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2014

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Effects Of Early Life Exposure To Methylmercury On Predator Response In Daphnia Pulex, Megan Lisa Steed Jan 2014

Effects Of Early Life Exposure To Methylmercury On Predator Response In Daphnia Pulex, Megan Lisa Steed

All ETDs from UAB

Knowledge of the health effects of toxic chemicals is largely based on single chemical models rather than a multi-factor model, which more accurately captures realworld exposures. This study investigated how methylmercury affects Daphnia pulex in the presence of predatory stress chemical. A kairomone is an infochemical released by an animal that can be detected by another animal. Daphnia pulex detects kairomone released by Danio rerio resulting in the induction of morphological and life history changes. Danio rerio were kept in COMBO media for 24 hours at a density of 2 fish per liter. Daphnids were then housed in kairomone-containing COMBO …

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Translocation Of Shed Syndecan-1 To The Nucleus: A Novel Mechanism Of Tumor-Host Crosstalk, Mark Stewart Jan 2014

Translocation Of Shed Syndecan-1 To The Nucleus: A Novel Mechanism Of Tumor-Host Crosstalk, Mark Stewart

All ETDs from UAB

Multiple myeloma is a hematological malignancy of plasma cells that disseminates throughout the body. Crosstalk between myeloma and host cells is critical to the establishment of a microenvironment conducive to tumor growth and progression. An important mediator of this crosstalk is syndecan-1, a heparan sulfate proteoglycan. Syndecan-1 is proteolytically shed from the surface of myeloma cells and is abundant in the bone marrow microenvironment and serum of myeloma patients. Shed syndecan-1 facilitates tumor-host crosstalk within the microenvironment to drive tumor growth, angiogenesis, and metastasis. We now report for the first time that shed syndecan-1 can be taken up by a …

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Usp16 And Histone H2a Deubiquitination In Mouse Embryonic Stem Cell Function, Wei Yang Jan 2014

Usp16 And Histone H2a Deubiquitination In Mouse Embryonic Stem Cell Function, Wei Yang

All ETDs from UAB

In eukaryotic cells, genomic DNA is packaged into a chromatin structure by association with histone and non-histone proteins. Posttranslational modifications of histones play important roles in the regulation of chromatin structure and function. Ubiquitination of histone H2A (ubH2A) represents a predominate modification, occurring on ~10% of total cellular H2A. While H2A ubiquitination is primarily conferred by Polycomb Repressive Complex 1 (PRC1), H2A deubiquitination has been attributed to multiple H2A deubiquitinases. Our laboratory previously reported the purification and functional characterization of a H2A-specific deubiquitinase, USP16 (initially named as Ubp-M) in human cells. However, whether USP16 represents a general and important regulator …

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The Roles Of Mammalian Tribbles Homolog 3 (Trib3) In Coordinating Energy Metabolism And Development Of Insulin Resistance, Wei Zhang Jan 2014

The Roles Of Mammalian Tribbles Homolog 3 (Trib3) In Coordinating Energy Metabolism And Development Of Insulin Resistance, Wei Zhang

All ETDs from UAB

Insulin resistance in diabetics comprises of a reversible component treatable with intensive glycemic control and a non-reversible component present in pre-diabetes that may lead to the development of overt diabetes. The reversible component is induced and exacerbated by hyperglycemia in both uncontrolled type 1 and type 2 diabetes, a process known as glucose-induced insulin resistance (GIIR) or glucose toxicity. The tribbles homolog 3 (TRIB3) has been identified as a pseudokinase that inhibits Akt activity by physically blocking its phosphorylation site. Expression of TRIB3 has been associated with various signals such as endoplasmic reticulum (ER) stress and nutrient availability in pancreatic …

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Truth And Magic, Kylie Adkins Jan 2014

Truth And Magic, Kylie Adkins

Honors Capstones

No abstract provided.

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A Low-Power Multichannel Telemetry System For High-Speed Wireless Neural Recordings, Yang-Guo Li Jan 2014

A Low-Power Multichannel Telemetry System For High-Speed Wireless Neural Recordings, Yang-Guo Li

All ETDs from UAB

The advances in microelectronics and wireless communication are going to change our lifestyles and benefit our healthcare system in the foreseeable future. New conception named "Ubiquitous Healthcare" has been proposed. It envisions a continuous, real-time, remote monitoring on the health conditions of people through the wireless communication network. Traditional biosignal monitoring devices need wire-connections for the recording, which may cause skin rupture and body infection. The physical connections also limited the number of the integrated recording channels. A low-power implantable multichannel telemetry system which can be implanted in the body and transmit recordings wirelessly can solve the problem of the …

