Finn, Yaming Wang, Alice Shen, Thomas E. Mahan, Hong Jiang, Floy R. Stewart, Laura Piccio, Marco Colonna, David M. Holtman

Open Access Publications

Astrocytes Modulate The Polarization Of Cd4+ T Cells To Th1 Cells, Eleonore Beurel, Laurie E. Harrington, William Buchser, Vance Lemmon, Richard S. Jope

Open Access Publications

Genetic Modulation Of Soluble Aβ Rescues Cognitive And Synaptic Impairment In A Mouse Model Of Alzheimer's Disease, Stephanie W. Fowler, Angie C A Chiang, Ricky R. Savjani, Mathew A. Sherman, Dorothy R. Schuler, Sylvain E. Lesne, Joanna L. Jankowsky, John R. Cirrito

Open Access Publications

Designing Vaccines To Neutralize Effective Toxin Delivery By Enterotoxigenic Escherichia Coli, James M. Fleckenstein, Alaullah Sheikh

Open Access Publications

Phosphorylation Of Ribosomal Protein S6 Confers Parp Inhibitor Resistance In Brca1-Deficient Cancers, Chong-Kui Sun, Fan Zhang, Tao Xiang, Qianming Chen, Tej K. Pandita, Yuping Huang, Mickey C T Hu, Qin Yang

Open Access Publications

Cns Amyloid-Β, Soluble App-Α And-Β Kinetics During Bace Inhibition, Justyna A. Dobrowolska, Bruce W. Patterson, Robert Chott, Vitality Ovod, Yuriy Pyatkivskyy, Kristin R. Wildsmith, Tom Kasten, Kevin E. Yarasheski, Randall J. Bateman, Et Al

Open Access Publications

Inputs Drive Cell Phenotype Variability, James Park, Anthony Brureau, Kate Kernan, Alexandria Starks, Sonali Gulati, Babatunde Ogunnaike, James Schwaber, Rajanikanth Vadigepalli

Open Access Publications

Open Access Publications

In Vivo Evaluation Of A Reverse Thermosensitive Polymer For Ureteroscopy With Laser Lithotripsy: Porcine Model, Jonathan M. Mobley, Goutham Vemana, Marshall Strother, Robert Sherburne Figenshau, Joel M. Vetter, Jeffrey Larson, Brian M. Benway

Open Access Publications

Tibet Orbivirus, A Novel Orbivirus Species Isolated From Anopheles Maculatus Mosquitoes In Tibet, China, Minghua Li, Yayun Zheng, Guoyan Zhao, Shihong Fu, David Wang, Zhiyu Wang, Guodong Liang

Open Access Publications

Open Access Publications

The Role Of Muscle Loading On Bone (Re)Modeling At The Developing Enthesis, Alexander M. Tatara, Justin H. Lipner, Rosalina Das, H. Mike Kim, Nikunj Patel, Eleni Ntouvali, Matthew J. Silva, Stavros Thomopoulos

Open Access Publications

Sirt6 Is Required For Normal Retinal Function, Dafne M. Silberman, Kenneth Ross, Pablo H. Sande, Shunsuke Kubota, Sridhar Ramaswamy, Rajendra S. Apte, Raul Mostoslavsky

Open Access Publications

Evaluating New Therapies In Gastrointestinal Stromal Tumor Using In Vivo Molecular Optical Imaging, Harvey Hensley, Karthik Devarajan, James R. Johnson, David Piwnica-Worms, Andrew K. Godwin, Margaret Von Mehren, Lori Rink

Open Access Publications

Heterogeneous Immunological Landscapes And Medieval Plague : An Invitation To A New Dialogue Between Historians And Immunologists., Fabian Crespo, Matthew B. Lawrenz

Faculty and Staff Scholarship

Genetic Engineering, A Hope For Sustainable Biofuel Production : Review., Sudip Paudel, Michael Menze

Faculty and Staff Scholarship

Leukocyte Recruitment To The Peritoneum Of Cultured Summer Flounder (Paralichthys Dentatus) During Bacterial, Pilar Juliet Nelson

Open Access Master's Theses

Slow Swimming, Fast Strikes: Effects Of Feeding Behavior On Scaling Of Anaerobic Metabolism In Epipelagic Squid, Lloyd A. Trueblood, Brad A. Seibel

Biological Sciences Faculty Publications

Partial Pathogen Protection By Tick-Bite Sensitization And Epitope Recognition In Peptide-Immunized Hla Dr3 Transgenic Mice, Wendy M. C. Shattuck, Megan C. Dyer, Joe Desrosiers, Loren D. Fast, Frances E. Terry, William D. Martin, Leonard Moise, Anne S. De Groot, Thomas N. Mather

Institute for Immunology and Informatics Faculty Publications

Peptide-Pulsed Dendritic Cells Induce The Hepatitis C Viral Epitope-Specific Responses Of Naïve Human T Cells, Sasmita Mishra, Phyllis T. Losikoff, Alyssa A. Self, Frances Terry, Matthew T. Ardito, Ryan Tassone, William D. Martin, Anne S. De Groot, Stephen H. Gregory

Institute for Immunology and Informatics Faculty Publications

Tregitope: Immunomodulation Powerhouse, Leslie Cousens, Nader Najafian, William D. Martin, Anne S. De Groot

Institute for Immunology and Informatics Faculty Publications

Human Leptospirosis In The Federated States Of Micronesia: A Hospital-Based Febrile Illness Survey, Susannah Colt, Boris I. Pavlin, Jacob L. Kool, Eliaser Johnson, Judith P. Mccool, Alistair J. Woodward

Cell and Molecular Biology Faculty Publications

Transcriptional Regulation Of Neurogenic Atrophy-Induced Gene Expression By Muscle Ring Finger-1 And Myogenic Regulatory Factors, Theodore Olson

UNF Graduate Theses and Dissertations

Food For Thought And Thought For Food: Applying Care Ethics To The American Eater, Catherine Manners Bucolo

UNF Graduate Theses and Dissertations

Effects Of Osteoarthritis And Chronic Pain Management For Companion Animals, Rebecca A. Cason

Research Papers

Promoting A Shared Vision: Identifying Intersections Between Food And Fiber Systems Literacy Benchmarks And Illinois State Board Of Education Standards, Daniel P. Ingold Mr.

Research Papers

Modification And Optimization Of A Gaussian Noise Generation System For The Study Of Noise-Induced Hearing Loss, Kelly Wepsiec

Research Papers

The Effects Of Sampling Design On Abundance And Distribution Of Bottlenose Dolphins In The St. Johns River, Florida, Samantha Ryanne Nekolny

UNF Graduate Theses and Dissertations