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Expression Of The Influenza Protein M2 During Viral Infection Inhibits Cftr Activity, James David Londino Jan 2014

Expression Of The Influenza Protein M2 During Viral Infection Inhibits Cftr Activity, James David Londino

All ETDs from UAB

The purpose of these dissertation studies was to 1) determine whether influenza infection alters CFTR activity in polarized epithelium; 2) measure CFTR expression and activity in cells co-expressing influenza M2 protein; and 3) examine the role of M2 on the alteration of CFTR during viral infection. We determined that infection of polarized primary epithelial cells with influenza decreases CFTR expression and activity. In addition, individual cells infected with influenza had decreased CFTR conductance as measured by whole-cell patch clamp. We also found that the influenza ion channel, matrix protein 2 (M2), alone reduced CFTR expression and activity. M2 is expressed …

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Interaction Between A Low-Iron Diet And Early-Life Methylmercury Exposure In Daphnia Pulex, Sherri Hudson Jan 2014

Interaction Between A Low-Iron Diet And Early-Life Methylmercury Exposure In Daphnia Pulex, Sherri Hudson

All ETDs from UAB

Methylmercury (MeHg) is a known neurotoxicant and bioaccumulates in fish, with exposure to humans in utero being of highest concern. Iron deficiency (ID) accounts for approximately 50% of anemia cases. Anemia is estimated to affect 1.62 billion people worldwide, and is particularly problematic during pregnancy and early life. Previous studies have shown that ID exacerbates toxicity associated with exposure to metals, including lead, manganese, and cadmium. The overall purpose of this thesis research is to investigate the interaction between a low-iron (Fe) diet and early-life exposure to MeHg in Daphnia pulex. I hypothesized when D. pulex are fed a low-Fe …

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Starlings Fell On Alabama, Sarah Hayden Jennings Jan 2014

Starlings Fell On Alabama, Sarah Hayden Jennings

All ETDs from UAB

Starlings Fell on Alabama is a collection of stories that explores the impact of relationships. The characters in this collection have been deeply affected by another person or are affecting another person. They are all in the grip of deep psychological and emotional turmoil as they deal with loss, desire, illness, and grief. And in order to find themselves, Walter, Louise, Robin, and Rose must confront their invisible tethers. Some will find a way to exist without those tethers, those relationships, and others will find themselves pulled deeper into the connections that sustain them.

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Automatic Elections, Michael M. Oswalt Jan 2014

Automatic Elections, Michael M. Oswalt

Faculty Articles, Papers, and Other Scholarship

The idea that the right mix of conditions will spark workers to engage in mass collective action is a theme sometimes invoked by labor movement writers, activists, and reformers. It is also an assumption found — and intentionally embedded — in labor law’s basic statutory system for forming a union. To establish a certified bargaining representative under the National Labor Relations Act (NLRA), a group of workers must first get together and petition the government for the right to vote for the union in a secret ballot election. While the fact that the law predicates elections on stirrings of collective …

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An Investigation Into Ground Effect For An Underwater Biologically Inspired Flapping Foil, Paulstephen Chierico Jan 2014

An Investigation Into Ground Effect For An Underwater Biologically Inspired Flapping Foil, Paulstephen Chierico

Open Access Master's Theses

The topic that was investigated was whether there is a lift and thrust benefit to flapping an underwater, biologically inspired three dimensional foil near the solid bottom surface (so that it was in ground effect). The experimental method used a dual canister device that allowed actuation in roll and pitch, with force sensors attached to the pitch shaft, in order to record the forces produced by the foil as it flapped. The dual canister was towed on a carriage at a constant speed in a large tow tank that had been configured to have a long run of constant, deep …

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Review: Russian Case Morphology And The Syntactic Categories, John Frederick Bailyn Jan 2014

Review: Russian Case Morphology And The Syntactic Categories, John Frederick Bailyn

Russian Language Journal

David Pesetsky’s Russian Case Morphology and the Syntactic Categories (MIT Press, 2013) is one of the most thought-provoking works of theoretical linguistics to appear in many years. It provides a startlingly original analysis of a well-known thorny problem of Russian morpho-syntax, embedding the analysis of that puzzle within a radical rethinking of the role of case in syntactic theory, and taking us on a journey of consequences and extensions that challenge one’s views of many aspects of minimalist theory, including key components of case theory, phrase structure, locality and others. If a monograph is to be judged by its creativity, …

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The Unrelenting Libertarian Challenge To Public Accommodations Law, Samuel R. Bagenstos Jan 2014

The Unrelenting Libertarian Challenge To Public Accommodations Law, Samuel R. Bagenstos

Articles

There seems to be a broad consensus that Title II of the Civil Rights Act of 1964, which prohibits race discrimination in “place[s] of public accommodation,” was a remarkable success. But the consensus is illusory. Laws prohibiting discrimination by public accommodations currently exist under a significant legal threat. And this threat is merely the latest iteration in the controversy over public accommodations laws that began as early as Reconstruction. This Article begins by discussing the controversy in the Reconstruction and Civil Rights Eras over the penetration of antidiscrimination principles into the realm of private businesses’ choice of customers. Although the …

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Genetically Modified Crops: Why Cultivation Matters, Hilary Weiss Jan 2014

Genetically Modified Crops: Why Cultivation Matters, Hilary Weiss

Brooklyn Journal of International Law

No abstract provided.

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Flemming Rose's Rejection Of The American Free Speech Canon And The Poverty Of Comparative Constitutional Theory, Robert A. Kahn Jan 2014

Flemming Rose's Rejection Of The American Free Speech Canon And The Poverty Of Comparative Constitutional Theory, Robert A. Kahn

Brooklyn Journal of International Law

No abstract provided.

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Ending Blind Spot Justice: Broadening The Transparency Trend In International Arbitration, Robert Argen Jan 2014

Ending Blind Spot Justice: Broadening The Transparency Trend In International Arbitration, Robert Argen

Brooklyn Journal of International Law

No abstract provided.

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Adapting Like The Animals: The Endangered Species Act As A Model For Human Adaptation To Climate Change, Meghan C. Boland Jan 2014

Adapting Like The Animals: The Endangered Species Act As A Model For Human Adaptation To Climate Change, Meghan C. Boland

Brooklyn Journal of International Law

No abstract provided.

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Bringing Down The Island: Rebellion, Colonial Hierarchy, And Individualized Leadership In Nuñez’S Novel Prospero’S Daughter, Kristin M.S. Bezio Jan 2014

Bringing Down The Island: Rebellion, Colonial Hierarchy, And Individualized Leadership In Nuñez’S Novel Prospero’S Daughter, Kristin M.S. Bezio

Jepson School of Leadership Studies articles, book chapters and other publications

“Bringing Down the Island: Rebellion, Colonial Hierarchy, and Individualized Leadership in Nuñez’s novel Prospero’s Daughter” offers an analysis of Elizabeth Nuñez’s (2006) novel Prospero’s Daughter and Aimé Césaire’s A Tempest (1969), both of which draw upon multicultural tradition of European and Caribbean literatures, retelling Shakespeare’s The Tempest (1611). The paper is concerned with the ways in which leadership has been transformed from the original story, through Césaire’s text, and into Nuñez’s. Each work acts as an agent of leadership in literary and social terms, attempting to enact paradigmatic shifts away from hierarchy and classification and toward individualized transformational leadership.

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Legal And Economic Development With Sui Generis Chinese Characteristics: A Systems Theorist's Perspective, Dr. Xiao Li Jan 2014

Legal And Economic Development With Sui Generis Chinese Characteristics: A Systems Theorist's Perspective, Dr. Xiao Li

Brooklyn Journal of International Law

No abstract provided.

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Posthumous Reputation And Posthumous Privacy In China: The Dead, The Law, And Social Transition, Dr. Bo Zhao Jan 2014

Posthumous Reputation And Posthumous Privacy In China: The Dead, The Law, And Social Transition, Dr. Bo Zhao

Brooklyn Journal of International Law

No abstract provided.

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"Asleep At The Switch"? The Need To Hold Sophisticated Creditors To Higher Standards In Chapter 11, Liana-Marie Lien Jan 2014

"Asleep At The Switch"? The Need To Hold Sophisticated Creditors To Higher Standards In Chapter 11, Liana-Marie Lien

Brooklyn Journal of Corporate, Financial & Commercial Law

No abstract provided.

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Silos: Establishing The Distributional Baseline In Cross-Border Bankruptcies, Edward J. Janger Jan 2014

Silos: Establishing The Distributional Baseline In Cross-Border Bankruptcies, Edward J. Janger

Brooklyn Journal of Corporate, Financial & Commercial Law

No abstract provided.

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Beyond Carve-Outs And Toward Reliance: A Normative Framework For Cross-Border Insolvency Choice Of Law, John A. E. Pottow Jan 2014

Beyond Carve-Outs And Toward Reliance: A Normative Framework For Cross-Border Insolvency Choice Of Law, John A. E. Pottow

Brooklyn Journal of Corporate, Financial & Commercial Law

No abstract provided.

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First Report Of Satellite Males During Breeding In Leptodactylus Latrans (Amphibia, Anura), Gabriel Laufer, Noelia Gobel, José M. Mautone, María Galán, Rafael O. De Sá Jan 2014

First Report Of Satellite Males During Breeding In Leptodactylus Latrans (Amphibia, Anura), Gabriel Laufer, Noelia Gobel, José M. Mautone, María Galán, Rafael O. De Sá

Biology Faculty Publications

Individual males can adopt alternative mating tactics. The occurrence of satellite males is a common behaviour across anuran taxa (e.g., Lithobates clamitans, Wells, 1977; Anaxyrus cognatus, Krupa, 1989; Dendropsophus ebraccatus, Miyamoto and Cane, 1980; Rhinella crucifer, Forester and Lynken, 1986). Satellite males take peripheral positions to calling males, and adopt alternate mating tactics in an attempt to intercept females that are attracted to calling males (Wells, 2007) to increase their own mating success. Satellite males could have an inexpensive form of mate-locating, avoiding predators, and saving energy (Arak, 1983). Furthermore, this strategy could play an important role in the genetic …

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Picturesque Violence: Tourism, The Film Industry, And The Heritagization Of ‘Bandoleros’ In Spain, 1905–1936, Eugenia Afinoguénova, Eduardo Rodríguez Merchán Jan 2014

Picturesque Violence: Tourism, The Film Industry, And The Heritagization Of ‘Bandoleros’ In Spain, 1905–1936, Eugenia Afinoguénova, Eduardo Rodríguez Merchán

Spanish Languages and Literatures Research and Publications

This article examines the debates about the Andalusian ‘bandoleros’ (bandits) in the context of early tourism as a state-guided policy in Spain. As we argue, the development of tourism made Spanish intellectuals reconsider the real armed activity in Andalucía as part of Spanish national heritage and a tourist attraction. Consistent with the stereotypical image of Spain coined by the Romantic travelers, such an early heritagization of brigandry reveals the role of the élites in recasting exotic imagery into modern tourism-shaped identities: in the hands of early century writers, bandits were reshaped as part of the ‘modern picturesque’. Furthermore, the role …

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What Cognitive Dissonance Tells Us About Tone In Persuasion, Kathryn Stanchi Jan 2014

What Cognitive Dissonance Tells Us About Tone In Persuasion, Kathryn Stanchi

Journal of Law and Policy

No abstract provided.

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Drugs: You Use, You Gain? Why Courts Should Uphold Long-Term Disability Benefits For Recovering Addicts, Gregory M. Juell Jan 2014

Drugs: You Use, You Gain? Why Courts Should Uphold Long-Term Disability Benefits For Recovering Addicts, Gregory M. Juell

Journal of Law and Policy

No abstract provided.

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Research And The Professional : Navigating A Spectrum Of Legal Resources., Erin K Gow Jan 2014

Research And The Professional : Navigating A Spectrum Of Legal Resources., Erin K Gow

Faculty and Staff Scholarship

Legal research is complicated by the growing amount of information available, and there is evidence that legal practitioners require additional training in order to enhance their information literacy and legal research skills. Librarians have a key role to play in developing legal research training, and examples taken from Middle Temple's library are used to illustrate ways in which librarians can offer beneficial training to their library users. This involves assessing the skills, motivation, and needs of the average library user in order to design legal research training that is educationally sound and appealing to the target audience.

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And By The Grace Of God, We'll Travel West, Aaron White Jan 2014

And By The Grace Of God, We'll Travel West, Aaron White

Masters Theses

No abstract provided.

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The Effects Of Theophylline And 8-Cyclopentyltheophylline On The Respiratory Response To Carbon Dioxide In Neonatal Rats, Christine E. Albers Jan 2014

The Effects Of Theophylline And 8-Cyclopentyltheophylline On The Respiratory Response To Carbon Dioxide In Neonatal Rats, Christine E. Albers

Masters Theses

Premature infants are often plagued with respiration problems ranging from periodic breathing to apnea. These respiratory complications can be a result of underdeveloped respiratory organs, immaturity of the brainstem respiratory control center, genetic irregularities, or a combination of all three. This study sought to increase respiration with the administration of methylxanthines, which are respiratory stimulants, coupled with carbon dioxide (CO2), also a respiratory stimulant. Neonatal rats aged 4 to 7 days old were used to mimic premature infants' response to the interaction of methylxanthines and CO2. Before beginning the respiratory studies, sections of a 4- and …

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